Hicabi Sezgin - Academia.edu (original) (raw)

Papers by Hicabi Sezgin

Jinekoloji Obstetrik Pediatri ve Pediatrik Cerrahi Dergisi, 2013

Nigerian Journal of Clinical Practice, 2017

Introduction: This study is aimed to assess the functional results of cases with lower extremity ... more Introduction: This study is aimed to assess the functional results of cases with lower extremity malignant and metastatic bone tumours that were treated with modular tumour resection prostheses. Materials and Methods: 49 patients were retrospectively examined. 27 (55.1%) patients had a primary bone tumour, and 22 (44.9%) had a metastatic bone tumour. Although most tumours located in the proximal femur were metastatic, tumours located around the knee were mostly primary malignant bone tumours. The functional assessments of our patients were made according to the Musculoskeletal Tumour Society (MSTS) scoring system. The Student's t-test and the Chi-square test were used for statistical analyses. Results: 30 (61.2%) of the patients were men, and 19 (38.8%) were women. The average age was 46.2 ± 1.9 years. Tumours were located in the proximal femur in 27 (55.1%) patients, distal femur in 16 (32.7%) patients and proximal tibia in 6 (12.2%) patients. 14 (28.6%) patients had a pathological fracture on admission. The average follow-up period of our patients was 27.4 ± 3.4 months, and the average MSTS score was 74.3 ± 13%. Complications developed at any time in 34.7% of the patients, and the most common symptoms were aseptic loosening (8.2%) and prosthesis infection (8.2%). Local relapse was found in one (2%) patient. The 5-year survival rate was 68.3% in patients with a primary tumour and 30% in patients with a metastatic tumour. Conclusion: Although endoprosthesis reconstruction had advantages of giving very good functional results in the early phases, it was found to cause mechanical complications, especially in patients with primary bone tumours during the mid and late phases.

Turkish Journal of Pediatrics

This study aimed to evaluate pediatric cases treated surgically for an initial diagnosis of bone ... more This study aimed to evaluate pediatric cases treated surgically for an initial diagnosis of bone and soft tissue tumor between January 1987 and January 2012. This retrospective study evaluated 328 patients with pathologically confirmed tumor from a total of 374 patients hospitalized with an initial diagnosis of tumor. The cases were analyzed with respect to frequency, age, gender, and localization. One hundred and eighty (54.8%) males and 148 (45.2%) females, with a mean age of 13 years (range: 1-18 years), were included in the study. The tumors were determined as 258 (78.6%) bone tumors and 70 (21.4%) soft tissue tumors. The most common benign bone tumor was observed to be osteochondroma (n=61, 30.7%), and the most common malignant bone tumor was osteosarcoma (n=31, 52.6%). The most common benign soft tissue tumor was hemangioma, which is a vascular tumor (n=28, 43.8%), and the most common malignant soft tissue tumor was rhabdomyosarcoma (n=5, 83.3%). It is thought that similar stu...

Distribution of pediatric bone and soft tissue tumors in the central Black

DÜMF Mühendislik Dergisi, 2020

Amac: Travmatik anterior omuz instabilitesi cerrahi tedavisinde acik ve artroskopik Bankart tamir... more Amac: Travmatik anterior omuz instabilitesi cerrahi tedavisinde acik ve artroskopik Bankart tamirinin klinik sonuclarinin karsilastirilmasi amaclandi. Materyal ve Metod: Ocak 2005 ile Ocak 2013 yillari arasinda tekrarlayan anterior omuz instabilitesi nedeniyle cerrahi tedavi uygulanan 23 hastadan son kontrolleri yapilan 20 hasta (17 erkek, 3 kadin) calismaya dahil edildi. Hastalarin 10’una (ort. yas 30, dagilim 17-43) acik Bankart tamiri, 10’una (ort. yas 21, dagilim 18-49) artroskopik Bankart tamiri uygulandi. Agri degerlendirmesi vizuel analog skalasina (VAS) gore yapilirken klinik sonuclar Rowe skalasi kullanilarak degerlendirildi. Ameliyat sonrasi ortalama takip suresi acik tamir grubunda 37.4±27.1 ay iken, artroskopik tamir grubunda 23±6.9 ay idi. Istatistiksel degerlendirmede Shapiro-Wilk testi ile Mann-Whitney U testi kullanildi. Bulgular: VAS skoru acik tamir grubunda 5.7±2.5, artroskopik tamir grubunda 4.1±1.9, Rowe skoru acik tamir grubunda 97.5 (dagilim 80-100), artroskop...

OBJECTIVE The purpose of this study was to determine cutoff scores for the Biodex Balance System ... more OBJECTIVE The purpose of this study was to determine cutoff scores for the Biodex Balance System (BBS) and verify if they could be used to discriminate older people with nonspecific low back pain (NSLBP) with poor postural performance from those with good postural performance. METHODS This cross-sectional study included 52 participants with NSLBP older than 65 years. One level of stability (level 5; intraclass correlation ≥0.70) and 2 conditions (eyes open and eyes closed) were selected for the testing procedure. Anterior-posterior stability index (APSI), medial-lateral stability index (MLSI), and overall stability index (OSI) scores were calculated. The participants were classified into 2 groups: high risk of falling and low risk of falling. Both the receiver operating characteristic and the area under the curve were used to determine the best BBS cutoff values. Binary logistic regression analysis was used to investigate the ability of BBS scores to predict risk of falling. RESULTS...

OZET Amac: Travmatik anterior omuz instabilitesi cerrahi tedavisinde acik ve artroskopik Bankart ... more OZET Amac: Travmatik anterior omuz instabilitesi cerrahi tedavisinde acik ve artroskopik Bankart tamirinin klinik sonuclarinin karsilastirilmasi amaclandi. Materyal ve Metod: Ocak 2005 ile Ocak 2013 yillari arasinda tekrarlayan anterior omuz instabilitesi nedeniyle cerrahi tedavi uygulanan 23 hastadan son kontrolleri yapilan 20 hasta (17 erkek, 3 kadin) calismaya dahil edildi. Hastalarin 10’una (ort. yas 30, dagilim 17-43) acik Bankart tamiri, 10’una (ort. yas 21, dagilim 18-49) artroskopik Bankart tamiri uygulandi. Agri degerlendirmesi vizuel analog skalasina (VAS) gore yapilirken klinik sonuclar Rowe skalasi kullanilarak degerlendirildi. Ameliyat sonrasi ortalama takip suresi acik tamir grubunda 37.4±27.1 ay iken, artroskopik tamir grubunda 23±6.9 ay idi. Istatistiksel degerlendirmede Shapiro-Wilk testi ile Mann-Whitney U testi kullanildi. Bulgular: VAS skoru acik tamir grubunda 5.7±2.5, artroskopik tamir grubunda 4.1±1.9, Rowe skoru acik tamir grubunda 97.5 (dagilim 80-100), artr...

Middle Black Sea Journal of Health Science, 2020

Objective: Dynamic thiol/disulfide homeostasis plays a pivotal role in many physiologic mechanism... more Objective: Dynamic thiol/disulfide homeostasis plays a pivotal role in many physiologic mechanisms. In the present study, we aimed to elucidate the relationship between postoperative pain and thiol/disulfide homeostasis in patients who underwent primary total knee arthroplasty for primary knee osteoarthritis. Methods: This prospective uncontrolled study included 28 patients (10 male, 18 female) with a diagnosis of primary gonarthrosis who underwent primary total knee arthroplasty and met the study inclusion criteria. Venous blood samples were taken from the patients and pain values were recorded simultaneously using the visual analog scale (VAS) preoperatively and at the 4th postoperative week. Thiol/disulfide hemostasis levels were measured using a new fully-automated and spectrophotometric method developed by Erel and Neselioglu. Results: The average age of the patients participating in the study was 66.25 ± 8.29 years and 18 (64.3%) of the patients were female. B values for preoperative native/total thiol (+7,652), preoperative disulfide/native thiol (+10,550), and postoperative total thiol (+128), positively affected the difference in VAS values. B values for preoperative disulfide (-219), postoperative disulfide (-1,297), postoperative native/total thiol (-4,238), and postoperative disulfide/native thiol (-3,316) negatively affected the difference in VAS values. Conclusion: The disulfide level, an oxidized form in thiol/disulfide homeostasis, appears to be a valuable marker for evaluating the effect of oxidative stress on postoperative pain.

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2020

Background: Limited drug penetration into solid tumors has been one of the potential causes of re... more Background: Limited drug penetration into solid tumors has been one of the potential causes of resistance to chemotherapy for the treatment of bladder cancer. The aim of the study is to develop non-toxic self-nanoemulsifying formulations (SNEFs) of paclitaxel and to evaluate their ability to serve as a tool increasing the stability and solubility of paclitaxel in formulations utilizing the drug intravesical administration. Methods: Various oil-in-water non-toxic self-nanoemulsifying formulations (SNEFs) were developed using Cremercoor MCT, Kollisolv MCT, Miglyol 812, 810, Capmul MCM, Imwitor 988, Imwitor 742 with TO106V, Tween 85, HCO30, Kolliphor EL and Cremophor RH40 at size ranges from approximately 19 to 110 nm that are capable of enhancing the solubility and stability of paclitaxel. Visual assessment and droplet size measurements were taken into initial consideration for optimised SNEFs. Paclitaxel was added with the oil/surfactant mixture before dispersing the mixture in water to form SNEF. The cytotoxicity of the optimal SNEFs was compared with the raw paclitaxel dispersion in vitro. Results: Initial characterisation and solubility studies showed that mixed glycerides of Kollisolv MCT/Imwitor 742 with water-soluble surfactant (high HLB) containing formulations generated highly efficient SNEFs as they are stable and produced lower nanodroplets with higher drug loading. The results have demonstrated that the SNEFs have good ability to retain its characteristics under conditions similar to that found in the urinary bladder up to 48 hours. However, the results also showed that chemosensitivity of cancer cells exposed to paclitaxel was attenuated in the presence of SNEFs. Larger size SNEFs have shown to induce more inhibitory effects on paclitaxel activity. Conclusion: optimised SNEFs have demonstrated the ability to enhance the solubility of paclitaxel with stable construction of SNEFs under variable physiological conditions. The reduction of the efficacy of SNEF-loaded paclitaxel indicates a strong 3 encapsulation of the drug within the nano-carriers causing limitation in drug release. Such drug encapsulation may facilitate the penetration due to reduced cellular metabolism the drug. Further investigations are warranted.

Sakarya Medical Journal, 2018

Objective: The purpose was to evaluate the effect of combined administration of TXA on total bloo... more Objective: The purpose was to evaluate the effect of combined administration of TXA on total blood loss, hidden blood loss, drain output, cost effectiveness and periprosthetic infection rate in patients undergoing unilateral primary knee arthroplasty.

Journal of Clinical and Analytical Medicine, 2016

Amaç: Osteosarkom nedeniyle tümör rezeksiyon protezi uygulanan olguların değerlendirilmesi amaçla... more Amaç: Osteosarkom nedeniyle tümör rezeksiyon protezi uygulanan olguların değerlendirilmesi amaçlandı. Gereç ve Yöntem: Kliniğimizde 2000 ile 2012 yılları arasında Osteosarkom nedeniyle tümör rezeksiyon protezi uygulanan ve yeterli takipleri olan 14 olgu değerlendirildi. Olgular cinsiyet, yaş, yön, tümör yerleşimi, takip süresi, tedavi başarısı, komplikasyon, nüks ve sağkalım açısından incelendi. Elde edilen veriler SPSS 15.0 programına aktarılarak analiz edildi. Verilerin normal dağılıma uygunluğu Shapiro-Wilk testi ile değerlendirildi. Bulgular: 14 olgunun 8'i erkek, 6'sı kadın ve ortalama yaş 21.9±7.02 idi. Osteosarkom 9 (%64.3) hastada femur distalinde, 5 (%35.7) hastada tibia proksimalinde, 5 hastada sağ ve 9 hastada sol alt ekstremitede idi. Ortalama takip süresi 33 (dağılım, 3-144) ay idi. Ortalama MSTS skoru 81.9 (dağılım, 53-96) hesaplandı, 11 hastada (%78.6) mükemmel, 3 hastada (%21.4) yetersiz sonuç elde edildi. Komplikasyon olarak 3 olguda aseptik gevşeme, 2 olguda peroneal sinir felci, 2 olguda cilt nekrozu, 2 olguda periprostatik kırık, 1 olguda protez enfeksiyonu ve 1 olguda lokal nüks gözlendi. Peroneal sinir felci olan 2 olgu dısında komplikasyonlar sorunsuz iyileşti. Lokal nüks gelişen hasta akciğer metastazı nedeniyle kaybedildi. Tartışma: Osteosarkomun tümör rezeksiyon protezi ile tedavisi, uzun dönemde protezin sağkalımını etkileyecek olan olası komplikasyonlar nedeniyle kullanımında soru işareti yaratmaktadır. Ancak stabilite, erken yük verme ve osteosentez kaygısından uzak olması nedeniyle avantajlı ve amputasyona kıyasla psikolojik olarak yüz güldürücüdür.

Journal of Physical Therapy Science, 2016

To evaluate the short-term effects of kinesio tape on joint position sense, isokinetic measuremen... more To evaluate the short-term effects of kinesio tape on joint position sense, isokinetic measurements, kinesiophobia, symptoms, and functional limitations in patients with patellofemoral pain syndrome. [Subjects and Methods] A total of 90 patients (112 knees) with patellofemoral pain syndrome were randomized into a kinesio tape group (n=45) or placebo kinesio tape group (n=45). Baseline isokinetic quadriceps muscle tests and measurements of joint position sense were performed in both groups. Pain was measured with a Visual Analog Scale, kinesiophobia with the Tampa kinesiophobia scale, and symptoms and functional limitations with the Kujala pain scale. Measurements were repeated 2 days after kinesio tape application. [Results] No differences were found between baseline isokinetic muscle measurements and those taken 2 days after application. However, significant improvements were observed in the kinesio tape group, with regard to joint position sense, pain, kinesiophobia, symptoms, and functional limitations after treatment. Examination of the differences between pre-and post-treatment values in both groups revealed that the kinesio tape group demonstrated greater improvements compared to the placebo kinesio tape group. [Conclusion] Although short-term kinesio tape application did not increase hamstring muscle strength, it may have improved joint position sense, pain, kinesiophobia, symptoms, and daily limitations.

Haseki Tıp Bülteni, 2015

Osteoid osteoma (OO) kemiğin sık görülen benign kemik tümörlerinden biridir. Tedavide amaç nidusu... more Osteoid osteoma (OO) kemiğin sık görülen benign kemik tümörlerinden biridir. Tedavide amaç nidusun çıkarılması ve ağrının giderilmesidir. Yazımızda tolere edilemeyen ağrılı osteoid osteomalı hastalara uyguladığımız cerrahi tedavi sonuçlarının incelenmesi amaçlanmıştır. Yöntemler: Kliniğimizde OO tanısıyla cerrahi tedavi uyguladığımız ve son kontrolleri yapılan 39 hasta çalışmaya dahil edildi. Hastaların klinik özellikleri, radyolojik bulguları, cerrahi tedavi yöntemi ve başarısı incelendi. Bulgular: Otuz dokuz hastanın 24'ü erkek, 15'i kadın ve yaş ortalaması 19,6 yıl olarak bulundu. En sık femur (17) ve tibiada (11) tutulum tesbit edildi. Direkt grafide 39 hastadan 18'inde, bilgisayarlı tomografi (BT) çekilen 32 hastadan 28'inde, manyetik rezonans görüntüleme (MRG) ile incelenen 24 hastadan 11'inde nidus gösterildi. Kemik sintigrafisi çekilen 18 hastadan 10'unda nidus tesbit edildi. Otuz dokuz hastadan dördünde nüks görüldü, üçüne tekrar cerrahi tedavi uygulandı. Sonuç: Tanı için anamnezde ağrının özelliklerinden ve radyolojik olarak özellikle ince kesit BT'de nidusun görüntülenmesinden faydalanılmalıdır. Osteoid osteoma tedavisinde nidusun tamamen çıkarılması gereklidir. Tedavinin başarılı olduğu ağrının geçmesi ve radyolojik olarak nidusun çıkarıldığının gösterilmesi ile mümkündür.

Acta orthopaedica et traumatologica turcica, 2014

The aim of this study was to investigate Legg-Calvé-Perthes disease (PD) pathogenesis by comparin... more The aim of this study was to investigate Legg-Calvé-Perthes disease (PD) pathogenesis by comparing absolute circulating endothelial progenitor cell (EPC) counts, serum levels of vascular endothelial growth factor-A (VEGF-A) and immunoglobulins between PD patients and controls. The study included 28 PD cases (mean age: 8 ± 3.8) and 25 healthy age-matched control subjects. EPC, serum VEGF-A and immunoglobulin levels were measured in peripheral blood samples. Comparisons and correlation analysis were performed. In the PD group, 17 subjects were in the fragmentation stage and 11 in the healing stage. Four patients had bilateral disease and 14 had hypogammaglobulinemia. Median EPC count of the PD group was 80 and was significantly higher than those of the control group (p=0.011). No significant difference was determined in serum VEGF-A levels (p=0.354). EPC count were inversely correlated with serum IgG levels of the PD group (r=0.403, p=0.03). Absolute EPC count was also significantly h...

The Turkish journal of pediatrics

Neural regeneration research, Jan 25, 2013

It is well known that peripheral nerve injury should be treated immediately in the clinic, but in... more It is well known that peripheral nerve injury should be treated immediately in the clinic, but in some instances, repair can be delayed. This study investigated the effects of immediate versus delayed (3 days after injury) neurorrhaphy on repair of transected sciatic nerve in New Zealand rabbits using stereological, histomorphological and biomechanical methods. At 8 weeks after immediate and delayed neurorrhaphy, axon number and area in the sciatic nerve, myelin sheath and epineurium thickness, Schwann cell morphology, and the mechanical property of nerve fibers did not differ obviously. These results indicate that delayed neurorrhaphy do not produce any deleterious effect on sciatic nerve repair.

Journal of Experimental and Clinical Medicine, 2012