Hieu Bui - Academia.edu (original) (raw)
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Papers by Hieu Bui
From Parallel to Emergent Computing, 2019
Recently, solution-based systems for DNA computation have demonstrated the enormous potential of ... more Recently, solution-based systems for DNA computation have demonstrated the enormous potential of DNA nanosystems to do computation at the molecular-scale. These use DNA strands to encode values and use DNA hybridization reactions to perform computations. But most of these prior DNA computation systems relied on the diffusion of DNA strands to transport values during computations. During diffusion, DNA molecules randomly collide and interact in a three-dimensional fluidic space. At low concentrations and temperatures, diffusion can be quite slow and could impede the kinetics of these systems whereas at higher concentrations and temperature, unintended spurious interactions during diffusion can hinder the computations. Hence, increasing the concentration of DNA strands to speed up DNA hybridization reactions has the unfortunate side effect of increasing leaks, which are undesired hybridization reactions in the absence of input strands. Also, diffusion-based systems possess global states encoded via concentration of various species and hence exhibit only limited parallel ability. To address these challenges, this dissertation describes a novel design for DNA computation called a localized hybridization network, where diffusion of Dedication To Melissa and Abigail.
ACS Photonics, 2015
A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic de... more A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.
From Parallel to Emergent Computing, 2019
Recently, solution-based systems for DNA computation have demonstrated the enormous potential of ... more Recently, solution-based systems for DNA computation have demonstrated the enormous potential of DNA nanosystems to do computation at the molecular-scale. These use DNA strands to encode values and use DNA hybridization reactions to perform computations. But most of these prior DNA computation systems relied on the diffusion of DNA strands to transport values during computations. During diffusion, DNA molecules randomly collide and interact in a three-dimensional fluidic space. At low concentrations and temperatures, diffusion can be quite slow and could impede the kinetics of these systems whereas at higher concentrations and temperature, unintended spurious interactions during diffusion can hinder the computations. Hence, increasing the concentration of DNA strands to speed up DNA hybridization reactions has the unfortunate side effect of increasing leaks, which are undesired hybridization reactions in the absence of input strands. Also, diffusion-based systems possess global states encoded via concentration of various species and hence exhibit only limited parallel ability. To address these challenges, this dissertation describes a novel design for DNA computation called a localized hybridization network, where diffusion of Dedication To Melissa and Abigail.
ACS Photonics, 2015
A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic de... more A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.