Hiroshi Takami - Academia.edu (original) (raw)
Papers by Hiroshi Takami
World Journal of Endocrine Surgery, 2012
Advanced thyroid carcinomas, which are difficult to control and are refractory to treatment, are ... more Advanced thyroid carcinomas, which are difficult to control and are refractory to treatment, are sometimes encountered in the clinical setting. In recent years, molecular targeted drugs which inhibit various kinases involved in tumor growth or angiogenesis have been developed and have been demonstrated to exhibit efficacy against many carcinomas. Their usefulness has been explored in such malignancies as advanced, radioactive iodine (RAI), refractory differentiated thyroid cancer, local advanced or metastatic medullary thyroid and anaplastic carcinomas. In tumor cells of thyroid cancer, variants of RAS and B-RAF that act downstream from RET or RTK, both being receptor tyrosine kinases (RTKs), occur frequently and abnormality in this serial signaling cascade contributes to tumor growth. Angiogenic factors secreted from tumors, such as vascular endothelial growth factor (VEGF), on the other hand, act upon vascular endothelial cells RKTs, i.e. vascular endothelial growth factor receptor (VEGF-R) and platelet-derived growth factor receptor (PDGF-R), to facilitate angiogenesis. Clinical trials of inhibitors of the kinases which interfere with growth signals in tumor cells or with angiogenetic signals in vascular endothelial cells in patients with thyroid cancer are under way. The ongoing clinical trials for differentiated thyroid carcinoma include studies of sorafenib, which inhibits RAF, RET and VEGF-R, 1-4 a trial of axitinib, which is an inhibitor of VEGF-R, C-KIT and PDGF-R 5 trials of pazopanib, which is an inhibitor of VEGF-R and PDGF-R, and those of sunitinib, which is an inhibitor of E7080, VEGF-R, RET and PDGF-R. Further, vandetanib, which is an inhibitor of VEGF-R, RET and EGF-R, has proven to be promising in the treatment of medullary thyroid carcinoma. 6 The toxicity (adverse reactions) of molecular targeted drugs differs slightly from that of the usual anticancer agents and primarily includes easy fatigability, hypertension, anorexia, diarrhea and skin disorders. This group of drugs basically requires to be given for a long term; eventually, dosage reduction or discontinuation becomes unavoidable because of adverse reactions, resulting in a substantial diminution of the antitumor effect. Since, elevation of the serum TSH level occurs with the use of kinase inhibitors, patients should be followed up by periodic checkups and may need to be administered an oral thyroid hormone preparation. Various markers have been assessed for their efficacy in predicting antitumor responses. Biochemically, markers, such as VEGF and VEGF-R, are used. The diagnostic imaging modalities include fluorodeoxyglucose positron emission tomography (FDG-PET), magnetic resonance imaging (MRI), computerized tomography (CT) and ultrasonography (US). However, all of these measures have their limitations. Thyroglobulin (Tg) is useful for differentiated thyroid cancer but is liable to be affected by anti-Tg antibody as well as by changes in the serum thyroid stimulating hormone (TSH) level. It is widely recognized that serum calcitonin and carcinoembryonic antigen (CEA) serve as satisfactory markers in patients with medullary thyroid carcinoma.
British Journal of Cancer, 1980
The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were st... more The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and plasma significantly increased 1 week after tumour inoculation. Three weeks after inoculation, however, putrescine levels in the erythrocytes showed a greater increase than those in plasma. Spermidine and spermine levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the spermidine levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store polyamines released into the circulation. This finding was subsequently applied to human studies. Fifty-two untreated patients with solid tumours were examined in the preoperative period. All erythrocyte polyamine levels from patients were significantly higher than those from control subjects. Plasma spermidine levels in patients were significantly higher than those in controls, whereas plasma putrescine and spermine levels showed no significant increase. The frequency of raised levels of putrescine, spermidine and spermine in erythrocytes was significantly greater than in plasma. These results suggest that polyamine levels in erythrocytes may provide useful information for the detection of cancer.
![Research paper thumbnail of Current status of molecularly targeted drugs for the treatment of advanced thyroid cancer [Review]](https://attachments.academia-assets.com/85263177/thumbnails/1.jpg)
](Endocrine Journal, 2011
The prognosis of almost all thyroid cancers is good, but some patients have indications for these... more The prognosis of almost all thyroid cancers is good, but some patients have indications for these molecularly targeted drugs. Some of these drugs, i.e., vandetanib, XL-184, sorafenib, motesanib, axitinib, and pazopanib, are clearly useful clinically.
The journal of the Japanese Practical Surgeon Society, 1987
ABSTRACT Total parathyroidectomy and parathyroid autotransplantation were carried out in 22 patie... more ABSTRACT Total parathyroidectomy and parathyroid autotransplantation were carried out in 22 patients for renal hyperparathyroidism from 1982.Severe renal osteopathy (bone pain and/or radiologic signs) was found in all of the patients. Calcium and cPTH levels in the sera were elevated in 36.4% and 100% of the patients, respectively. After total parathyroidectomy, parathyroid tissue was immediately autografted in a forearm muscle. All of the patients showed some improvement in their bone and joint pains. 81.8% of them noted great improvement in these symptoms.Radiologic signs of renal osteopathy were improved postoperatively within six months. No patient is on replacement therapy or has undergone reoperation for recurrent hypercalcemic hyperparathyroidism. The only postoperative complication was pallsy of the left recurrent nerve in one patient. The six-to 52-month results after total parathyroidectomy with autotransplantation for renal hyperparathyroidism are considered to be satisfactory.
The Journal of Hand Surgery, Jan 7, 1997
Three cases of large volar plate avulsion fracture at the base of the middle phalanx with signifi... more Three cases of large volar plate avulsion fracture at the base of the middle phalanx with significant displacement are reported. In each case, the fracture fragment involved about 30% of the articular surface and was rotated 90 degrees. The proximal interphalangeal (PIP) joint showed loss of volar stability with hyperextension stress. This unusual variant of volar plate injury is thought to be caused by subluxation of the PIP joint. All patients underwent open reduction and internal fixation. The fracture healed in anatomic alignment without articular incongruity or instability in all cases.
Proceedings Ipemc 2000 Third International Power Electronics and Motion Control Conference, 2000
Japanese Journal of Clinical Oncology, Jun 1, 1994
ABSTRACT Ornithine decarboxylase (ODC) activity was determined in tumorous lesions of the human c... more ABSTRACT Ornithine decarboxylase (ODC) activity was determined in tumorous lesions of the human colon, and the possibility of ODC acting as a marker of colon tumorigenesis investigated. In adenoma, ODC activity, in pmoles/h/mg protein, was 164 +/- 82 in tumorous tissue, which was higher than the 19.6 +/- 10.5 in macroscopically normal mucosa (control tissue) around the tumorous tissue, while 8.7 +/- 4.1 in normal colon mucosa. In carcinoma-in-adenoma and carcinoma, ODC activities in the control tissue were 15.3 +/- 11.9 and 27.5 +/- 15.0, respectively. The levels were respectively higher than in normal tissue. These results suggest ODC to be a potential indicator of colon tumorigenesis.
Conference Record of the 2000 Ieee Industry Applications Conference Thirty Fifth Ias Annual Meeting and World Conference on Industrial Applications of Electrical Energy, Feb 1, 2000
The American Journal of Geriatric Psychiatry, Jul 31, 2007
Previous studies have suggested that, in elderly patients, prior depression plays a role in the r... more Previous studies have suggested that, in elderly patients, prior depression plays a role in the recurrence of depression. The aim of this study was to investigate cerebral brain function in recovered depressed elderly and investigate the relationship between this brain function and the number of depressive episodes. Twenty elderly depressive patients in recovery and 10 healthy volunteers were included in this study. The depressive patients were divided into those who had experienced a single depressive episode and those who had experienced multiple episodes. Functional magnetic resonance imaging was performed in each participant during a verbal fluency task. The data were analyzed using statistical parametric mapping. Activation in the anterior cingulate cortex was significantly attenuated in patients who had experienced multiple depressive episodes, compared with the other two groups. There were no significant differences in areas of activation between patients with a single depressive episode and healthy volunteers. These findings suggest that attenuated activation in the anterior cingulate cortex may be associated with multiple episodes of depression in the elderly and with the vulnerability to cycling or recurrence.
Data Revues 07533322 V58i6 7 S0753332204000800, Aug 23, 2010
The familial form of medullary thyroid carcinoma (MTC) is caused by mutations of the RET protoonc... more The familial form of medullary thyroid carcinoma (MTC) is caused by mutations of the RET protooncogene. We registered 60 multiple endocrine neoplasia (MEN) 2A patients, 12 familial non-MEN medullary carcinoma (FMTC) patients, and three MEN2B patients with a confirmed RET germline mutation. All 60 MEN2A patients had RET mutations in a cysteine-rich domain. Seven of the FMTC patients had a mutation in cysteine-rich domain, and the other five had a mutation in codon 768, which encodes a tyrosine-kinase domain. Two of the MEN2B patients had a mutation in codon 918, and one patient had a double mutation, one in codon 804 and the other in codon 806, both of which are all encoded tyrosine-kinase domain. The genotype-phenotype correlations of our data will allow individualized recommendations for the optimal timing of prophylactic surgery.
Cancer Research, Jun 1, 1979
The nuclear proteins of regenerating and fetal rat liver, slow growing Morris hepatoma 961 8A, an... more The nuclear proteins of regenerating and fetal rat liver, slow growing Morris hepatoma 961 8A, and fast-growing Morris hepatoma 3924A, sequentially extracted from nuclei with (a) 0.075 M NaCl/0.O25 M EDTA, (b) 10 mMTnis,(c) 0.35 M NaCl, (d) 0.6 M NaCI, and (e) 3 M NaCI/7 M urea, were analyzed by two-dimensional, isoelectric-focusing sodium dodecyl sulfate gel electrophoresis. Many of the protein spots were common to these tissues as well as to the Novikoff hepatoma and normal liver. The protein patterns of the regenerating liver and slow growing 961 8A hepatoma were more similar to that of normal liver than to those of other tissues. Many similarities were found between the fetal liver and the fast-growing 3924A and Novikoff hepatomas. Four protein spots, 64/5.9, 60/6.3, 51 /5.3, and 38/7.3 (M.W. x 1O'3/pI), were only found in the fast-growing 3924A and Novikoff hepatomas. Proteins 79/6.4 and 61/7.2 were only found in the three hepatomas. Protein 37/6.3 was dense in the three hepatornas and much less dense in the regenerating and fetal livers. Two proteins, 28/5.0 and 27/ 4.9, were detected only in the fast-growing 3924A and Novikoft hepatomas and fetal liven. Proteins 125/8.2 and 98/8.4 were found in the fetal liver and the three hepatomas; these proteins may be â€ẫ€˜oncofetal' â€p roteins. Three proteins, 61 /5.5, 56/5.8, and 53/7.5, that were absent from other tissues were present in the regenerating liver, fast-growing 3924A and Novikoff hepatomas, fetal liver, and slow-growing 961 8A hepatoma. These proteins may be related to growth processes of normal and tumor tissues studied.
A feasibility study is presented concerning an application of a superconducting linear synchronou... more A feasibility study is presented concerning an application of a superconducting linear synchronous motor (LSM) to a large-scale rocket launcher, whose acceleration guide tube of LSM armature windings is constructed 1,500 meters under the ground. The rocket is released from the linear launcher just after it gets to a peak speed of about 900 kilometers per hour, and it flies out of the guide tube to obtain the speed of 700 kilometers per hour at the height of 100 meters above ground. The linear launcher is brought to a stop at the ground surface for a very short time of 5 seconds by a quick control of deceleration. Very large current variations in the single-layer windings of the LSM armature, which are produced at the higher speed region of 600 to 900 kilometers per hour, are controlled successfully by adopting the double-layer windings. The proposed control method makes the rocket launcher ascend stably in the superconducting LSM system, controlling the Coriolis force.
Cancer Research, Feb 1, 1979
Animals and Tumor Cells. Novikoff hepatoma ascites cells were obtained by drainage of the ascites... more Animals and Tumor Cells. Novikoff hepatoma ascites cells were obtained by drainage of the ascites fluid 6 days after implantation into 200-g male albino rats (Holtzman Co., Madison, Wis.). The ascites cells were filtered through 2 The abbreviation used is:SDS, sodium dodecyl sulfate.
Archives of Orthopaedic and Trauma Surgery, Feb 1, 2000
Treatment of a mallet finger due to an intra-articular fracture of the distal phalanx involving o... more Treatment of a mallet finger due to an intra-articular fracture of the distal phalanx involving one-third or more of the articular surface is controversial. Thirty-three digits with such fractures were treated by open reduction and internal fixation with Kirschner wires. Of these 33 fractures, 13 were associated with subluxation of the distal phalanx. After an average follow-up period of 29 months, the average loss of extension of the distal phalanx was 4 degrees, and the average flexion of the distal interphalangeal joint was 67 degrees. Radiographs of the distal joint in 27 digits appeared normal, while in the remaining 6 digits, slight degenerative changes were noted. In one there was a minor surgical complication. By using the operative technique described, a congruous reduction of the inta-articular fracture and satisfactory function were achieved.
International Journal of Infrared and Millimeter Waves, Jan 2, 1989
A new far-IR grating monochromator of Czerny-Turner type has been devised and constructed which h... more A new far-IR grating monochromator of Czerny-Turner type has been devised and constructed which has an output optical system comprising two small spherical mirrors to compensate astigmatism of the Czerny-Turner system. Anastigmatism of the system has been confirmed by ray tracing. The far-IR monochromator covers 100-240 micron wavelengths, and is useful for measuring the spectral response of stressed Ge:Ga photoconductors having response up to 200 microns, which have been studied for applications to far-IR astronomical and atmospheric observations by balloons.
Oncology Reports, 1998
To combine the rapid hypocalcemic effects of calcitonin with the delayed effects of pamidronate, ... more To combine the rapid hypocalcemic effects of calcitonin with the delayed effects of pamidronate, a combination of a single dose of pamidronate and serial doses of eel calcitonin was administered to five patients with malignant hypercalcemia for 2 to 5 days. The serum calcium levels of all five patients fell within 24 h after administration of pamidronate and the first dose of calcitonin and decreased to normal within 4 days. The mean level of corrected serum calcium fell from 15.3 mg/dl (range 14.1-16.4 ) to 9.2 mg/dl (8.9-9. 6) at the nadir. No toxicity or side effects were found. The results of this study demonstrate the value of combining the rapidly acting antiresorptive and renal calciuretic effects of calcitonin with the slower, but more potent effects of pamidronate. The combination of calcitonin and pamidronate allowed rapid, long-term control of hypercalcemia and it is regarded as the first choice of treatment in severe hypercalcemia.
Archives of Surgery, Jun 1, 1996
To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of f... more To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin. Retrospective review. University medical center. Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals. Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease. Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years. In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n = 8). Seven patients (50%) had recurrences during follow-up. Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.
Nippon Rinsho Japanese Journal of Clinical Medicine, Nov 1, 2007
True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived fr... more True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells. Follicular adenoma is well-circumscribed, with no evidence of capsular or vascular invasion. The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor. Adenomatous goiter, a hyperplastic lesion of follicles, is the most common tumorous lesion of thyroid gland. The gland is distorted with a nodular surface. The hyperplasia is followed by involution of the follicles leading to large follicles of varying size. Mature or immature teratoma is also observed in the thyroid gland. Mechanical implantation and parasitic nodule should not be misdiagnosed as lymph nodes harboring metastatic carcinoma.
World Journal of Endocrine Surgery, 2012
Advanced thyroid carcinomas, which are difficult to control and are refractory to treatment, are ... more Advanced thyroid carcinomas, which are difficult to control and are refractory to treatment, are sometimes encountered in the clinical setting. In recent years, molecular targeted drugs which inhibit various kinases involved in tumor growth or angiogenesis have been developed and have been demonstrated to exhibit efficacy against many carcinomas. Their usefulness has been explored in such malignancies as advanced, radioactive iodine (RAI), refractory differentiated thyroid cancer, local advanced or metastatic medullary thyroid and anaplastic carcinomas. In tumor cells of thyroid cancer, variants of RAS and B-RAF that act downstream from RET or RTK, both being receptor tyrosine kinases (RTKs), occur frequently and abnormality in this serial signaling cascade contributes to tumor growth. Angiogenic factors secreted from tumors, such as vascular endothelial growth factor (VEGF), on the other hand, act upon vascular endothelial cells RKTs, i.e. vascular endothelial growth factor receptor (VEGF-R) and platelet-derived growth factor receptor (PDGF-R), to facilitate angiogenesis. Clinical trials of inhibitors of the kinases which interfere with growth signals in tumor cells or with angiogenetic signals in vascular endothelial cells in patients with thyroid cancer are under way. The ongoing clinical trials for differentiated thyroid carcinoma include studies of sorafenib, which inhibits RAF, RET and VEGF-R, 1-4 a trial of axitinib, which is an inhibitor of VEGF-R, C-KIT and PDGF-R 5 trials of pazopanib, which is an inhibitor of VEGF-R and PDGF-R, and those of sunitinib, which is an inhibitor of E7080, VEGF-R, RET and PDGF-R. Further, vandetanib, which is an inhibitor of VEGF-R, RET and EGF-R, has proven to be promising in the treatment of medullary thyroid carcinoma. 6 The toxicity (adverse reactions) of molecular targeted drugs differs slightly from that of the usual anticancer agents and primarily includes easy fatigability, hypertension, anorexia, diarrhea and skin disorders. This group of drugs basically requires to be given for a long term; eventually, dosage reduction or discontinuation becomes unavoidable because of adverse reactions, resulting in a substantial diminution of the antitumor effect. Since, elevation of the serum TSH level occurs with the use of kinase inhibitors, patients should be followed up by periodic checkups and may need to be administered an oral thyroid hormone preparation. Various markers have been assessed for their efficacy in predicting antitumor responses. Biochemically, markers, such as VEGF and VEGF-R, are used. The diagnostic imaging modalities include fluorodeoxyglucose positron emission tomography (FDG-PET), magnetic resonance imaging (MRI), computerized tomography (CT) and ultrasonography (US). However, all of these measures have their limitations. Thyroglobulin (Tg) is useful for differentiated thyroid cancer but is liable to be affected by anti-Tg antibody as well as by changes in the serum thyroid stimulating hormone (TSH) level. It is widely recognized that serum calcitonin and carcinoembryonic antigen (CEA) serve as satisfactory markers in patients with medullary thyroid carcinoma.
British Journal of Cancer, 1980
The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were st... more The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and plasma significantly increased 1 week after tumour inoculation. Three weeks after inoculation, however, putrescine levels in the erythrocytes showed a greater increase than those in plasma. Spermidine and spermine levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the spermidine levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store polyamines released into the circulation. This finding was subsequently applied to human studies. Fifty-two untreated patients with solid tumours were examined in the preoperative period. All erythrocyte polyamine levels from patients were significantly higher than those from control subjects. Plasma spermidine levels in patients were significantly higher than those in controls, whereas plasma putrescine and spermine levels showed no significant increase. The frequency of raised levels of putrescine, spermidine and spermine in erythrocytes was significantly greater than in plasma. These results suggest that polyamine levels in erythrocytes may provide useful information for the detection of cancer.
Endocrine Journal, 2011
The prognosis of almost all thyroid cancers is good, but some patients have indications for these... more The prognosis of almost all thyroid cancers is good, but some patients have indications for these molecularly targeted drugs. Some of these drugs, i.e., vandetanib, XL-184, sorafenib, motesanib, axitinib, and pazopanib, are clearly useful clinically.
The journal of the Japanese Practical Surgeon Society, 1987
ABSTRACT Total parathyroidectomy and parathyroid autotransplantation were carried out in 22 patie... more ABSTRACT Total parathyroidectomy and parathyroid autotransplantation were carried out in 22 patients for renal hyperparathyroidism from 1982.Severe renal osteopathy (bone pain and/or radiologic signs) was found in all of the patients. Calcium and cPTH levels in the sera were elevated in 36.4% and 100% of the patients, respectively. After total parathyroidectomy, parathyroid tissue was immediately autografted in a forearm muscle. All of the patients showed some improvement in their bone and joint pains. 81.8% of them noted great improvement in these symptoms.Radiologic signs of renal osteopathy were improved postoperatively within six months. No patient is on replacement therapy or has undergone reoperation for recurrent hypercalcemic hyperparathyroidism. The only postoperative complication was pallsy of the left recurrent nerve in one patient. The six-to 52-month results after total parathyroidectomy with autotransplantation for renal hyperparathyroidism are considered to be satisfactory.
The Journal of Hand Surgery, Jan 7, 1997
Three cases of large volar plate avulsion fracture at the base of the middle phalanx with signifi... more Three cases of large volar plate avulsion fracture at the base of the middle phalanx with significant displacement are reported. In each case, the fracture fragment involved about 30% of the articular surface and was rotated 90 degrees. The proximal interphalangeal (PIP) joint showed loss of volar stability with hyperextension stress. This unusual variant of volar plate injury is thought to be caused by subluxation of the PIP joint. All patients underwent open reduction and internal fixation. The fracture healed in anatomic alignment without articular incongruity or instability in all cases.
Proceedings Ipemc 2000 Third International Power Electronics and Motion Control Conference, 2000
Japanese Journal of Clinical Oncology, Jun 1, 1994
ABSTRACT Ornithine decarboxylase (ODC) activity was determined in tumorous lesions of the human c... more ABSTRACT Ornithine decarboxylase (ODC) activity was determined in tumorous lesions of the human colon, and the possibility of ODC acting as a marker of colon tumorigenesis investigated. In adenoma, ODC activity, in pmoles/h/mg protein, was 164 +/- 82 in tumorous tissue, which was higher than the 19.6 +/- 10.5 in macroscopically normal mucosa (control tissue) around the tumorous tissue, while 8.7 +/- 4.1 in normal colon mucosa. In carcinoma-in-adenoma and carcinoma, ODC activities in the control tissue were 15.3 +/- 11.9 and 27.5 +/- 15.0, respectively. The levels were respectively higher than in normal tissue. These results suggest ODC to be a potential indicator of colon tumorigenesis.
Conference Record of the 2000 Ieee Industry Applications Conference Thirty Fifth Ias Annual Meeting and World Conference on Industrial Applications of Electrical Energy, Feb 1, 2000
The American Journal of Geriatric Psychiatry, Jul 31, 2007
Previous studies have suggested that, in elderly patients, prior depression plays a role in the r... more Previous studies have suggested that, in elderly patients, prior depression plays a role in the recurrence of depression. The aim of this study was to investigate cerebral brain function in recovered depressed elderly and investigate the relationship between this brain function and the number of depressive episodes. Twenty elderly depressive patients in recovery and 10 healthy volunteers were included in this study. The depressive patients were divided into those who had experienced a single depressive episode and those who had experienced multiple episodes. Functional magnetic resonance imaging was performed in each participant during a verbal fluency task. The data were analyzed using statistical parametric mapping. Activation in the anterior cingulate cortex was significantly attenuated in patients who had experienced multiple depressive episodes, compared with the other two groups. There were no significant differences in areas of activation between patients with a single depressive episode and healthy volunteers. These findings suggest that attenuated activation in the anterior cingulate cortex may be associated with multiple episodes of depression in the elderly and with the vulnerability to cycling or recurrence.
Data Revues 07533322 V58i6 7 S0753332204000800, Aug 23, 2010
The familial form of medullary thyroid carcinoma (MTC) is caused by mutations of the RET protoonc... more The familial form of medullary thyroid carcinoma (MTC) is caused by mutations of the RET protooncogene. We registered 60 multiple endocrine neoplasia (MEN) 2A patients, 12 familial non-MEN medullary carcinoma (FMTC) patients, and three MEN2B patients with a confirmed RET germline mutation. All 60 MEN2A patients had RET mutations in a cysteine-rich domain. Seven of the FMTC patients had a mutation in cysteine-rich domain, and the other five had a mutation in codon 768, which encodes a tyrosine-kinase domain. Two of the MEN2B patients had a mutation in codon 918, and one patient had a double mutation, one in codon 804 and the other in codon 806, both of which are all encoded tyrosine-kinase domain. The genotype-phenotype correlations of our data will allow individualized recommendations for the optimal timing of prophylactic surgery.
Cancer Research, Jun 1, 1979
The nuclear proteins of regenerating and fetal rat liver, slow growing Morris hepatoma 961 8A, an... more The nuclear proteins of regenerating and fetal rat liver, slow growing Morris hepatoma 961 8A, and fast-growing Morris hepatoma 3924A, sequentially extracted from nuclei with (a) 0.075 M NaCl/0.O25 M EDTA, (b) 10 mMTnis,(c) 0.35 M NaCl, (d) 0.6 M NaCI, and (e) 3 M NaCI/7 M urea, were analyzed by two-dimensional, isoelectric-focusing sodium dodecyl sulfate gel electrophoresis. Many of the protein spots were common to these tissues as well as to the Novikoff hepatoma and normal liver. The protein patterns of the regenerating liver and slow growing 961 8A hepatoma were more similar to that of normal liver than to those of other tissues. Many similarities were found between the fetal liver and the fast-growing 3924A and Novikoff hepatomas. Four protein spots, 64/5.9, 60/6.3, 51 /5.3, and 38/7.3 (M.W. x 1O'3/pI), were only found in the fast-growing 3924A and Novikoff hepatomas. Proteins 79/6.4 and 61/7.2 were only found in the three hepatomas. Protein 37/6.3 was dense in the three hepatornas and much less dense in the regenerating and fetal livers. Two proteins, 28/5.0 and 27/ 4.9, were detected only in the fast-growing 3924A and Novikoft hepatomas and fetal liven. Proteins 125/8.2 and 98/8.4 were found in the fetal liver and the three hepatomas; these proteins may be â€ẫ€˜oncofetal' â€p roteins. Three proteins, 61 /5.5, 56/5.8, and 53/7.5, that were absent from other tissues were present in the regenerating liver, fast-growing 3924A and Novikoff hepatomas, fetal liver, and slow-growing 961 8A hepatoma. These proteins may be related to growth processes of normal and tumor tissues studied.
A feasibility study is presented concerning an application of a superconducting linear synchronou... more A feasibility study is presented concerning an application of a superconducting linear synchronous motor (LSM) to a large-scale rocket launcher, whose acceleration guide tube of LSM armature windings is constructed 1,500 meters under the ground. The rocket is released from the linear launcher just after it gets to a peak speed of about 900 kilometers per hour, and it flies out of the guide tube to obtain the speed of 700 kilometers per hour at the height of 100 meters above ground. The linear launcher is brought to a stop at the ground surface for a very short time of 5 seconds by a quick control of deceleration. Very large current variations in the single-layer windings of the LSM armature, which are produced at the higher speed region of 600 to 900 kilometers per hour, are controlled successfully by adopting the double-layer windings. The proposed control method makes the rocket launcher ascend stably in the superconducting LSM system, controlling the Coriolis force.
Cancer Research, Feb 1, 1979
Animals and Tumor Cells. Novikoff hepatoma ascites cells were obtained by drainage of the ascites... more Animals and Tumor Cells. Novikoff hepatoma ascites cells were obtained by drainage of the ascites fluid 6 days after implantation into 200-g male albino rats (Holtzman Co., Madison, Wis.). The ascites cells were filtered through 2 The abbreviation used is:SDS, sodium dodecyl sulfate.
Archives of Orthopaedic and Trauma Surgery, Feb 1, 2000
Treatment of a mallet finger due to an intra-articular fracture of the distal phalanx involving o... more Treatment of a mallet finger due to an intra-articular fracture of the distal phalanx involving one-third or more of the articular surface is controversial. Thirty-three digits with such fractures were treated by open reduction and internal fixation with Kirschner wires. Of these 33 fractures, 13 were associated with subluxation of the distal phalanx. After an average follow-up period of 29 months, the average loss of extension of the distal phalanx was 4 degrees, and the average flexion of the distal interphalangeal joint was 67 degrees. Radiographs of the distal joint in 27 digits appeared normal, while in the remaining 6 digits, slight degenerative changes were noted. In one there was a minor surgical complication. By using the operative technique described, a congruous reduction of the inta-articular fracture and satisfactory function were achieved.
International Journal of Infrared and Millimeter Waves, Jan 2, 1989
A new far-IR grating monochromator of Czerny-Turner type has been devised and constructed which h... more A new far-IR grating monochromator of Czerny-Turner type has been devised and constructed which has an output optical system comprising two small spherical mirrors to compensate astigmatism of the Czerny-Turner system. Anastigmatism of the system has been confirmed by ray tracing. The far-IR monochromator covers 100-240 micron wavelengths, and is useful for measuring the spectral response of stressed Ge:Ga photoconductors having response up to 200 microns, which have been studied for applications to far-IR astronomical and atmospheric observations by balloons.
Oncology Reports, 1998
To combine the rapid hypocalcemic effects of calcitonin with the delayed effects of pamidronate, ... more To combine the rapid hypocalcemic effects of calcitonin with the delayed effects of pamidronate, a combination of a single dose of pamidronate and serial doses of eel calcitonin was administered to five patients with malignant hypercalcemia for 2 to 5 days. The serum calcium levels of all five patients fell within 24 h after administration of pamidronate and the first dose of calcitonin and decreased to normal within 4 days. The mean level of corrected serum calcium fell from 15.3 mg/dl (range 14.1-16.4 ) to 9.2 mg/dl (8.9-9. 6) at the nadir. No toxicity or side effects were found. The results of this study demonstrate the value of combining the rapidly acting antiresorptive and renal calciuretic effects of calcitonin with the slower, but more potent effects of pamidronate. The combination of calcitonin and pamidronate allowed rapid, long-term control of hypercalcemia and it is regarded as the first choice of treatment in severe hypercalcemia.
Archives of Surgery, Jun 1, 1996
To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of f... more To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin. Retrospective review. University medical center. Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals. Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease. Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years. In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n = 8). Seven patients (50%) had recurrences during follow-up. Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.
Nippon Rinsho Japanese Journal of Clinical Medicine, Nov 1, 2007
True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived fr... more True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells. Follicular adenoma is well-circumscribed, with no evidence of capsular or vascular invasion. The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor. Adenomatous goiter, a hyperplastic lesion of follicles, is the most common tumorous lesion of thyroid gland. The gland is distorted with a nodular surface. The hyperplasia is followed by involution of the follicles leading to large follicles of varying size. Mature or immature teratoma is also observed in the thyroid gland. Mechanical implantation and parasitic nodule should not be misdiagnosed as lymph nodes harboring metastatic carcinoma.