Hisao Ogawa - Academia.edu (original) (raw)

Papers by Hisao Ogawa

Assessment of platelet-derived thrombogenicity by the total thrombus-formation analysis system in coronary artery disease patients on antiplatelet therapy

Journal of thrombosis and haemostasis : JTH, Jan 16, 2016

Accurate evaluation of thrombogenicity helps prevent thrombosis and excessive bleeding. The total... more Accurate evaluation of thrombogenicity helps prevent thrombosis and excessive bleeding. The total thrombus-formation analysis system (T-TAS) was developed for quantitative analysis of platelet thrombus formation using microchips with thrombogenic surfaces (collagen, PL chip; collagen plus tissue factor, AR chip). We examined the utility of T-TAS in the assessment of the efficacy of antiplatelet therapy in patients with coronary artery disease (CAD). In this cross-sectional study, 372 consecutive patients admitted to the cardiovascular department were divided into three groups; patients not on any antiplatelet therapy (control, n=56), on aspirin only (n=69), and on aspirin and clopidogrel (n=149). Blood samples were used for T-TAS to measure platelet thrombus formation area under the curve at various shear rates [1500 s(-1) (termed PL18 -AUC10 ), 2000 s(-1) (PL24 -AUC10 ) for PL chip; 300 s(-1) (AR10 -AUC30 ) for AR chip]. The on-clopidogrel platelet aggregation was measured by P2Y12...

Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy

European journal of heart failure, Jan 13, 2016

Dilated cardiomyopathy (DCM) has a variety of causes, and no useful approach to predict left vent... more Dilated cardiomyopathy (DCM) has a variety of causes, and no useful approach to predict left ventricular (LV) remodelling and long-term outcome has yet been established. Myocardial tenascin-C (TNC) is known to appear under pathological conditions, possibly to regulate cardiac remodelling. The aim of this study was to clarify the significance of myocardial TNC expression in LV remodelling and the long-term outcome in DCM. One hundred and twenty-three consecutive DCM patients who underwent endomyocardial biopsy for initial diagnosis were studied. Expression of TNC in biopsy sections was analysed immunohistochemically to quantify the ratio of the TNC-positive area to the whole myocardial tissue area (TNC area). Clinical parameters associated with TNC area were investigated. The patients were divided into two groups based on receiver operating characteristic analysis of TNC area to predict death: high TNC group with TNC area ≥2.3% (22 patients) and low TNC group with TNC area <2.3% (...

PJ-918 Aldosterone-mediated Cardiovascular Remodeling and Vascular Endothelial Dysfunction in Mice,Through Apoptosis Signal-Regulating Kinase 1 (ASK1)(Neurohumoral factors(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Circulation Journal Official Journal of the Japanese Circulation Society, Mar 1, 2008

Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling

Cell reports, 2015

Angiogenesis is a multicellular phenomenon driven by morphogenetic cell movements. We recently re... more Angiogenesis is a multicellular phenomenon driven by morphogenetic cell movements. We recently reported morphogenetic vascular endothelial cell (EC) behaviors to be dynamic and complex. However, the principal mechanisms orchestrating individual EC movements in angiogenic morphogenesis remain largely unknown. Here we present an experiment-driven mathematical model that enables us to systematically dissect cellular mechanisms in branch elongation. We found that cell-autonomous and coordinated actions governed these multicellular behaviors, and a cell-autonomous process sufficiently illustrated essential features of the morphogenetic EC dynamics at both the single-cell and cell-population levels. Through refining our model and experimental verification, we further identified a coordinated mode of tip EC behaviors regulated via a spatial relationship between tip and follower ECs, which facilitates the forward motility of tip ECs. These findings provide insights that enhance our mechanis...

Background-Transplantation of endothelial progenitor cells has been proposed as a potential strat... more Background-Transplantation of endothelial progenitor cells has been proposed as a potential strategy for therapeutic revascularization. However, the limited endogenous cell pool and the related technical difficulties constitute clinically important disadvantages to autologous transplantation. In this study we investigated whether fully differentiated endothelial cells (ECs) modified with gene transfer of Id1, a helix-loop-helix transcription factor involved in angiogenesis, have the potential to contribute to therapeutic angiogenesis. Methods and Results-The Id1 gene was transferred into human umbilical vein ECs (HUVECs) via a Sendai virus vector.

protein-1 and tissue factor levels in patients with myocardial infarction Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant

Abstract 10758: Prognostic Importance of Late Gadolinium Enhancement Cardiac Magnetic Resonance as a Potential Novel Risk Factor in Patients with Dilated Cardiomyopathy

Circulation, Nov 20, 2012

PJ-570 Pioglitazone Prevents Stroke in Hypertensive Rats and Enhances Brain Protective Effect of AT1 Receptor Blocker(Cerebrovascular circulation/Stroke-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Circulation Journal Official Journal of the Japanese Circulation Society, Mar 1, 2007

Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization

Journal of Cardiology, 2015

The majority of patients who undergo coronary arteriography are discharged from the hospital on t... more The majority of patients who undergo coronary arteriography are discharged from the hospital on the day of the procedure or on the following day. The aim of this study is to investigate whether the change in serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) on the day following cardiac catheterization can predict the development of contrast-induced nephropathy (CIN). This is a multicenter prospective observational study, which consists of 860 patients who underwent cardiac catheterization. We measured SCr and eGFR before cardiac catheterization, on the following day, and 48-72h post-procedure. Definition of CIN is changes in SCr ≥0.5mg/dL or ≥25% from baseline 48-72h after contrast exposure. CIN occurred in 40 patients. SCr levels significantly increased from a baseline of 1.55±1.08mg/dL to 1.79±1.26mg/dL on the following day in patients with CIN (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), but significantly decreased from a baseline of 1.21±0.65mg/dL to 1.18±0.61mg/dL on the following day in those without CIN (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001). eGFR significantly decreased from a baseline of 47.3±28.3mL/min/1.73m(2) to 40.6±26.7mL/min/1.73m(2) on the following day in patients with CIN (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), but significantly increased from a baseline of 53.1±22.0mg/dL to 53.6±21.2mg/dL on the following day in those without CIN (p=0.0236). Receiver operating characteristic curve analysis indicated that SCr change ≥0.1mg/dL [area under the curve (AUC)=0.852, sensitivity 72.5%, specificity 86.1%] and eGFR change ≤-1.1mL/min/1.73m(2) (AUC=0.789, sensitivity 85.0%, specificity 64.9%) were the best cut-off values for predicting CIN. Multivariate logistic regression showed that a change in SCr ≥0.1mg/dL [odds ratio (OR), 29.3; 95% confidence interval (CI), 10.8-96.2] and change in eGFR ≤-1.1mL/min/1.73m(2) (OR, 69.7; 95% CI, 13.3-952) were powerful independent predictors of CIN. Changes in SCr and eGFR on the day following cardiac catheterization predict the development of CIN.

Abstract 13508: Patients with Vasospastic Angina Survived from Out-of-Hospital Cardiac Arrest as a High-Risk Population for Major Adverse Cardiac Events -A Report from the Nationwide Multi-Center Registry by the Japanese Coronary Spasm Association

Circulation, Nov 23, 2010

Abstract 4567: Prognostic Significance of Life-Threatening Arrhythmias During Spontaneous Attack of Vasospastic Angina -Multicenter Registry Study of the Japanese Coronary Spasm Association

Circulation, Nov 3, 2009

Abstract 3728: Angiotensin II is Involved in Hepatic Steatosis and Cardiovascular Injury in Obesity and Diabetes, via the Activation of Apoptosis Signal-Regulating Kinase 1

Circulation, Oct 28, 2008

Clinical Significance of Whole Exome Analysis Using Next Generation Sequencing in the Genotype-negative Long-QT Syndrome

Circulation, Nov 25, 2014

Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes

Japanese Circulation Journal, Sep 1, 1998

The levels of circulating monocyte chemoattractant protein-1 (MCP-1) and tissue factor (TF) were ... more The levels of circulating monocyte chemoattractant protein-1 (MCP-1) and tissue factor (TF) were examined on admission in 46 consecutive patients with acute coronary syndromes (ACS) and 30 patients with stable exertional angina (SEA). The plasma levels of both MCP-1 and TF were higher in the ACS patients than in the SEA patients (MCP-1: p<0.001; TF: p<0.001). Only the circulating TF level related to the number of diseased vessels. A positive correlation between plasma MCP-1 and TF levels was found (r=0.476, p<0.001). These results suggest that circulating MCP-1 plays an important role in the pathogenesis and/or development of ACS.

Abstract 9477: Gender Differences in Clinical Characteristics and Risk Factors of Patients with Vasospastic Angina -A Report from the Nationwide Multi-Center Registry by the Japanese Coronary Spasm Association

Circulation, Nov 22, 2011

1010 Characteristics of Changes of Plasminogen Activator Inhibitor Activity in Patients With Spontaneous Recanalization in Acute Myocardial Infarction

Japanese Circulation Journal, Jun 20, 1997

Comparison of Cardiovascular Mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes – A Large-Scale Data Analysis of Death Certificates –

Circulation Journal, 2015

Large earthquakes have been associated with cardiovascular disease (CVD) mortality. In Japan, the... more Large earthquakes have been associated with cardiovascular disease (CVD) mortality. In Japan, the 1995 Great Hanshin-Awaji (H-A) Earthquake was an urban-underground-type earthquake, whereas the 2011 Great East Japan (GEJ) Earthquake was an ocean-trench type. In the present study, we examined how these different earthquake types affected CVD mortality.Methods and Results:We examined death certificate data from 2008 to 2012 for 131 municipalities in Iwate, Miyagi, and Fukushima prefectures (n=320,348) and from 1992 to 1996 for 220 municipalities in Hyogo, Osaka, and Kyoto prefectures (n=592,670). A Poisson regression model showed significant increases in the monthly numbers of acute myocardial infarction (AMI)-related deaths (incident rate ratio [IRR] GEJ=1.34, P=0.001; IRR of H-A=1.57, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) and stroke-related deaths (IRR of GEJ=1.42, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001; IRR of H-A=1.33, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) after the earthquakes. Two months after the earthquakes, AMI deaths remained significant only for H-A (IRR=1.13, P=0.029). When analyzing the standardized mortality ratio (SMR) after the earthquakes using the Cochran-Armitage trend test, seismic intensity was significantly associated with AMI mortality for 2 weeks after both the GEJ (P for trend=0.089) and H-A earthquakes (P for trend=0.005). Following the GEJ and H-A earthquakes, there was a sharp increase in CVD mortality. The effect of the disaster was sustained for months after the H-A earthquake, but was diminished after the GEJ Earthquake. (Circ J 2015; 79: 1000-1008).

Abstract 12999: Different Response to Exercise Testing between Andersen-Tawil Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia

Circulation, Nov 20, 2012

Abstract 18697: “Forgotten” Cluster with Moderately-impaired LV Diastolic Function Determined by Doppler Echocardiography

Circulation, Nov 25, 2014

Abstract 16060: Electrocardiographic Analysis of Arrhythmogenic Right Ventricular Cardiomyopathy: Cardiovascular Events and the Epsilon Wave

Circulation, Nov 26, 2013

Assessment of platelet-derived thrombogenicity by the total thrombus-formation analysis system in coronary artery disease patients on antiplatelet therapy

Journal of thrombosis and haemostasis : JTH, Jan 16, 2016

Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy

European journal of heart failure, Jan 13, 2016

Circulation Journal Official Journal of the Japanese Circulation Society, Mar 1, 2008

Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling

Cell reports, 2015

protein-1 and tissue factor levels in patients with myocardial infarction Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant

Abstract 10758: Prognostic Importance of Late Gadolinium Enhancement Cardiac Magnetic Resonance as a Potential Novel Risk Factor in Patients with Dilated Cardiomyopathy

Circulation, Nov 20, 2012

Circulation Journal Official Journal of the Japanese Circulation Society, Mar 1, 2007

Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization

Journal of Cardiology, 2015

Circulation, Nov 23, 2010

Abstract 4567: Prognostic Significance of Life-Threatening Arrhythmias During Spontaneous Attack of Vasospastic Angina -Multicenter Registry Study of the Japanese Coronary Spasm Association

Circulation, Nov 3, 2009

Abstract 3728: Angiotensin II is Involved in Hepatic Steatosis and Cardiovascular Injury in Obesity and Diabetes, via the Activation of Apoptosis Signal-Regulating Kinase 1

Circulation, Oct 28, 2008

Clinical Significance of Whole Exome Analysis Using Next Generation Sequencing in the Genotype-negative Long-QT Syndrome

Circulation, Nov 25, 2014

Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes

Japanese Circulation Journal, Sep 1, 1998

Circulation, Nov 22, 2011

1010 Characteristics of Changes of Plasminogen Activator Inhibitor Activity in Patients With Spontaneous Recanalization in Acute Myocardial Infarction

Japanese Circulation Journal, Jun 20, 1997

Comparison of Cardiovascular Mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes – A Large-Scale Data Analysis of Death Certificates –

Circulation Journal, 2015

Abstract 12999: Different Response to Exercise Testing between Andersen-Tawil Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia

Circulation, Nov 20, 2012

Abstract 18697: “Forgotten” Cluster with Moderately-impaired LV Diastolic Function Determined by Doppler Echocardiography

Circulation, Nov 25, 2014

Abstract 16060: Electrocardiographic Analysis of Arrhythmogenic Right Ventricular Cardiomyopathy: Cardiovascular Events and the Epsilon Wave

Circulation, Nov 26, 2013