M. Hod - Academia.edu (original) (raw)
Papers by M. Hod
Israel journal of medical sciences, 1990
Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue... more Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue myo-inositol following culture from day 9.5 to 11.5 of development in the presence of increased amounts of glucose. Reductions of myo-inositol and increased malformations are not corrected by aldose reductase inhibitors. In contrast, supplementation of culture medium with myo-inositol (1.5 mg/ml) restores tissue myo-inositol content, lowers the incidence of dysmorphogenic embryos (from 51.1 to 28.6%, P less than 0.001) and reduces the incidence of neural tube defects to control levels (from 33.3 to 6%, P less than 0.001). These results suggest that myo-inositol depletion is involved in the mechanism of diabetic embryopathy.
Breech presentation is prevalent among preterm deliveries and contributes to neonatal mortality f... more Breech presentation is prevalent among preterm deliveries and contributes to neonatal mortality far beyond its prevalence. The management of a preterm breech delivery is controversial. We present our retrospective experience with 185 consecutive preterm breech deliveries, part delivered by cesarean section and part delivered vaginally as assisted breech delivery or total breech extraction), and compare the perinatal outcome between these two groups in terms of perinatal mortality (PPD) and perinatal morbidity (neonatal asphyxia). No statistically significant difference was found for either variable in the two examined groups. We therefore conclude that the method of delivery of low birth weight (1000-2500) breeches has no effect on perinatal outcome.
BACKGROUND Microalbuminuria is an important risk factor for underlying vascular disease. Its dete... more BACKGROUND Microalbuminuria is an important risk factor for underlying vascular disease. Its detection after pregnancy complicated by pre-eclampsia may have predictive value for the later development of chronic hypertension or renal disease. METHOD The study group consisted of 48 women in whom pregnancy had been complicated by pre-eclampsia. Urinary albumin excretion rate, blood pressure, and renal function parameters were assessed 2-4 months and 3-5 years after the pregnancy. Results were compared with those in 44 women after normal pregnancy. RESULTS Mean urinary albumin excretion rate was significantly higher in the study group than in the controls both at 2-4 months after delivery (27.0 +/- 33 vs 6.1 +/- 3.3 mg/24 h) and at 3-5 years after delivery (23.5 +/- 26.8 vs 6.7 +/- 2.8 mg/24 h) (P = 0.001). The rate of occurrence of microalbuminuria was not significantly different between the early (58%) and late (42%) time-points within the study group or between the nulliparous and th...
Ofloxacin can cause retarded ossification and arthropathy in young animals, but there is no publi... more Ofloxacin can cause retarded ossification and arthropathy in young animals, but there is no published information about its teratogenicity in humans. A 36-year-old woman was treated with ofloxacin 200 mg bid for 6 days during the 19th week of gestation. Ultrasound follow-up of the measurements and structure of the fetal long bones revealed no abnormalities. The neonate's physical examination and X-rays of the chest and long bones were normal. Although no teratogenic or toxic effects were observed in this patient, the use of ofloxacin in human pregnancy should only be a clinical consideration until sufficient evidence regarding its safety in the human fetus has been published.
Endocrinología y Nutrición
Diabetologie und Stoffwechsel, 2007
BJOG: An International Journal of Obstetrics & Gynaecology, 2016
Israel journal of medical sciences
This study presents kinetic parameters of glycine metabolism during pregnancy and the influence o... more This study presents kinetic parameters of glycine metabolism during pregnancy and the influence of fuel availability in the maternal compartment. The effect of gestational diabetes mellitus (diet treated) and pre-gestational diabetes mellitus (diet and insulin treated), accompanied by increased fetal growth on [15N]glycine kinetic parameters, compared to normal pregnancies with normal fetal growth, has been determined. This process was measured by administration of a single-dose of [15N]glycine to post-absorptive normal and diabetic pregnant women during the third trimester of pregnancy. Gas chromatography-mass spectrometry was used to determine the 15N enrichment of plasma glycine, and to calculate the pool sizes, turnover rate constants, fluxes and metabolic clearance rates. Glycine pool sizes in pre-gestational diabetes were significantly larger than those in normal pregnancy and gestational diabetes. Glycine turnover rate constants and metabolic clearance rates were not signific...
The International journal of risk & safety in medicine, 1994
Indomethacin was utilized in 89 patients in preterm labor; the mean gestational age at the start ... more Indomethacin was utilized in 89 patients in preterm labor; the mean gestational age at the start of indomethacin therapy was 25.4 weeks (± 4.1), mean duration of indomethacin treatment was 43.9 days (± 31.3), mean gestational age at delivery was 33.6 weeks (± 3.2). Long-term ( > 48 h) indomethacin tocolysis evoked serious maternal side effects in 30.3% of patients studied. These side effects included exaggerated hypertensive responses in patients treated concomitantly with beta-blockers, gastric erosion and bleeding, fever, interstitial nephritis and postpartum hemorrhage.
European journal of epidemiology, 2000
The purpose of this work is to clarify by path analysis which of the predictor factors of mortali... more The purpose of this work is to clarify by path analysis which of the predictor factors of mortality in a cohort of 423 singletons VLBW infants born at Beilinson Medical Center during the years 1980-1990 (pre-surfactant era) exert direct or indirect effect on mortality. A direct risk factor was defined as a factor having an immediate effect on the outcome without working through an intermediate variable. By contrast, an indirect risk factor was defined as a factor that does not have a direct effect on the risk of mortality but instead works through an intermediate variable. Evaluation of mortality was done at three points over time (pre-delivery, at birth and post-delivery). In the pre-delivery model, gestational age, appropriateness for gestational age, mother's age and fetal distress work directly on mortality in VLBW infants. At birth, mother's age, birth weight and Apgar score at the fifth minute work directly on the risk of mortality. When the assessment of the risk of d...
Clinical nephrology, 2000
The preconception and intraconception parameters that are relevant to outcome in women with under... more The preconception and intraconception parameters that are relevant to outcome in women with underlying renal disease remain controversial. We analyzed the types and frequencies of short- and long-term (2 years after delivery) maternal and neonatal complications in 38 patients with primary renal disease (46 pregnancies), 24 IDDM patients with diabetic nephropathy (24 pregnancies), and 27 patients with a functioning renal allograft (42 pregnancies), most of them with mild renal insufficiency. Logistic regression models were formulated to predict successful outcome. Successful pregnancy outcome (live, healthy infant without severe handicap 2 years after delivery) was observed in 98% of the patients with primary renal disease, 96% of the IDDM patients with diabetic nephropathy, and 89% of the patients with a functioning renal allograft. Factors found to be significantly predictive of successful outcome were absence of preexisting hypertension in all groups, in addition to low preconcept...
Diabetes care, 1998
We sought to determine whether strict glycemic control during diabetic pregnancy combined with el... more We sought to determine whether strict glycemic control during diabetic pregnancy combined with elective early induction of labor reduces the rate of cesarean delivery and fetal birth trauma. We used a population-based longitudinal design covering three periods corresponding to changes in the management protocol for diabetic pregnancy at our center: 1) 1980-1989: no set level of maternal glycemia, elective cesarean section when estimated fetal weight was 4,500 g or more, and no elective early induction; 2) 1990-1992: desired mean maternal glycemia < or = 5.8 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 40 weeks for large-for-gestational-age fetuses; 3) 1993-1995: desired mean maternal glycemia < or = 5.3 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 38 weeks for large-for-gestational-age fetuses. Outcome of diabetic pregnancies was compared ...
Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy, 1996
Evidence supports the theory that in diabetic pregnant women, it is the degree of metabolic imbal... more Evidence supports the theory that in diabetic pregnant women, it is the degree of metabolic imbalance present during the crucial time of organogenesis that determines the organogenetic congenital defects. The precise mechanism responsible for abnormal fetal organogenesis is unclear, but fuels such as sugars (glucose, galactose, mannose), ketones, fuel-related principles such as somatomedin inhibitors, insulin, trace elements and, lately, myoinositol, arachidonic acid and free oxygen radicals have all been implicated. The plasma-membrane lipids, in addition to serving as barriers that separate intracellular from extracellular fluid, are the actual sources of signal molecules. In one case, the signal molecule (diphosphoinositol) is derived from a variant of a common membrane lipid. This is similar to the situation in which a hormone, or similar extracellular messenger, binds to its membrane receptor and activates an enzyme that hydrolyzes plasma-membrane phospholipids to liberate arac...
Israel journal of medical sciences, 1996
The literature contains reports of 2,309 pregnancies in some 1,600 women who have undergone renal... more The literature contains reports of 2,309 pregnancies in some 1,600 women who have undergone renal transplantation. Certain pre-pregnancy factors, especially hypertension, renal graft dysfunction and short interval between transplant and pregnancy, appear to increase the neonatal risks. We describe the outcome of 42 pregnancies in 27 allograft recipients at Beilinson Medical Center in Israel during the last 8 years. All were treated with combination immunosuppression regimens. The average interval from time of transplantation to conception was 3.7 +/- 0.4 years (2 months to 9 years). Rejection episodes occurred in 37% prior to pregnancy but in none during or immediately after pregnancy. Of the 42 pregnancies 28% ended in therapeutic or spontaneous abortions, and 29 of the 30 deliveries ended in a life birth. The prematurity rate (65%) was similar to that described in the literature. Renal deterioration was evident in seven women (26%) within 2 years after delivery. Despite this signi...
Israel journal of medical sciences, 1995
The Journal of Maternal-Fetal & Neonatal Medicine, 2014
Israel journal of medical sciences, 1990
Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue... more Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue myo-inositol following culture from day 9.5 to 11.5 of development in the presence of increased amounts of glucose. Reductions of myo-inositol and increased malformations are not corrected by aldose reductase inhibitors. In contrast, supplementation of culture medium with myo-inositol (1.5 mg/ml) restores tissue myo-inositol content, lowers the incidence of dysmorphogenic embryos (from 51.1 to 28.6%, P less than 0.001) and reduces the incidence of neural tube defects to control levels (from 33.3 to 6%, P less than 0.001). These results suggest that myo-inositol depletion is involved in the mechanism of diabetic embryopathy.
Breech presentation is prevalent among preterm deliveries and contributes to neonatal mortality f... more Breech presentation is prevalent among preterm deliveries and contributes to neonatal mortality far beyond its prevalence. The management of a preterm breech delivery is controversial. We present our retrospective experience with 185 consecutive preterm breech deliveries, part delivered by cesarean section and part delivered vaginally as assisted breech delivery or total breech extraction), and compare the perinatal outcome between these two groups in terms of perinatal mortality (PPD) and perinatal morbidity (neonatal asphyxia). No statistically significant difference was found for either variable in the two examined groups. We therefore conclude that the method of delivery of low birth weight (1000-2500) breeches has no effect on perinatal outcome.
BACKGROUND Microalbuminuria is an important risk factor for underlying vascular disease. Its dete... more BACKGROUND Microalbuminuria is an important risk factor for underlying vascular disease. Its detection after pregnancy complicated by pre-eclampsia may have predictive value for the later development of chronic hypertension or renal disease. METHOD The study group consisted of 48 women in whom pregnancy had been complicated by pre-eclampsia. Urinary albumin excretion rate, blood pressure, and renal function parameters were assessed 2-4 months and 3-5 years after the pregnancy. Results were compared with those in 44 women after normal pregnancy. RESULTS Mean urinary albumin excretion rate was significantly higher in the study group than in the controls both at 2-4 months after delivery (27.0 +/- 33 vs 6.1 +/- 3.3 mg/24 h) and at 3-5 years after delivery (23.5 +/- 26.8 vs 6.7 +/- 2.8 mg/24 h) (P = 0.001). The rate of occurrence of microalbuminuria was not significantly different between the early (58%) and late (42%) time-points within the study group or between the nulliparous and th...
Ofloxacin can cause retarded ossification and arthropathy in young animals, but there is no publi... more Ofloxacin can cause retarded ossification and arthropathy in young animals, but there is no published information about its teratogenicity in humans. A 36-year-old woman was treated with ofloxacin 200 mg bid for 6 days during the 19th week of gestation. Ultrasound follow-up of the measurements and structure of the fetal long bones revealed no abnormalities. The neonate's physical examination and X-rays of the chest and long bones were normal. Although no teratogenic or toxic effects were observed in this patient, the use of ofloxacin in human pregnancy should only be a clinical consideration until sufficient evidence regarding its safety in the human fetus has been published.
Endocrinología y Nutrición
Diabetologie und Stoffwechsel, 2007
BJOG: An International Journal of Obstetrics & Gynaecology, 2016
Israel journal of medical sciences
This study presents kinetic parameters of glycine metabolism during pregnancy and the influence o... more This study presents kinetic parameters of glycine metabolism during pregnancy and the influence of fuel availability in the maternal compartment. The effect of gestational diabetes mellitus (diet treated) and pre-gestational diabetes mellitus (diet and insulin treated), accompanied by increased fetal growth on [15N]glycine kinetic parameters, compared to normal pregnancies with normal fetal growth, has been determined. This process was measured by administration of a single-dose of [15N]glycine to post-absorptive normal and diabetic pregnant women during the third trimester of pregnancy. Gas chromatography-mass spectrometry was used to determine the 15N enrichment of plasma glycine, and to calculate the pool sizes, turnover rate constants, fluxes and metabolic clearance rates. Glycine pool sizes in pre-gestational diabetes were significantly larger than those in normal pregnancy and gestational diabetes. Glycine turnover rate constants and metabolic clearance rates were not signific...
The International journal of risk & safety in medicine, 1994
Indomethacin was utilized in 89 patients in preterm labor; the mean gestational age at the start ... more Indomethacin was utilized in 89 patients in preterm labor; the mean gestational age at the start of indomethacin therapy was 25.4 weeks (± 4.1), mean duration of indomethacin treatment was 43.9 days (± 31.3), mean gestational age at delivery was 33.6 weeks (± 3.2). Long-term ( > 48 h) indomethacin tocolysis evoked serious maternal side effects in 30.3% of patients studied. These side effects included exaggerated hypertensive responses in patients treated concomitantly with beta-blockers, gastric erosion and bleeding, fever, interstitial nephritis and postpartum hemorrhage.
European journal of epidemiology, 2000
The purpose of this work is to clarify by path analysis which of the predictor factors of mortali... more The purpose of this work is to clarify by path analysis which of the predictor factors of mortality in a cohort of 423 singletons VLBW infants born at Beilinson Medical Center during the years 1980-1990 (pre-surfactant era) exert direct or indirect effect on mortality. A direct risk factor was defined as a factor having an immediate effect on the outcome without working through an intermediate variable. By contrast, an indirect risk factor was defined as a factor that does not have a direct effect on the risk of mortality but instead works through an intermediate variable. Evaluation of mortality was done at three points over time (pre-delivery, at birth and post-delivery). In the pre-delivery model, gestational age, appropriateness for gestational age, mother's age and fetal distress work directly on mortality in VLBW infants. At birth, mother's age, birth weight and Apgar score at the fifth minute work directly on the risk of mortality. When the assessment of the risk of d...
Clinical nephrology, 2000
The preconception and intraconception parameters that are relevant to outcome in women with under... more The preconception and intraconception parameters that are relevant to outcome in women with underlying renal disease remain controversial. We analyzed the types and frequencies of short- and long-term (2 years after delivery) maternal and neonatal complications in 38 patients with primary renal disease (46 pregnancies), 24 IDDM patients with diabetic nephropathy (24 pregnancies), and 27 patients with a functioning renal allograft (42 pregnancies), most of them with mild renal insufficiency. Logistic regression models were formulated to predict successful outcome. Successful pregnancy outcome (live, healthy infant without severe handicap 2 years after delivery) was observed in 98% of the patients with primary renal disease, 96% of the IDDM patients with diabetic nephropathy, and 89% of the patients with a functioning renal allograft. Factors found to be significantly predictive of successful outcome were absence of preexisting hypertension in all groups, in addition to low preconcept...
Diabetes care, 1998
We sought to determine whether strict glycemic control during diabetic pregnancy combined with el... more We sought to determine whether strict glycemic control during diabetic pregnancy combined with elective early induction of labor reduces the rate of cesarean delivery and fetal birth trauma. We used a population-based longitudinal design covering three periods corresponding to changes in the management protocol for diabetic pregnancy at our center: 1) 1980-1989: no set level of maternal glycemia, elective cesarean section when estimated fetal weight was 4,500 g or more, and no elective early induction; 2) 1990-1992: desired mean maternal glycemia < or = 5.8 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 40 weeks for large-for-gestational-age fetuses; 3) 1993-1995: desired mean maternal glycemia < or = 5.3 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 38 weeks for large-for-gestational-age fetuses. Outcome of diabetic pregnancies was compared ...
Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy, 1996
Evidence supports the theory that in diabetic pregnant women, it is the degree of metabolic imbal... more Evidence supports the theory that in diabetic pregnant women, it is the degree of metabolic imbalance present during the crucial time of organogenesis that determines the organogenetic congenital defects. The precise mechanism responsible for abnormal fetal organogenesis is unclear, but fuels such as sugars (glucose, galactose, mannose), ketones, fuel-related principles such as somatomedin inhibitors, insulin, trace elements and, lately, myoinositol, arachidonic acid and free oxygen radicals have all been implicated. The plasma-membrane lipids, in addition to serving as barriers that separate intracellular from extracellular fluid, are the actual sources of signal molecules. In one case, the signal molecule (diphosphoinositol) is derived from a variant of a common membrane lipid. This is similar to the situation in which a hormone, or similar extracellular messenger, binds to its membrane receptor and activates an enzyme that hydrolyzes plasma-membrane phospholipids to liberate arac...
Israel journal of medical sciences, 1996
The literature contains reports of 2,309 pregnancies in some 1,600 women who have undergone renal... more The literature contains reports of 2,309 pregnancies in some 1,600 women who have undergone renal transplantation. Certain pre-pregnancy factors, especially hypertension, renal graft dysfunction and short interval between transplant and pregnancy, appear to increase the neonatal risks. We describe the outcome of 42 pregnancies in 27 allograft recipients at Beilinson Medical Center in Israel during the last 8 years. All were treated with combination immunosuppression regimens. The average interval from time of transplantation to conception was 3.7 +/- 0.4 years (2 months to 9 years). Rejection episodes occurred in 37% prior to pregnancy but in none during or immediately after pregnancy. Of the 42 pregnancies 28% ended in therapeutic or spontaneous abortions, and 29 of the 30 deliveries ended in a life birth. The prematurity rate (65%) was similar to that described in the literature. Renal deterioration was evident in seven women (26%) within 2 years after delivery. Despite this signi...
Israel journal of medical sciences, 1995
The Journal of Maternal-Fetal & Neonatal Medicine, 2014