Holly D Tanton - Academia.edu (original) (raw)

Holly D Tanton

I am a wastewater lab scientist with an interest in chemistry, microbiology, biochemistry, and molecular biology.
Supervisors: Alexander Kofman

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Papers by Holly D Tanton

Research paper thumbnail of Multiple genetic polymorphisms within microRNA targets and homologous microRNA-binding sites: two more factors influencing microRNA-mediated regulation of gene expression

IntechOpen eBooks, Aug 13, 2023

Research paper thumbnail of NEIL (Nucleotide Expression, Inspiration, and Logic): a new Computational Approach to the Analysis of MicroRNA-Related Nucleotide Variations

Biomedical Journal of Scientific & Technical Research, 2019

Genetic variations of microRNAs and their target sites among individuals are increasingly recogni... more Genetic variations of microRNAs and their target sites among individuals are increasingly recognized as possible factors underlying various human disorders. Currently, the computer-assisted predictions of microRNA-binding sites rely exclusively on one or few reference genomic sequences and do not take into consideration significant variations within human genomes. There is a need to develop computational approaches to assess the probability of excessively strong or completely disabled microRNA-binding sites upon the known SNP frequencies. We developed the software NEIL to align the individual microRNA and mRNA sequences in the setting of the corresponding genomic SNP map of the targeted gene. This approach allows us to visualize the presence of SNPs within and in the proximity of microRNA-target sites in order to predict the combinatorial effects of SNPs on microRNA-mRNA binding and the expression of the microRNA-regulated genes.

Research paper thumbnail of Nucleotide Variations in microRNA-Binding Sites: The Need of Novel Tools for the Nucleic Acid Alignment

Biomedical Journal of Scientific & Technical Research, 2019

It has been proposed that naturally-occurring variations in microRNAs and their target sites on m... more It has been proposed that naturally-occurring variations in microRNAs and their target sites on messenger RNAs may be linked with various human pathologies, including cancer. The growing number of reports clearly indicates the need of the development of complementary sequence alignment algorithms, where the interaction of two complementary RNAs (specifically microRNA and its target mRNA) can be assessed in the context of the multiple single nucleotide polymorphisms.

Research paper thumbnail of Multiple genetic polymorphisms within microRNA targets and homologous microRNA-binding sites: two more factors influencing microRNA-mediated regulation of gene expression

IntechOpen eBooks, Aug 13, 2023

Research paper thumbnail of NEIL (Nucleotide Expression, Inspiration, and Logic): a new Computational Approach to the Analysis of MicroRNA-Related Nucleotide Variations

Biomedical Journal of Scientific & Technical Research, 2019

Genetic variations of microRNAs and their target sites among individuals are increasingly recogni... more Genetic variations of microRNAs and their target sites among individuals are increasingly recognized as possible factors underlying various human disorders. Currently, the computer-assisted predictions of microRNA-binding sites rely exclusively on one or few reference genomic sequences and do not take into consideration significant variations within human genomes. There is a need to develop computational approaches to assess the probability of excessively strong or completely disabled microRNA-binding sites upon the known SNP frequencies. We developed the software NEIL to align the individual microRNA and mRNA sequences in the setting of the corresponding genomic SNP map of the targeted gene. This approach allows us to visualize the presence of SNPs within and in the proximity of microRNA-target sites in order to predict the combinatorial effects of SNPs on microRNA-mRNA binding and the expression of the microRNA-regulated genes.

Research paper thumbnail of Nucleotide Variations in microRNA-Binding Sites: The Need of Novel Tools for the Nucleic Acid Alignment

Biomedical Journal of Scientific & Technical Research, 2019

It has been proposed that naturally-occurring variations in microRNAs and their target sites on m... more It has been proposed that naturally-occurring variations in microRNAs and their target sites on messenger RNAs may be linked with various human pathologies, including cancer. The growing number of reports clearly indicates the need of the development of complementary sequence alignment algorithms, where the interaction of two complementary RNAs (specifically microRNA and its target mRNA) can be assessed in the context of the multiple single nucleotide polymorphisms.

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