Hugo Heymans - Academia.edu (original) (raw)

Papers by Hugo Heymans

Research paper thumbnail of Short-term protein intake and stimulation of protein synthesis in stunted children with cystic fibrosis

The American Journal of Clinical Nutrition, 2005

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Research paper thumbnail of Intestinal permeability in premature infants. † 1437

Pediatric Research, 1997

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Research paper thumbnail of Intestinal Permeability in Preterm Neonates is not Related to Gestational Age or Birth Weight. 75

Pediatric Research, 1996

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Research paper thumbnail of Mortality and causes of death of end-stage renal disease in children: A Dutch cohort study

Kidney International, 2002

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Research paper thumbnail of Cardiac disease in young adult patients with end-stage renal disease since childhood: A Dutch cohort study

Kidney International, 2003

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Research paper thumbnail of Severe bone disease and low bone mineral density after juvenile renal failure

Kidney International, 2003

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Research paper thumbnail of Increased Arterial Stiffness in Young Adults with End-Stage Renal Disease since Childhood

Journal of the American Society of Nephrology, 2002

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Research paper thumbnail of The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population

European Journal of Gastroenterology & Hepatology, 1997

It has been suggested that the amount of gluten intake in populations offers an explanation for d... more It has been suggested that the amount of gluten intake in populations offers an explanation for differences in the epidemiology of coeliac disease. Investigations into first-degree relatives of coeliac disease patients have often shown that relatives exhibit intermediate features of coeliac disease, possibly due to a low gluten intake. The aim of this study was to investigate the pattern of gluten consumption in the general Dutch population for different age and sex groups and for different product groups, and to investigate the daily gluten intake of first-degree relatives of coeliac disease patients. Questionnaires concerning the gluten intake of 55 first-degree relatives of coeliac disease patients were analysed. To determine the gluten intake of the general Dutch population, the results of a mass investigation were used. The amount of gluten in the gluten-rich products was estimated by multiplying the amount of vegetable proteins by 0.8. The median daily gluten intake of the relatives was 12.9 g (range: 3.8-31.3). The mean daily gluten intake of the study population in the Netherlands was 1 3.1 g. The gluten intake of first-degree relatives of coeliac disease patients was the same as that of the general population. Thus, a low gluten intake apparently does not explain the aspecific presentation and prevalence of coeliac disease in first-degree relatives of coeliac disease patients.

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Research paper thumbnail of Dental enamel defects in children with coeliac disease

BDJ, 2007

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Research paper thumbnail of Use of tracheal auscultation for the assessment of bronchial responsiveness in asthmatic children

Thorax, 1996

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Research paper thumbnail of Kanker op de kinderleeftijd in Nederland (1989-1997)

Cancer in children in the Netherlands (1989-1997). – In a recent report by the Society of Integra... more Cancer in children in the Netherlands (1989-1997). – In a recent report by the Society of Integral Cancer Centres in the Netherlands, attention was devoted to the incidence of cancer in children and the mortality arising from this. In recent years the growing diagnostic and therapeutic possibilities have changed the perspective of childhood cancer enormously. Based on a careful classification and clinical staging, national and internaNed Tijdschr Geneeskd 2001 28 juli;145(30) 1443 tional investigations have resulted in new and successful therapeutical strategies. Overall prognoses of childhood cancer have improved dramatically from a 5-year survival rate in the 1960s and 1970s of less than 30%, to an 8-year survival rate of more than 70% between 1989 and 1997. However, this success means that more investigations into the long-term effects of childhood cancer and its treatment are needed. In a study at the Amsterdam University Hospital, 700 adult survivors of childhood cancer were re...

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Research paper thumbnail of Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology?

European Journal of Gastroenterology & Hepatology, 2000

Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD ... more Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of screening parameters for the detection and estimation of CD prevalence in first-degree relatives. The screening was performed in 338 first-degree relatives of 134 coeliac families. Questionnaires and a physical examination followed by haematological analyses and serologyfor IgA anti-endomysium (EMA)/IgA antigliadin (AGA) antibodies were used in orderto selectthe candidates for small-bowel biopsy. The small-bowel biopsy was indicated on the basis of clinical complaints, laboratory tests and serology performed in 96 (28%) of the study group. CD was diagnosed in 17/96 cases. Six of the 17 showed total villous atrophy (VA) (Marsh IIIc), five subtotal VA (Marsh IIIb) and six partial VA (Marsh IIIa). EMA and AGA were strongly positive in the six patients whose intestinal biopsy showed total VA. However, only one coeliac out of the six patients with partial VA had positive EMA and AGA. A significant proportion of coeliacs may be missed if cases are screened by serology only. Although endomysial antibody assay has been reported as a highly sensitive and specific test for detection of CD, we argue that using only EMA and AGA in screening is not enough for investigation of the true prevalence of CD. A combination of clinical parameters as described in this study and laboratory/serological tests is an important and practical contribution to improving the detection rate of CD.

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Research paper thumbnail of Screening for child abuse using a checklist and physical examinations in the emergency department led to the detection of more cases

Acta paediatrica (Oslo, Norway : 1992), Jan 10, 2018

We studied the accuracy of a screening checklist (SPUTOVAMO), complete physical examination (top-... more We studied the accuracy of a screening checklist (SPUTOVAMO), complete physical examination (top-to-toe inspection, TTI) and their combination in detecting child abuse in the emergency department (ED). Consecutive patients admitted to the ED of the Academic Medical Center in Amsterdam between January 2011 and 1 July 2013 were included. An Expert Panel assigned a consensus diagnosis to positive cases. For all other and missed cases, the Child Abuse Counselling and Reporting Centre diagnosis was used. We included 17 229 admissions of 12 198 patients. In 46%, SPUTOVAMO was performed, in 33% TTI; 421 children (4.3%) tested positive on either or both, with 68 positive consensus diagnoses. In eight children not reported to the Expert Panel, the Child Abuse Counselling and Reporting Center diagnosis was positive. Ten of 3519 (0.3%) children testing negative on both were child abuse cases; 0.88% of the study group had a final child abuse diagnosis. The estimated PPV was 0.46 for SPUTOVAMO, ...

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Research paper thumbnail of Assessments carried out by a child abuse and neglect team in an Amsterdam teaching hospital led to interventions in most of the reported cases

Acta paediatrica (Oslo, Norway : 1992), Jan 30, 2016

This study described cases of child abuse and neglect (CAN) that were reported to the multiagency... more This study described cases of child abuse and neglect (CAN) that were reported to the multiagency CAN team at the Emma Children's Hospital in Amsterdam and the resulting interventions. We carried out a retrospective review of all cases that were reported to the CAN team from 1 January 2010 to 31 December 2012. There were 27 prenatal cases, 92 referrals based on parental characteristics and 523 children. Overall, 1.2% of the children visiting the emergency department of our hospital, attending the outpatients department or being admitted were reported to the team. More than half of the referrals (55.1%) were confirmed as CAN. The most common diagnoses were as follows: witnessing intimate partner violence, physical neglect and emotional abuse. If CAN was confirmed an intervention was offered in 98.3% of cases. If a CAN diagnosis was undetermined or rejected, the figures were still 83.5% and 64.2%, respectively. Our results showed that CAN affected more than one in every 100 childr...

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Research paper thumbnail of Comparing the effect of Livercell Transplantation (LCTX) in Gunn rats using either immunesuppresive therapy or immunetolerance inducing techniques

J Pediat Gastroenterol Nutr, 1998

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Research paper thumbnail of The pharmacokinetics of nelfinavir in HIV-1-infected children

Therapeutic Drug Monitoring, Aug 1, 2002

The authors investigated the steady-state plasma pharmacokinetics of nelfinavir in HIV-1-infected... more The authors investigated the steady-state plasma pharmacokinetics of nelfinavir in HIV-1-infected children in a dosage of 30 mg/kg every 8 hours and 45 mg/kg every 12 hours in 12 HIV-1-infected children (aged 2.1 to 10.8 years) participating in an open-label study of nelfinavir in combination with stavudine and lamivudine. Median values of the primary pharmacokinetic parameters of nelfinavir 30 mg/kg every-8-hours (n = 8) and 45 mg/kg every 12 hours (n = 10) were, respectively, for the area under the plasma concentration-time curve over 24 hours, 90.5 and 71.9 h x microg/mL, for the trough concentration 1.9 and 1.0 microg/mL, and for the maximal concentration 6.3 and 5.2 microg/mL. Overall, a 7-fold interpatient variability was observed for the exposure to nelfinavir. Nelfinavir 30 mg/kg every-8-hours or 45 mg/kg every 12 hours in HIV-1-infected children generally resulted in plasma concentrations higher than those obtained in adults. However, due to a large interpatient variability in the exposure, individual dosage adjustments based on plasma concentrations may be necessary for both dosing regimens to ensure optimal treatment.

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Research paper thumbnail of Endoscopic Balloon Dilatation as Treatment of Gastric Outlet Obstruction in Infancy and Childhood: 79

Pediat Res, 1987

ABSTRACT

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Research paper thumbnail of Small Intestinal Biopsy

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Research paper thumbnail of De ziekte van Fabry: etiologie, kliniek en behandeling

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Research paper thumbnail of Kindermishandeling, diagnostische en therapeutische dilemma's

Tijdschrift Voor Kindergeneeskunde, 2005

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Research paper thumbnail of Short-term protein intake and stimulation of protein synthesis in stunted children with cystic fibrosis

The American Journal of Clinical Nutrition, 2005

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Research paper thumbnail of Intestinal permeability in premature infants. † 1437

Pediatric Research, 1997

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Intestinal Permeability in Preterm Neonates is not Related to Gestational Age or Birth Weight. 75

Pediatric Research, 1996

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mortality and causes of death of end-stage renal disease in children: A Dutch cohort study

Kidney International, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cardiac disease in young adult patients with end-stage renal disease since childhood: A Dutch cohort study

Kidney International, 2003

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Severe bone disease and low bone mineral density after juvenile renal failure

Kidney International, 2003

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Increased Arterial Stiffness in Young Adults with End-Stage Renal Disease since Childhood

Journal of the American Society of Nephrology, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population

European Journal of Gastroenterology & Hepatology, 1997

It has been suggested that the amount of gluten intake in populations offers an explanation for d... more It has been suggested that the amount of gluten intake in populations offers an explanation for differences in the epidemiology of coeliac disease. Investigations into first-degree relatives of coeliac disease patients have often shown that relatives exhibit intermediate features of coeliac disease, possibly due to a low gluten intake. The aim of this study was to investigate the pattern of gluten consumption in the general Dutch population for different age and sex groups and for different product groups, and to investigate the daily gluten intake of first-degree relatives of coeliac disease patients. Questionnaires concerning the gluten intake of 55 first-degree relatives of coeliac disease patients were analysed. To determine the gluten intake of the general Dutch population, the results of a mass investigation were used. The amount of gluten in the gluten-rich products was estimated by multiplying the amount of vegetable proteins by 0.8. The median daily gluten intake of the relatives was 12.9 g (range: 3.8-31.3). The mean daily gluten intake of the study population in the Netherlands was 1 3.1 g. The gluten intake of first-degree relatives of coeliac disease patients was the same as that of the general population. Thus, a low gluten intake apparently does not explain the aspecific presentation and prevalence of coeliac disease in first-degree relatives of coeliac disease patients.

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Research paper thumbnail of Dental enamel defects in children with coeliac disease

BDJ, 2007

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Use of tracheal auscultation for the assessment of bronchial responsiveness in asthmatic children

Thorax, 1996

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Research paper thumbnail of Kanker op de kinderleeftijd in Nederland (1989-1997)

Cancer in children in the Netherlands (1989-1997). – In a recent report by the Society of Integra... more Cancer in children in the Netherlands (1989-1997). – In a recent report by the Society of Integral Cancer Centres in the Netherlands, attention was devoted to the incidence of cancer in children and the mortality arising from this. In recent years the growing diagnostic and therapeutic possibilities have changed the perspective of childhood cancer enormously. Based on a careful classification and clinical staging, national and internaNed Tijdschr Geneeskd 2001 28 juli;145(30) 1443 tional investigations have resulted in new and successful therapeutical strategies. Overall prognoses of childhood cancer have improved dramatically from a 5-year survival rate in the 1960s and 1970s of less than 30%, to an 8-year survival rate of more than 70% between 1989 and 1997. However, this success means that more investigations into the long-term effects of childhood cancer and its treatment are needed. In a study at the Amsterdam University Hospital, 700 adult survivors of childhood cancer were re...

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Research paper thumbnail of Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology?

European Journal of Gastroenterology & Hepatology, 2000

Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD ... more Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of screening parameters for the detection and estimation of CD prevalence in first-degree relatives. The screening was performed in 338 first-degree relatives of 134 coeliac families. Questionnaires and a physical examination followed by haematological analyses and serologyfor IgA anti-endomysium (EMA)/IgA antigliadin (AGA) antibodies were used in orderto selectthe candidates for small-bowel biopsy. The small-bowel biopsy was indicated on the basis of clinical complaints, laboratory tests and serology performed in 96 (28%) of the study group. CD was diagnosed in 17/96 cases. Six of the 17 showed total villous atrophy (VA) (Marsh IIIc), five subtotal VA (Marsh IIIb) and six partial VA (Marsh IIIa). EMA and AGA were strongly positive in the six patients whose intestinal biopsy showed total VA. However, only one coeliac out of the six patients with partial VA had positive EMA and AGA. A significant proportion of coeliacs may be missed if cases are screened by serology only. Although endomysial antibody assay has been reported as a highly sensitive and specific test for detection of CD, we argue that using only EMA and AGA in screening is not enough for investigation of the true prevalence of CD. A combination of clinical parameters as described in this study and laboratory/serological tests is an important and practical contribution to improving the detection rate of CD.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Screening for child abuse using a checklist and physical examinations in the emergency department led to the detection of more cases

Acta paediatrica (Oslo, Norway : 1992), Jan 10, 2018

We studied the accuracy of a screening checklist (SPUTOVAMO), complete physical examination (top-... more We studied the accuracy of a screening checklist (SPUTOVAMO), complete physical examination (top-to-toe inspection, TTI) and their combination in detecting child abuse in the emergency department (ED). Consecutive patients admitted to the ED of the Academic Medical Center in Amsterdam between January 2011 and 1 July 2013 were included. An Expert Panel assigned a consensus diagnosis to positive cases. For all other and missed cases, the Child Abuse Counselling and Reporting Centre diagnosis was used. We included 17 229 admissions of 12 198 patients. In 46%, SPUTOVAMO was performed, in 33% TTI; 421 children (4.3%) tested positive on either or both, with 68 positive consensus diagnoses. In eight children not reported to the Expert Panel, the Child Abuse Counselling and Reporting Center diagnosis was positive. Ten of 3519 (0.3%) children testing negative on both were child abuse cases; 0.88% of the study group had a final child abuse diagnosis. The estimated PPV was 0.46 for SPUTOVAMO, ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Assessments carried out by a child abuse and neglect team in an Amsterdam teaching hospital led to interventions in most of the reported cases

Acta paediatrica (Oslo, Norway : 1992), Jan 30, 2016

This study described cases of child abuse and neglect (CAN) that were reported to the multiagency... more This study described cases of child abuse and neglect (CAN) that were reported to the multiagency CAN team at the Emma Children's Hospital in Amsterdam and the resulting interventions. We carried out a retrospective review of all cases that were reported to the CAN team from 1 January 2010 to 31 December 2012. There were 27 prenatal cases, 92 referrals based on parental characteristics and 523 children. Overall, 1.2% of the children visiting the emergency department of our hospital, attending the outpatients department or being admitted were reported to the team. More than half of the referrals (55.1%) were confirmed as CAN. The most common diagnoses were as follows: witnessing intimate partner violence, physical neglect and emotional abuse. If CAN was confirmed an intervention was offered in 98.3% of cases. If a CAN diagnosis was undetermined or rejected, the figures were still 83.5% and 64.2%, respectively. Our results showed that CAN affected more than one in every 100 childr...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Comparing the effect of Livercell Transplantation (LCTX) in Gunn rats using either immunesuppresive therapy or immunetolerance inducing techniques

J Pediat Gastroenterol Nutr, 1998

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The pharmacokinetics of nelfinavir in HIV-1-infected children

Therapeutic Drug Monitoring, Aug 1, 2002

The authors investigated the steady-state plasma pharmacokinetics of nelfinavir in HIV-1-infected... more The authors investigated the steady-state plasma pharmacokinetics of nelfinavir in HIV-1-infected children in a dosage of 30 mg/kg every 8 hours and 45 mg/kg every 12 hours in 12 HIV-1-infected children (aged 2.1 to 10.8 years) participating in an open-label study of nelfinavir in combination with stavudine and lamivudine. Median values of the primary pharmacokinetic parameters of nelfinavir 30 mg/kg every-8-hours (n = 8) and 45 mg/kg every 12 hours (n = 10) were, respectively, for the area under the plasma concentration-time curve over 24 hours, 90.5 and 71.9 h x microg/mL, for the trough concentration 1.9 and 1.0 microg/mL, and for the maximal concentration 6.3 and 5.2 microg/mL. Overall, a 7-fold interpatient variability was observed for the exposure to nelfinavir. Nelfinavir 30 mg/kg every-8-hours or 45 mg/kg every 12 hours in HIV-1-infected children generally resulted in plasma concentrations higher than those obtained in adults. However, due to a large interpatient variability in the exposure, individual dosage adjustments based on plasma concentrations may be necessary for both dosing regimens to ensure optimal treatment.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Endoscopic Balloon Dilatation as Treatment of Gastric Outlet Obstruction in Infancy and Childhood: 79

Pediat Res, 1987

ABSTRACT

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Small Intestinal Biopsy

Bookmarks Related papers MentionsView impact

Research paper thumbnail of De ziekte van Fabry: etiologie, kliniek en behandeling

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Kindermishandeling, diagnostische en therapeutische dilemma's

Tijdschrift Voor Kindergeneeskunde, 2005

Bookmarks Related papers MentionsView impact