Hui-min Hsieh - Academia.edu (original) (raw)

Papers by Hui-min Hsieh

Research paper thumbnail of Cost-Effectiveness of a Diabetes Pay-For-Performance Program in Diabetes Patients with Multiple Chronic Conditions

PLOS ONE, 2015

Pay for performance (P4P) has been used as a strategy to improve quality for patients with chroni... more Pay for performance (P4P) has been used as a strategy to improve quality for patients with chronic illness. Little was known whether care provided to individuals with multiple chronic conditions in a P4P program were cost-effective. This study investigated cost effectiveness of a diabetes P4P program for caring patients with diabetes alone (DM alone) and diabetes with comorbid hypertension and hyperlipidemia (DMHH) from a single payer perspective in Taiwan. Analyzing data using population-based longitudinal databases, we compared costs and effectiveness between P4P and non-P4P diabetes patient groups in two cohorts. Propensity score matching (PSM) was used to match comparable control groups for intervention groups. Outcomes included life-years, quality-adjusted life-years (QALYs), program intervention costs, cost-savings and incremental cost-effectiveness ratios (ICERs). QALYs for P4P patients and non-P4P patients were 2.80 and 2.71 for the DM alone cohort and 2.74 and 2.66 for the DMHH patient cohort. The average incremental intervention costs per QALYs was TWD$167,251 in the DM alone cohort and TWD$145,474 in the DMHH cohort. The average incremental all-cause medical costs saved by the P4P program per QALYs were TWD$434,815 in DM alone cohort and TWD$506,199 in the DMHH cohort. The findings indicated that the P4P program for both cohorts were cost-effective and the resulting return on investment (ROI) was 2.60:1 in the DM alone cohort and 3.48:1 in the DMHH cohort. We conclude that the diabetes P4P program in both cohorts enabled the long-term cost-effective use of resources and cost-savings, especially for patients with multiple comorbid conditions.

Research paper thumbnail of Effects of Changes in Diabetes Pay-for-Performance Incentive Designs on Patient Risk Selection

Health Services Research, 2015

Taiwan's National Health Insurance (NHI) Program implemented a Diabetes Pay-for-P... more Taiwan's National Health Insurance (NHI) Program implemented a Diabetes Pay-for-Performance Program (P4P) based on process-of-care measures in 2001. In late 2006, that P4P program was reformed to also include achievement of intermediate health outcomes. This study examined how the change in design affected patient risk selection. Study populations were identified from a 2002 to 2003 period (Phase 1) and a 2007 to 2008 period (Phase 2), spanning pre- and postimplementation of reforms in the P4P incentive design. Phase 1 had 74,529 newly enrolled P4P patients and 215,572 non-P4P patients, and Phase 2 had 76,901 newly enrolled P4P patients and 299,573 non-P4P patients. Logistic regression models were used to estimate the effect of changes in design on P4P patient selection. Patients with greater disease severity and comorbidity were more likely to be excluded from the P4P program in both phases. Furthermore, the additional financial incentive for patients' intermediate outcomes moderately worsened patient risk selection. Policy makers need to carefully monitor the care of the diabetes patients with more severe and complex disease statuses after the changes of P4P financial incentive design.

Research paper thumbnail of Does Loss of Safety Net Hospitals in a Community Disproportionately Affect Racial and Ethnic Minority Groups?

Research Objective: Safety net hospitals (SNHs) are thought to play a critical role in the U.S. h... more Research Objective: Safety net hospitals (SNHs) are thought to play a critical role in the U.S. health system by providing health care services for vulnerable populations. SNHs also frequently offer a variety of social and outreach services, which could potentially reduce disparities among ethnic and racial minority groups. This may be especially true for minority individuals living near an SNH because they will have ready access to these facilitating services. Our study examined whether closure or ownership conversions of nearby SNHs had a disproportionate effect on uninsured and Medicaid patients, especially for non-Hispanic black and Hispanic individuals. Study Design: Hospital discharge data for the states of Arizona, California, Florida, and Wisconsin were examined from the early 1990s to 2003. Our primary access measure was distance traveled by patients to hospitals for inpatient care. Both closure and for-profit conversion represent events that reduce safety net resources ava...

Research paper thumbnail of Ambient Melamine Exposure and Urinary Biomarkers of Early Renal Injury

Journal of the American Society of Nephrology : JASN, Jan 4, 2015

Information about environmental exposure to melamine and renal injury in adults is lacking. We in... more Information about environmental exposure to melamine and renal injury in adults is lacking. We investigated this relationship in 44 workers at two melamine tableware manufacturing factories in Taiwan (16 manufacturers, eight grinders, ten packers, and ten administrators) and 105 nonexposed workers (controls) at one shipbuilding company who were enrolled in August-December of 2012. For melamine workers, personal and area air samples were obtained at the worksite over 1 workweek (Monday-Friday). In the same week, pre- and post-shift one-spot urine samples were collected each workday and one first-spot urine sample was collected on each weekend morning and the following Monday morning. For each control, a one-spot urine sample was collected on Friday morning. A blood sample was also obtained from each participant at this time. Melamine levels were measured in air, urine, and serum, and early renal injury biomarkers were measured in urine. Urinary melamine concentrations in manufacturer...

Research paper thumbnail of Health care utilization and expenditures of persons with diabetes comorbid with anxiety disorder: a national population-based cohort study

General Hospital Psychiatry, 2015

The aim of this study was to investigate and compare health care utilization and expenditures bet... more The aim of this study was to investigate and compare health care utilization and expenditures between persons with diabetes comorbid with and without anxiety disorder in Taiwan. Health care utilization and expenditures among persons with diabetes with and without comorbid anxiety disorder in the period 2000-2004 were examined using the Taiwan's National Health Insurance claims data. Health care utilization included outpatient visits and use of hospital inpatient services, while expenditures included outpatient, inpatient and total medical expenditures. General estimation equation (GEE) models were used to analyze the factors associated with outpatient visits and expenditures, and multiple logistic regression analysis was applied to identify factors associated with hospitalization. In the study period, the average number of annual outpatient visits was 43.11-50.37 and 29.82-31.42 for persons with diabetes comorbid with anxiety disorder and for those without anxiety disorder, respectively. The average annual total expenditure was NT$74,875-92,781 and NT$63,764-81,667, respectively. Controlling for covariates, the GEE models revealed that age and time were associated with outpatient visits. Income and time factor were associated with total expenditure. Health care utilization and expenditures for persons with diabetes with comorbid anxiety disorder are significantly higher than those without anxiety disorder. The factors associated with health care utilization and expenditures are age, income and time.

Research paper thumbnail of Long-Term Prescription of α-Blockers Decrease the Risk of Recurrent Urolithiasis Needed for Surgical Intervention-A Nationwide Population-Based Study

PloS one, 2015

α1 receptors and subtypes have been confirmed to distribute in human pelvis and calyces recently.... more α1 receptors and subtypes have been confirmed to distribute in human pelvis and calyces recently. As used in ureteral stones, α-blocker treatment may facilitate kidney stone passage and long-term prescription of α-blocker may decrease the risk of recurrent urolithiasis. The aim of this study is to determine if use of α-blockers 180 days or more can decrease the risk of recurrent urolithiasis needed for surgical intervention. A representative database of 1,000,000 patients from Taiwan's National Health Insurance was analyzed. Eligible patients were those who had received the first-time procedure for upper urinary stone removal, including extracorporeal shock-wave lithotripsy, ureterorenoscopic lithotripsy, or both, between 2000 and 2010. After completing a 180-day treatment for first event, patients were prospectively followed-up until a second set of stone procedures was performed (proxy of stone recurrence), loss to follow-up, or end of study. The effect of percentage of total ...

Research paper thumbnail of Association of Physician Certification Policy and Quality of Care: Evidence of percutaneous coronary intervention certification program in Taiwan

Health policy (Amsterdam, Netherlands), Jan 21, 2015

The aim of this study was to compare procedural, short-term and two-year outcomes of percutaneous... more The aim of this study was to compare procedural, short-term and two-year outcomes of percutaneous coronary intervention (PCI) between board-certified and non-board certified interventional cardiologists in Taiwan. Most studies of associations between quality and certification have analyzed populations in the Western developed countries. This retrospective population-based study analyzed 2057 patients who had received PCI in 11 hospitals in 2007. The outcome measures were procedural, 30-day, and 2-year adverse events. Sixty certified physicians performed 1771 PCI procedures whereas 84 non-certified physicians performed 286 procedures. Patients treated by non-certified physicians had significantly higher rates of in-hospital mortality (6.99% vs. 2.82%, respectively; p≤0.001) and same-stay CABG (1.40% vs. 0.06%, respectively; p≤0.001). The results of multilevel logistic regression and Cox multivariate regression indicated that patients treated by non-certified physicians also had highe...

Research paper thumbnail of A short-term risk-benefit analysis of occasional and regular use of low-dose aspirin in primary prevention of vascular diseases: a nationwide population-based study

BMJ open, 2015

To calculate the short-term risk-benefit effect of occasional and regular use of low-dose aspirin... more To calculate the short-term risk-benefit effect of occasional and regular use of low-dose aspirin (≤100 mg/day) in primary prevention. Two retrospective cohort studies. Taiwan. 63 788 and 24 910 patients of two nationwide population-based studies were examined. Two databases of 1 000 000 patients were randomly sampled from data of Taiwan's National Health Insurance (NHI) for years 1997-2000 (NHI 2000) and 2005 (NHI 2005). In NHI 2000, 63 788 patients 30-95 years of age were found not to have previously been prescribed aspirin before 1 January 2000, but to have first been prescribed low-dose aspirin after that date. They were also found to be at risk of first hospitalisation for any major vascular diseases including haemorrhage (major gastrointestinal haemorrhage or cerebral haemorrhage) and ischaemia (acute myocardial infarction or ischaemic stroke) after their first prescription. We also applied it to NHI 2005, and the number of eligible patients was 24 910. Patients prescribed...

Research paper thumbnail of A Short-Term Effect of Low-Dose Aspirin on Major Hemorrhagic Risks in Primary Prevention: A Case-Crossover Design

Research paper thumbnail of Cost-Effectiveness of Diabetes Pay-for-Performance Incentive Designs

Research paper thumbnail of Did Budget Cuts in Medicaid Disproportionate Share Hospital Payment Affect Hospital Quality of Care?

Research paper thumbnail of Community Benefit Activities of Private, Nonprofit Hospitals

Journal of Health Politics, Policy and Law, 2010

Research paper thumbnail of Treatment pattern changes in high-risk patients newly initiated on statin monotherapy in a managed care setting

Journal of Clinical Lipidology, 2013

Research paper thumbnail of The Effects of Safety Net Hospital Closures and Conversions on Patient Travel Distance to Hospital Services

Health Services Research, 2012

Research paper thumbnail of Impacts of market and organizational characteristics on hospital efficiency and uncompensated care

Health Care Management Review, 2010

Research paper thumbnail of Hospital Financial Conditions and the Provision of Unprofitable Services

Atlantic Economic Journal, 2009

Research paper thumbnail of Medicaid Disproportionate Share Hospital Payment: How Does It Impact Hospitals' Provision of Uncompensated Care?

Research paper thumbnail of Cost-Effectiveness of a Diabetes Pay-For-Performance Program in Diabetes Patients with Multiple Chronic Conditions

PLOS ONE, 2015

Pay for performance (P4P) has been used as a strategy to improve quality for patients with chroni... more Pay for performance (P4P) has been used as a strategy to improve quality for patients with chronic illness. Little was known whether care provided to individuals with multiple chronic conditions in a P4P program were cost-effective. This study investigated cost effectiveness of a diabetes P4P program for caring patients with diabetes alone (DM alone) and diabetes with comorbid hypertension and hyperlipidemia (DMHH) from a single payer perspective in Taiwan. Analyzing data using population-based longitudinal databases, we compared costs and effectiveness between P4P and non-P4P diabetes patient groups in two cohorts. Propensity score matching (PSM) was used to match comparable control groups for intervention groups. Outcomes included life-years, quality-adjusted life-years (QALYs), program intervention costs, cost-savings and incremental cost-effectiveness ratios (ICERs). QALYs for P4P patients and non-P4P patients were 2.80 and 2.71 for the DM alone cohort and 2.74 and 2.66 for the DMHH patient cohort. The average incremental intervention costs per QALYs was TWD$167,251 in the DM alone cohort and TWD$145,474 in the DMHH cohort. The average incremental all-cause medical costs saved by the P4P program per QALYs were TWD$434,815 in DM alone cohort and TWD$506,199 in the DMHH cohort. The findings indicated that the P4P program for both cohorts were cost-effective and the resulting return on investment (ROI) was 2.60:1 in the DM alone cohort and 3.48:1 in the DMHH cohort. We conclude that the diabetes P4P program in both cohorts enabled the long-term cost-effective use of resources and cost-savings, especially for patients with multiple comorbid conditions.

Research paper thumbnail of Effects of Changes in Diabetes Pay-for-Performance Incentive Designs on Patient Risk Selection

Health Services Research, 2015

Taiwan's National Health Insurance (NHI) Program implemented a Diabetes Pay-for-P... more Taiwan's National Health Insurance (NHI) Program implemented a Diabetes Pay-for-Performance Program (P4P) based on process-of-care measures in 2001. In late 2006, that P4P program was reformed to also include achievement of intermediate health outcomes. This study examined how the change in design affected patient risk selection. Study populations were identified from a 2002 to 2003 period (Phase 1) and a 2007 to 2008 period (Phase 2), spanning pre- and postimplementation of reforms in the P4P incentive design. Phase 1 had 74,529 newly enrolled P4P patients and 215,572 non-P4P patients, and Phase 2 had 76,901 newly enrolled P4P patients and 299,573 non-P4P patients. Logistic regression models were used to estimate the effect of changes in design on P4P patient selection. Patients with greater disease severity and comorbidity were more likely to be excluded from the P4P program in both phases. Furthermore, the additional financial incentive for patients' intermediate outcomes moderately worsened patient risk selection. Policy makers need to carefully monitor the care of the diabetes patients with more severe and complex disease statuses after the changes of P4P financial incentive design.

Research paper thumbnail of Does Loss of Safety Net Hospitals in a Community Disproportionately Affect Racial and Ethnic Minority Groups?

Research Objective: Safety net hospitals (SNHs) are thought to play a critical role in the U.S. h... more Research Objective: Safety net hospitals (SNHs) are thought to play a critical role in the U.S. health system by providing health care services for vulnerable populations. SNHs also frequently offer a variety of social and outreach services, which could potentially reduce disparities among ethnic and racial minority groups. This may be especially true for minority individuals living near an SNH because they will have ready access to these facilitating services. Our study examined whether closure or ownership conversions of nearby SNHs had a disproportionate effect on uninsured and Medicaid patients, especially for non-Hispanic black and Hispanic individuals. Study Design: Hospital discharge data for the states of Arizona, California, Florida, and Wisconsin were examined from the early 1990s to 2003. Our primary access measure was distance traveled by patients to hospitals for inpatient care. Both closure and for-profit conversion represent events that reduce safety net resources ava...

Research paper thumbnail of Ambient Melamine Exposure and Urinary Biomarkers of Early Renal Injury

Journal of the American Society of Nephrology : JASN, Jan 4, 2015

Information about environmental exposure to melamine and renal injury in adults is lacking. We in... more Information about environmental exposure to melamine and renal injury in adults is lacking. We investigated this relationship in 44 workers at two melamine tableware manufacturing factories in Taiwan (16 manufacturers, eight grinders, ten packers, and ten administrators) and 105 nonexposed workers (controls) at one shipbuilding company who were enrolled in August-December of 2012. For melamine workers, personal and area air samples were obtained at the worksite over 1 workweek (Monday-Friday). In the same week, pre- and post-shift one-spot urine samples were collected each workday and one first-spot urine sample was collected on each weekend morning and the following Monday morning. For each control, a one-spot urine sample was collected on Friday morning. A blood sample was also obtained from each participant at this time. Melamine levels were measured in air, urine, and serum, and early renal injury biomarkers were measured in urine. Urinary melamine concentrations in manufacturer...

Research paper thumbnail of Health care utilization and expenditures of persons with diabetes comorbid with anxiety disorder: a national population-based cohort study

General Hospital Psychiatry, 2015

The aim of this study was to investigate and compare health care utilization and expenditures bet... more The aim of this study was to investigate and compare health care utilization and expenditures between persons with diabetes comorbid with and without anxiety disorder in Taiwan. Health care utilization and expenditures among persons with diabetes with and without comorbid anxiety disorder in the period 2000-2004 were examined using the Taiwan's National Health Insurance claims data. Health care utilization included outpatient visits and use of hospital inpatient services, while expenditures included outpatient, inpatient and total medical expenditures. General estimation equation (GEE) models were used to analyze the factors associated with outpatient visits and expenditures, and multiple logistic regression analysis was applied to identify factors associated with hospitalization. In the study period, the average number of annual outpatient visits was 43.11-50.37 and 29.82-31.42 for persons with diabetes comorbid with anxiety disorder and for those without anxiety disorder, respectively. The average annual total expenditure was NT$74,875-92,781 and NT$63,764-81,667, respectively. Controlling for covariates, the GEE models revealed that age and time were associated with outpatient visits. Income and time factor were associated with total expenditure. Health care utilization and expenditures for persons with diabetes with comorbid anxiety disorder are significantly higher than those without anxiety disorder. The factors associated with health care utilization and expenditures are age, income and time.

Research paper thumbnail of Long-Term Prescription of α-Blockers Decrease the Risk of Recurrent Urolithiasis Needed for Surgical Intervention-A Nationwide Population-Based Study

PloS one, 2015

α1 receptors and subtypes have been confirmed to distribute in human pelvis and calyces recently.... more α1 receptors and subtypes have been confirmed to distribute in human pelvis and calyces recently. As used in ureteral stones, α-blocker treatment may facilitate kidney stone passage and long-term prescription of α-blocker may decrease the risk of recurrent urolithiasis. The aim of this study is to determine if use of α-blockers 180 days or more can decrease the risk of recurrent urolithiasis needed for surgical intervention. A representative database of 1,000,000 patients from Taiwan's National Health Insurance was analyzed. Eligible patients were those who had received the first-time procedure for upper urinary stone removal, including extracorporeal shock-wave lithotripsy, ureterorenoscopic lithotripsy, or both, between 2000 and 2010. After completing a 180-day treatment for first event, patients were prospectively followed-up until a second set of stone procedures was performed (proxy of stone recurrence), loss to follow-up, or end of study. The effect of percentage of total ...

Research paper thumbnail of Association of Physician Certification Policy and Quality of Care: Evidence of percutaneous coronary intervention certification program in Taiwan

Health policy (Amsterdam, Netherlands), Jan 21, 2015

The aim of this study was to compare procedural, short-term and two-year outcomes of percutaneous... more The aim of this study was to compare procedural, short-term and two-year outcomes of percutaneous coronary intervention (PCI) between board-certified and non-board certified interventional cardiologists in Taiwan. Most studies of associations between quality and certification have analyzed populations in the Western developed countries. This retrospective population-based study analyzed 2057 patients who had received PCI in 11 hospitals in 2007. The outcome measures were procedural, 30-day, and 2-year adverse events. Sixty certified physicians performed 1771 PCI procedures whereas 84 non-certified physicians performed 286 procedures. Patients treated by non-certified physicians had significantly higher rates of in-hospital mortality (6.99% vs. 2.82%, respectively; p≤0.001) and same-stay CABG (1.40% vs. 0.06%, respectively; p≤0.001). The results of multilevel logistic regression and Cox multivariate regression indicated that patients treated by non-certified physicians also had highe...

Research paper thumbnail of A short-term risk-benefit analysis of occasional and regular use of low-dose aspirin in primary prevention of vascular diseases: a nationwide population-based study

BMJ open, 2015

To calculate the short-term risk-benefit effect of occasional and regular use of low-dose aspirin... more To calculate the short-term risk-benefit effect of occasional and regular use of low-dose aspirin (≤100 mg/day) in primary prevention. Two retrospective cohort studies. Taiwan. 63 788 and 24 910 patients of two nationwide population-based studies were examined. Two databases of 1 000 000 patients were randomly sampled from data of Taiwan's National Health Insurance (NHI) for years 1997-2000 (NHI 2000) and 2005 (NHI 2005). In NHI 2000, 63 788 patients 30-95 years of age were found not to have previously been prescribed aspirin before 1 January 2000, but to have first been prescribed low-dose aspirin after that date. They were also found to be at risk of first hospitalisation for any major vascular diseases including haemorrhage (major gastrointestinal haemorrhage or cerebral haemorrhage) and ischaemia (acute myocardial infarction or ischaemic stroke) after their first prescription. We also applied it to NHI 2005, and the number of eligible patients was 24 910. Patients prescribed...

Research paper thumbnail of A Short-Term Effect of Low-Dose Aspirin on Major Hemorrhagic Risks in Primary Prevention: A Case-Crossover Design

Research paper thumbnail of Cost-Effectiveness of Diabetes Pay-for-Performance Incentive Designs

Research paper thumbnail of Did Budget Cuts in Medicaid Disproportionate Share Hospital Payment Affect Hospital Quality of Care?

Research paper thumbnail of Community Benefit Activities of Private, Nonprofit Hospitals

Journal of Health Politics, Policy and Law, 2010

Research paper thumbnail of Treatment pattern changes in high-risk patients newly initiated on statin monotherapy in a managed care setting

Journal of Clinical Lipidology, 2013

Research paper thumbnail of The Effects of Safety Net Hospital Closures and Conversions on Patient Travel Distance to Hospital Services

Health Services Research, 2012

Research paper thumbnail of Impacts of market and organizational characteristics on hospital efficiency and uncompensated care

Health Care Management Review, 2010

Research paper thumbnail of Hospital Financial Conditions and the Provision of Unprofitable Services

Atlantic Economic Journal, 2009

Research paper thumbnail of Medicaid Disproportionate Share Hospital Payment: How Does It Impact Hospitals' Provision of Uncompensated Care?