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![Research paper thumbnail of [Diagnostic performance of anti-cyclic citrullinated antibodies and IgM rheumatoid factor in rheumatoid arthritis]](https://a.academia-assets.com/images/blank-paper.jpg)
](Acta reumatológica portuguesa
The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the ... more The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the classification of rheumatoid arthritis RA . To compare the sensitivity and specificity of two diagnostic markers for RA in Portuguese patients the 2nd generation anti-cyclic citrullinated peptide antibodies anti-CCP2 and the RF-M. Serum samples from 56 patients with established RA 44 women and 12 men mean disease duration 9 5 -8 5 years were evaluated for the presence of anti-CCP2 and RF-M. Results were compared with 93 samples from a control group with identical demographic characteristics 43 from patients with spondylarthropaties and 50 from healthy blood donors . The determination of anti-CCP2 antibodies was performed by enzymatic fluroimunoassay and RF-M was measured by microElisa. Anti-CCP2 antibodies were positive in 40 patients with RA 71 4 at a mean antibody concentration of 350 5 UA ml range 11-1670 UA ml and negative in all controls. The RF-M was positive in 34 patients with RA...
Acta reumatológica portuguesa
The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the ... more The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the classification of rheumatoid arthritis RA . To compare the sensitivity and specificity of two diagnostic markers for RA in Portuguese patients the 2nd generation anti-cyclic citrullinated peptide antibodies anti-CCP2 and the RF-M. Serum samples from 56 patients with established RA 44 women and 12 men mean disease duration 9 5 -8 5 years were evaluated for the presence of anti-CCP2 and RF-M. Results were compared with 93 samples from a control group with identical demographic characteristics 43 from patients with spondylarthropaties and 50 from healthy blood donors . The determination of anti-CCP2 antibodies was performed by enzymatic fluroimunoassay and RF-M was measured by microElisa. Anti-CCP2 antibodies were positive in 40 patients with RA 71 4 at a mean antibody concentration of 350 5 UA ml range 11-1670 UA ml and negative in all controls. The RF-M was positive in 34 patients with RA...
Nephrology Dialysis Transplantation, 1998
supplementation in haemodialysis patients. No significant adverse reactions to iron therapy were ... more supplementation in haemodialysis patients. No significant adverse reactions to iron therapy were observed. Background. The aim of this prospective study was to test a new protocol for iron supplementation in haemo-Key words: erythropoietin; ferritin; haemodialysis; iron; dialysis patients, as well as to assess the utility of intravenous different iron metabolism markers in common use and their 'target' values for the correction of iron deficiency. Methods. Thirty-three of 56 chronic haemodialysis patients were selected for long-term (6 months) i.v. Introduction iron therapy at 20 mg three times per week postdialysis based on the presence of at least one of the With the widespread utilization of rHuEpo in haemofollowing iron metabolism markers: percentage of dialysis, prolonged or chronic iron overload and transferrin saturation (%TSAT) <20%; percentage of haemosiderosis have almost disappeared. Eryhypochromic erythrocytes (%HypoE) >10% and thropoietin promotes the use of iron deposits in the serum ferritin (SF) <400 mg/l. Reasons for patient bone marrow, and consequently iron deficiency is a exclusion were active inflammatory or infectious disfrequent problem resulting in resistance to the full eases, haematological diseases, psychosis, probable effect of rHuEpo. It is well known that a negative iron iron overload (SF Á400 mg/l) and/or acute need of balance may occur-up to 2 g/year [1]-and it is not blood transfusion mostly due to haemorrhage and well established whether there is a compensatory change in renal replacement treatment. increase in intestinal absorption in haemodialysis Results. More than half (51.8%) of the patients of our patients when they are iron deficient [2-5]. Oral dialysis centre proved to have some degree of iron supplementation is plagued by poor patient adherence deficiency in spite of their regular oral iron due to frequent side-effects, and interference of other supplementation. At the start of the study the mean medication with the digestive absorption [6 ]. Several haemoglobin was 10.8 g/dl and increased after the 6 studies have demonstrated the utility of i.v. iron months of iron treatment to 12.8 g/dl (P<0.0001). supplementation in correcting anaemia and sparing The use of erythropoietin decreased from 118 rHuEpo [7-10]. However the multiple publications units/kg/week to 84 units/kg/week. The criterion for evaluating the criteria to detect and to treat patients iron supplementation with the best sensitivity/specifiwith iron deficiency and the several protocols adopted city relationship (100/87.9%) was ferritin <400 mg/l. to correct this situation clearly show that there is no Patients with ferritin <100 mg/l and those with ferritin consensus [11-18]. between 100 mg/l and 400 mg/l had the same increase We administered 20 mg iron i.v. post-dialysis on a in haemoglobin but other parameters of iron metabollong-term basis because it allows approximated conism were different between the two groups. tinuous availability of iron to be incorporated into Conclusions. Routine supplementation of iron in haemoglobin under the action of rHuEpo and allowed haemodialysis patients should be performed intraveneasy control to prevent the oversaturation of transferously. Target ferritin values should be considered indirin [19,20] and iron overload. vidually and the best mean haemoglobin values were We evaluated rHuEpo dose and haemoglobin during achieved at 6 months with a mean ferritin of 456 mg/l long-term i.v. iron therapy for 6 months and evaluated (variation from to 919 mg/l). The percentage of transthe best markers to monitor this therapy. Prior to this ferrin saturation, percentage of hypochromic erythrostudy, iron status was assessed on a 3-month basis by cytes and ferritin <100 mg/l, were not considered serum ferritin (SF) and the percentage of transferrin useful parameters to monitor routine iron saturation (%TSAT); iron supplementation was given orally as a routine and the i.v. route was reserved for
Acta reumatológica portuguesa
The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the ... more The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the classification of rheumatoid arthritis RA . To compare the sensitivity and specificity of two diagnostic markers for RA in Portuguese patients the 2nd generation anti-cyclic citrullinated peptide antibodies anti-CCP2 and the RF-M. Serum samples from 56 patients with established RA 44 women and 12 men mean disease duration 9 5 -8 5 years were evaluated for the presence of anti-CCP2 and RF-M. Results were compared with 93 samples from a control group with identical demographic characteristics 43 from patients with spondylarthropaties and 50 from healthy blood donors . The determination of anti-CCP2 antibodies was performed by enzymatic fluroimunoassay and RF-M was measured by microElisa. Anti-CCP2 antibodies were positive in 40 patients with RA 71 4 at a mean antibody concentration of 350 5 UA ml range 11-1670 UA ml and negative in all controls. The RF-M was positive in 34 patients with RA...
Acta reumatológica portuguesa
The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the ... more The presence of IgM class rheumatoid factor RF-M in the serum is one of the ACR criteria for the classification of rheumatoid arthritis RA . To compare the sensitivity and specificity of two diagnostic markers for RA in Portuguese patients the 2nd generation anti-cyclic citrullinated peptide antibodies anti-CCP2 and the RF-M. Serum samples from 56 patients with established RA 44 women and 12 men mean disease duration 9 5 -8 5 years were evaluated for the presence of anti-CCP2 and RF-M. Results were compared with 93 samples from a control group with identical demographic characteristics 43 from patients with spondylarthropaties and 50 from healthy blood donors . The determination of anti-CCP2 antibodies was performed by enzymatic fluroimunoassay and RF-M was measured by microElisa. Anti-CCP2 antibodies were positive in 40 patients with RA 71 4 at a mean antibody concentration of 350 5 UA ml range 11-1670 UA ml and negative in all controls. The RF-M was positive in 34 patients with RA...
Nephrology Dialysis Transplantation, 1998
supplementation in haemodialysis patients. No significant adverse reactions to iron therapy were ... more supplementation in haemodialysis patients. No significant adverse reactions to iron therapy were observed. Background. The aim of this prospective study was to test a new protocol for iron supplementation in haemo-Key words: erythropoietin; ferritin; haemodialysis; iron; dialysis patients, as well as to assess the utility of intravenous different iron metabolism markers in common use and their 'target' values for the correction of iron deficiency. Methods. Thirty-three of 56 chronic haemodialysis patients were selected for long-term (6 months) i.v. Introduction iron therapy at 20 mg three times per week postdialysis based on the presence of at least one of the With the widespread utilization of rHuEpo in haemofollowing iron metabolism markers: percentage of dialysis, prolonged or chronic iron overload and transferrin saturation (%TSAT) <20%; percentage of haemosiderosis have almost disappeared. Eryhypochromic erythrocytes (%HypoE) >10% and thropoietin promotes the use of iron deposits in the serum ferritin (SF) <400 mg/l. Reasons for patient bone marrow, and consequently iron deficiency is a exclusion were active inflammatory or infectious disfrequent problem resulting in resistance to the full eases, haematological diseases, psychosis, probable effect of rHuEpo. It is well known that a negative iron iron overload (SF Á400 mg/l) and/or acute need of balance may occur-up to 2 g/year [1]-and it is not blood transfusion mostly due to haemorrhage and well established whether there is a compensatory change in renal replacement treatment. increase in intestinal absorption in haemodialysis Results. More than half (51.8%) of the patients of our patients when they are iron deficient [2-5]. Oral dialysis centre proved to have some degree of iron supplementation is plagued by poor patient adherence deficiency in spite of their regular oral iron due to frequent side-effects, and interference of other supplementation. At the start of the study the mean medication with the digestive absorption [6 ]. Several haemoglobin was 10.8 g/dl and increased after the 6 studies have demonstrated the utility of i.v. iron months of iron treatment to 12.8 g/dl (P<0.0001). supplementation in correcting anaemia and sparing The use of erythropoietin decreased from 118 rHuEpo [7-10]. However the multiple publications units/kg/week to 84 units/kg/week. The criterion for evaluating the criteria to detect and to treat patients iron supplementation with the best sensitivity/specifiwith iron deficiency and the several protocols adopted city relationship (100/87.9%) was ferritin <400 mg/l. to correct this situation clearly show that there is no Patients with ferritin <100 mg/l and those with ferritin consensus [11-18]. between 100 mg/l and 400 mg/l had the same increase We administered 20 mg iron i.v. post-dialysis on a in haemoglobin but other parameters of iron metabollong-term basis because it allows approximated conism were different between the two groups. tinuous availability of iron to be incorporated into Conclusions. Routine supplementation of iron in haemoglobin under the action of rHuEpo and allowed haemodialysis patients should be performed intraveneasy control to prevent the oversaturation of transferously. Target ferritin values should be considered indirin [19,20] and iron overload. vidually and the best mean haemoglobin values were We evaluated rHuEpo dose and haemoglobin during achieved at 6 months with a mean ferritin of 456 mg/l long-term i.v. iron therapy for 6 months and evaluated (variation from to 919 mg/l). The percentage of transthe best markers to monitor this therapy. Prior to this ferrin saturation, percentage of hypochromic erythrostudy, iron status was assessed on a 3-month basis by cytes and ferritin <100 mg/l, were not considered serum ferritin (SF) and the percentage of transferrin useful parameters to monitor routine iron saturation (%TSAT); iron supplementation was given orally as a routine and the i.v. route was reserved for