Hung Solitary - Academia.edu (original) (raw)

Papers by Hung Solitary

Major hepatic resection is safe and provides favorable long-term survival for cirrhotic patients ... more Major hepatic resection is safe and provides favorable long-term survival for cirrhotic patients with a small solitary hepatocellular carcinoma. Retrospective case series. Tertiary referral center. From January 1, 1989, to December 31, 2001, 218 cirrhotic patients with a solitary hepatocellular carcinoma 5 cm or less in diameter underwent either a major hepatic resection (n = 84) or a minor hepatic resection (n = 134). Perioperative morbidity and mortality, and long-term survival rates. The major resection group had significantly larger tumors (median, 3.5 vs 2.5 cm; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001) and better liver function (median indocyanine green retention at 15 minutes, 9.3% vs 12.9%; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001) than the minor resection group. Postoperative morbidity (46.4% vs 39.6%) and mortality (8.3% vs 3.0%) were higher in the major resection group than in the minor resection group, but the differences did not reach statistical significance (P =.32 and P =.11, respectively). The median overall survival did not differ significantly between the 2 groups (102.0 vs 72.3 months; P =.25). However, the median disease-free survival in the major resection group was significantly better than that in the minor resection group (59.0 vs 29.5 months; P =.03). On further subgroup analysis, both disease-free and overall survival rates were significantly better in the major hepatic resection group for tumors of 3 to 5 cm. In well-selected cirrhotic patients with a small, solitary hepatocellular carcinoma, major hepatic resection is safe and may offer a better long-term survival over minor hepatic resection for patients with tumors of 3 to 5 cm.

Cancer Investigation, 2003

The purpose of this preliminary study is to evaluate the characteristics of solitary pulmonary le... more The purpose of this preliminary study is to evaluate the characteristics of solitary pulmonary lesions in patients using extrapulmonary neoplasmas with 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Thirty-two patients with extrapulmonary neoplasmas who had solitary pulmonary lesions and were suspected for pulmonary metastasis underwent an oncological survey with FDG-PET. Standard uptake value (SUV) and the ratio of lesion-to-background (L/B ratio) were used as parameters to differentiate and characterize the solitary pulmonary lesions. Using SUV &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 2.5 or L/B ratio &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 3 as the cutoff to diagnose malignancy, FDG-PET correctly identified 29 true-positive cases. However, FDG-PET failed to interpret two false-positive and one false-negative cases. The accuracy of FDG-PET was 91%. We concluded that FDG-PET is an accurate modality to differentiate solitary pulmonary lesions in patients with extrapulmonary neoplasmas.

Journal of Pediatric Surgery, 1982

Thirty-nine children and adolescents with a solitary nodule of the thyroid gland were seen over a... more Thirty-nine children and adolescents with a solitary nodule of the thyroid gland were seen over a 16-yr period and 35 had their nodules removed surgically. All of the patients had preoperative thyroid scintiscans, of which 27 showed a cold nodule. The most common cause of solitary thyroid nodules was follicular adenoma. Five of the 27 cold nodules were malignant (18.5%) while no malignancies were present in the warm or hot nodules. Available diagnostic methods of attempting differentiation of benign from malignant solitary nodules are reviewed and an approach to the clinical management of such nodules as derived from our experience is presented.

Ocean Engineering, 2007

Experimental investigations on internal solitary wave (ISW) propagation and their reflection from... more Experimental investigations on internal solitary wave (ISW) propagation and their reflection from a smooth uniform slope were conducted in a two-layered fluid system with a free surface. A 12-meter-long wave flume was in use which incorporated with: (1) a movable vertical gate for generating ISW; (2) six ultrasonic probes for measuring the fluctuation of an ISW; and (3) a steep uniform slope (from one of y ¼ 301, 501, 601, 901, 1201 and 1301) much greater than those ever published in the literature. This paper presents the wave profile properties of the ISW recorded in the flume and their nonlinear features in comparison with the existing Korteweg de Vries (KdV) and modified Korteweg-de Vries (MKdV) theories. Experimental results show that the KdV theory is suitable for most small-amplituded ISWs and MKdV theory is appropriate for the reflected ISWs from various uniform slopes. In addition, both the amplitude-based reflection coefficient and reflected energy approach a constant value asymptotically when plotted against the slope and the characteristic length ratio, respectively. The reflected wave amplitudes calculated from experimental data agree well with those reported elsewhere. The optimum reflection coefficient is found within the limit of 0.85 for wave amplitude, among the test runs from steep normal slope of 301 to inverse angle of 1301, and around 0.75 for the reflected wave energy, produced by an ISW on a vertical wall. r

Dermatologica Sinica, 2010

Hepatic solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. Here we rep... more Hepatic solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months' follow up.

Ocean Engineering, 2010

While shoaling from deep water in a stratified ocean, an internal wave may encounter different ty... more While shoaling from deep water in a stratified ocean, an internal wave may encounter different types of submarine topography. As it travels, the wave may generate vortex motion on a slope, turbulent mixing between the upper and bottom layer, and even waveform inversion on the plateau of a slope-shelf feature. Although many oceanographers have believed that the inversion from depression to elevation may commence at the turning point where the upper and low layer are equal in depth, this phenomenon has not been fully verified in field observations or numerical schemes. In order to clarify this unique phenomenon, a series of laboratory experiments were conducted on the evolution of an interfacial solitary wave of depression across a slope followed by a horizontal plateau on slope-shelf obstacle. Experimental results indicate the length of the plateau may become a proxy to determine whether the inverted waveform could maintain its strength or be weakened swiftly, which could inflict direct impact on the ecology of the local oceanic environment. Comparison on the internal flow field is also presented in this paper to illustrate the process of waveform inversion as an internal wave propagating over a trapezoidal, triangular ridge and uniform long slope, respectively.

The purpose of this preliminary study was to evaluate the efficacy of positron emission tomograph... more The purpose of this preliminary study was to evaluate the efficacy of positron emission tomography (PET) with [ 18 F]fluoro-2-deoxyglucose (FDG) for differentiating benign from malignant solitary pulmonary nodules. Methods: Twenty-six patients (12 females, 14 males, age 27-79 years) with radiographically indeterminate solitary pulmonary nodules underwent FDG-PET and the findings were compared with the results of pathological examination of biopsy samples. FDG activity in the lesion was expressed as the ratio of lesion-to-background counts (L/B ratio) for semiquantitative analysis. Results: The mean L/B ratio of malignant lesions (8.81 ± 3.71, n = 20) was not significantly higher than that of benign lesions (4.71 ± 3.00, n = 6) (p = 1.00). Using a cut-off L/B ratio of 5.0 for malignancy, FDG-PET correctly detected 19 true positive and three true negative cases, but failed to detect three false positive (two abscesses and one cryptococcus) cases and one false negative (adenocarcinoma) case. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 95, 50, 86, 75 and 85%, respectively. Conclusions: FDG-PET is a sensitive modality for detecting malignancy, but is not specific enough. Benign lung lesion with active inflammation could demonstrate high FDG uptake, making it difficult to differentiate from malignancy. In the future, we will increase the case numbers to evaluate further the utility of FDG-PET for differentiating radiographically indeterminate solitary pulmonary nodules.

International Journal of Clinical Practice, 2006

The efficacy of thyroxine (T4) for solitary non-toxic thyroid nodule remains uncertain. In this s... more The efficacy of thyroxine (T4) for solitary non-toxic thyroid nodule remains uncertain. In this study, 60 patients with solitary non-toxic thyroid nodule were divided randomly into two groups. Group I (n = 30) received thyroxine 100 µg/day for 6 months and group II (n = 30) received placebo. The volume of the thyroid nodules in 11 patients decreased more than 50% after thyroxine therapy (36.7%, responders). In these 11 patients, the mean serum thyroglobulin level decreased significantly (340 ± 115 to 162 ± 86 µg/l, p < 0.01). Compared with the non-responders (n = 19, 63.3%), the serum thyroglobulin level before treatment was significantly higher (340 ± 115 vs. 220 ± 102 µg/l, p < 0.05). Thyroxine-suppressive therapy is proved as a useful tool in reducing nodule size in some patients with solitary thyroid nodules. The patients with a higher serum thyroglobulin level generally respond better to thyroxine-suppressive therapy.