Huri Yılmaz - Academia.edu (original) (raw)

Papers by Huri Yılmaz

Respiratory Care, Feb 25, 2013

Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2012

Turkish Journal of Thoracic and Cardiovascular Surgery, Jul 17, 2012

Journal of International Environmental Application and Science, 2019

The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberr... more The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberration (CA) and micronucleus (MN) tests in human peripheral lymphocytes. Cells were treated to ZnOTiO 2 NPs concentrations in the range of 12.5 to 125 µg/mL for 24 and 48 hours. In addition, it induced structural CA at all concentrations with ZnOTiO 2 NPs treatment. However, nanoparticles did not stimulate CA in a dose-dependent manner for 24 and 48 hours of treatment, and there were no statistically significant differences between both the administration time and the concentrations (P > 0.05). The formation of MN induced by ZnOTiO 2 NPs increased depending on concentration and dose. In particular, the highest 2 concentrations (100 and 125 µg/ml ) were observed to be significantly increased during the 24 and 48 hour treatment period (P > 0.05). Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).

Arşiv Kaynak Tarama Dergisi, 2018

European Respiratory Journal, Sep 1, 2011

Objective: In our study we aimed to evaluate acute and chronic term results of kyphoscoliotic pat... more Objective: In our study we aimed to evaluate acute and chronic term results of kyphoscoliotic patients admitted to ICU with acute respiratory failure in 9 years period. Method: Kyphoscoliotic patients applied to ICU between 2002-2010 enrolled in the study.Patient9s demographics,comorbity,APACHE II score on admission, presence of sepsis, arterial blood gas analysis (on admission and first control), invasive (IMV) and noninvasive mechanical ventilation (NIV) application and duration, length of stay in ICU,ICU mortality, chronic term follow-up,mortality were recorded. Data were summarized with descriptive analysis.Variables were given as median and interquartile ratio (IQR). Results: 84 kyphoscoliotic patients (46 male) with median age 50 (IQR: 36-64) accepted to ICU were included. %78.3 (n=65) of cases has comorbidity and%23.8 (n=20) of patients were in long term oxygen therapy (LOT) and mechanical ventilation at home. APACHE II score 15 (12-19), presence of sepsis %42.9 (n=36), NIV and IMV application was %79.8 (n=67), %32.1 (n=27) respectively. Length of stay in ICU was 8 (4-14) days and mortalitiy was %10.7 (n=9, 7 under IMV). After ICU discharge mechanical ventilator at home (HMV) was reported to %39.8 (n=33) of patients, LOT was reported to %21.3 (n=16) of patients. A total of 53 patients have HMV, 51 of these patients were followed long term. One patient after 2 months, 2 patients died after 5 years. 12 patients didnot come to controls regularly. Conclusion: In patients with kyphoscoliosis accepted to ICU due to acute respiratory failure, mortality is significantly higher while in patiens with mechanical ventilation at home compliance and follow-up is better, mortality is lower.

European Respiratory Journal, Sep 1, 2011

Aim: We intended to evaluate the follow up and mortality rate (MR) of cancer patients (CP) admitt... more Aim: We intended to evaluate the follow up and mortality rate (MR) of cancer patients (CP) admitted to intensive care unit (ICU) with acute respiratory failure (ARF) Material-method: Retrospective desciptive clinical study. Between January 2002-December 2010, all CP under medical treatment in ICU of Sureyyapasa Chest Diseases and Thoracic Surgery Teaching Hospital were included. CP were grouped as pulmonary tumors and extrapulmonary tumors. The demographics, initial APACHE II score, application of noninvasive and invasive mechanical ventilation (NIV, IMV),length of stay (LOS), resectional surgery for lung cancer (LC) and tracheostomy, MR and distribution of cases according to years were investigated. Above data of mortal cases were compared with cases without mortality. Results: Median age of 223 CP in ICU was 65 (57-71; 25%-75%), 81.2% (n=181) were male. Number of CP according to years 2002, 2010 was 5 and 72, respectively. Rate of LC and resectable LC cases were 72.2% (n=161) and 29% (n=65), respectively. The median initial APACHE II and LOS in ICU were 21 (16-27;25%-75%) and 6 (3-12;25%-75%). Use of NIMV, IMV and tracheostomy were 63.7% (n=142), 48% (n=107), 3.1% (n=7), respectively. MR was 37.6% (n=84) for all CP. The MR for IMV and all CP were 63.7% (n=142) and 37.6% (n=84), respectively. APACHE II score and male gender were detected to be significantly high in mortal cases (p Conclusion: As MR of CP followed in ICU has declined, high APACHE II score and IMV need significantly increase mortality. We assume that MR for CP will decrease if proper therapy is chosen with NIV for CP at third or fourth level of ICU admission priority.

European Respiratory Journal, Sep 1, 2011

Aim: We intended to evaluate seasonal analysis, cost and general mortality of community acquire p... more Aim: We intended to evaluate seasonal analysis, cost and general mortality of community acquire pneumonia (CAP) cases requiring intensive care unit (ICU) follow up. Mateial-method: Retrospective, descriptive cohort study. Between 2008-2010 demographics, initial APACHE II, pneumonia severity index (PSI), CURB score, duration and application of invasive mechanical ventilation (IMV), length of stay (LOS) in ICU, cost and mortality of CAP cases followed in 20 bed ICU were recorded. Seasonal variation was investigated. Patient9s data were summarized with descriptive statistics. Numerical values were presented as median and inter quartile ratio (IQR). Results: In specified period 218 CAP cases (192 males) were retrieved in the study. The median value of age, APACHE II, PSI and CURB were 65 (53-76), 20 (16-26), 130 (103-162), 2 (1-3), respectively. IMV was applied in 96 (34%) patients, the median value of LOS in ICU and cost according to seasons were 7 (5-13) days, 3953 (2418-6821)TL in autumn; 7 (4-11) days, 3372 (2023-6694)TL in winter; 8 (3-12)days, 5215 (1634-6751)TL in spring; 6 (3-9)days, 2937 (1634-4268)TL in summer, respectively. CAP/mortality rate according to seasons were 88 (31.4%)/43.1% for autumn; 80 (28.6%)/27.5% for winter; 49 (17.5%)/15.7% for spring; 63 (22.5%)/13.7% for summer, respectively. The cost and general mortality in CAP were 3417 (1916-6114) and 18.1%, respectively. Conclusion: As general cost of CAP cases requiring ICU and mortality of these cases have increased by 1.5 times in spring and 3 times in autumn, respectively, it should be advised to beware of LOS in ICU and risk of mortality in those seasons.

European Respiratory Journal, 2015

Methods: A retrospective evaluation of database from 2007 to 2009 of 136 non-small cell lung canc... more Methods: A retrospective evaluation of database from 2007 to 2009 of 136 non-small cell lung cancer patients were assessed. The variables as age, gender, smoking habits, radiological / bronchoscopic procedures, diagnostic and scanning methods for metastases were determined. Clinical staging (cTNM) was assessed in the 6th and 7th TNM staging systems. Results: Of the patients 123(90.4%) were male, 13(9.6%) were female, median age was 60.8 years (range:25-83), 41(30.1%) were squamous cell, 29(21.3%) were adenocarcinoma and 66(48.5%) were histologically undifferentiated non-small cell lung cancer. In 23 of the patients staging differed in the 7th system. 15 had “down stage”. Most striking changes were observed in stages IIIA and IIIB. Stage I remained the same. In the 6th staging system; 72(%52.9) had no metastases, 64(%47.1) had metastatic disease. 7th staging model transferred one patient to the nonmetastatic group; 73(%53.6).Of them,17(%12.5) had intrapulmonary metastases (M1a), 46(% 33.9) had distant metastases (M1b). N status did not change. Conclusion: Comparison of the 6th and 7th staging systems revealed that they were in concordance of 96.9%(r:0.968;p Comparison: 6 th TNM staging system Stage IA 10(%7.4), Stage IB 13(%9.6),Stage IIA 1(% 0.7),Stage IIB 3 (%2.2), Stage IIIA 19 (%14), Stage IIIB 26 (%19.1), Stage IV 64 (%47). In 7 th TNM Revision ModelStage IA 10(%7.4), Stage IB 9(%6.6),Stage IIA 3(% 2.2),Stage IIB 5 (%3.7), Stage IIIA 28 (%20.6), Stage IIIB 18 (%13.2), Stage IV 63 (%46.3).

European Respiratory Journal, Sep 1, 2011

Aim: We aimed to evaluate outcomes of patients with interstitial fibrosis (IF) and diffuse lung p... more Aim: We aimed to evaluate outcomes of patients with interstitial fibrosis (IF) and diffuse lung parenchymal diseases admitted to intensive care unit (ICU) due to acute respiratory failure (ARF). Methods: We included patients with ARF due to IF and diffuse parenchymal lung diseases in ICU between 2008-2010 in retrospective cohort study. Patients9 demographics, APACHE II score on admission to the ICU, application of mechanical ventilation; invasive (IMV) or noninvasive (NIV), arterial blood gases values, type of feeding (oral, enteral, paranteral), length of stay (LOS) in ICU and mortality were recorded from patients9 file. Continous variables were given as median and interquartile ratio (IQR). Patients were compared according to mortality and logistic regression analysis was used for mortality risk factors. Results: In study period 44 patients (26 male) and median age was 59 (IQR, 45-73). APACHE II score was 20 (17-26), and application of NIV and IMV were 20 (%45.5), 17 (%38.6) respectively. Oral, enteral and paranteral feeding as follow: 20 (%45.5), 16 (%36.4), 8 (%18.1). LOS in ICU was 5 (2-9) days and mortality rate in ICU was%45.5 (n=20). Risk factors for mortality were found IMV aplicaton and enteral-paranteral feeding, p values Odd ratio (OR) and confidence interval%95 (CI) respectively p Conclusion: Patients with diffuse parenchymal lung diseases and IF have higher mortality in ICU if conditions with ARF prevent oral nutrition and there is need for continous mechanical ventilation. Physicians should think carefully about ICU demand for those patients.

Respiratory Care, Feb 25, 2013

Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2012

Turkish Journal of Thoracic and Cardiovascular Surgery, Jul 17, 2012

Journal of International Environmental Application and Science, 2019

The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberr... more The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberration (CA) and micronucleus (MN) tests in human peripheral lymphocytes. Cells were treated to ZnOTiO 2 NPs concentrations in the range of 12.5 to 125 µg/mL for 24 and 48 hours. In addition, it induced structural CA at all concentrations with ZnOTiO 2 NPs treatment. However, nanoparticles did not stimulate CA in a dose-dependent manner for 24 and 48 hours of treatment, and there were no statistically significant differences between both the administration time and the concentrations (P > 0.05). The formation of MN induced by ZnOTiO 2 NPs increased depending on concentration and dose. In particular, the highest 2 concentrations (100 and 125 µg/ml ) were observed to be significantly increased during the 24 and 48 hour treatment period (P > 0.05). Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).

Arşiv Kaynak Tarama Dergisi, 2018

European Respiratory Journal, Sep 1, 2011

Objective: In our study we aimed to evaluate acute and chronic term results of kyphoscoliotic pat... more Objective: In our study we aimed to evaluate acute and chronic term results of kyphoscoliotic patients admitted to ICU with acute respiratory failure in 9 years period. Method: Kyphoscoliotic patients applied to ICU between 2002-2010 enrolled in the study.Patient9s demographics,comorbity,APACHE II score on admission, presence of sepsis, arterial blood gas analysis (on admission and first control), invasive (IMV) and noninvasive mechanical ventilation (NIV) application and duration, length of stay in ICU,ICU mortality, chronic term follow-up,mortality were recorded. Data were summarized with descriptive analysis.Variables were given as median and interquartile ratio (IQR). Results: 84 kyphoscoliotic patients (46 male) with median age 50 (IQR: 36-64) accepted to ICU were included. %78.3 (n=65) of cases has comorbidity and%23.8 (n=20) of patients were in long term oxygen therapy (LOT) and mechanical ventilation at home. APACHE II score 15 (12-19), presence of sepsis %42.9 (n=36), NIV and IMV application was %79.8 (n=67), %32.1 (n=27) respectively. Length of stay in ICU was 8 (4-14) days and mortalitiy was %10.7 (n=9, 7 under IMV). After ICU discharge mechanical ventilator at home (HMV) was reported to %39.8 (n=33) of patients, LOT was reported to %21.3 (n=16) of patients. A total of 53 patients have HMV, 51 of these patients were followed long term. One patient after 2 months, 2 patients died after 5 years. 12 patients didnot come to controls regularly. Conclusion: In patients with kyphoscoliosis accepted to ICU due to acute respiratory failure, mortality is significantly higher while in patiens with mechanical ventilation at home compliance and follow-up is better, mortality is lower.

European Respiratory Journal, Sep 1, 2011

Aim: We intended to evaluate the follow up and mortality rate (MR) of cancer patients (CP) admitt... more Aim: We intended to evaluate the follow up and mortality rate (MR) of cancer patients (CP) admitted to intensive care unit (ICU) with acute respiratory failure (ARF) Material-method: Retrospective desciptive clinical study. Between January 2002-December 2010, all CP under medical treatment in ICU of Sureyyapasa Chest Diseases and Thoracic Surgery Teaching Hospital were included. CP were grouped as pulmonary tumors and extrapulmonary tumors. The demographics, initial APACHE II score, application of noninvasive and invasive mechanical ventilation (NIV, IMV),length of stay (LOS), resectional surgery for lung cancer (LC) and tracheostomy, MR and distribution of cases according to years were investigated. Above data of mortal cases were compared with cases without mortality. Results: Median age of 223 CP in ICU was 65 (57-71; 25%-75%), 81.2% (n=181) were male. Number of CP according to years 2002, 2010 was 5 and 72, respectively. Rate of LC and resectable LC cases were 72.2% (n=161) and 29% (n=65), respectively. The median initial APACHE II and LOS in ICU were 21 (16-27;25%-75%) and 6 (3-12;25%-75%). Use of NIMV, IMV and tracheostomy were 63.7% (n=142), 48% (n=107), 3.1% (n=7), respectively. MR was 37.6% (n=84) for all CP. The MR for IMV and all CP were 63.7% (n=142) and 37.6% (n=84), respectively. APACHE II score and male gender were detected to be significantly high in mortal cases (p Conclusion: As MR of CP followed in ICU has declined, high APACHE II score and IMV need significantly increase mortality. We assume that MR for CP will decrease if proper therapy is chosen with NIV for CP at third or fourth level of ICU admission priority.

European Respiratory Journal, Sep 1, 2011

Aim: We intended to evaluate seasonal analysis, cost and general mortality of community acquire p... more Aim: We intended to evaluate seasonal analysis, cost and general mortality of community acquire pneumonia (CAP) cases requiring intensive care unit (ICU) follow up. Mateial-method: Retrospective, descriptive cohort study. Between 2008-2010 demographics, initial APACHE II, pneumonia severity index (PSI), CURB score, duration and application of invasive mechanical ventilation (IMV), length of stay (LOS) in ICU, cost and mortality of CAP cases followed in 20 bed ICU were recorded. Seasonal variation was investigated. Patient9s data were summarized with descriptive statistics. Numerical values were presented as median and inter quartile ratio (IQR). Results: In specified period 218 CAP cases (192 males) were retrieved in the study. The median value of age, APACHE II, PSI and CURB were 65 (53-76), 20 (16-26), 130 (103-162), 2 (1-3), respectively. IMV was applied in 96 (34%) patients, the median value of LOS in ICU and cost according to seasons were 7 (5-13) days, 3953 (2418-6821)TL in autumn; 7 (4-11) days, 3372 (2023-6694)TL in winter; 8 (3-12)days, 5215 (1634-6751)TL in spring; 6 (3-9)days, 2937 (1634-4268)TL in summer, respectively. CAP/mortality rate according to seasons were 88 (31.4%)/43.1% for autumn; 80 (28.6%)/27.5% for winter; 49 (17.5%)/15.7% for spring; 63 (22.5%)/13.7% for summer, respectively. The cost and general mortality in CAP were 3417 (1916-6114) and 18.1%, respectively. Conclusion: As general cost of CAP cases requiring ICU and mortality of these cases have increased by 1.5 times in spring and 3 times in autumn, respectively, it should be advised to beware of LOS in ICU and risk of mortality in those seasons.

European Respiratory Journal, 2015

Methods: A retrospective evaluation of database from 2007 to 2009 of 136 non-small cell lung canc... more Methods: A retrospective evaluation of database from 2007 to 2009 of 136 non-small cell lung cancer patients were assessed. The variables as age, gender, smoking habits, radiological / bronchoscopic procedures, diagnostic and scanning methods for metastases were determined. Clinical staging (cTNM) was assessed in the 6th and 7th TNM staging systems. Results: Of the patients 123(90.4%) were male, 13(9.6%) were female, median age was 60.8 years (range:25-83), 41(30.1%) were squamous cell, 29(21.3%) were adenocarcinoma and 66(48.5%) were histologically undifferentiated non-small cell lung cancer. In 23 of the patients staging differed in the 7th system. 15 had “down stage”. Most striking changes were observed in stages IIIA and IIIB. Stage I remained the same. In the 6th staging system; 72(%52.9) had no metastases, 64(%47.1) had metastatic disease. 7th staging model transferred one patient to the nonmetastatic group; 73(%53.6).Of them,17(%12.5) had intrapulmonary metastases (M1a), 46(% 33.9) had distant metastases (M1b). N status did not change. Conclusion: Comparison of the 6th and 7th staging systems revealed that they were in concordance of 96.9%(r:0.968;p Comparison: 6 th TNM staging system Stage IA 10(%7.4), Stage IB 13(%9.6),Stage IIA 1(% 0.7),Stage IIB 3 (%2.2), Stage IIIA 19 (%14), Stage IIIB 26 (%19.1), Stage IV 64 (%47). In 7 th TNM Revision ModelStage IA 10(%7.4), Stage IB 9(%6.6),Stage IIA 3(% 2.2),Stage IIB 5 (%3.7), Stage IIIA 28 (%20.6), Stage IIIB 18 (%13.2), Stage IV 63 (%46.3).

European Respiratory Journal, Sep 1, 2011

Aim: We aimed to evaluate outcomes of patients with interstitial fibrosis (IF) and diffuse lung p... more Aim: We aimed to evaluate outcomes of patients with interstitial fibrosis (IF) and diffuse lung parenchymal diseases admitted to intensive care unit (ICU) due to acute respiratory failure (ARF). Methods: We included patients with ARF due to IF and diffuse parenchymal lung diseases in ICU between 2008-2010 in retrospective cohort study. Patients9 demographics, APACHE II score on admission to the ICU, application of mechanical ventilation; invasive (IMV) or noninvasive (NIV), arterial blood gases values, type of feeding (oral, enteral, paranteral), length of stay (LOS) in ICU and mortality were recorded from patients9 file. Continous variables were given as median and interquartile ratio (IQR). Patients were compared according to mortality and logistic regression analysis was used for mortality risk factors. Results: In study period 44 patients (26 male) and median age was 59 (IQR, 45-73). APACHE II score was 20 (17-26), and application of NIV and IMV were 20 (%45.5), 17 (%38.6) respectively. Oral, enteral and paranteral feeding as follow: 20 (%45.5), 16 (%36.4), 8 (%18.1). LOS in ICU was 5 (2-9) days and mortality rate in ICU was%45.5 (n=20). Risk factors for mortality were found IMV aplicaton and enteral-paranteral feeding, p values Odd ratio (OR) and confidence interval%95 (CI) respectively p Conclusion: Patients with diffuse parenchymal lung diseases and IF have higher mortality in ICU if conditions with ARF prevent oral nutrition and there is need for continous mechanical ventilation. Physicians should think carefully about ICU demand for those patients.