Huseyin Oz - Academia.edu (original) (raw)

Papers by Huseyin Oz

Background: Intensive care units (ICUs) are special units providing intensive observation, monito... more Background: Intensive care units (ICUs) are special units providing intensive observation, monitoring and supportive treatments, which can be applied as standardised and continuous patient care. Patients at the terminal stage of illness require monitoring in special units that are staffed by a multi-disciplinary team, which are known as a “hospice unit”. In this study, we determined whether or not there is a need for a ‘hospice unit’. Material and method: In this retrospective study, data for demographic characteristics, diagnoses, comorbidities, examination and laboratory findings were obtained from the emergency department patient records for each patient. Predicted mortality (PM) rates were calculated for each patient using the Acute Physiology and Chronic Health Evaluation (APACHE) II score and the Simplified Acute Physiology Score (SAPS) II score. The Surveillance, Epidemiology and End Results (SEER) grading score was used for grading the patients diagnosed with cancer. Results...

Medeniyet Medical Journal, 2019

The aim of this study was to evaluate the effects of antithrombin III (AT III) and pentoxifylline... more The aim of this study was to evaluate the effects of antithrombin III (AT III) and pentoxifylline treatments on the gram negative septic patients with disseminated intravascular coagulation (DIC). Method: For six days after plasma AT III activity dropped lower than 80% in Gram-patients who developed DIC were treated with AT III (90-120 IU/kg/day in 6 hours) or pentoxifylline (1.5 mg/ kg/h in 6 hours) Fibrinogen, FDP, D-dimer, complete blood count, AT III activity, and DIC scores were calculated and recorded. Results: The coagulation tests, AT III activity and FDP started to improve from the second day of treatment with both treatments (p<0.05). D-Dimer started to decrease on the second day of treatment with pentoxifylline (p<0.001) and fourth day of AT III treatment (p<0.05). Fibrinogen levels decreased on the second day of pentoxifylline treatment (p<0.05) and on the last day of AT III treatment (p<0.001). DIC scores started to decrease on the last day of treatment with AT III treatment (p<0.001) and on the third day of treatment with pentoxifylline (p<0.05). Conclusion: Both ATIII and pentoxifylline treatments had positive effects on fibrinogen, FDP, D-Dimer, AT III activity and DIC scores in patients with Gram-negative sepsis who developed DIC.

Critical Care, 2001

P14 Facial continuous positive airway pressure therapy for cardiogenic pulmonary oedema: a study ... more P14 Facial continuous positive airway pressure therapy for cardiogenic pulmonary oedema: a study of its efficacy in an emergency department setting within the UK

Turkiye Klinikleri Journal of Case Reports, 2016

Ain-Shams Journal of Anesthesiology, 2020

Background The aim of this study was to investigate the risk factors effective in perioperative m... more Background The aim of this study was to investigate the risk factors effective in perioperative morbidity and mortality in 161 living donor liver transplantations (LDLT). Results The most common indication for living donor transplantation was cryptogenic cirrhosis. The most common complication was biliary problems in 62.16% cases. Sepsis was the most common cause of in 52%. Patients in whom sepsis was observed, significantly prolonged stay under mechanical ventilation and prolonged ICU stay were detected. In patient group in whom mortality was observed, higher amounts of erythrocytes, fresh frozen plasma (FFP), and platelets were transfused, and patients remained longer under mechanical ventilation treatment, and in the ICU. Conclusion Perioperative morbidity and mortality was found to be significantly related with higher amounts of erythrocytes and FFP transfusions and longer operative and warm ischemia times. Sepsis was found to be the most common cause of mortality.

Turkish Journal of Trauma and Emergency Surgery, 2020

BACKGROUND: The number of people actively participating in society has decreased following the co... more BACKGROUND: The number of people actively participating in society has decreased following the coronavirus disease 2019 (COVID-19) pandemic as a result of the measures taken to reduce the risk of transmission, such as interruption to education, social isolation, and curfews. Accordingly, change in the etiology of emergency surgery and characteristics of patients may be expected. The current study aimed to compare emergency surgery between the COVID-19 pre-pandemic and pandemic periods and to present the data and emergency anesthesia management of patients with suspected COVID-19. METHODS: Patients who underwent emergency surgery in our hospital between January 22 and April 29, 2020, were examined retrospectively. The patients were divided into two groups: Those operated before March 11, 2020 (Group 1) and those operated from this date April 29, 2020 (Group 2). The data of the two groups were compared. Routine emergency anesthesia and surgical approach were applied to all patients in Group 1 and those without suspected COVID-19 in Group 2. Patients with suspected COVID-19 in Group 2 were treated with an algorithm created in accordance with the guidelines of official institutions and scientific associations. RESULTS: Age, gender, chronic medical diseases, ASA classification, Mallampati score, surgical department, surgical procedures, surgical etiology, duration of surgery, and length of hospital stay were similar in both groups. The number of patients undergoing general anesthesia and spinal anesthesia was 198 (82.5%) and 42 (17.5%) for Group 1 while it was 161 (73.9%) and 57 (26.1%), respectively, for Group 2 (p=0.025). CONCLUSION: The clinical data and surgical features of emergency patients during the pandemic were similar to those before the pandemic; however, the rate of spinal anesthesia was higher in the former. Personal protective equipment standards should be followed to prevent cross-infection among the anesthesiology team during anesthesia procedures for emergency operations. We consider that necessary emergency interventions can be safely performed and COVID-19 nosocomial infection can be prevented in the operating room by following the Ministry of Health recommendations and guidelines that are updated regularly.

ENT Updates, 2016

We encounter multiple cranial, thoracal, abdominal, and extremity lesions caused by traffic accid... more We encounter multiple cranial, thoracal, abdominal, and extremity lesions caused by traffic accidents and fall from a height. Follow-up and treatment of these cases in intensive care units (ICUs) are arranged within the discipline of approach to a case of injury. In the present case, we are dealing with a 38-year-old female patient who had head trauma caused by a fall from a minibus. The patient was presented to our ICU with tracheal rupture.

Purpose: To describe the epidemiology of the acute respiratory distress syndrome (ARDS) in a Braz... more Purpose: To describe the epidemiology of the acute respiratory distress syndrome (ARDS) in a Brazilian ICU. Methods: This prospective observational, non-interventional study, included all consecutive patients with ARDS criteria [1] admitted in the ICU of a Brazilian tertiary hospital, between January 1997 and September 2001. Were collected in a prospective fashion the following variables: age, gender, APACHE II score at ICU admission and at ARDS diagnosis, cause of ARDS, presence of AIDS, cancer and immunosuppression, occurrence of barotrauma, performance of traqueostomy, mortality, duration of mechanical ventilation (MV), length of stay (LOS) in ICU and in hospital. The lung injury score (LIS) [2] was used to quantify the degree of pulmonary injury in the first week of ARDS. Results: There was 2182 patients (P) admitted in ICU during the study period, of whom 141 (6.46%) had ARDS criteria. Seventy-six (54%) were men, the mean age was 46 ± 18 years, APACHE II 18 ± 7 and 19 ± 7 at admission and at ARDS diagnosis, respectively. Septic shock accounted for 42% (60 P) of the ARDS causes, sepsis 22% (31 P), diffuse pulmonary infection 16% (23 P), aspiration pneumonia 11% (15 P), non-septic shock 5% (7 P) and others 4% (5 P). Ten percent (14 P) had AIDS, 30% (43 P) cancer and 25% (36 P) immunosuppression. All patients were mechanically ventilated with Tidal Volume between 4 and 8 ml/kg. Only 3.5% (5 P) had barotrauma and 10% (14 P) performed traqueostomy. Mortality rate was 79% in the ICU. The patients required 12 ± 10 days on MV, ranging from 1 to 55 days. The LOS in ICU and hospital was 14 ± 13 (1-69) days and 28 ± 32 (1-325) days, respectively. There was a time delay of 3.7 ± 4.5 days between admission in ICU and the onset of ARDS. The Murray score (mean ± SD) was 3.2 ± 0.4, 3 ± 0.5, 3 ± 0.5, 2.9 ± 0.6, 2.8 ± 0.7, 2.7 ± 0.7 and 2.6 ± 0.8 in the first 7 days, respectively. Conclusions: ARDS in our hospital has a similar incidence of reports in the USA and Europe. There was a higher mortality, which could be explained by a high incidence of infection causes of ARDS, mainly septic shock, and elevated combined occurrence of AIDS, cancer and immunosuppression, along the degree of LIS. The incidence of barotrauma was low, as a consequence of the current mechanical ventilation strategies.

Gerçekten çok a¤›r olmasalar dahi tüm zehirlenme olgular›, hayat› tehdit alt›nda olan zehirlenme ... more Gerçekten çok a¤›r olmasalar dahi tüm zehirlenme olgular›, hayat› tehdit alt›nda olan zehirlenme olgular› gibi tedavi edilmeli ve tedavi mümkün olduunca erken bafllay›p, belli bir prosedüre göre yap›lmal›d›r. Acil yap›lmas› gereken hava yollar›n›n aç›lmas›, solunumun-dolafl›m›n›n salan- mas› ve konvülziyonlar›n önlenmesinin ard›ndan ileri teflhis ve tedaviye geçilmelidir. Amaç öncelikle hastan›n yaflamas›n› salamaya yönelik olmal›d›r. ‹zlenecek yol Tablo 1'de özetlenmifltir.

The Bulletin of Legal Medicine, Aug 1, 2006

Adli Tıp Bulteni, Aug 1, 2006

Cerrahpasa Tıp Dergisi, 1999

Turkish Journal of Trauma and Emergency Surgery, 2015

BACKGROUND: The study aimed to evaluate and compare the effects of a single dose of etomidate and... more BACKGROUND: The study aimed to evaluate and compare the effects of a single dose of etomidate and the use of a steroid injection prior to etomidate during rapid sequence intubation on hemodynamics and cortisol levels. METHODS: Sixty patients were divided into three groups (n=20). Before intubation, and at 4 and 24 hours, blood samples were taken for cortisol measurements and hemodynamic parameters (systolic-diastolic-mean arterial pressure, heart rate), and SOFA scores were recorded. Intubation was achieved with 0.3 mg/kg etomidate IV in Group I, 0.3 mg/kg etomidate following 2 mg/kg methylprednisolone IV in Group II, and 0.15 mg/kg IV midazolam in Group III. RESULTS: Mean arterial pressure values were lower in Group I at the 24 th hour when compared to Groups II and III. In Group I, heart rate values were higher compared to the other Groups. Cortisol levels were lower in Group I at the 4 th and at the 24 th hour in Groups II and III. CONCLUSION: Administration of methylprednisolone 2-4 minutes prior to etomidate use in emergency situations can prevent adrenal insufficiency in patients undergoing rapid sequence intubation. Moreover, midazolam can be used in low induction doses as an alternative to etomidate.

Brazilian Journal of Anesthesiology (English Edition), 2015

The local anesthetics may cause neurotoxicity. We aimed to compare the neurotoxic potential of di... more The local anesthetics may cause neurotoxicity. We aimed to compare the neurotoxic potential of different local anesthetics, local anesthetic induced nerve damage and pathological changes of a peripheral nerve. Methods: Sixty Wistar rats weighing 200-350 g were studied. Rats were assigned into 3 groups and 26-gauge needle was inserted under magnification into the left sciatic nerve and 0.2 mL of 0.5% bupivacaine, 5% levobupivacaine, and 2% lidocaine were injected intraneurally. An individual who was blind to the specifics of the injection monitored the neurologic function on postoperative 1st day, and daily thereafter. Neurologic examination included assessment for the presence and severity of nociception and grasping reflexes. At the 7th day sciatic nerve specimen was taken for evaluation of histopathologic changes. Results: There was no statistical difference detected among groups regarding grasping reflex and histopathologic evaluation. Tw o cases in bupivacaine group, 1 case in levobupivacaine group and 2 cases in lidocaine group had slight grasping, while 1 case in lidocaine group had no grasping reflex on the seventh day. Severe axonal degeneration was observed in all groups, respectively in bupivacaine group 4 (20%), levobupivacaine group 3 (15%), and lidocaine group 6 (30%). Conclusion: In all groups, histopathological damage frequency and severity were more than the motor deficiency.

Asia Pacific journal of clinical nutrition, 2014

Our aim was to compare the effects of intravenous, enteral, and enteral plus intravenous suppleme... more Our aim was to compare the effects of intravenous, enteral, and enteral plus intravenous supplemented glutamine on plasma transferrin, nitrogen balance, and creatinine/height index in septic patients with malnutrition. Blood and urine samples were collected for transferrin, urea and creatinine measurements. Samples, SOFA score and protein-calorie intake values were repeated on days 7 and 15. Patients (n:120) were randomly divided into 4 groups. Group I received 30 g/day IV glutamine, group II received 30 g/day enteral glutamine, group III received 15 g/day IV and 15 g/day enteral glutamine. Group IV received only enteral feeding as a control group. Transferrin levels decreased in group IV (p<0.01 0-7 days, p<0.01 7-15 days, p<0.01 0-15 days). Nitrogen balance levels were highest in group IV when compared with group I (p<0.05, p<0.001), group II (p<0.001), and group III (p<0.05, p<0.001) on days 7-15. Creatinine/height indexes increased in group I (p<0.001)...

Middle East journal of anaesthesiology, 2006

The aim of this study was to investigate the rate, timing, the incidence of complications of perc... more The aim of this study was to investigate the rate, timing, the incidence of complications of percutaneous dilatational tracheostomy (PDT) and its effects by on nosocomial pneumonia. The study is a retrospective analysis of 104 patients (56 males, 48 females) > or = 18 years (54 +/- 19) who had undergone a PDT for respiratory failure during the five years 1998-2003. Among 238 patients requiring mechanical ventilation > or = 48 hours, 104 (43.7%) required PDT. PDT was performed after 4.3 +/- 2.3 days of ventilation and the disconnection from mechanical ventilation was 13.6 +/- 8.5 days. Lower airway tract infection was detected in 88 patients: 55 patients (62.5%) before PDT and in 33 patients (37.5%) after PDT. The nosocomial pneumonia was observed after 5.9 +/- 1.67 days of ventilation. Our results suggest that PDT was performed relatively early, with an acceptable complication rate and that our post-PDT nosocomial pneumonia incidence is low.

Critical care (London, England), 2004

The aim of the present study was to investigate the effects of the stress response on plasma insu... more The aim of the present study was to investigate the effects of the stress response on plasma insulin, cortisol, glucose, and urinary vanilmandelic acid during weaning and after extubation, using pressure support (PS), continuous positive airway pressure (CPAP) and T-piece modes. Sixty patients were randomly divided into three groups (n = 20). The PS group received FiO2 </= 0.4, PS </= 10 cmH2O, and positive end expiratory pressure </= 5 cmH2O for 2 hours. The CPAP group was given FiO2 </= 0.4 and CPAP 5 </= cmH2O for 2 hours. The T-piece group (group T) received 4 l/min oxygen via a T-piece for 2 hours. After 1 hour and 2 hours in their respective weaning modes, blood and urine samples were taken for insulin, cortisol, glucose and vanilmandelic acid measurements. Forty-eight hours after extubation, blood and urine samples were again taken. Plasma insulin was greater in group T than in the PS and CPAP groups (P < 0.01 and P < 0.01). The plasma cortisol concentrat...

European Journal of Anaesthesiology, 2014

Medical Science and Discovery, 2015

The purpose of present study was to compare the effects of desflurane and sevoflurane on blood vi... more The purpose of present study was to compare the effects of desflurane and sevoflurane on blood viscosity in three different shear rates and plasma viscosity. Forty male patients, ASAI-II, undergone tympanoplasty were included in this study. Patients were randomly categorized as anaesthetized either with sevoflurane or desflurane. Anaesthesia was maintained with inspiratory concentrations of sevoflurane 1-1.5 MAC or desflurane. The samples were taken for hemorheological and biochemical examinations before induction of anaesthesia (initial time) and at 60 th and 120 th min of the operation. Blood viscosities were measured by rotational viscometer. Plasma viscosity was measured by capillary viscometer. Patients receiving desflurane showed steady decrease at 23 1/sec shear rate at 60 th and 120 th min and in blood viscosity at 115 1/sec shear rate in 120 th min. Statistically significant decrease in the level of plasma viscosity was observed in the patient group anesthetized with desflurane, between initial time vs 60 th min (p<0.01), initial time vs 120 th min. (p<0.01). Desflurane produced stable effects on the blood circulation. The differences in the blood viscosity should not be overlooked.