IBRAHIM MOMOH - Academia.edu (original) (raw)

Papers by IBRAHIM MOMOH

Tropical Doctor, Apr 1, 2001

Intestinal obstruction Obstructed inguinal Herniorrhaphy 2 2 hernai Obstruction of the Laparotomy... more Intestinal obstruction Obstructed inguinal Herniorrhaphy 2 2 hernai Obstruction of the Laparotomy resection 5 4 small intestine and anastomosis Carcinoma of the Laparotomy and biopsy gall bladder of tumour infiltrating the transverse colon Peritonitis from Laparotomy, drainage typhoid perforation of abscess, repair of perforation Total 17 10

Gas sensors have a wide range of applications, and many of these applications require very high s... more Gas sensors have a wide range of applications, and many of these applications require very high sensitivity. Types of gas sensors include electrochemical, chemiresistor, infrared point, infrared imaging, semiconductors, ultrasonic and holographic sensors. Nanotechnology is a branch of engineering and science that deals with materials, processes, and devices at nanoscale, one billionth of a meter. Using nanotechnology highly sensitive sensors can be produced. This poster will present chemiresistor sensors developed using nanotechnology at Integrated Nanosystems Development Institute (INDI). Poly (vinylidene fluoride-co-hexafluoropropene) (PVDF-HFP), Carbon black, and carbon nanotube materials were used. Sensors were fabricated using photolithography and spin-coating or spraying methods. The sensors were then tested with acetone, ethanol, water vapor, and other gasses using a sensor testing setup and a data logger system. The poster will present fabrication methods and experimental results.

Dutse Journal of Pure and Applied Sciences

Prenatal stress is known to affect the offspring later in life. Lauric acid is a known antioxidan... more Prenatal stress is known to affect the offspring later in life. Lauric acid is a known antioxidant shown to play a protective role in experimental animals. This study examines the role of Lauric acid on sleep deprivation-induced stress on serum corticosterone level and birth weight in male rat pups. Pregnant dams were sleep-deprived using the modified multiple water platform for 20hrs daily from gestational day 9-19. Animals in groups 1 and 2 served as normal and stressed controls respectively, groups 3,4 and 5 received Lauric acid of doses 125mg/kg, 250mg/kg and 500mg/kg respectively while group 6 received Vitamin C 300mg/kg. Male offspring birth weight was recorded and at PND 28-36, were sacrificed and blood was collected for corticosterone assay. Serum corticosterone was significantly higher (p< 0.05) in the sleep-deprivation-induced stress group. Its level was also significantly lower (p<0.05) in the LA and vitamin C treated groups. Birth weight was significantly lower (p&...

Network Modeling Analysis in Health Informatics and Bioinformatics, 2020

Alzheimer disease (AD) is the most common form of dementia contributing to about 60-70% of cases.... more Alzheimer disease (AD) is the most common form of dementia contributing to about 60-70% of cases. β-Site amyloid precursor protein cleaving enzyme-1 (BACE1) plays an important role in the onset of AD and has become one of the important drug targets for AD. This approach has led to the development of promising BACE1 inhibitors, many of which are going through different phases of clinical trials. Nonetheless, the high failure rate of lead drug candidates targeting BACE1 brought to the forefront the need for finding new drugs to uncover the mystery behind AD. This study focused on virtual screening of ~ 33,000 natural compounds to find potential BACE1 inhibitors. Multiple ligands pharmacophore model was generated using PHASE to screen retrieved compounds against a four-site (ADDR) hypothesis. Molecular docking was performed to predict the binding status of the natural compounds. Based on binding affinity, the top eight compounds were chosen for further analysis. The docked complexes were analyzed for binding free energy using PRIME MM/GBA calculation. The compounds were filtered for drug-likeness using ADME/TOX (absorption, distribution, metabolism, excretion and toxicity) prediction. AutoQSAR (automated quantitative structure activity relationship) was used to build a model for the prediction of compounds bioactivities. Despite retrieving a large number of compounds with favorable binding affinity, only a few were selected to be promising based on their ADME/TOX proprieties, binding free energy and predicted pIC 50. This study identified four natural compounds (NPC469686, NPC262328, NPC29763 and NPC86744) as novel BACE1 inhibitors. The insights obtained from this study could be employed to produce next-generation drug for AD.

Blood, 2011

4368 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired bone marrow disorder character... more 4368 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired bone marrow disorder characterised by intravascular hemolysis with resultant anemia often leading to transfusion dependence, severe disabling symptoms and, frequently, life threatening thrombosis. Historically the management of PNH was largely supportive, relatively ineffective and resulted in frequent visits to hospital, admissions, an inability to function normally including loss of employment or other daily activities. PNH is a chronic condition and in most patients persists for the remainder of the patient’s life. Eculizumab was first used for PNH in 2002 and has been licensed since 2007. Eculizumab has been reported to improve all symptoms due to hemolysis in PNH as well as preventing the common complications, such as thrombosis and renal failure and normalising survival. However eculizumab has to be given as an intravenous infusion every 2 weeks indefinitely. In the UK PNH is managed in a shared care model betw...

Blood, 2010

4240 Background: PNH is an acquired haemolytic anaemia which is characterised by intravascular ha... more 4240 Background: PNH is an acquired haemolytic anaemia which is characterised by intravascular haemolysis. The disease is due to a somatic mutation of the PIG-A gene in haematopoietic stem cells resulting in loss (complete or partial) of glycosylphosphatidylinositol-(GPI) anchored proteins on the cell surface. The lack of CD59, one of the GPI-anchored proteins, on the red cell surface leads to increased susceptibility to complement-mediated intravascular haemolysis. Eculizumab is a monoclonal antibody that inhibits the complement protein C5 by preventing its cleavage and leads to transfusion independence in 50% of the patients. Objective: To determine the role of C3 –mediated opsonisation of PNH cells, as we found a significant number of patients treated with Eculizumab still needing transfusion. Results: Twenty six PNH patients treated with Eculizumab and 22 patients from an untreated non transfusion dependant PNH cohort were analysed. Transfusion dependency was present in 14 of 26...

British Journal of Cardiac Nursing, 2010

Anaemia is a condition commonly encountered in many clinical specialities, including chronic hear... more Anaemia is a condition commonly encountered in many clinical specialities, including chronic heart disease, haemato-oncology, gastroenterology, gynaecology/obstetrics, renal disease and care of the elderly. In recent years, anaemia has emerged as a significant public health issue due to the appreciation that it has profound implications as a comorbid factor for other illnesses, while in itself presenting a serious health risk factor. This article explores the definition, classification and current treatment options for anaemia. It describes the move within a central London acute trust to a nurse-led service and the favourable patient satisfaction results that have emerged from an initial survey.

Journal of Blood Transfusion, 2012

Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemi... more Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemia and can be used to avoid or reduce the requirement for allogeneic blood transfusion. Several intravenous iron preparations are available commercially which differ in cost, mode of administration and side effect profile. There are few data directly comparing the efficacy of these preparations. In this retrospective single-centre study, we present the results from two hundred and eight patients treated using three different iron preparations (iron dextran, iron sucrose and ferric carboxymaltose) and compare the effect on haemoglobin levels and other measures of iron deficiency six weeks after treatment. Within the limitations of our study design, we show a statistically and clinically significant difference in efficacy between these preparations.

West African Journal of Radiology, 2006

The aim of this study was to assess whether introduction of Docetaxel into the management will im... more The aim of this study was to assess whether introduction of Docetaxel into the management will improve palliation of symptoms, quality of life, response rate and probably survival in breast cancer patients. A total of 19 patients referred from different medical centers in Nigeria were entered into the study. The age range was 25 to 52 years with a median of 34 years. The sex incidence was 18 females, 1 male. There were 7 patients in stage III and the duration of median response was 30 months. There were 12 patients in stage IV. Out of these 3 patients with brain metastasis had median response of 4 months. 4 patients with liver metastasis average duration of response was 22 months. 5 patients with pulmonary metastasis average duration of response was 20 months. In all, 16, out of the 19 patients (84%) had median response duration of 20 30 months. Better response rate could have been in patients with cerebral metastasis but for the fact that Docetaxel does not penetrate brain barrier. Multicentre studies are now needed to reconfirm the superiority of Doxetacel over existing cytotoxic chemotherapeutic drugs currently in use in the management of advanced and metastatic breast cancer in Nigeria.

Risk Management and Healthcare Policy, 2013

This article describes the initiation and evolution of the Rapid-Access Anemia Clinic (RAAC) at G... more This article describes the initiation and evolution of the Rapid-Access Anemia Clinic (RAAC) at Guy's and St Thomas' Hospitals, London, UK. This clinic was set up to provide diagnosis and treatment, and to coordinate investigative procedures, where necessary, into the underlying causes of anemia. Initially piloted with anemic preoperative orthopedic patients, the clinic now treats a wide range of conditions, deriving from both internal and external referrals. Treatment includes dietary advice, supplementation with iron, vitamin B 12 and folate, and blood transfusion. Most patients at the RAAC need iron replacement, the majority of which require intravenous (IV) iron. Therefore the first-line IV iron-administration protocol is carefully considered to ensure viability of the service and patient satisfaction. Four IV irons available in the UK are discussed, with explanation of the benefits and drawbacks of each product and the reasoning behind the IV iron choice at different stages of the RAAC's development. Costs to the service, affected by IV iron price and administration regimen, are considered, as well as the product's contraindications. Finally, the authors reflect on the success of the RAAC and how it has improved patients' quality-of-treatment experience, in addition to benefiting the hospital and National Health Service in achieving specific health-care mandates and directives. Drawing from the authors' experiences, recommendations are given to assist others in setting up and providing a successful rapid-access anemia service or similar facility.