Izumi Sugihara - Academia.edu (original) (raw)
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Papers by Izumi Sugihara
The Journal of General Physiology, Feb 1, 1998
Journal of Neurophysiology, Jul 1, 1996
The Journal of Neuroscience the Official Journal of the Society For Neuroscience, May 15, 2000
Neuroscience Research Supplements, 1994
Neuroscience Research Supplements, 1993
The Journal of Neuroscience, Oct 1, 2001
Cerebellum (London, England), Jan 19, 2016
For many decades, the predominant view in the cerebellar field has been that the olivocerebellar ... more For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here, we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum and might also play a role in development. We then consider the potential problems and benefits of it having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, and variable complex spike waveforms) make it more or less sui...
Neuroreport, 1996
In this study, we examined the decremental response in the hair cell-afferent fibre synapse of go... more In this study, we examined the decremental response in the hair cell-afferent fibre synapse of goldfish. This decremental response is a transient reduction in sound-evoked EPSPs associated with a step reduction in sound intensity. To determine its presynaptic correlates, a patch clamp study was performed on oscillatory-type hair cells isolated from the sacculus of goldfish. Injection of depolarizing current produced a damped oscillation in the membrane potential of such cells. When the current intensity was reduced in steps, instead of simply being turned off, very marked dips were produced as off-oscillation in the hair cell membrane potential. These dips correlated with the decremental response in EPSPs.
Brain Research, Dec 2, 2010
The Journal of Physiology, Dec 1, 1995
1. Ionic currents underlying the oscillatory response of membrane potential were studied in oscil... more 1. Ionic currents underlying the oscillatory response of membrane potential were studied in oscillatory-type hair cells isolated from the goldfish sacculus with the whole-cell recording method using a patch pipette. 2. Bath application of 4-aminopyridine (4-AP; 10 mM) reversibly produced moderate depolarization of the resting potential along with complete suppression of the oscillatory response. Sustained injection of a small depolarizing current also suppressed the oscillatory response. 3. A 4-AP-sensitive atypical A-type K+ current which had a high threshold voltage for inactivation (IA(H)) was found to be a major outward current underlying the oscillatory response. 4. IA(H) was activated with a time constant of 0.4-10 ms and was inactivated slowly with a time constant of 0.6-2 s. IA(H) activation and inactivation occurred mostly at membrane potentials more positive than -70 mV. 5. There was a clear correlation between activation speed of IA(H) and the frequency of pulse-evoked oscillation. A 'hump'-type response was produced in about one-quarter of the oscillatory-type hair cells.
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
Nippon seirigaku zasshi. Journal of the Physiological Society of Japan
Journal of Neurophysiology
Handbook of the Cerebellum and Cerebellar Disorders, 2013
Handbook of the Cerebellum and Cerebellar Disorders, 2013
Neuroscience Research Supplements, 1991
The Journal of General Physiology, Feb 1, 1998
Journal of Neurophysiology, Jul 1, 1996
The Journal of Neuroscience the Official Journal of the Society For Neuroscience, May 15, 2000
Neuroscience Research Supplements, 1994
Neuroscience Research Supplements, 1993
The Journal of Neuroscience, Oct 1, 2001
Cerebellum (London, England), Jan 19, 2016
For many decades, the predominant view in the cerebellar field has been that the olivocerebellar ... more For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here, we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum and might also play a role in development. We then consider the potential problems and benefits of it having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, and variable complex spike waveforms) make it more or less sui...
Neuroreport, 1996
In this study, we examined the decremental response in the hair cell-afferent fibre synapse of go... more In this study, we examined the decremental response in the hair cell-afferent fibre synapse of goldfish. This decremental response is a transient reduction in sound-evoked EPSPs associated with a step reduction in sound intensity. To determine its presynaptic correlates, a patch clamp study was performed on oscillatory-type hair cells isolated from the sacculus of goldfish. Injection of depolarizing current produced a damped oscillation in the membrane potential of such cells. When the current intensity was reduced in steps, instead of simply being turned off, very marked dips were produced as off-oscillation in the hair cell membrane potential. These dips correlated with the decremental response in EPSPs.
Brain Research, Dec 2, 2010
The Journal of Physiology, Dec 1, 1995
1. Ionic currents underlying the oscillatory response of membrane potential were studied in oscil... more 1. Ionic currents underlying the oscillatory response of membrane potential were studied in oscillatory-type hair cells isolated from the goldfish sacculus with the whole-cell recording method using a patch pipette. 2. Bath application of 4-aminopyridine (4-AP; 10 mM) reversibly produced moderate depolarization of the resting potential along with complete suppression of the oscillatory response. Sustained injection of a small depolarizing current also suppressed the oscillatory response. 3. A 4-AP-sensitive atypical A-type K+ current which had a high threshold voltage for inactivation (IA(H)) was found to be a major outward current underlying the oscillatory response. 4. IA(H) was activated with a time constant of 0.4-10 ms and was inactivated slowly with a time constant of 0.6-2 s. IA(H) activation and inactivation occurred mostly at membrane potentials more positive than -70 mV. 5. There was a clear correlation between activation speed of IA(H) and the frequency of pulse-evoked oscillation. A 'hump'-type response was produced in about one-quarter of the oscillatory-type hair cells.
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
Nippon seirigaku zasshi. Journal of the Physiological Society of Japan
Journal of Neurophysiology
Handbook of the Cerebellum and Cerebellar Disorders, 2013
Handbook of the Cerebellum and Cerebellar Disorders, 2013
Neuroscience Research Supplements, 1991