Ibrahim Sakr - Academia.edu (original) (raw)

Papers by Ibrahim Sakr

Journal of Advances in Medicine and Medical Research, 2022

Background: osteoporosis is a common morbidity characterized by a systemic impairment of bone mas... more Background: osteoporosis is a common morbidity characterized by a systemic impairment of bone mass and microarchitecture that results in bone fragility fractures leading to decreased quality of life. Methods: This study was conducted upon 30 adult patients with osteoporotic spine subjected to bone cement augmentation in the department of Neurosurgery, Tanta University Hospitals between January 2020 and January 2021. Results: Oswestry Disability Index (ODI) ranged from 64-85 with mean 78±18.8 before surgery and 21-44 after surgery with mean 33±15.6. Visual Analog Scale for Pain (VAS) ranged from 7-9 pre-operatively with a mean value 8.2±1.8 and from 1-3 post-operatively with a mean value 2.3±1.6.

Annals of Medicine, 2021

Background: Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory... more Background: Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There is no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor's (PPAR's) activation is associated with insulin sensitisation and improved glucose metabolism. PPAR-c was reported to alleviate FM allodynia. Limited data are discussing its effect on motor disorders. Objective: To investigate the potential effect of PPAR-c agonists (pioglitazone, as one member of thiazolidinediones (TZD)) on motor dysfunction in reserpine-induced FM in a rat model. Materials and methods: Thirty-six male Wistar rats were divided into negative control (n ¼ 9) and reserpine-induced FM (n ¼ 27) groups. The latter was subdivided into three equal subgroups (n ¼ 9), positive control (untreated FM model), pioglitazone-treated and GW9662-treated. We evaluated muscle functions and activity of chloramphenicol acetyltransferase, superoxide dismutase, malondialdehyde, and serum levels of interleukin-8 and monocyte chemoattractant protein-1. Results: Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-c antagonist, aggravated the FM manifestations in the rat model. Conclusion: PPAR-c agonists show a promising role against FM-associated motor dysfunctions.

Egyptian Journal of Radiology and Nuclear Medicine, Dec 1, 2019

Background: To review the most common causes of Anterior knee pain (AKP), with an emphasis on the... more Background: To review the most common causes of Anterior knee pain (AKP), with an emphasis on their MRI findings; 70 patients were included (24 males and 46 females). Their age range is 10-53 years with a mean ± SD of 28.8 ± 9.06 years. All patients performed MRI of the affected knee. Results: Eleven disease entities were encompassed in this study; the patellar causes were dominating, where the chondromalacia patella being found in 43% of cases (n = 30), patellar instability was found in 19% (n = 13), transient patellar dislocation was found in 7% (n = 5), patellar tendinopathy was found in 4% (n = 3), and bipartite patella was found in 1% (n = 1). Hoffa's disease was found in 14% (n = 10); the anterior meniscal tear was found in 13% (n = 9). Quadriceps tendinopathy was found in 3% (n = 2), and quadriceps tear was found in 4% (n = 3). Cartilage disease was found in 6% (n = 4); Osgood-Schlatter disease was found in 4% (n = 3); the coexistence of more than an entity was found in 13 cases (18.5%). Conclusions: MRI provided a safe and accurate modality in the diagnosis of different causes of AKP with a high specification in detecting the grades and the types of some diseases.

Menoufia Medical Journal, 2015

Objectives The aim of the study was to estimate the incidence of amblyopia in children aged betwe... more Objectives The aim of the study was to estimate the incidence of amblyopia in children aged between 5 and 15 years and ascertain the most common causes of amblyopia in this age group in the Menoufia University outpatient clinic. Background Amblyopia is one of the leading causes of acquired preventable monocular visual impairment. Methods This is a cross-sectional clinical study that was carried out between March 2012 and September 2012 in children between the ages of 5 and 15 years (mean age 8.013 ΁ 3.381 years) attending the Menoufia University outpatient clinic. After obtaining patient consent all patients underwent refraction, vision, and subjective refraction tests. Amblyopia was defined as best-corrected visual acuity with a two-line interocular optotype acuity difference with no pathology. Results The study was conducted on 510 patients; 38 of them (6.3% of male patients and 8.6% of female patients) had amblyopia, with an estimated incidence of 7.45%. Amblyopia decreased significantly with age (P = 0.002). Of the 38 amblyopic patients, 26 (68.42%) had anisometropic amblyopia and 12 (31.58%) had strabismic amblyopia. The most common type of amblyopia was anisometropia, followed by strabismic amblyopia. Hypermetropia was the most common refractive error in anisometropic amblyopia. Conclusion The incidence of amblyopia in this study was 7.45%, which is high compared with other studies; however, the sample in this study was taken from diseased persons attending the outpatient clinic and not from a healthy population. Proper ophthalmological screening of preschool children should be carried out, including extraocular examination, fundus examination, and visual acuity testing, with special emphasis on detection of errors of refraction.

International Journal of Coal Geology, 2019

Abstract CO2 interaction-induced mechanical alteration in coal is imperative in the context of CO... more Abstract CO2 interaction-induced mechanical alteration in coal is imperative in the context of CO2 geo-sequestration, as it governs the project safety, in general. Accurate estimations of mechanical characteristics are thus essential prior to the implementation of field projects. Through this study, we numerically model the alterations in coal compressive strength, caused by CO2 interaction. The combined effect of both free and adsorbed CO2 on coal strength is evaluated based on the Mohr-Coulomb failure criterion, in which a modified-cohesion model is derived to define the adjusted-failure envelope, by integrating the CO2 adsorption-induced surface energy change. The model is initially validated with two experimental studies conducted under confined- and unconfined-stress conditions. The validation results confirm that the model is capable of successfully simulating the effect of confining stress, and the effect of free and adsorbed CO2 on the alterations of coal compressive strength. The calibrated model is used to estimate the strength alterations at relatively large confining stresses (i.e. Pb ≈ 25 MPa) and at incremental pore pressures (i.e. 0.1 MPa 12 MPa) due to the matrix-compression, caused by the elevated pore pressure, and the developed modified-cohesion model is capable of capturing this behaviour. The model is highly sensitive to the Biot's coefficient, as it defines the fraction of pore pressure that contributes to the effective stress, and ultimately to both free and adsorbed CO2-induced strength alteration. The sensitivity analysis highlights the significance of the Langmuir constants, as they play a critical role in modelling the fully-coupled process, thus should be precisely determined for a given coal type, in order to accurately simulate the overall strength alterations.

Journal of Medical Science And clinical Research, 2016

A gastric ulcer is a break in the normal gastric mucosa integrity that extends through the muscul... more A gastric ulcer is a break in the normal gastric mucosa integrity that extends through the muscularis mucosa into the sub-mucosa or deeper. This work aimed to study the effect of chronic administration of vinegar on gastric acid secretion, and if this action has any effect on stress-induced ulcer in male albino rats. Study groups included 24 rats divided into 2 main groups (12 rats/group): pyloric ligation group (A) and water immersion-induced gastric ulceration group (as a form of stress) (B). We evaluated; free and total HCL secretion in group A, ulcer score, ulcer index, percentage ulcer protection, , eNOS enzyme activity, COX-2 enzyme activity, glutathione reductase gene expression, CCK gene expression and proton pump (H + /K + ATPase) gene expression in group B. We revealed significant decrease in free and total acidity, ulcer score and index, COX-2 enzyme activity and Proton pump (H + /K + ATPase) gene expression among vinegar fed rats compared with the results of the control group. On the other hand there was significant elevation in the percentage ulcer protection, eNOS enzyme activity, glutathione reductase gene expression and CCK gene expression among vinegar fed rats compared to control group. In conclusion, the present study revealed protective effect of vinegar on stress-induced gastric ulceration.

2019 Far East NDT New Technology & Application Forum (FENDT), 2019

With the increase of fatigue rolling cycles between the wheel and rail, it’s easy to generate sma... more With the increase of fatigue rolling cycles between the wheel and rail, it’s easy to generate small angle microcracks on the surface or shallow surface of the rail, which is located in the blind spot of ultrasonic detection. Therefore, pulsed eddy current thermography (ECPT) is selected for detection. In this paper, the finite element software was used to simulate the thermal characteristics of microcracks, and the data was extracted for simulation data analysis. Then principal component analysis(PCA), tensor CANDECOMP/PARAFAC de- composition(CP), and Tucker decomposition were compared horizontally, and the signal-to-noise ratios (SNR) of the three algorithms were obtained by experimental data. Experimental analysis shows that the characteristics of microcracks are very weak, the optimal extraction time is in the beginning of the heating stage, and the tensor algorithm can improve the SNR ratio of the microcrack effectively.

Archives of Medical Science

IntroductionType 2 diabetes mellitus (DM) and Alzheimer’s disease (AD) are two major medical cond... more IntroductionType 2 diabetes mellitus (DM) and Alzheimer’s disease (AD) are two major medical conditions that constitute a significant financial burden on most healthcare systems. Due to AD sharing “insulin resistance” mechanistic features with DM, some scientists have proposed “type 3 DM” terminology for it. This study aims to compare the prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 DM.Material and methodsTwo groups of rats were included in the study: the control group (n = 15) and the streptozotocin-induced type 2 diabetic group (n = 45). The diabetic group was subdivided into three equal subgroups: a sedentary non-treated diabetic group, an exercised group, and a metformin-treated group. We estimated step-down avoidance task latency, serum glucose, insulin, free fatty acids (FFA), cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TG), brain A-42 and glucose, histological changes by tolui...

Pan African Medical Journal