Ifeoluwa T Oyeyemi - Academia.edu (original) (raw)

Papers by Ifeoluwa T Oyeyemi

Current Traditional Medicine

: Hoslundia opposita is an aromatic plant of the family Lamiaceae and the only member of the Hosl... more : Hoslundia opposita is an aromatic plant of the family Lamiaceae and the only member of the Hoslundia genus. It is traditionally for the treatment of HIV/AIDs related diseases, Breast cancer, Gonorrhea, Syphilis, Appendicitis, Epilepsy and convulsion, Malaria e.t.c. A review of relevant literature on biology, folkloric uses, phytochemistry and pharmacology were done. The electronic databases searched included Google Scholar, PubMed, Science Direct, Wiley and Springer. Sixteen bioactive compounds have been isolated from the plants namely; 3-O-benzoylhosloppone, 3-O-cinnamoylhosloppone, 3-O-benzoylhinokiol, 3-O-benzoylhosloquine, Euscaphic acid, 5,7-dimethoxy6-methylflavone, Hoslunddiol, Oppositin, 5-O-methylhoslundin, Tectochrysin, Hoslundin, Hoslunfuranine, 5-O-methylhoslunfuranine, Hosloppin, Hoslundal and Ursolic acid. The plant as its phytochemicals has shown various pharmacological effects such as antimalarial, antidiabetes, antioxidant, anti-inflammatory, anticancer and immunomodulatory effects. This review presented scientific findings on the therapeutic potential of Hoslundia opposita against several infectious and non-infectious diseases. There is a need for further investigation of the mechanism underlying the therapeutic potential of this plant against various diseases. There is also a need for clinical trials which will validate its efficacy and safety.

Aims: One of the ways to manage the current coronavirus disease 2019 (COVID-19) pandemic is monit... more Aims: One of the ways to manage the current coronavirus disease 2019 (COVID-19) pandemic is monitoring of public knowledge, risk perceptions, adherence to preventive measures and preparedness behaviors. This is of utmost importance in resource limited countries. This study determined the knowledge and perception about COVID-19; adherence to COVID-19 preventive measures; as well as predictors of self-perceived risk of contracting COVID-19 among Nigerian adults.Methods: A cross-sectional study was conducted among Nigerian adults ≥ 18 years using an online survey. Participants were recruited using the authors’ social networks. Data was analysed using descriptive and inferential statistics at 5% level of statistical significance.Results: Generally, a high proportion of respondents had correct knowledge about COVID-19. However, only about half (49.8% and 49.9%) had correct knowledge that obesity was a risk factor for COVID-19 and that antibiotics cannot be used to treat COVID-19. Most (8...

South African Journal of Botany, 2019

An ethnobotanical survey of the plants used for the traditional management of malaria by the resi... more An ethnobotanical survey of the plants used for the traditional management of malaria by the residents of Ondo State, Nigeria was carried out. Data was collected by interviews using a semi-structured questionnaire. A total of 162 indigenous people were interviewed [male, 110 (68%); female, 52(32%)]. A total of 97 plant species belonging to 52 different families were identified. Detailed information about their vernacular names, modes of preparation and previous investigations of their antiplasmodial/antimalarial effects was also compiled. Of the plants identified, the family Euphorbiaceae is predominant while Mangifera indica, Anacardium occidentale and Cymbopogon citratus are the most cited species. Only a few (37%) of the plants identified have been subjected to scientific investigations, most of which are only preliminary. Of the tested plants, some have shown in vivo activities comparable with that of orthodox antimalarial drugs. There is, therefore, a need to scientifically investigate the antimalarial potential of these plants as they serve as potential source of lead compounds for malaria therapy.

Journal of basic and clinical physiology and pharmacology, Jan 10, 2017

Curcumin and nisin have been widely reported for their antibacterial and anticancer potency. Howe... more Curcumin and nisin have been widely reported for their antibacterial and anticancer potency. However, their therapeutic applications are hampered by several factors, which necessitate their development into nanosize ranges for improved delivery and activities. Their incorporation into a single nanosynthesized form may suggest desirable efficacy on parasites. The aim of the study was to assess the ovicidal activity of the curcumin-nisin polylactic acid (PLA) entrapped nanoparticle on the Fasciola eggs and its reproductive toxicity. The nanoparticle was formulated by double emulsion method. The eggs of the adult Fasciola spp. were exposed to different concentrations (0.3125-5 mg/mL) of the nanoparticle to monitor hatchability. Mice were exposed to 0.5 mL of the formulated drug at varying concentrations (10-20 mg/kg) and then sacrificed for sperm morphology assay. The mean particle size, polydispersity index, and drug entrapment efficiency of the formulated drug were 288.4±24.3 nm, 0.2...

Beni-Suef University Journal of Basic and Applied Sciences, 2017

Vernonia amygdalina, a widely grown shrub plant in Africa is consumed as vegetable and has high m... more Vernonia amygdalina, a widely grown shrub plant in Africa is consumed as vegetable and has high medicinal value. It has gained wide application in the treatment and management of various diseases. The leaves are useful components for herbal medicine constitution. The plant's activities is a result of diverse bioactive compounds isolated from the different parts of the plant. These metabolites have specifically been efficacious against parasites especially worms. The mechanisms of activities include paralysis of worm, interference with energy generation and impairment with nutrient absorption, motility, and reproduction. The lack of considerable toxicity associated with the plant makes it a choice for further drug discovery. Effort should be made towards standardizing the extract(s) of V. amygdalina for use in alternative medicine for treatment of helminth-related diseases.

Int. J. Anim. Veter. …, 2011

Data on karyotype of fishes in Nigeria is limited. In this study, chromosome analysis of Clarias

Nova Biotechnologica et Chimica, 2020

This study investigated the protective effective of Sida acuta leaf extracts against the genotoxi... more This study investigated the protective effective of Sida acuta leaf extracts against the genotoxic effect of lead nitrate, a toxic heavy metal that easily permeate the ecosystem. The genotoxic and anti-genotoxic effects of the aqueous extract of S. acuta on onion cells (Allium cepa L.) was evaluated using the Allium cepa L. assay. Onion bulbs were exposed to 0.25 – 2.5 mg.mL-1 concentrations of the plant extract for analyses of induction of cytogenetic damage. There was observeda concentration-dependent decrease in mitotic index of the A. cepa roots cells compared to the negative control. Lead nitrate significantly induced chromosomal aberration in A. cepa root cells. This effect, however, was significantly ameliorated by the S. acuta leaf extract. This effect was demonstrated by the lower frequency of chromosome aberrations in lead nitrate treated root cells after exposure to the extract. Furthermore, the extract restricted the extent of lead-induced cytological aberrations in A. c...

Forum of Clinical Oncology

Cryptosporidiosis is an important protozoan disease with serious public health implications. The ... more Cryptosporidiosis is an important protozoan disease with serious public health implications. The contribution of Cryptosporidium to colorectal cancer is still vaguely studied, but little evidence from experimental and epidemiological studies has suggested a possible association. This review discusses the epidemiology of cryptosporidiosis and colorectal cancer and attempts to unravel the possible link between the two diseases using epidemiological, pathological, molecular, and immunological evidence. The review stressed the need to undertake more studies in this relatively neglected field.

Journal of Interdisciplinary Medicine

Background: The lack of empirical data on the malaria status of orphans and vulnerable children (... more Background: The lack of empirical data on the malaria status of orphans and vulnerable children (OVC), access to long-lasting insecticide-treated nets (LLINs), and knowledge about the disease can hamper the development of effective policies and programs to address their malaria-related needs. Aim: The aim of this study was to evaluate knowledge of malaria transmission and utilization of LLINs among OVC in Ondo metropolis, Nigeria. Materials and Methods: A cross-sectional study was conducted in Ondo City, Ondo State, Nigeria, between January and March 2018. The study was carried out among 66 OVC (age 5–19 years) using questionnaires. Information on socio-demography, LLIN utilization, knowledge and risks of malaria transmission among OVC was sought. Results: The use of LLINs (80.9%) among OVC was significantly higher than the use of insecticide spray (6.1%) and mosquito coils (12.1%) (p <0.0001). Knowledge about malaria transmission was relatively high, and the majority of children...

Journal of Basic and Clinical Physiology and Pharmacology, 2017

Background:(NL) is an aquatic perennial plant used traditionally in the management of various liv... more Background:(NL) is an aquatic perennial plant used traditionally in the management of various liver diseases. In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CClMethods:Male Wistar rats were assigned into six groups of five rats each. Group I received corn oil (0.5 mL p.o.) and served as control, group II received CClResults:The activities of alanine aminotransaminase (ALT), aspartate aminotransferase (AST), and levels of total bilirubin (TB) in the serum, thiobarbituric acid reactive substances (TBARS), superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione (GSH) in the liver, and histopathology of the liver were determined using standard procedures. NL significantly (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) lowered the levels of ALT, AST, and TB and exhibited antioxidant potentials in rats exposed to CClConclusions:The data suggest that NL exhibited hepatoprotective effects in CCl

Annals of Science and Technology, 2020

Access to potable water is a major problem confronting most developing nations particularly with ... more Access to potable water is a major problem confronting most developing nations particularly with the overwhelming health burden posed by polluted water and its sources. In this review, studies on the level of contamination of drinking water sources in different geopolitical zones in Nigeria were assessed. The anthropogenic activities eliciting the pollutions were extensively discussed. Overall, the level of Nigeria preparedness in meeting the sustainable development goal number 6 (SDG no 6: to ensure availability and sustainable management of water and sanitation for all) was evaluated. Cogent methods that could enhance the achievement of SDG no. 6 were suggested. From our analysis of published literature, pre- and post- SDG implementation in Nigeria, it is clear that no significant progress has been made in providing potable water for all in Nigeria. All implementing partners must therefore rejig the process to ensure the availability of potable water, in order to achieve the susta...

Moringa oleifera is a multipurpose plant with nutritional and medicinal value. Despite its widely... more Moringa oleifera is a multipurpose plant with nutritional and medicinal value. Despite its widely acclaimed therapeutic benefits in traditional medicine, there are reports on its toxicity in living cells. Information is however, limited on toxic effect of the plant on the genetic component and male reproductive cells. We evaluated genotoxicity of aqueous extract of the leaves of M. oleifera using the Allium cepa chromosome aberration (CA) and mouse sperm morphology assays. Roots of onion bulbs were exposed to 0.5–20% of the extract for analysis of root growth inhibition, mitotic index (MI) and CA. Swiss male mice orally exposed to the aqueous extract (50–800 mg/kg) for 35 consecutive days were analysed for body and testes weight, testicular histology and sperm morphology. There was a significant (p < 0.05) root growth inhibition, decrease in MI and induction of CA compared to the negative control bulbs. The extract did not cause adverse effect on body and testes weight, but matur...

Journal of Public Health: From Theory to Practice, 2020

Aims One of the ways to manage the current coronavirus disease 2019 (COVID-19) pandemic is to mon... more Aims One of the ways to manage the current coronavirus disease 2019 (COVID-19) pandemic is to monitor the public knowledge, risk perceptions, adherence to preventive measures, and level of preparedness behaviors. This is important in resourcelimited countries. This study determined the knowledge and perception regarding COVID-19; adherence to COVID-19 preventive measures; as well as predictors of self-perceived risk of contracting COVID-19 among Nigerian adults. Methods A cross-sectional study was conducted among Nigerian adults ≥18 years using an online survey. A convenience sampling method was utilized to recruit a total of 1022 study participants. The participants were recruited using the authors' social media networks. Data were analyzed using descriptive and inferential statistics at a 5% level of statistical significance. Results Generally, a high proportion of respondents had correct knowledge about COVID-19. However, only approximately half (49.8% and 49.9%) had correct ...

African Journal of Urology

Objective: To correlate the levels of bladder tumour antigen (BTA) with aflatoxin M1 (AFM) in a h... more Objective: To correlate the levels of bladder tumour antigen (BTA) with aflatoxin M1 (AFM) in a human population in Nigeria. Subjects and methods: A pilot, observational study was conducted with 22 human subjects randomly recruited from a Nigerian rural community. Serum and first morning urine of participants were analysed for human BTA and AFM1, respectively, using quantitative ELISA assays. Results: All the subjects were positive to AFM1 (mean = 0.235 ± 0.072 ng/mL) while 19 were positive to BTA (mean = 2.340 ± 1.741 ng/mL). A negative relationship occurred between human BTA and AFM level (r = −0.239; P = 0.285). Human BTA (2.86 ± 2.43 ng/mL; P = 0.306) and AFM1 (0.258 ± 0.065 ng/mL; P = 0.643) were higher in subjects 1-20 years. The two biomarkers were not also associated with sexes of the participants (P > 0.05), although they were higher in the female subjects.

Titanium dioxide nanoparticles (TiO 2 NPs) are widely used and may impact the environment. Thus, ... more Titanium dioxide nanoparticles (TiO 2 NPs) are widely used and may impact the environment. Thus, this study used a high concentration of TiO 2 NP (1000 mg/L) to verify the defense mechanisms triggered by a plant system-an indicator of toxicity. Furthermore, this study aimed at completely characterizing TiO 2 NP suspensions to elucidate their toxic behavior. TiO 2 NPs were taken up by meristematic cells of Allium cepa, leading to slight inhibition of seed germination and root growth. However, severe cellular and DNA damages were observed in a concentration-dependent manner (10, 100, and 1000 mg/L). For this reason, we used the highest tested concentration (1000 mg/L) to verify if the plant cells developed defense mechanisms against the TiO 2 NPs and evaluated other evidences of TiO 2 NP genotoxicity. Nucleolar alterations and plant defense responses (i.e., increased lytic vacuoles, oil bodies and NP phase change) were observed in meristematic cells exposed to TiO 2 NP at 1000 mg/L. In summary, TiO 2 NPs can damage the genetic material of plants; however, plants displayed defense mechanisms against the deleterious effects of these NPs. In addition, A. cepa was found to be a suitable test system to evaluate the cyto-and genotoxicity of NPs.

Interdisciplinary Toxicology, 2015

Spondias mombin (Linn), Nymphaea lotus (Linn) and Luffa cylindrica (Linn) (syn Luffa aegyptiaca M... more Spondias mombin (Linn), Nymphaea lotus (Linn) and Luffa cylindrica (Linn) (syn Luffa aegyptiaca Mill) are plants traditionally used as food ingredients and in the management of diseases, including cancer, in Nigeria. Despite the therapeutic potentials attributed to these plants, reports on their genotoxicity are scanty. In this study, the genotoxicity of the aqueous and hydro-methanol extract of these plants was evaluated using mouse bone marrow micronucleus and sperm morphology assays. Antigenotoxicity was assessed by the bone marrow micronucleus test. The highest attainable dose of 5 000 mg/kg according to OECD guidelines was first used to assess acute toxicity of the aqueous and hydro-methanol extracts in Swiss albino mice. For each extract, there were five groups of mice (n=4/group) treated with different concentrations of the extract as against the negative and positive control group for the genotoxicity study. In the antigenotoxicity study, five groups of mice were exposed to five different concentrations of the extracts along with 60 mg/kg of methyl methane sulfonate (MMS), which was used to induce genotoxicity. The mice were administered 0.2 mL of extract per day for 10 days in the genotoxicity and antigenotoxicity groups. Administration of each of the extracts at the concentration of 5 000 mg/kg did not induce acute toxicity in mice. At the concentrations tested, all the extracts, except aqueous S. mombin, increased micronucleated polychromatic erythrocytes. The aqueous and hydro-methanol extracts of N. lotus increased the frequency of aberrant sperm cells. All the extracts were also able to ameliorate MMS induced genotoxicity in bone marrow cells of the exposed mice. The results showed the potential of the extracts to induce somatic and germ cell mutation in male mice. The extracts also ameliorated the genotoxic effect of MMS.

Annals of Science and Technology

The combination of antiretroviral (ARV) drugs: lamivudine, tenofovir disoproxil fumarate (TDF) an... more The combination of antiretroviral (ARV) drugs: lamivudine, tenofovir disoproxil fumarate (TDF) and efavirenz is among the preferred first-line regimens for adolescents and adults infected with HIV. However, knowledge on in vivo genetic and reproductive toxicity of each of these drugs and their combination is limited. We evaluated the genotoxicity of lamivudine, TDF, efavirenz and their combination utilizing the mouse micronucleus (MN) and sperm morphology tests. Histopathological analysis of the testes of exposed mice was also carried out. 0.016, 0.032, 0.064 and 0.129 mg/kg bwt of lamivudine, TDF and the combination; and 0.032, 0.064, 0.129 and 0.259 mg/kg bwt of efavirenz corresponding to 0.125, 0.250, 0.500 and 1.000 x the human therapeutic daily dose (HTD) of each of the ARVs and their combinations were administered to mice for 5 consecutive days. Data on MN showed a significant increase (p ---lt--- 0.05) across the tested doses of TDF, efavirenz and the combination, with the co...

Parasitology

Toxoplasmosis is a global health threat in which occurrence in pregnant women poses grave consequ... more Toxoplasmosis is a global health threat in which occurrence in pregnant women poses grave consequences to fetal wellbeing. Studies on prenatal Toxoplasma gondii infection are generally limited in sub-Saharan African countries, including Nigeria. The risk of transmission of toxoplasmosis is very high in Nigeria due to the favourable climatic conditions and prevailing behavioural and socio-economic factors that could aid transmission. Currently, there are no systematic and organized procedures for diagnosis and treatment of maternal toxoplasmosis in Nigeria. These conditions forecast possible unabated transmission in many areas and exponential impact on associated adverse events of the disease during pregnancy. This paper highlights the importance of early diagnosis and treatment during pregnancy which may forestall subsequent development of infection in children delivered by infected mothers. Inclusion of toxoplasmosis control policy in the routine antenatal care of pregnant women is...