Igbiks Tamuno - Academia.edu (original) (raw)

Papers by Igbiks Tamuno

Immunotherapy: Open Access, 2016

Background: At present renal dysfunction in clinical practice is measured using serum creatinine ... more Background: At present renal dysfunction in clinical practice is measured using serum creatinine values to calculate eGFR (estimated glomerular filtration rate) but creatinine is a late marker of renal dysfunction and is only raised when up to 30-50% of renal function is lost. Methods: Serial urine samples were analyzed by enzyme-linked immunosorbent assay for IL-18. Urinary IL-18 together with other common indicators of renal damage was assessed in 325 HIV patients; of which 66 developed renal dysfunction after 12 weeks of follow-up. Result: Marked increase in IL-18 (p=0.000) was observed at an earlier stage in the renal disease group compared to a delayed elevation of eGFR, serum creatinine, fractional excretion of phosphate and fractional excretion of uric acid which was evident only after 4 weeks. Conclusion: This finding seems to suggest that IL-18 can be used as an early marker of subclinical renal tubular dysfunction in HIV-infected patients, owing to the fact that IL-18 increases in urine only under conditions of marked tubular damage, apoptotic tubular cell shedding, and cell necrosis, associated with deterioration of renal function.

erence to treatment plan. Randomly selected records of 200 patients attending the hypertension cl... more erence to treatment plan. Randomly selected records of 200 patients attending the hypertension clinic of a Nigerian teaching Hospital were studied. Information on antihypertensive prescription, blood pressure control and adherence to treatment plan were evaluated. Sixty percent of the patients were males with an average age of 50.6years (SD=13.7). 91.5% of the patients were on antihypertensive drug combinations with 85 (42.5%), 61(30.5%), 34(17.0%), 2(1%) and 1(0.5%) patients on combination of two, three, four, five, and six drugs respectively. Diuretics were the most commonly prescribed antihypertensive drug class in 88% of all prescriptions. This is followed by angiotensin converting enzyme inhibitors (62%), calcium channel blockers (59%), centrally acting drugs (15.5%) and beta blockers (14.5%). Diabetes mellitus and hyperlipidemia were the most common comorbid conditions (13% and 9.5%). The BP control rate was 34.5% and 23.1% in all patients and those with diabetes respectively....

Supplemental material, sj-pdf-1-std-10.1177_0956462420918515 for The utility of kidney injury mol... more Supplemental material, sj-pdf-1-std-10.1177_0956462420918515 for The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV by Mohammed I Danjuma, Shaikha Al Shokri, Nadia Bakhsh, Mohammed A Alamin, Mohamed GH Mohamedali and Igbiks Tamuno in International Journal of STD & AIDS

African Health Sciences

Background: Moringa oleifera Lam. is known to be of high nutritional and medicinal importance and... more Background: Moringa oleifera Lam. is known to be of high nutritional and medicinal importance and has been demonstrated to possess a variety of biological activities. Objective: This study investigated the beneficial role of M. oleifera (moringa) supplementation in HIV positive subjects receiving antiretroviral drugs. Methods: Adult HIV positive individuals (104) attending the medical outpatient clinic in a tertiary health institution in Nigeria receiving highly active anti-retroviral therapies (HAARTs) were recruited in a randomized fashion for the study. Half of the subjects received moringa supplement (20 mg daily) additionally, while the others received only HAART and represented the control group. All subjects were monitored for 3 months during which their immunological status (CD4 counts and TNF-α), and hematological abnormalities at pre (baseline) and post study periods were determined. Results: Baseline levels of CD4 increased while TNF-α decreased significantly in control a...

International Blood Research & Reviews, 2017

Aims: To profile CD4 count, TNFα levels and cytopenia in HIV seropositive patients on ART and als... more Aims: To profile CD4 count, TNFα levels and cytopenia in HIV seropositive patients on ART and also evaluate the prevalence of hematological cytopenia. Study Design: The present study is a cross sectional study and was carried out in the department of immunology, hematology and blood transfusion, department of pharmacology university of Port Harcourt and university of port-Harcourt teaching hospital, between May 2016 and July 2016. One hundred patients (45 males and 55 females) were recruited for this study, patients included in this study were HIV positive and on anti-retroviral treatment for at least three months, they were not on any mind altering medications and were mentally sound and above 18 years 4 patients dropped out of the study.

The Internet Journal of Gynecology and Obstetrics, 2011

Background: There is limited data on the use of herbal medicine by pregnant women in Nigeria. Thi... more Background: There is limited data on the use of herbal medicine by pregnant women in Nigeria. This study was aimed at determining the prevalence of use, socio-demographic pattern, knowledge and attitude of pregnant women to the use of herbal medicine among those attending the antenatal clinic of the Aminu Kano Teaching Hospital, Kano, a tertiary hospital in Northern Nigeria.Methods: A pre-piloted structured questionnaire was administered on 500 pregnant women attending the clinic to collect data on demographic s, obstetric factors, knowledge and use of herbal medicine during pregnancy. Results: 31.4% of pregnant women used herbal medicines in the subsisting pregnancy. Over 40% of respondents had at least primary education while nearly 30% had an income of less than 20,000 naira(130 USD) monthly. Statistically Significant associations were found between herbal medicine use and no formal education(p<.05), low economic status (p<5) and self medication with orthodox drugs(p<.05). Ginger (zingiber officinale) and Garlic (allium sativa) were the most commonly used herbal medicines recalled by respondents. There was a significant association between education of respondents and their knowledge on safety of herbal medicines while a disparity was found between their views and practice.Conclusion: Use of herbal medicine among pregnant women in this environment was high. Clinicians and caregivers should have knowledge of the herbs commonly used by pregnant women and the potentials for toxicity. Attention should be given to enlightenment of pregnant women and the community on the dangers of herbal drug use during pregnancy.

Purpose: To evaluate the prescribing pattern of clinicians in the general outpatient unit of the ... more Purpose: To evaluate the prescribing pattern of clinicians in the general outpatient unit of the Aminu Kano Teaching Hospital, Kano (AKTH),. Methods: This was a descriptive retrospective study conducted using 500 prescriptions made at the general outpatient unit of AKTH between April and July 2009. Results: A total of 497 prescriptions were successfully analyzed. The average number of drugs per encounter in the facility was 3.04. Generic prescribing was low at 42.7 % while antibiotic prescription was high at 34.4 %. Injections were prescribed in 4 % of encounters while 36.2, 19.1, 25.8 and 1 % of encounters had analgesics, antimalarials, antihypertensives and anxiolytics prescribed, respectively. Vitamins were prescribed in 9.7 % of encounters. Conclusion: Polypharmacy, low rate of generic prescriptions and overuse of antibiotics still remain a problem in health care facilities in Nigeria.. This calls for sustained interventional strategies and periodic audit at all levels of health...

Self-medication is becoming a common type of self-care behavior among the population of many coun... more Self-medication is becoming a common type of self-care behavior among the population of many countries. Many international studies have investigated the prevalence and nature of self-medication practices at the population level. In Nigeria, some workers have also looked at the population prevalence of self-medication in general; however the prevalence of antibiotic self-medication among medical undergraduates has not yet been studied. The interest in studying this practice among this select group is due to the fact that they are the future prescribers and health educators of the population of Nigeria. The study was a cross-sectional pre-tested questionnaire-based study carried out among medical students of the Bayero University, Kano, North-West Nigeria during a two-week period in August 2008. The information from the returned questionnaire were coded, entered and analyzed using SPSS Version 12 statistical software. A total of 183 students filled and returned the questionnaire givin...

Annals of Tropical Medicine and Public Health, 2017

Background: Most men who have sex with men (MSM) in Nigeria are said to engage in high-risk sexua... more Background: Most men who have sex with men (MSM) in Nigeria are said to engage in high-risk sexual practices. This study aims to highlight these risk practices and proffer probable control solutions. Materials and Methods: A descriptive cross-sectional design and a purposive sampling method were used to interview 101 MSM linked to a clandestine network in a city suburb in Port Harcourt in October 2014. Data was analyzed using SPSS version 21.0. Univariate analysis was done to establish associated risk factors. Confidence limit was set at P = 0.05. Results: The age of study participants ranged between 18 and 45 years (mean = 25.35 years). The majority, 88 (87.1%) were single, had tertiary education and bisexuals, 85 (84.2%). Most, 62 (61.4%) reported to have between two and five sexual partners, while only 57 (53.4%) used condoms consistently with casual partners. All participants have heard about HIV, but only 70 (69.3%) had ever tested for HIV, while only 25 (28.1%) knew the HIV st...

Purpose: Antibiotic access is made easier in developing countries by availability and poor regula... more Purpose: Antibiotic access is made easier in developing countries by availability and poor regulatory and weak health systems This study was designed to evaluate the pattern of antibiotic self medication amongst students of Bayero University Kano, North western Nigeria. Method: Self administered, pretested, semistructured questionnaires were used to collect data from 354 students pursuing different courses of study and at different stages, using multistage sampling. Different aspects of self medication were explored by the questionnaires. Results: Over seventy percent of the students studied were between the ages of 20-24 years with 65.5% of them being males. 24.9% were in second year of study while 11.9% were in their fifth year of study. 50.3% of the students studied had engaged in self medication with antibiotics in the last six months. Fever was the most common reason for use (48.4%). Metronidazole was the most common antibiotic involved (23.2%) while chloramphenicol (1.1%) was ...

International Blood Research & Reviews

International Journal of STD & AIDS

There are increasing reports of antiretroviral therapy (ART) drug-related kidney dysfunction. Tra... more There are increasing reports of antiretroviral therapy (ART) drug-related kidney dysfunction. Traditional markers of kidney dysfunction such as urine protein/creatinine ratio and estimated glomerular filtration rate (eGFR) have thus far proven ineffective at detecting some sub-clinical forms of ART-related kidney injury. This is a cross-sectional examination of 114 people living with HIV (PLWH), either naïve ( N =104) or treatment experienced ( N =10). Urinary kidney injury molecule-1 (KIM-1 ng/mg) thresholds were estimated using electrochemiluminescent assays from stored urine samples and normalised for urinary creatinine excretion (KIM-1/Cr). Correlation coefficients and predictors of kidney tubular injury were compared and derived for both adjusted and unadjusted urinary KIM-1/CR (ng/mg). In PLWH (both ART-naïve and treatment experienced) had a higher baseline unadjusted and adjusted median (≥3.7 ng/mg) and upper tertile (≥6.25 ng/mg) urinary KIM-1/Cr levels compared to either no...

The epidemiology of HIV disease is not homogenous but continues to evolve. This study was aimed a... more The epidemiology of HIV disease is not homogenous but continues to evolve. This study was aimed at identifying the sociodemographic profile and presenting symptoms of the disease amongst patients attending the virology clinic at the Aminu Kano Teaching Hospital (AKTH), Kano, and to assess the relationship with known confounding factors. A total of 430 HIV infected patients attending the virology clinic at AKTH were recruited into the study. Medical records as obtained from the center were reviewed and pretested, structured and mainly closed ended questionnaires were administered on the patients to extract data on socio demographics, symptoms and attitude to retroviral tests. Data on 400 out of 430 patients were analysed with a mean age of 33.6 years. 67.2% of them were females and 29.5% had no formal education with 10.5% having postgraduate education. Only 12% earned above 35000 naira (230 USD) per month. Nearly 40% of them had at least 2 sexual partners and 60% of the study populat...

Research Journal of Medical Sciences, 2012

facilities, 2011

... Geneva: WHO; 2008. [10] Ohaju-Obodo JO, Isah AO, Mabadeje AFB. Prescribing pattern of clinici... more ... Geneva: WHO; 2008. [10] Ohaju-Obodo JO, Isah AO, Mabadeje AFB. Prescribing pattern of clinicians in private health institutions in Edo and Delta States of Nigeria. Niger Quart J Hosp Med 1998; 8(2): 91-94. [11] Damanhori AHH, Khaja KAJA, Sequeira RP, Al-Ansar TM. ...

Asian Pacific Journal of Tropical Medicine, 2011

To investigate the prevalence of use of traditional medicines amongst patients with HIV infection... more To investigate the prevalence of use of traditional medicines amongst patients with HIV infection receiving therapies of antiretroviral (ARV) drugs at the Aminu Kano Teaching Hospital (AKTH), Kano, Northwest Nigeria, and to assess the attitude of these patients to their ARV therapy. A cross sectional prospective study using pretested structured questionnaires administered on 430 patients with antiretroviral therapy attending the AKTH between April and June 2009. Data was collected on socio-demographic characteristics, use of traditional medicine and attitude to antiretroviral therapy. A mean age of (33.6#20381;8.4) years old was found with 67.2% females and 32.8% males. A total of 29% had no formal education while 10.5% had postgraduate education; 12% earned above 35,000 naira (230 USD) per month; 63.8% were married; 39.8% had at least 2 sexual partners; 27.5% used traditional medicine before commencement of antiretroviral therapy (ART), but only 4.25% of patients used ARV and traditional medicine concurrently. There was no significant difference in most of the socio-demographic indices between the concurrent users and other patients (P>0.05). A total of 28.8% HIV patients, 14.6% patients used traditional medicine before ART and 29.4% concurrent users had missed at least a dose of their ARVs since commencement of therapy. 148 (37%) of the patients had their drug regimen changed at least once while 23 (20.90%) patients receiving traditional medicine before ART and 5 (29.41%) patients having two treatments had their drug regimen changed. A total of 4.25% patients used ARV and traditional medicine concurrently. In conclusion, the widespread use of traditional medicine by patients living with HIV/AIDS should be of concern to clinicians and policy makers.

Tropical Journal of Pharmaceutical Research, 2012