Ilhan Yetkin - Academia.edu (original) (raw)

Papers by Ilhan Yetkin

PubMed, Apr 30, 2002

Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cas... more Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cases and may cause definite autonomic symptoms. Because conventional electrophysiological methods do not assess the autonomic nervous system, simple reproducible tests were developed. One of them is sympathetic skin response (SSR) which provides useful information about the status of sympathetic postganglionic function. The aim of this study is to perform SSR in diabetic patients to see whether this test can be used as an electrophysiological method for the diagnosis and confirmation of diabetic autonomic neuropathy. 20 diabetic patients who had electrophysiologically confirmed polyneuropathy but showed no symptoms or signs referable to autonomic system dysfunction were included. 14 (70%) patients demonstrated abnormal SSR. 2 abnormal patterns were observed. An absent response in at least one tested lower extremity (50%) and prolonged foot with normal hand latency (20%). 6 patients (30%) demonstrated no abnormalities. Foot and hand latencies in diabetics did not differ significantly from those of normal controls (p: 0.4, p: 0.1) and no correlation could be found with latencies and duration of sickness, patient's age and HbA1c values. We believe latency measurement is an objective measure of conduction in multineural pathways and can detect subclinical involvement of sympathetic nervous system in diabetics who do not manifest symptoms or signs referable to autonomic system dysfunction.

Thyroid, Dec 1, 2006

Hypothyroidism is associated with changes in appetite and body weight. Ghrelin is an orexigenic p... more Hypothyroidism is associated with changes in appetite and body weight. Ghrelin is an orexigenic peptide, and it stimulates appetite and increases food intake. However, the potential relationship between circulating ghrelin levels, hypothyroidism, and thyroid antibodies has not been adequately studied. Design: Fortyseven patients with hypothyroidism due to Hashimoto's thyroiditis and 48 euthyroid subjects were enrolled in the study. Thyroid hormones and antibodies, insulin, glucose, ghrelin levels, and lipid parameters were measured in all the subjects. Main Outcome: Hypothyroid group showed significantly decreased serum levels of ghrelin and ghrelin=body mass index (BMI) compared to euthyroid group (31.9 ± 21.5 pg=mL vs. 50.5 ± 34.8 pg=mL, p < 0.001; and 1.24 ± 0.93 vs. 2.12 ± 1.53, p < 0.0001). In hypothyroid group, 6 months after treatment, ghrelin levels and ghrelin/BMI remained lower than euthyroid group (33.2 ± 21.1 pg/mL vs. 50.5 ± 34.8 pg/mL, p < 0.001; and 1.27 ± 0.86 vs. 2.12 ± 1.53, p < 0.0001). Ghrelin levels were decreased in hypothyroid patients with high thyroid peroxidase antibody (TPOAb) titre compared to hypothyroid patients with low TPOAb titre (19.1 ± 23.1 pg/ mL vs. 35.3 ± 17.4 pg/mL, p < 0.01). Ghrelin levels correlated positively with free triiodothyronine (FT3) and free thyroxine (FT4), and negatively with age, thyroglobulin antibody (TAb), TPOAb, total cholesterol (T-C), lowdensity lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TG) in hypothyroid group. In euthyroid group, circulating ghrelin levels correlated negatively with age, FT3, FT4, TG, and VLDL-C levels. No significant correlation was observed between ghrelin and homeostasis model assessment for insulin resistance (HOMA-IR) and between ghrelin and quantitative insulin sensitivity check index (QUICKI) in both groups. Regression analysis revealed that FT3 level is the most important predictor of ghrelin levels. Conclusion: Thyroid hormones and antibodies seem to have a potential effect on serum ghrelin levels in patients with hypothyroidism.

PubMed, Jun 1, 2006

Aim: The aim of this paper was to define the gait deviations in patients with diabetes mellitus (... more Aim: The aim of this paper was to define the gait deviations in patients with diabetes mellitus (DM), to investigate the associations between electrophysiological findings and gait characteristics, and to interpret the findings in preventive and therapeutic rehabilitation protocols. Methods: Forty-six patients with DM and 20 healthy control subjects were enrolled into this controlled study. Electrophysiological studies and computerized gait analysis were performed. Gait deviations of DM patients with diabetic peripheral neuropathy (DPN) (n=20), without diabetic peripheral neuropathy (NDPN) (n=26) and healthy control subjects (C) (n=20) were compared, and associations between electrophysiological findings and gait characteristics were investigated. Results: NDPN, but not DPN, group revealed slower gait, shorter steps, limited knee and ankle mobility, lower ankle plantar flexor moment and power than C group, and the difference was statistically significant. HbA1c levels and F-wave latency were significantly correlated with ankle mobility, peak ankle plantar flexion moment and power. Conclusion: Neuropathy may not be the only reason for gait deviations in DM patients. Considering the spectrum of hyperglycemic complications including the mechanical characteristics of bones, muscles and soft tissues, patients with DM should start mobility and strengthening exercises in early stages.

Türkiye fiziksel tıp ve rehabilitasyon dergisi, 2013

Endocrine Abstracts, May 1, 2015

BMC Endocrine Disorders, Jun 7, 2022

Nuclear Medicine Communications, Dec 1, 2011

The aims of this study were to evaluate subclinical pulmonary injury in patients with noninsulin-... more The aims of this study were to evaluate subclinical pulmonary injury in patients with noninsulin-dependent diabetes mellitus (NIDDM) who showed normal chest radiograph and pulmonary function test results by using technetium-99 hexamethylpropylene amine oxime (Tc-99m-HMPAO) scintigraphy and to investigate the relationship between Tc-99m-HMPAO lung uptake and duration of diabetes, glycemic control, and the presence of diabetes-related microvascular complications. A total of 40 patients with NIDDM (19 men, 21 women; age 56.5 ± 6.8 years; duration of diabetes: 13.1 ± 6.7 years) were included in this study. The pulmonary vascular damage was represented as lung/liver uptake ratios (L/L ratios) calculated by Tc-99m-HMPAO lung scintigraphy. Results were compared with those of age-matched controls. The L/L ratio was 0.36 ± 0.07 in normal controls and 0.51 ± 0.16 in patients with NIDDM. The L/L ratio was significantly higher in NIDDM patients than in the control group (P=0.002). No correlation was observed between L/L ratio and the presence of diabetic complications, glycemic control, and diabetes duration. Tc-99m-HMPAO lung scintigraphy is a sensitive and an objective method for the detection of subclinical lung injury in NIDDM patients. Tc-99m-HMPAO lung uptake serves as an indicator of pulmonary injury due to diabetes, regardless of diabetes age, glycemic control, and the presence of other diabetes-related microvascular complications.

Journal of diabetes research, 2016

Thyroid, Apr 1, 2005

In this study, orbital gallium-67 citrate (67 Ga) scintigraphy was evaluated as a disease activit... more In this study, orbital gallium-67 citrate (67 Ga) scintigraphy was evaluated as a disease activity parameter that can predict the therapeutic response to immunosuppressive treatment in Graves' ophthalmopathy. Orbital scintigraphic analysis was performed on 32 patients demonstrating moderate to severe Graves' ophthalmopathy. Single-photon emission computed tomography (SPECT) images were obtained 48 hours after intravenous injection of 148 MBq of radioactive 67 Ga complex, and orbit/occipital (O/Occ) ratios were calculated to correct the background activity. Intravenous methylprednisolone was given as immunosuppressive treatment to 24 patients (group 1) and 8 patients were followed up without any treatment and evaluated as controls (group 2). Orbital 67 Ga scintigraphy was repeated in all patients after 6 months to analyze the changes in clinical findings and orbital 67 Ga accumulation. In Group 1, the mean Ϯ standard deviation (SD) 67 Ga O/Occ ratio of responders (2.23 Ϯ 0.2, 16 cases) was statistically different from nonresponders (1.49 Ϯ 0.1, 8 cases, p Ͻ 0.001). Additionally, the corticosteroid treatment provided a significant decrease in orbital 67 Ga accumulation in responders (p Ͻ 0.001), however, it did not change statistically in nonresponders (p:0.13). In group 2, the patients did not demonstrate clinical improvement and orbital 67 Ga uptake did not change after the follow-up period (p:0.81). The receiver-operator-characteristic curve showed that the best threshold for discriminating responder and nonresponder groups was 1.70 (sensitivity, 94%; specificity, 88%). This study demonstrated that orbital 67 Ga scintigraphy may be a useful imaging technique in predicting the therapeutic response to immunosuppressive treatment in Graves' ophthalmopathy.

The Journal of Clinical Endocrinology and Metabolism, Jun 1, 2015

Endocrine Abstracts, Apr 17, 2014

Trace elements and electrolytes, Apr 1, 2019

Marmara medical journal, 2011

Tip 1 diabetes mellitus pankreas beta hücrelerinin immün aracılı harabiyeti ile karakterize olan ... more Tip 1 diabetes mellitus pankreas beta hücrelerinin immün aracılı harabiyeti ile karakterize olan ve genetik olarak yatkın bireylerde çevresel faktörlerin etkisi sonucu gelişen kronik otoimmün bir hastalıktır. İnsidansı dünya çapında giderek artmaktadır. Etiyolojisi karmaşıktır ve halen tam bilinmemektedir. Bu derlemede tip 1 diyabete yatkınlıkla ilişkili olabilecek olası genetik faktörler tartışılacaktır.

Diabetes-metabolism Research and Reviews, Sep 1, 2001

Turkish Journal of Endocrinology and Metabolism, Sep 7, 2022

Turkiye Klinikleri Journal of Endocrinology, 2004

Endocrine Abstracts, Apr 17, 2014

Turkish Journal of Internal Medicine

Coronavirus disease-2019 (COVID-19) has become a serious health problem in Turkey and the world. ... more Coronavirus disease-2019 (COVID-19) has become a serious health problem in Turkey and the world. The diagnosis stage of many chronic diseases, the treatment process and the status of being affected by COVID-19 have become the focus of attention in the medical community during the pandemic, which has been continuing for nine months. We will discuss the course of COVID-19 infection over a 32-year-old and 76-year-old female patient with Cushing syndrome who applied to our clinic as a tertiary referral centre.

Endocrine Abstracts, 2016

PubMed, Apr 30, 2002

Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cas... more Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cases and may cause definite autonomic symptoms. Because conventional electrophysiological methods do not assess the autonomic nervous system, simple reproducible tests were developed. One of them is sympathetic skin response (SSR) which provides useful information about the status of sympathetic postganglionic function. The aim of this study is to perform SSR in diabetic patients to see whether this test can be used as an electrophysiological method for the diagnosis and confirmation of diabetic autonomic neuropathy. 20 diabetic patients who had electrophysiologically confirmed polyneuropathy but showed no symptoms or signs referable to autonomic system dysfunction were included. 14 (70%) patients demonstrated abnormal SSR. 2 abnormal patterns were observed. An absent response in at least one tested lower extremity (50%) and prolonged foot with normal hand latency (20%). 6 patients (30%) demonstrated no abnormalities. Foot and hand latencies in diabetics did not differ significantly from those of normal controls (p: 0.4, p: 0.1) and no correlation could be found with latencies and duration of sickness, patient's age and HbA1c values. We believe latency measurement is an objective measure of conduction in multineural pathways and can detect subclinical involvement of sympathetic nervous system in diabetics who do not manifest symptoms or signs referable to autonomic system dysfunction.

Thyroid, Dec 1, 2006

Hypothyroidism is associated with changes in appetite and body weight. Ghrelin is an orexigenic p... more Hypothyroidism is associated with changes in appetite and body weight. Ghrelin is an orexigenic peptide, and it stimulates appetite and increases food intake. However, the potential relationship between circulating ghrelin levels, hypothyroidism, and thyroid antibodies has not been adequately studied. Design: Fortyseven patients with hypothyroidism due to Hashimoto's thyroiditis and 48 euthyroid subjects were enrolled in the study. Thyroid hormones and antibodies, insulin, glucose, ghrelin levels, and lipid parameters were measured in all the subjects. Main Outcome: Hypothyroid group showed significantly decreased serum levels of ghrelin and ghrelin=body mass index (BMI) compared to euthyroid group (31.9 ± 21.5 pg=mL vs. 50.5 ± 34.8 pg=mL, p < 0.001; and 1.24 ± 0.93 vs. 2.12 ± 1.53, p < 0.0001). In hypothyroid group, 6 months after treatment, ghrelin levels and ghrelin/BMI remained lower than euthyroid group (33.2 ± 21.1 pg/mL vs. 50.5 ± 34.8 pg/mL, p < 0.001; and 1.27 ± 0.86 vs. 2.12 ± 1.53, p < 0.0001). Ghrelin levels were decreased in hypothyroid patients with high thyroid peroxidase antibody (TPOAb) titre compared to hypothyroid patients with low TPOAb titre (19.1 ± 23.1 pg/ mL vs. 35.3 ± 17.4 pg/mL, p < 0.01). Ghrelin levels correlated positively with free triiodothyronine (FT3) and free thyroxine (FT4), and negatively with age, thyroglobulin antibody (TAb), TPOAb, total cholesterol (T-C), lowdensity lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TG) in hypothyroid group. In euthyroid group, circulating ghrelin levels correlated negatively with age, FT3, FT4, TG, and VLDL-C levels. No significant correlation was observed between ghrelin and homeostasis model assessment for insulin resistance (HOMA-IR) and between ghrelin and quantitative insulin sensitivity check index (QUICKI) in both groups. Regression analysis revealed that FT3 level is the most important predictor of ghrelin levels. Conclusion: Thyroid hormones and antibodies seem to have a potential effect on serum ghrelin levels in patients with hypothyroidism.

PubMed, Jun 1, 2006

Aim: The aim of this paper was to define the gait deviations in patients with diabetes mellitus (... more Aim: The aim of this paper was to define the gait deviations in patients with diabetes mellitus (DM), to investigate the associations between electrophysiological findings and gait characteristics, and to interpret the findings in preventive and therapeutic rehabilitation protocols. Methods: Forty-six patients with DM and 20 healthy control subjects were enrolled into this controlled study. Electrophysiological studies and computerized gait analysis were performed. Gait deviations of DM patients with diabetic peripheral neuropathy (DPN) (n=20), without diabetic peripheral neuropathy (NDPN) (n=26) and healthy control subjects (C) (n=20) were compared, and associations between electrophysiological findings and gait characteristics were investigated. Results: NDPN, but not DPN, group revealed slower gait, shorter steps, limited knee and ankle mobility, lower ankle plantar flexor moment and power than C group, and the difference was statistically significant. HbA1c levels and F-wave latency were significantly correlated with ankle mobility, peak ankle plantar flexion moment and power. Conclusion: Neuropathy may not be the only reason for gait deviations in DM patients. Considering the spectrum of hyperglycemic complications including the mechanical characteristics of bones, muscles and soft tissues, patients with DM should start mobility and strengthening exercises in early stages.

Türkiye fiziksel tıp ve rehabilitasyon dergisi, 2013

Endocrine Abstracts, May 1, 2015

BMC Endocrine Disorders, Jun 7, 2022

Nuclear Medicine Communications, Dec 1, 2011

The aims of this study were to evaluate subclinical pulmonary injury in patients with noninsulin-... more The aims of this study were to evaluate subclinical pulmonary injury in patients with noninsulin-dependent diabetes mellitus (NIDDM) who showed normal chest radiograph and pulmonary function test results by using technetium-99 hexamethylpropylene amine oxime (Tc-99m-HMPAO) scintigraphy and to investigate the relationship between Tc-99m-HMPAO lung uptake and duration of diabetes, glycemic control, and the presence of diabetes-related microvascular complications. A total of 40 patients with NIDDM (19 men, 21 women; age 56.5 ± 6.8 years; duration of diabetes: 13.1 ± 6.7 years) were included in this study. The pulmonary vascular damage was represented as lung/liver uptake ratios (L/L ratios) calculated by Tc-99m-HMPAO lung scintigraphy. Results were compared with those of age-matched controls. The L/L ratio was 0.36 ± 0.07 in normal controls and 0.51 ± 0.16 in patients with NIDDM. The L/L ratio was significantly higher in NIDDM patients than in the control group (P=0.002). No correlation was observed between L/L ratio and the presence of diabetic complications, glycemic control, and diabetes duration. Tc-99m-HMPAO lung scintigraphy is a sensitive and an objective method for the detection of subclinical lung injury in NIDDM patients. Tc-99m-HMPAO lung uptake serves as an indicator of pulmonary injury due to diabetes, regardless of diabetes age, glycemic control, and the presence of other diabetes-related microvascular complications.

Journal of diabetes research, 2016

Thyroid, Apr 1, 2005

In this study, orbital gallium-67 citrate (67 Ga) scintigraphy was evaluated as a disease activit... more In this study, orbital gallium-67 citrate (67 Ga) scintigraphy was evaluated as a disease activity parameter that can predict the therapeutic response to immunosuppressive treatment in Graves' ophthalmopathy. Orbital scintigraphic analysis was performed on 32 patients demonstrating moderate to severe Graves' ophthalmopathy. Single-photon emission computed tomography (SPECT) images were obtained 48 hours after intravenous injection of 148 MBq of radioactive 67 Ga complex, and orbit/occipital (O/Occ) ratios were calculated to correct the background activity. Intravenous methylprednisolone was given as immunosuppressive treatment to 24 patients (group 1) and 8 patients were followed up without any treatment and evaluated as controls (group 2). Orbital 67 Ga scintigraphy was repeated in all patients after 6 months to analyze the changes in clinical findings and orbital 67 Ga accumulation. In Group 1, the mean Ϯ standard deviation (SD) 67 Ga O/Occ ratio of responders (2.23 Ϯ 0.2, 16 cases) was statistically different from nonresponders (1.49 Ϯ 0.1, 8 cases, p Ͻ 0.001). Additionally, the corticosteroid treatment provided a significant decrease in orbital 67 Ga accumulation in responders (p Ͻ 0.001), however, it did not change statistically in nonresponders (p:0.13). In group 2, the patients did not demonstrate clinical improvement and orbital 67 Ga uptake did not change after the follow-up period (p:0.81). The receiver-operator-characteristic curve showed that the best threshold for discriminating responder and nonresponder groups was 1.70 (sensitivity, 94%; specificity, 88%). This study demonstrated that orbital 67 Ga scintigraphy may be a useful imaging technique in predicting the therapeutic response to immunosuppressive treatment in Graves' ophthalmopathy.

The Journal of Clinical Endocrinology and Metabolism, Jun 1, 2015

Endocrine Abstracts, Apr 17, 2014

Trace elements and electrolytes, Apr 1, 2019

Marmara medical journal, 2011

Tip 1 diabetes mellitus pankreas beta hücrelerinin immün aracılı harabiyeti ile karakterize olan ... more Tip 1 diabetes mellitus pankreas beta hücrelerinin immün aracılı harabiyeti ile karakterize olan ve genetik olarak yatkın bireylerde çevresel faktörlerin etkisi sonucu gelişen kronik otoimmün bir hastalıktır. İnsidansı dünya çapında giderek artmaktadır. Etiyolojisi karmaşıktır ve halen tam bilinmemektedir. Bu derlemede tip 1 diyabete yatkınlıkla ilişkili olabilecek olası genetik faktörler tartışılacaktır.

Diabetes-metabolism Research and Reviews, Sep 1, 2001

Turkish Journal of Endocrinology and Metabolism, Sep 7, 2022

Turkiye Klinikleri Journal of Endocrinology, 2004

Endocrine Abstracts, Apr 17, 2014

Turkish Journal of Internal Medicine

Coronavirus disease-2019 (COVID-19) has become a serious health problem in Turkey and the world. ... more Coronavirus disease-2019 (COVID-19) has become a serious health problem in Turkey and the world. The diagnosis stage of many chronic diseases, the treatment process and the status of being affected by COVID-19 have become the focus of attention in the medical community during the pandemic, which has been continuing for nine months. We will discuss the course of COVID-19 infection over a 32-year-old and 76-year-old female patient with Cushing syndrome who applied to our clinic as a tertiary referral centre.

Endocrine Abstracts, 2016