Imane Baghad - Academia.edu (original) (raw)

Papers by Imane Baghad

Research paper thumbnail of Les cancers bronchiques secondaires: à propos de 10 cas

Les cancers bronchiques secondaires: à propos de 10 cas

Revue des Maladies Respiratoires, 2006

Research paper thumbnail of HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis

Journal of Viral Hepatitis, 2011

Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of gen... more Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of genotype 3. Steatosis and/or mechanisms underlying steatogenesis can contribute to hepatocarcinogenesis. The aim of this retrospective study was to assess the impact of infection with HCV genotype 3 on hepatocellular carcinoma (HCC) occurrence in patients with ongoing HCV cirrhosis. Three hundred and fifty-three consecutive patients (193 men, mean age 58 ± 13 years), with histologically proven HCV cirrhosis and persistent viral replication prospectively followed and screened for HCC between 1994 and 2007. Log-rank test and Cox model were used to compare the actuarial incidence of HCC between genotype subgroups. The patients infected with a genotype 3 (n = 25) as compared with those infected with other genotypes (n = 328) had a lower prothrombin activity [78 (interquartile range 60-85) vs 84 (71-195) %, P = 0.03] and higher rate of alcohol abuse (48% vs 29%, P = 0.046). During a median follow-up of 5.54 years [2.9-8.6], 11/25 patients (44%) and 87/328 patients (26%) with a genotype 3 and non-3 genotype, respectively, develop a HCC. HCC incidences were significantly different among the genotype subgroups (P = 0.001). The 5-year occurrence rate of HCC was 34% (95% CI, 1.3-6.3) and 17% (95% CI, 5.7-9.2) in genotype 3 and non-3 genotype groups, respectively (P = 0.002). In multivariate analysis, infection with a genotype 3 was independently associated with an increased risk of HCC occurrence [hazard ratio 3.54 (95% CI, 1.84-6.81), P = 0.0002], even after adjustment for prothrombin activity and alcohol abuse [3.58 (1.80-7.13); P = 0.003]. For patients with HCV cirrhosis and ongoing infection, infection with genotype 3 is independently associated with an increased risk of HCC development.

Research paper thumbnail of Survival after radiofrequency ablation and salvage transplantation in patients with hepatocellular carcinoma and Child-Pugh A cirrhosis

Journal of Hepatology, 2012

Research paper thumbnail of 652 Multipolar Radiofrequency Ablation (Mrfa) for the Treatment of Hepatocellular Carcinoma (HCC) in Patients with Cirrhosis: Preliminary Experience in 109 Patients

Journal of Hepatology, 2011

Fatigue was common postradioembolisation (112 patients; 61.2%), mostly as grade 1 (84.9% of cases... more Fatigue was common postradioembolisation (112 patients; 61.2%), mostly as grade 1 (84.9% of cases), and affected a significantly higher proportion with ECOG '1'-'2' than ECOG '0' (69.9% vs. 27.0%; p < 0.001). Other AEs included: nausea and/or vomiting (31.0%); abdominal pain (28.4%), fever (12.0%) and gastrointestinal ulcer (4.4%). Grade 3/4 changes in bilirubin were observed in 6.0% of patients (p = 0.002). No other significant changes were observed in LFTs including: albumin, prothrombin, ALT and platelet counts. Conclusions: Radioembolisation was well-tolerated in patients with BCLC 'C' disease with no significant differences for the defining characteristics (PVO, PS, and EHD).

Research paper thumbnail of HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis

Journal of Viral Hepatitis, Sep 14, 2011

Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of gen... more Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of genotype 3. Steatosis and/or mechanisms underlying steatogenesis can contribute to hepatocarcinogenesis. The aim of this retrospective study was to assess the impact of infection with HCV genotype 3 on hepatocellular carcinoma (HCC) occurrence in patients with ongoing HCV cirrhosis. Three hundred and fifty-three consecutive patients (193 men, mean age 58 ± 13 years), with histologically proven HCV cirrhosis and persistent viral replication prospectively followed and screened for HCC between 1994 and 2007. Log-rank test and Cox model were used to compare the actuarial incidence of HCC between genotype subgroups. The patients infected with a genotype 3 (n = 25) as compared with those infected with other genotypes (n = 328) had a lower prothrombin activity [78 (interquartile range 60-85) vs 84 (71-195) %, P = 0.03] and higher rate of alcohol abuse (48% vs 29%, P = 0.046). During a median follow-up of 5.54 years [2.9-8.6], 11/25 patients (44%) and 87/328 patients (26%) with a genotype 3 and non-3 genotype, respectively, develop a HCC. HCC incidences were significantly different among the genotype subgroups (P = 0.001). The 5-year occurrence rate of HCC was 34% (95% CI, 1.3-6.3) and 17% (95% CI, 5.7-9.2) in genotype 3 and non-3 genotype groups, respectively (P = 0.002). In multivariate analysis, infection with a genotype 3 was independently associated with an increased risk of HCC occurrence [hazard ratio 3.54 (95% CI, 1.84-6.81), P = 0.0002], even after adjustment for prothrombin activity and alcohol abuse [3.58 (1.80-7.13); P = 0.003]. For patients with HCV cirrhosis and ongoing infection, infection with genotype 3 is independently associated with an increased risk of HCC development.

Research paper thumbnail of Association du polymorphisme de la méthylènetétrahydrofolate réductase C677T avec le risque de cancer colorectal sporadique

The Pan African Medical Journal, 2021

Le cancer colorectal (CCR) est un problème majeur de santé publique dans le monde. Le métabolisme... more Le cancer colorectal (CCR) est un problème majeur de santé publique dans le monde. Le métabolisme des folates est impliqué dans la synthèse, la réparation et la méthylation de de l´ADN. La méthylènetétrahydrofolate réductase (MTHFR) est une enzyme clé dans le métabolisme folique. Un polymorphisme commun de la MTHFR, le C677T, a été corrélé aux CCR. Cette étude cas témoins a été menée pour analyser l´association entre ce polymorphisme et le risque de CCR sporadique dans une population marocaine. Soixante-seize (76) patients atteints de cancer colorectal sporadique confirmé histologiquement et 182 témoins sans antécédents de cancer ont été recrutés pour cette étude. L´ADN a été isolé à partir de sang périphériques et les génotypes ont été déterminés par PCR-RFLP. Le risque d´association a été estimé par le calcul de l´odds ratio (OR) avec un intervalle de confiance à 95%. La fréquence des génotypes MTHFR chez les patients et les témoins a été de 34.1%CC; 56.6%CT; 9.21%TT et 51,6%CC; 4...

Research paper thumbnail of Risk of Colorectal Cancer and Clotting Factor Gene Polymorphisms in Moroccan Population

International Journal of Advanced Research, 2017

student of Centre of Doctoral study in health science-Doctoral training in genetics and molecular... more student of Centre of Doctoral study in health science-Doctoral training in genetics and molecular pathology

Research paper thumbnail of Adamantinome du pérone ( A propos d'un cas et revue de littérature )

Adamantinome du pérone ( A propos d'un cas et revue de littérature )

Research paper thumbnail of Les cancers bronchiques secondaires: à propos de 10 cas

Les cancers bronchiques secondaires: à propos de 10 cas

Revue des Maladies Respiratoires, 2006

Research paper thumbnail of HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis

Journal of Viral Hepatitis, 2011

Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of gen... more Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of genotype 3. Steatosis and/or mechanisms underlying steatogenesis can contribute to hepatocarcinogenesis. The aim of this retrospective study was to assess the impact of infection with HCV genotype 3 on hepatocellular carcinoma (HCC) occurrence in patients with ongoing HCV cirrhosis. Three hundred and fifty-three consecutive patients (193 men, mean age 58 ± 13 years), with histologically proven HCV cirrhosis and persistent viral replication prospectively followed and screened for HCC between 1994 and 2007. Log-rank test and Cox model were used to compare the actuarial incidence of HCC between genotype subgroups. The patients infected with a genotype 3 (n = 25) as compared with those infected with other genotypes (n = 328) had a lower prothrombin activity [78 (interquartile range 60-85) vs 84 (71-195) %, P = 0.03] and higher rate of alcohol abuse (48% vs 29%, P = 0.046). During a median follow-up of 5.54 years [2.9-8.6], 11/25 patients (44%) and 87/328 patients (26%) with a genotype 3 and non-3 genotype, respectively, develop a HCC. HCC incidences were significantly different among the genotype subgroups (P = 0.001). The 5-year occurrence rate of HCC was 34% (95% CI, 1.3-6.3) and 17% (95% CI, 5.7-9.2) in genotype 3 and non-3 genotype groups, respectively (P = 0.002). In multivariate analysis, infection with a genotype 3 was independently associated with an increased risk of HCC occurrence [hazard ratio 3.54 (95% CI, 1.84-6.81), P = 0.0002], even after adjustment for prothrombin activity and alcohol abuse [3.58 (1.80-7.13); P = 0.003]. For patients with HCV cirrhosis and ongoing infection, infection with genotype 3 is independently associated with an increased risk of HCC development.

Research paper thumbnail of Survival after radiofrequency ablation and salvage transplantation in patients with hepatocellular carcinoma and Child-Pugh A cirrhosis

Journal of Hepatology, 2012

Research paper thumbnail of 652 Multipolar Radiofrequency Ablation (Mrfa) for the Treatment of Hepatocellular Carcinoma (HCC) in Patients with Cirrhosis: Preliminary Experience in 109 Patients

Journal of Hepatology, 2011

Fatigue was common postradioembolisation (112 patients; 61.2%), mostly as grade 1 (84.9% of cases... more Fatigue was common postradioembolisation (112 patients; 61.2%), mostly as grade 1 (84.9% of cases), and affected a significantly higher proportion with ECOG '1'-'2' than ECOG '0' (69.9% vs. 27.0%; p < 0.001). Other AEs included: nausea and/or vomiting (31.0%); abdominal pain (28.4%), fever (12.0%) and gastrointestinal ulcer (4.4%). Grade 3/4 changes in bilirubin were observed in 6.0% of patients (p = 0.002). No other significant changes were observed in LFTs including: albumin, prothrombin, ALT and platelet counts. Conclusions: Radioembolisation was well-tolerated in patients with BCLC 'C' disease with no significant differences for the defining characteristics (PVO, PS, and EHD).

Research paper thumbnail of HCV genotype 3 is associated with a higher hepatocellular carcinoma incidence in patients with ongoing viral C cirrhosis

Journal of Viral Hepatitis, Sep 14, 2011

Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of gen... more Liver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of genotype 3. Steatosis and/or mechanisms underlying steatogenesis can contribute to hepatocarcinogenesis. The aim of this retrospective study was to assess the impact of infection with HCV genotype 3 on hepatocellular carcinoma (HCC) occurrence in patients with ongoing HCV cirrhosis. Three hundred and fifty-three consecutive patients (193 men, mean age 58 ± 13 years), with histologically proven HCV cirrhosis and persistent viral replication prospectively followed and screened for HCC between 1994 and 2007. Log-rank test and Cox model were used to compare the actuarial incidence of HCC between genotype subgroups. The patients infected with a genotype 3 (n = 25) as compared with those infected with other genotypes (n = 328) had a lower prothrombin activity [78 (interquartile range 60-85) vs 84 (71-195) %, P = 0.03] and higher rate of alcohol abuse (48% vs 29%, P = 0.046). During a median follow-up of 5.54 years [2.9-8.6], 11/25 patients (44%) and 87/328 patients (26%) with a genotype 3 and non-3 genotype, respectively, develop a HCC. HCC incidences were significantly different among the genotype subgroups (P = 0.001). The 5-year occurrence rate of HCC was 34% (95% CI, 1.3-6.3) and 17% (95% CI, 5.7-9.2) in genotype 3 and non-3 genotype groups, respectively (P = 0.002). In multivariate analysis, infection with a genotype 3 was independently associated with an increased risk of HCC occurrence [hazard ratio 3.54 (95% CI, 1.84-6.81), P = 0.0002], even after adjustment for prothrombin activity and alcohol abuse [3.58 (1.80-7.13); P = 0.003]. For patients with HCV cirrhosis and ongoing infection, infection with genotype 3 is independently associated with an increased risk of HCC development.

Research paper thumbnail of Association du polymorphisme de la méthylènetétrahydrofolate réductase C677T avec le risque de cancer colorectal sporadique

The Pan African Medical Journal, 2021

Le cancer colorectal (CCR) est un problème majeur de santé publique dans le monde. Le métabolisme... more Le cancer colorectal (CCR) est un problème majeur de santé publique dans le monde. Le métabolisme des folates est impliqué dans la synthèse, la réparation et la méthylation de de l´ADN. La méthylènetétrahydrofolate réductase (MTHFR) est une enzyme clé dans le métabolisme folique. Un polymorphisme commun de la MTHFR, le C677T, a été corrélé aux CCR. Cette étude cas témoins a été menée pour analyser l´association entre ce polymorphisme et le risque de CCR sporadique dans une population marocaine. Soixante-seize (76) patients atteints de cancer colorectal sporadique confirmé histologiquement et 182 témoins sans antécédents de cancer ont été recrutés pour cette étude. L´ADN a été isolé à partir de sang périphériques et les génotypes ont été déterminés par PCR-RFLP. Le risque d´association a été estimé par le calcul de l´odds ratio (OR) avec un intervalle de confiance à 95%. La fréquence des génotypes MTHFR chez les patients et les témoins a été de 34.1%CC; 56.6%CT; 9.21%TT et 51,6%CC; 4...

Research paper thumbnail of Risk of Colorectal Cancer and Clotting Factor Gene Polymorphisms in Moroccan Population

International Journal of Advanced Research, 2017

student of Centre of Doctoral study in health science-Doctoral training in genetics and molecular... more student of Centre of Doctoral study in health science-Doctoral training in genetics and molecular pathology

Research paper thumbnail of Adamantinome du pérone ( A propos d'un cas et revue de littérature )

Adamantinome du pérone ( A propos d'un cas et revue de littérature )