Imran Ali - Academia.edu (original) (raw)

Papers by Imran Ali

Minerals

The current study evaluated the use of pumice, a volcanic mineral and common sand, in treating re... more The current study evaluated the use of pumice, a volcanic mineral and common sand, in treating reverse osmosis membrane reject water (ROR) using a novel combined adsorption distillation (CAD) method. The CAD method is developed to separate the dissolved solids through adsorption distillation, i.e., leaving the vaporized distillate as freshwater and concentrated brine. The adsorption potential of pumice and sand was investigated at different adsorbent doses, i.e., 2, 5, and 10 g, and consecutive CAD adsorbent backwashing cycles. The improved results were achieved at a 10 g pumice dose. However, its adsorption efficiency declined in longer CAD cycles, i.e., due to the separated deposition of solids. After backwashing, the adsorbed and accumulated salts were slightly removed, and pumice adsorption capacity was maintained for up to 20 cycles of CAD. The properties of the pumice, i.e., before and after five CAD cycles and after backwashing, were characterized with scanning electron micro...

Catalysts

In this work, 3D-structured clay filters were prepared and coated with iron-doped titanium dioxid... more In this work, 3D-structured clay filters were prepared and coated with iron-doped titanium dioxide (Fe-TiO2) using 3D printing and sol–gel soaking and calcination techniques. Three-dimensional printing was employed to mold and shape the clay filters before annealing. The coated and uncoated filters were characterized for different properties, i.e., morphology, optical properties, and crystalline structure, using field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDS), UV/Vis diffused reflectance spectroscopy (DRS), and X-ray diffraction (XRD). The FESEM images show uniform coatings of round-shaped Fe-TiO2 on the tiny pore of the clay filter. The optical energy band gap of the obtained coating was around 2.8 eV, estimated by Tauc’s plot, compared with 3.2 eV of pristine anatase TiO2. The XRD spectra data processed through XRD software revealed the coatings of TiO2 on the filter surface with the obtained phase of anatase. The photocatalytic perf...

Water, 2022

Iron salt-modified biochar has been widely used to remove Cr(VI) pollution due to the combination... more Iron salt-modified biochar has been widely used to remove Cr(VI) pollution due to the combination of the generated iron oxides and biochar, which can bring positive charge and rich redox activity. However, there are few comprehensive studies on the methods of modifying biochar with different iron salts. In this study, two iron salt (FeCl3 and Fe(NO3)3) modification methods were used to prepare two Fe-modified biochar materials for removing Cr(VI) in simulated groundwater environment. It was revealed by systematic characterization that FeCl3@BC prepared via the FeCl3 modification method, has larger pore size, higher zeta potential and iron oxide content, and has higher Cr(VI) adsorption-reduction performance efficiency as compared to Fe(NO3)3@BC prepared via Fe(NO3)3 modification method. Combined with XRD and XPS analyses, Fe3O4 is the key active component for the reduction of Cr(VI) to Cr(III). The experimental results have shown that acidic conditions promoted Cr(VI) removal, while...

Encyclopedia of Chromatography, Third Edition (Print Version), 2009

DBPE on [Ca 2+ ] i levels within single SH-SY5Y cells………………………………………………………….. 3.2.5.1:(A) the eff... more DBPE on [Ca 2+ ] i levels within single SH-SY5Y cells………………………………………………………….. 3.2.5.1:(A) the effects of different of [HBCD] on the mitochondrial membrane depolarisation…………………………………………………………. 108 (B) the fluorescence images of SH-SY5Y, prior to 10µM HBCD exposure……………………………………………………………... 108 3.2.5.2: the effects of TBBPA, NP, DBPE and BPA on the mitochondrial membrane depolarisation of SH-SY5Y cells loaded with Rh123………. 109 3.2.6.1:(A) shows the effects of HBCD, TBBPA, NP, DBPE and BPA on ROS production as measured by increase in DCF fluorescence ………… 111 (B) the dose-dependent increase of DCF fluorescence intensity in cells after exposure to different concentrations of HBCD………….. 111 3.3: schematic representation of the effects summary of these compounds on SH-SY5Ycells………………………………………………………………. 4.2.1.1:(A-I)the inhibition of nine of BFRs on the skeletal muscle the Ca 2+-ATPase (SERCA1a) activity………………………………….. 4.2.1.2: the effect of Tg (A), NP (B) and BPA (C) on the skeletal muscle SR of Ca 2+-ATPase (SERCA1a) activity…………………………………… 4.2.1:(A-J) the inhibition of SH-SY5Y membranes and cerebellar microsomal the Ca 2+-ATPase activity by nine types of BFRs and NP…………………. 4.2.3.1:(A) shows the effects of HBCD on SH-SY5Y microsomal membranes Ca 2+ release………………………………………………………………. 128

Talanta, Jan 15, 2006

Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in hu... more Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. It has been found in wastewater released by some pharmaceutical industries leading to the contamination of surface and ground water. Therefore, a sensitive, inexpensive and reproducible HPLC-SPE method was developed for the analysis of domperidone in the wastewater. The column used was Waters symmetry C(18) (15 cm x 0.46 mm, 5 microm). The mobile phase used was phosphate buffer (50mM, pH 3.5) acetonitrile (80:20, v/v) at the flow rate 2.0 mL/min. The detection was achieved by using UV mode at 230 nm. The retention, separation and resolution factors were 2.63, 3.00 and 3.20, respectively. The percentage recovery of domperidone from wastewater was 95.0%. Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater.

Saudi Pharmaceutical Journal, 2010

After the success of human genome project, proteome is a new emerging field of biochemistry as it... more After the success of human genome project, proteome is a new emerging field of biochemistry as it provides the knowledge of enzymes (proteins) interactions with different body organs and medicines administrated into human body. Therefore, the study of proteomics is very important for the development of new and effective drugs to control many lethal diseases. In proteomics study, analyses of proteome is essential and significant from the pathological point of views, i.e., in several serious diseases such as cancer, Alzheimer's disease and aging, heart diseases and also for plant biology. The separation and identification of proteomics is a challenging job due to their

Journal of Colloid and Interface Science, 2003

Waste carbon slurries (generated in fertilizer plants) and blast furnace slag (generated in steel... more Waste carbon slurries (generated in fertilizer plants) and blast furnace slag (generated in steel plants) have been converted into low-cost potential adsorbents. The adsorbents have been characterized and tried for the removal of the dye basic red from wastewater. Studies were performed at different pH to find the pH at which maximum adsorption occurs. Equilibrium isotherms were determined to assess

Current Pharmaceutical Analysis, 2005

In a non-chiral environment, the enantiomers of a racemate possess the same physico-chemical prop... more In a non-chiral environment, the enantiomers of a racemate possess the same physico-chemical properties but in the biological systems they possess different activities. One of the enantiomers may be more toxic or carcinogenic, and, therefore, the present data available on the toxicity and carcinogenesis of the racemic mixtures of these chiral pollutants are not reliable and need modification in terms of the enantioselective toxicity and carcinogenesis. It is essential to explore the enantioselective toxicity and carcinogenesis due to the different enantiomers of the chiral pollutants. The knowledge of the stereoselective metabolisms of the chiral pollutants may be useful for the treatment of cancer and other diseases. The enantioselective toxicity and carcinogenesis due to the chiral pesticides, pollutants and some drugs have been discussed in this review article.

Current Drug Discovery Technologies, 2007

Increasing amount of data considering polymorphism, splice variants and various affinity states o... more Increasing amount of data considering polymorphism, splice variants and various affinity states of beta-adrenoceptors has resulted in a new range of opportunities for enantiopure beta-adrenergic and beta-adrenolytic drug discovery and continuous development of reliable high-throughput screening procedures enabling tissue specific pharmacological evaluation of these drugs. Design and fast pharmacological profiling of single enantiomeric molecules combining beta-adrenoceptor affinity with other pharmacophores is also still challenging ability. As the use of chiral stationary phases in HPLC has particularly benefited from results of supramolecular chemistry, this review summarises recent achievements provided by this technique in deciphering of enatiorecognition phenomena affecting pharmacological selectivity of beta-adrenergics and beta-adrenolytics and modifying the efficiency of currently proposed beta-adrenoceptor-targeted therapies. Detailed characteristic of chiral separation performance of these drugs in the range of available supramolecular HPLC systems has also been presented.

Chirality, 2007

U.S. Food and Drug Administration issues certain guidelines for marketing of optically active dru... more U.S. Food and Drug Administration issues certain guidelines for marketing of optically active drugs as some enantiomers racemize into human body, leading to the generation of other antipodes, which may be toxic or ballast to the human beings. Moreover, racemization reduces the administrated dosage concentration as optically active enantiomer converted into its inactive counter part. Therefore, the study of racemization of such type of drugs is an important and urgent need of today. This article describes in vitro and in vivo racemization of optically active drugs. The racemization process of various optically active drugs has been discussed considering the effect of different variables i.e. pH, temperature, concentration of the drug, ionic concentration, etc. Attempts have also been made to discuss the mechanisms of racemization. Besides, efforts have been made to suggest the safe dosages of such type of drugs too. Chirality, 2007. © 2007 Wiley‐Liss, Inc.

Biomedical Chromatography, 2003

The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebi... more The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (β‐adrenergic blockers), econazole, miconazole (anti‐fungal agents), cromakalim (anti‐hypertensive agent) and etodolac (anti‐inflammatory agent) was achieved on cellulose tris (3,5‐dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2‐propanol at 0.5 mL/min with detection at 220 nm. The separation factors (α) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed. Copyright © 2003 John Wiley & Sons, Ltd.

Analytical Letters, 2009

Thousands of organic compounds are present in our water resources and exist in dynamic equilibriu... more Thousands of organic compounds are present in our water resources and exist in dynamic equilibrium with sediment. Among them are drug and pharmaceutical residues. Many of these residues are chiral, and their metabolites or degradation products may also be chiral in nature. ...

Nanochromatography and Nanocapillary Electrophoresis, 2009

Current Drug Targets, 2014

ABSTRACT β-Blockers are globally used for the treatment of cardiovascular problems. Unfortunately... more ABSTRACT β-Blockers are globally used for the treatment of cardiovascular problems. Unfortunately, these are consumed as racemic mixture, causing serious side effects due to the presence of unwanted enantiomers. A simulation study of some commonly used β-blockers was carried out at supramolecular level to understand the importance of chirality of β-blockers in binding with receptor (β-ARs). The values of docking energy ranged from −6.58 to −9.11 and −7.05 to −9.15 kcal/mol for R- and S-enantiomers. In most of the cases, S-enantiomers bind strongly (in terms of docking energy) than their R-enantiomers with some exceptions (as no computational method is available, which can accurately predict the outcome with 100% accuracy). The results of the docking study reflected the pharmaceutical potencies of S-enantiomers in comparison to R-antipodes

Three green algae of Chlorella sp were used to investigate their ability for biohydrogen producti... more Three green algae of Chlorella sp were used to investigate their ability for biohydrogen production. Each strain was cultered normal BG-11 and sulfur-deprived BG-11 under anaerobic condition (at 28oC, 150 rpm for 48-72 hr) to monitor their growth. The results revealed that growth of all strains was suppressed in sulfur-deprived medium. Chlorella sp. TISTR 8262 yielded maximum hydrogen 13.03% of biogas produced, followed by C. ellipsoidea TISTR 8260 obtained at 3.05% of hydrogen, while there was no hydrogen production in case of C. vulgaris TISTR 8680.

Annals of Microbiology, 2012

This is the continuation study of obligate halophilic fungi isolated from a man-made solar salter... more This is the continuation study of obligate halophilic fungi isolated from a man-made solar saltern located in Phetchaburi province, Thailand. The isolation site was hypersaline extreme habitat. Six halophilic fungi which were screened for applications belonged to 4 species and 5 strains of Aspergillus genus namely A. flavus, A. gracilis, A. penicillioides (2 strains) and A. restrictus. A yeast namely, Sterigmatomyces halophilus was also one of the isolate screened for biotechnological potentials. Antibacterial, antioxidant and enzymatic activity were determined for each of the strains. All of the isolates in this study were found to have at least one of the applications screened. A. flavus, A. gracilis and A. penicillioides (1) were found to have high antibacterial potential. A. flavus and A. penicillioides (2) showed the most antioxidant activity while A. gracilis and A. restrictus were found to be most promising candidates for enzymes (of the five enzymes tested) having activity under saline conditions.

Arabian Journal of Chemistry, 2012

TLC-SPE methodologies were developed to ascertain biological interactions of norethindrone acetat... more TLC-SPE methodologies were developed to ascertain biological interactions of norethindrone acetate and dydrogesterone contraceptives with plasma progesterone receptor proteins. TLC solvent system for plain and Cu(II) impregnated silica gel plates was n-hexane-n-butanol (90:10, v/v), which took 20 min to run up to 10.0 cm. The best separation was on Cu(II) impregnated plates due to maximum difference in R f values and compact spots. The optimized SPE conditions were pH 2.0 and 3.0 of phosphate buffer (50 mM) for norethindrone acetate and dydrogesterone, respectively. The flow rate of plasma and eluting solvent (methanol) through C 18 cartridge was 0.10 mL/min. The interactions of these contraceptives with progesterone receptor proteins were analysed by TLC-SPE results, which were supported by modelling using PyMOL and Autodoc4 softwares. The dydrogesterone was found to be bound strongly than norethindrone acetate. Attempts have been made to discuss the drugs' interactions at chemo-supramolecular level.

Pesticides are notorious contaminants due to their toxic and carcinogenic nature and, unfortunate... more Pesticides are notorious contaminants due to their toxic and carcinogenic nature and, unfortunately, are distributed globally in air, water, sediment, soil and foods even to the places where they have not been used before. SPE and GC methods were developed to analyze organochlorine pesticides. The optimization was achieved by varying SPE conditions such as different pH of wastewater, flow rates of waste water, flow rates of solvents and different eluting solvents. Also optimization of GC conditions was obtained by using different columns, gases with various flow rates and temperatures. The optimized method was applied to analyze organochlorine pesticides in the Hindon river, India. The observed pesticides were α-BHC, β-BHC, γ-BHC, aldrin, endosulfan, DDE, DDD and methoxychlor of the concentration ranges from 8.1 to 26.8 µg/L. Extraction recoveries were 89.5, 90.0, 90.0, 92.3, 97.0, 97.9, 97.0 and 98.1 percentages for α-BHC, β-BHC, γ-BHC, aldrin, endosulfan, DDE, DDD and methoxychlor, respectively. It has been observed that the concentrations of pesticides increased from Behreki to Mohan Nagar sampling points, which may be due to the increase of pesticide pollution from agriculture, domestic and industrial activities. The concentration of α-BHC was found to be highest 26.8 µg/L. Validation of the developed methodology was carried out by using Microsoft Excel program.

Separation & Purification Reviews, 2011

In the present study electrocoagulation (EC) has been evaluated as a treatment technology for ars... more In the present study electrocoagulation (EC) has been evaluated as a treatment technology for arsenite [As(III)] and arsenate [As(V)] removal from water. Laboratory scale experiments were conducted with three electrode materials namely, iron, aluminum and titanium to assess their efficiency. Arsenic removal obtained was highest with iron electrodes. EC was able to bring down aqueous phase arsenic concentration to less than 10 lg l À1 with iron electrodes. Current density was varied from 0.65 to 1.53 mA cm À2 and it was observed that higher current density achieved rapid arsenic removal. Experimental results at different current densities indicated that arsenic removal was normalized with respect to total charge passed and therefore charge density has been used to compare the results. Effect of pH on arsenic removal was not significant in the pH range 6-8. Comparative evaluation of As(III) and As(V) removal by chemical coagulation (with ferric chloride) and electrocoagulation has been done. The comparison revealed that EC has better removal efficiency for As(III), whereas As(V) removal by both processes was nearly same. The removal mechanism of As(III) by EC seems to be oxidation of As(III) to As(V) and subsequent removal by adsorption/complexation with metal hydroxides generated in the process.