Ing-Liss Bryngelsson - Academia.edu (original) (raw)

Papers by Ing-Liss Bryngelsson

Objectives: Based on a pooled analysis of data from an international study, evaluate total and ca... more Objectives: Based on a pooled analysis of data from an international study, evaluate total and causespecific mortality among hardmetal production workers with emphasis on lung cancer. Methods: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. Results: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for

Annals of Work Exposures and Health

Objectives Several studies have demonstrated an increased risk of adverse health effects, includi... more Objectives Several studies have demonstrated an increased risk of adverse health effects, including reduced lung function and lung cancer among asphalt pavers, which has been related to occupational exposure to contaminants during asphalt paving. Consequently, occupational exposure among asphalt pavers must be reduced. The aim of this study was to compare the impact of hot mix asphalt (HMA) and warm mix asphalt (WMA) paving on occupational exposure levels during road paving in field experiments. Asphalt temperatures when paving with WMA are usually lower than when paving with HMA due to differences in the asphalt’s composition and method of application. Methods On 11 different road sections, one lane was paved with WMA and one with HMA during the same work shift under approximately identical weather conditions. The weather conditions and asphalt surface temperature were monitored during paving. Fifty-seven samples of fumes and vapor, organic and elemental carbon, amines, and respira...

Inom Naturvardsverkets programomradeHalsorelaterad miljoovervakning(HAMI), delprogramLuftfororeni... more Inom Naturvardsverkets programomradeHalsorelaterad miljoovervakning(HAMI), delprogramLuftfororening – exponeringsstudier ingar personburenmatning av vissa cancerframkallande och luftvagsirriterande amnen i tatortsluft.De ovriga orter som ingar i projektet ar Goteborg, Umea, Stockholm och Malmo.Lindesberg far har representera enmindre inlands kommun.Matningarna genomfors for att forsoka skatta allmanbefolkningens exponering forhalsoskadliga amnen och samtliga orter har nu genomfort tva matomgangar franstarten ar 2000. De amnen som ska matas ar bensen, butadien, formaldehyd,kvavedioxid, pratiklar PM 2,5 och benso(a)pyren.Lindesberg genomfor inga egna matningar av bakgrundshalter och vi har darforaven vid denna matomgang valt ut samma tva platser som vid foregaende matning.Raddningstjanstens tak (Kristinavagen) som representerar en trafikerad centralgata och Bergslagens Miljo- och Byggforvaltning (Kungsgatan). De uppmattalufthalterna ar pa samma laga nivaer som vid matningen ar 2005.Ba...

Occupational and Environmental Medicine, 2017

Introduction Nurses with long durations of rotating night shifts appear to be at increased risk f... more Introduction Nurses with long durations of rotating night shifts appear to be at increased risk for coronary heart disease. But industrial shift work among women has not been well-studied. Methods Women employed more than one year from cohorts of soft paper mills (n=3354) and pulp and paper mills (n=2278) were evaluated in this study. Mill-specific job exposure matrices for shift work and noise exposure were developed at department and job levels. Every worked year was classified for shift work as probable, possible (including shift with no nights) or not likely. Similarly, noise was classified into seven 5 dBA bins<75 dBA to >100 dBA. Here we present the cohort mortality from myocardial infarction for 1969–2013 as standardised mortality ratios (SMRs) with 95% confidence intervals (CI) compared to the general population in Sweden. Results Fatal myocardial infarctions (n=186) were increased in the cohort of women (SMR 123, 95% CI 106–142). Those classified as probable shift wor...

PLOS ONE, 2020

Video calling is one of the widely used method of communicating. Encryption is applied to video c... more Video calling is one of the widely used method of communicating. Encryption is applied to video call data to keep it secret. Real-time encryption is needed to support real-time communication such as video calling. Selective encryption is present as a solution to this problem. Skype is software that supports video calling. It cannot be ascertained whether Skype communication channel can be eavesdropped or not, since Skype communication protocol is very closed and concealed. Because of skype closed and concealed communication protocol, there is possibility that Skype party can eavesdrop communication in its communication channel. In this paper, we proposed a Skype client application made especially for video calling. Its main objective is to implement a selective encryption algorithm in video calling, especially via Skype. This Skype client is implemented in C++ programming language using Skypekit API from Skype. Testing proved that Skype client built support video calling with minor delay. Selective encryption algorithm is implemented to encrypt video in this Skype client.

Occupational and Environmental Medicine, 2019

BackgroundWork-related exposure to silica is a health hazard worldwide causing i.e. silicosis. In... more BackgroundWork-related exposure to silica is a health hazard worldwide causing i.e. silicosis. Inflammation is known to be a cause of cardiovascular diseases and some studies have presented elevated cardiovascular disease mortality in relation to silica exposure. The aim of this study was to investigate the relationship between inhalation of exposure to silica in Swedish iron foundries and markers of inflammation and coagulation in blood.MethodsPersonal sampling of respirable dust and silica was performed for 85 subjects in three Swedish iron foundries. Stationary measurements were used to study concentrations of respirable dust and silica, inhalable and total dust, PM10 and PM2.5, the particle surface area and the particle number concentrations. The markers of inflammation analyzed were, interleukins (IL-1β, IL-6, IL-8, IL-10 and IL-12), C-reactive protein, serum amyloid A (SAA), and markers of coagulation fibrinogen, factor VIII (FVIII), von Willebrand factor, and d-dimer were mea...

Occupational Medicine, 2018

pollen season. Outdoor workers should be informed; training should be addressed in order to promo... more pollen season. Outdoor workers should be informed; training should be addressed in order to promote collective and individual control and preventive measures. Being the Mediterranean area subject to thunderstorm episodes it is necessary the activation to specific planning to respond at these events.

BMJ Open, 2020

ObjectiveTo determine whether occupational exposure to silica dust causes an increased risk of de... more ObjectiveTo determine whether occupational exposure to silica dust causes an increased risk of developing Crohn’s disease (CD) and ulcerative colitis (UC).DesignCase–control study of CD (K50) and UC (K51) from 2007 through 2016. Controls were matched to cases (2:1) based on age, sex and county at the time of diagnosis. A job exposure matrix was used to estimate the occupational silica exposure of all cases and controls.SettingMedical and occupational data from the National Outpatient Register were used to implement a case–control analysis, while the two controls used for each case were selected from the National Register of the Total Population.ParticipantsAll men and women aged 20–65 years old who were diagnosed with CD (K50) and UC (K51) during the years of study were included and assigned two controls, resulting in 58 136 cases and 116 272 controls.Main outcomesSilica dust exposure correlates with an increased risk of developing UC in men and CD in women.ResultsThe prevalence of ...

Mediators of Inflammation, 2020

Purpose. To study the association between inhalation of particulate matter or quartz in Swedish i... more Purpose. To study the association between inhalation of particulate matter or quartz in Swedish iron foundries and the effects on NLRP3 inflammasome activation. Methods. Particle exposure measurements were performed during an eight-hour work day for 85 foundry workers at three Swedish iron foundries. Personal sampling was used for measurement of respirable quartz and dust and stationary measurements to obtain exposure measurements for inhalable dust and PM10. The NLRP3 inflammasome markers, interleukin- (IL-) 1β and IL-18, and inhibitors IL-1 receptor antagonist (IL-1Ra) and IL-18 binding protein (IL-18BP) were measured in plasma. Inflammasome activation was measured by caspase-1 enzymatic activity in monocytes in whole blood by flow cytometry, and expression of inflammasome-related genes was quantified using real-time PCR. Multiple linear regression analysis was used to investigate associations between PM exposures and inflammatory markers. Sex, age, smoking, current infection, BMI...

PLOS ONE, 2019

To study the relationship between respirable dust, quartz and chemical binders in Swedish iron fo... more To study the relationship between respirable dust, quartz and chemical binders in Swedish iron foundries and respiratory symptoms, lung function (as forced expiratory volume FEV 1 and vital capacity FVC), fraction of exhaled nitric oxide (FENO) and levels of club cell secretory protein 16 (CC16) and CRP. Methods Personal sampling of respirable dust and quartz was performed for 85 subjects in three Swedish iron foundries. Full shift sampling and examination were performed on the second or third day of a working week after a work free weekend, with additional sampling on the fourth or fifth day. Logistic, linear and mixed model analyses were performed including, gender, age, smoking, infections, sampling day, body mass index (BMI) and chemical binders as covariates. Results The adjusted average respirable quartz and dust concentrations were 0.038 and 0.66 mg/ m 3 , respectively. Statistically significant increases in levels of CC16 were associated with exposure to chemical binders (p = 0.05; p = 0.01) in the regression analysis of quartz and respirable dust, respectively. Non-significant exposure-responses were identified for cumulative quartz and the symptoms asthma and breathlessness. For cumulative chemical years, non-significant exposure-response were observed for all but two symptoms. FENO also exhibited a non significant exposure-response for both quartz and respirable dust. No exposure-response was determined for FEV 1 or FVC, CRP and respirable dust and quartz.

Pituitary, 2019

Background Studies on the incidence of Cushing's disease (CD) are few and usually limited by a sm... more Background Studies on the incidence of Cushing's disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. Methods Patients registered with a diagnostic code for Cushing's syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. Results Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confi

Journal of occupational and environmental medicine, 2017

Journal of occupational and environmental medicine, Jan 10, 2017

The aim of this study was to characterize the mortality at two hardmetal production factories in ... more The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

PloS one, 2017

There is controversy in the guidelines as to whether patients with atrial fibrillation and a low ... more There is controversy in the guidelines as to whether patients with atrial fibrillation and a low risk of stroke should be treated with anticoagulation, especially those with a CHA2DS2-VASc score of 1 point. In a retrospective, nationwide cohort study, we used the Swedish National Patient Registry, the National Prescribed Drugs Registry, the Swedish Registry of Education and the Population and Housing Census Registry. 48 433 patients were identified between 1 January 2006 and 31 December 2008 with incident atrial fibrillation who were divided in age categories, sex and a CHA2DS2-VASc score of 0, 1, 2 and ≥3 and they were included in a time-varying analysis of warfarin treatment versus no treatment. The primary end-point was cerebral infarction and stroke, and patients were followed until 31 December 2009. Patients with 1 point from the CHA2DS2-VASc score showed the following adjusted hazard ratios (HR) with a 95% confidence interval: men 65-74 years 0.46 (0.25-0.83), men <65 years...

European journal of endocrinology, 2017

Hypopituitarism has been associated with increased mortality. The excess mortality may be due to ... more Hypopituitarism has been associated with increased mortality. The excess mortality may be due to untreated growth hormone (GH) deficiency but also due to various underlying disorders. We therefore analysed mortality in patients with only one underlying disorder, non-functioning pituitary adenoma (NFPA), with and without GH replacement therapy (GHRT). Patients with NFPA in the western region of Sweden, 1997-2011, were identified through the National Patient Registry and cross-referenced with several National Health Registries. All patient records were reviewed. Standardised mortality ratios (SMRs) with 95% confidence intervals (CIs) were calculated using the general population as reference. Cox-regression models were performed to identify predictors of mortality. A total of 426 NFPA patients with 4599 patient-years were included, of whom 207 had used GHRT and 219 had not received GHRT. Median (range) follow-up in patients with and without GHRT was 12.2 (0-25) and 8.2 (0-27) years, re...

Occupational and Environmental Medicine, 2016

Access to the published version may require subscription. N.B. When citing this work, cite the or... more Access to the published version may require subscription. N.B. When citing this work, cite the original published paper.

Annals of Occupational Hygiene, 2016

Exposure to cobalt in the hard metal industry entails severe adverse health effects, including lu... more Exposure to cobalt in the hard metal industry entails severe adverse health effects, including lung cancer and hard metal fibrosis. The main aim of this study was to determine exposure air concentration levels of cobalt and tungsten for risk assessment and dose-response analysis in our medical investigations in a Swedish hard metal plant. We also present mass-based, particle surface area, and particle number air concentrations from stationary sampling and investigate the possibility of using these data as proxies for exposure measures in our study. Personal exposure full-shift measurements were performed for inhalable and total dust, cobalt, and tungsten, including personal real-time continuous monitoring of dust. Stationary measurements of inhalable and total dust, PM2.5, and PM10 was also performed and cobalt and tungsten levels were determined, as were air concentration of particle number and particle surface area of fine particles. The personal exposure levels of inhalable dust were consistently low (AM 0.15 mg m −3 , range <0.023-3.0 mg m −3) and below the present Swedish occupational exposure limit (OEL) of 10 mg m −3. The cobalt levels were low as well (AM 0.0030 mg m −3 , range 0.000028-0.056 mg m −3) and only 6% of the samples exceeded the Swedish OEL of 0.02 mg m −3. For continuous personal monitoring of dust exposure, the peaks ranged from 0.001 to 83 mg m −3 by work task. Stationary measurements showed lower average levels both for inhalable and total dust and cobalt. The particle number concentration of fine particles (AM 3000 p•cm −3) showed the highest levels at the departments of powder production, pressing and storage, and for the particle surface area concentrations (AM 7.6 µm 2 •cm −3) similar results were found. Correlating cobalt mass-based exposure measurements to cobalt stationary mass-based, particle area, and particle number concentrations by rank and department showed significant correlations for all measures except for particle number. Linear regression analysis of the same data showed statistically significant regression coefficients only for the mass-based aerosol measures. Similar results were seen for rank correlation in the stationary rig, and linear regression analysis implied significant correlation for mass-based and particle surface area measures. The mass-based air concentration levels of cobalt and tungsten in the hard metal plant in our study were low compared to Swedish OELs. Particle number and particle surface area concentrations were in the same order of magnitude as for other industrial settings. Regression analysis implied the use of stationary determined mass-based and particle surface area aerosol concentration as proxies for various exposure measures in our study.

International archives of occupational and environmental health, Jan 13, 2016

To study the relationship between exposure to airborne particles in a pulp and paper mill and mar... more To study the relationship between exposure to airborne particles in a pulp and paper mill and markers of inflammation and coagulation in blood. Personal sampling of inhalable dust was performed for 72 subjects working in a Swedish pulp and paper mill. Stationary measurements were used to study concentrations of total dust, respirable dust, PM10 and PM2.5, the particle surface area and the particle number concentrations. Markers of inflammation, interleukins (IL-1b, IL-6, IL-8, and IL-10), C-reactive protein (CRP), serum amyloid A (SAA), and fibrinogen and markers of coagulation factor VIII, von Willebrand, plasminogen activator inhibitor, and D-dimer were measured in plasma or serum. Sampling was performed on the last day of the work free period of 5 days, before and after the shift the first day of work and after the shifts the second and third day. In a mixed model analysis, the relationship between particulate exposures and inflammatory markers was determined. Sex, age, smoking, ...

Annals of Occupational Hygiene, 2015

Introduction: Chlorination is a method commonly used to keep indoor swimming pool water free from... more Introduction: Chlorination is a method commonly used to keep indoor swimming pool water free from pathogens. However, chlorination of swimming pools produces several potentially hazardous by-products as the chlorine reacts with nitrogen containing organic matter. Up till now, exposure assessments in indoor swimming pools have relied on stationary measurements at the poolside, used as a proxy for personal exposure. However, measurements at fixed locations are known to differ from personal exposure. Methods: Eight public swimming pool facilities in four Swedish cities were included in this survey. Personal and stationary sampling was performed during day or evening shift. Samplers were placed at different fixed positions around the pool facilities, at ~1.5 m above the floor level and 0-1 m from the poolside. In total, 52 personal and 110 stationary samples of trichloramine and 51 personal and 109 stationary samples of trihalomethanes, were collected. Results: The average concentration of trichloramine for personal sampling was 71 µg m −3 , ranging from 1 to 240 µg m −3 and for stationary samples 179 µg m −3 , ranging from 1 to 640 µg m −3. The air concentrations of chloroform were well below the occupational exposure limit (OEL). For the linear regression analysis and prediction of personal exposure to trichloramine from stationary sampling, only data from personal that spent >50% of their workday in the pool area were included. The linear regression analysis showed a correlation coefficient (r 2) of 0.693 and a significant regression coefficient β of 0.621; (95% CI = 0.329-0.912, P = 0.001). Conclusion: The trichloramine exposure levels determined in this study were well below the recommended air concentration level of 500 µg m −3 ; a WHO reference value based on stationary sampling. Our regression data suggest a relation between personal exposure and area sampling of 1:2, implying an OEL of 250 µg m −3 based on personal sampling.

The Journal of clinical endocrinology and metabolism, Jan 6, 2015

Patients with hypopituitarism of various etiologies have excess mortality. The mortality in patie... more Patients with hypopituitarism of various etiologies have excess mortality. The mortality in patients with non-functioning pituitary adenoma (NFPA) regardless of pituitary function is less well studied. Our aim was to investigate mortality in patients with NFPA and to examine whether age at diagnosis, gender, tumor treatments, or hormonal deficiencies influence the outcome. NFPA patients were identified and followed in nationwide health registries in Sweden, 1987-2011. The criteria for identification were tested and validated in a subpopulation of the patients. Nationwide population-based study. 2795 unique patients with NFPA (1502 men, 1293 women) were identified and included in the study. Mean age at diagnosis was 58 years (men 60, women 56) and mean follow-up time was 7 years (range 0-25). None. Standardized mortality ratios (SMRs) and annual incidence rates were calculated using the Swedish population as reference and presented with 95% confidence intervals. Annual incidence of N...