Inge Gies - Academia.edu (original) (raw)

Papers by Inge Gies

Additional file 2. Table S1. Database including all data extracted from selected studies. Databas... more Additional file 2. Table S1. Database including all data extracted from selected studies. Database concerning altered metabolites in paediatric patients with overweight and obesity in separate excel file, including first author and title, year of publication, continent, country of the study, study design, sample size, diagnostic criteria, characteristics of the study populations (age, Tanner stage and sex), analytical technique, biological matrix studied and quantitative findings, if these were available.

Journal of Intellectual Disability Research, Oct 1, 2014

42ste jaarlijks congres van de Belgische Vereniging voor Kindergeneeskunde, 2014

DCHG, medisch uitgeverij, 2013

Endocrinology, Diabetes & Metabolism Case Reports, 2022

Summary Vitamin D intoxication in children is rare but its incidence is increasing as vitamin D i... more Summary Vitamin D intoxication in children is rare but its incidence is increasing as vitamin D is supplemented more often and in higher doses. Children with cystic fibrosis (CF) are at risk for vitamin D intoxication due to incorrect compounded preparations of liposoluble vitamins. Here, we report a severe vitamin D intoxication in a 4-year-old girl with CF, due to an error in the compounded vitamin A, D, E, and K preparation, presenting clinically with weight loss, constipation, polydipsia, polyuria, and nycturia. The administered compounded preparation contained 10 000-fold the prescribed vitamin D dose. The patient was treated with hyperhydration, loop diuretics, and bisphosphonates. Serum calcium levels normalized after 4 days but serum 25-hydroxyvitamin D levels remained elevated even up to 2 months after treatment. Learning points Vitamin D intoxication should be ruled out when patients with cystic fibrosis (CF) present with acute polyuria, constipation, and weight loss. Prom...

Frontiers in Pediatrics, 2021

Background: Assessment of the endothelial function of the microvasculature by peripheral arterial... more Background: Assessment of the endothelial function of the microvasculature by peripheral arterial tonometry (PAT) has gained increasing popularity in pediatrics. Discomfort or experienced pain during fingertip PAT has only been studied in adolescents and adults.Methods: In 142 children (aged 4–11 years old), a fingertip PAT with a commercial device (EndoPAT 2000®) as well as a caliper and ultrasound examination of peripheral skinfolds were performed as part of a cross-sectional cohort study. In 110 children, Faces Pain Scale (FPS-R) data were collected after PAT and skinfold measurements by caliper and ultrasound.Results: In 111 out of the 142 PAT measurements (78.2%), a reactive hyperemia index (RHI) could be obtained. The most frequent error messages by the software was a “too noisy” and/or a “poor quality” signal. The success rate was higher in children aged older than 6 years (83.1 vs. 44.4%; p < 0.001). Median (range) FPS-R after PAT was 0 (range 0–6) but was significantly h...

Clinical Case Reports, 2021

Psychological stress is a risk factor for primary polydipsia in adolescents without psychiatric c... more Psychological stress is a risk factor for primary polydipsia in adolescents without psychiatric comorbidity. Taking a detailed family and social history can help to distinguish primary polydipsia from diabetes insipidus in adolescents with challenging presentations of polydipsia and polyuria. Polydipsia in children is defined as water volume consumption exceeding 2 L/m 2 /day. 1,2 Polydipsia is caused by several conditions including dehydration, exaggerated exercise, excessive water drinking (primary polydipsia), hyperglycemia (diabetes mellitus), or diabetes insipidus (DI) (central or nephrogenic). Primary polydipsia (PP) is a clinical disorder characterized by excessive thirst and a pathologically high fluid intake leading to hypotonic polyuria and a decreased serum osmolality. Four types of PP can be distinguished: (a) polydipsia in patients with neurodevelopmental disorders (such as autism and intellectual disabilities) and chronic psychotic disorders (such as schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression), (b) psychogenic polydipsia or compulsive water drinking, that is, polydipsia caused by psychiatric conditions such as obsessive-compulsive disorder, alcoholism, anxiety disorder, depression, and anorexia nervosa, (c) dipsogenic polydipsia, that is, polydipsia in patients with excessive thirst due to hypothalamic lesions caused by trauma, vascular or infiltrative diseases or patients with habitual polydipsia, and (d) iatrogenic polydipsia, that is, medical advice or act that leads to increased fluid intake. 3-8 During adolescence, PP has mainly been reported in young women with psychiatric comorbidity (Table 1). 9-12 Here, we report the sudden onset of excessive drinking of mainly cold water as an atypical presentation of PP in a 14-year-old girl, as a coping strategy for acute family stress due to parental burnout. 2 | CASE REPORT/CASE PRESENTATION A 14-year-old girl with complaints of acute polydipsia and polyuria in the last 5 days and a normal plasma glucose and negative urine dipstick analysis for glucose and protein was referred for suspicion of DI. She had a sudden onset of abnormal craving for cold fluids. Her fluid intake was ca. 10 liters of mostly cold water per day and she passed large volumes

Human Reproduction, 2020

STUDY QUESTION Is the distribution of immune cells and the testicular vasculature altered in test... more STUDY QUESTION Is the distribution of immune cells and the testicular vasculature altered in testicular biopsies from patients with Klinefelter syndrome (KS)? SUMMARY ANSWER Increased numbers of macrophages and mast cells, an increased expression of decorin and an increased blood vessel density were found in KS samples compared to controls. WHAT IS KNOWN ALREADY Most KS patients are infertile due to an early germ cell loss. From puberty onwards, testicular fibrosis can be detected. How this fibrotic process is initiated remains unknown. STUDY DESIGN, SIZE, DURATION In this study, the number of macrophages, mast cells and their secretory products were evaluated in KS, Sertoli cell only (SCO) and control patient samples. The association between immune cell numbers and level of fibrosis in KS tissue was examined. In addition, the vascularization within these testicular tissue biopsies was studied. For immunohistochemical evaluation, KS patients at different stages of testicular develop...

Fertility and Sterility, 2020

OBJECTIVE To characterize the tubular environment in testicular biopsy tissues from patients with... more OBJECTIVE To characterize the tubular environment in testicular biopsy tissues from patients with Klinefelter syndrome (KS). DESIGN Observational immunohistochemical study. SETTING Academic research unit. PATIENT(S) Males with KS and controls at different developmental time points: fetal, prepubertal, peripubertal, and adult. INTERVENTION(S) Immunohistochemical analysis of testicular biopsies samples to characterize maturation of Sertoli cells and tubular wall components-peritubular myoid cells (PTMC) and extracellular matrix (ECM) proteins. MAIN OUTCOME MEASURE(S) Intensity of antimüllerian hormone staining; proportion of Sertoli cells expressing androgen receptor (AR); and expression of tubular wall markers as characterized by identifying abnormal staining patterns. RESULT(S) Decreased expression for alpha smooth muscle actin 2 (ACTA2) was observed in peripubertal and adult KS as well as in Sertoli cell only (SCO) patients. Altered expression patterns for all ECM proteins were observed in SCO and KS biopsy tissues compared with controls. Only for collagen I and IV were altered expression patterns observed between KS and SCO patients. In peripubertal samples, no statistically significant differences were observed in the maturation markers, but altered ECM patterns were already present in some samples. CONCLUSION(S) The role of loss of ACTA2 expression in PTMC in the disintegration of tubules in KS patients should be further investigated. Future research is necessary to identify the causes of testicular fibrosis in KS patients. If the mechanism behind this fibrotic process could be identified, this process might be altered toward increasing the chances of fertility in KS patients.

Journal of the Endocrine Society, 2020

An early, normal or delayed pubertal onset have been described in overweight/ obese males(1). A g... more An early, normal or delayed pubertal onset have been described in overweight/ obese males(1). A greater prepubertal adiposity has been associated with a greater risk for delayed puberty in males, but an underlying mechanism was not explored(2). We investigated whether an increased testosterone aromatization or an higher degree of low-grade inflammation might be more prevalent in obese males with a delay in genital development. Pubertal status assessment by Tanner staging and measurement of morning serum testosterone, estradiol, leptin, and hSCRP by standard laboratory methods were performed in 191 male adolescents, aged between 10 and 18.6 yr (median 12.8 yr) with overweight (BMI z-score > 1.3), starting an ambulatory (n = 138) or a residential weight loss program (n = 55). Their median (range) BMI z-score was 2.32 (1.34 – 3.38). Delayed / slow and early / rapid genital development was defined by a Tanner genital stage respectively above the 90th or below 10th percentile age dist...

Endocrine Connections, 2019

Background Vitamin D deficiency is common in obese adolescents and a risk factor for insulin resi... more Background Vitamin D deficiency is common in obese adolescents and a risk factor for insulin resistance. We investigated if prevailing serum 25-OH vitamin D might predict the body fat loss in a group of obese adolescents undergoing a residential weight loss program. Methods In 92 (35 male) obese adolescents (aged 10.6–19 years) undergoing a residential weight loss program in Belgium, fasting serum 25-OH vitamin D (25-OH-D), insulin, glucose and lipid levels were measured and body composition was assessed by dual-energy X-ray absorptiometry (DXA). Results Baseline median (range) serum 25-OH-D level was 17.7 µg/L (3.8–41.8). In total, 55 adolescents had a serum 25-OH-D below 20 µg/L. In 31 adolescents with a low baseline 25-OH-D level, median increase in serum 25-OH-D was 2.4 µg/L (−4.2 to 7.2) after 10 months. This resulted in normal 25-OH-D levels in seven adolescents, whereas median BMI decreased with 1.0 SDS and body fat percentage diminished with 9.9%. Obese adolescents with or w...

BMJ Paediatrics Open, 2019

BackgroundThe offspring of obese pregnant women are at risk for adverse metabolic, inflammatory a... more BackgroundThe offspring of obese pregnant women are at risk for adverse metabolic, inflammatory and cardiovascular programming. Comprehensive long-term data are lacking on the contribution of changes in maternal weight after bariatric surgery before pregnancy compared with lifestyle interventions during pregnancy on the cardiovascular programming of the offspring.MethodsEFFECTOR is designed as a cross-sectional cohort follow-up study targeting the children of different groups of women who were previously studied during their pregnancy. Four subgroups of children are identified, based on maternal weight characteristics during pregnancy: normal weight women, obese women without any intervention and obese women who underwent a lifestyle intervention during or bariatric surgery before pregnancy. Data collection is performed as a single study visit at home. Data on the sociodemographic situation, food habits and psychomotor development are obtained through questionnaires. During the home...

PLOS ONE, 2018

Background Multidisciplinary management of Klinefelter cases is now considered good clinical prac... more Background Multidisciplinary management of Klinefelter cases is now considered good clinical practice in order to ensure optimal quality of life. Reproductive performance of Klinefelter men is an important issue however literature in this domain is limited and prone to bias. Study design This was a retrospective longitudinal cohort study performed at a tertiary referral University Centre for Reproductive Medicine and Genetics. One hundred thirty-eight non-mosaic azoospermic Klinefelter patients undergoing their first testicular biopsy (TESE) between 1994 and 2013, followed by intracytoplasmic sperm injection (ICSI) with fresh or frozen-thawed testicular sperm in the female partner, were followed-up longitudinally. The main outcome measure was cumulative live birth rate per Klinefelter patient embarking on TESE-ICSI. Findings In forty-eight men (48/138) sperm were successfully retrieved at the first TESE (34.8%). The mean age of the patients was 32.4 years. Younger age at first TESE was associated with a higher sperm retrieval rate (p<0.001). Overall 39 couples underwent 62 ICSI cycles and 13 frozen embryo transfer cycles resulting in in 20 pregnancies and 14 live birth deliveries (16 children). The mean age of the female partner was 28.1 years. The crude cumulative delivery rate after four ICSI cycles was 35.9%. Per intention-to-treat however, only 10.1% (14/138) of the Klinefelter men starting treatment succeeded in having their biologically own child(ren). Conclusion Non-mosaic Klinefelter patients with azoospermia seeking treatment by TESE-ICSI should be counseled that by intention-to-treat the chance of retrieving sperm is fair, however only a minority will eventually father genetically own children.

Journal of Cystic Fibrosis, 2017

Objectives: Patients with cystic fibrosis (CF) and exocrine pancreatic insufficiency (EPI) who re... more Objectives: Patients with cystic fibrosis (CF) and exocrine pancreatic insufficiency (EPI) who receive enteral nutrition (EN) experience decreased caloric intake and gastrointestinal (GI) symptoms due to fat malabsorption. We evaluated the safety, tolerability, and effect on fat absorption of RELiZORB, an in-line digestive cartridge that hydrolyzes fat in enteral formula during administration to patients with CF. Methods: Patients with CF and EPI receiving EN participated in a multicenter, randomized, double-blind, crossover trial with an openlabel safety evaluation period. Safety and tolerability endpoints included adverse device effects and GI symptoms of fat malabsorption. Fat absorption was assessed by measuring plasma concentrations of long chain polyunsaturated fatty acids (LCPUFAs). Results: Thirty-three participants were recruited from 11 CF centers; mean (SD) age was 14.5 (6.2) years, and 20 (60.6%) were male. Mean duration of EN use was 6.6 years. Mean body mass index (BMI) for subjects age 18 years and older was 19.5+1.1, and mean BMI percentile for subjects less than 18 years of age was 33.6%. At baseline, the mean plasma concentrations of LCPUFAs were approximately 60% of those found in normal healthy people. There were no unanticipated adverse device effects. RELiZORB use was associated with a decrease in the occurrence and severity of reported GI symptoms and an increase in reported preservation of appetite and ability to consume breakfast relative to baseline. Compared with placebo, RELiZORB use resulted in a 3.5-fold increase in plasma AUC 0-24 for LCPUFAs (P < 0.05). Conclusion: In CF patients with EPI receiving EN, use of this in-line digestive cartridge was safe and well tolerated, and compared with placebo, increased fat absorption as demonstrated by significantly higher plasma levels of LCPUFAs.

Clinical Endocrinology, 2017

Clinical Nutrition, 2017

Results: At the beginning of HPN the age of patients was between 2 and 221 month (range 6). At th... more Results: At the beginning of HPN the age of patients was between 2 and 221 month (range 6). At the end of the procedure the age was between 6 and 268 (range 41). Duration of HPN was between 0,5 and 221 months, range 53. Most of the patients (37) was qualified for HPN because of partial resection of small bowel. Second reason were neuromuscular bowel diseases (6), then Crohn disease (2) and other factors (4). The reasons of resections of small bowel were: intestinal torsion-6, bowel obstruction-6, necrotizing enterocolitis (NEC)-4, mesenteric torsion-4, congenital gastroschisis-4, Pagoda's syndrome-3, intestinal atresia-3 and others-7. Most of the patients (37) had preserved the ileocecal valve. From 10 patients who during parenteral nutrition have done intestinal anastomosis half of them weaned off HPN in the first year after the procedure, the rest-between 2 and 6 years. Patients after congenital gastroschisis despite small resections of short bowel, needed long-term parenteral nutrition (range 30 months). From 49 analyzed patients at the end of HPN 34 achieved regular weight and height according to WHO growth charts. Conclusion: The most frequent indication for HPN was resection of small bowel. Essential factors to weaned off parenteral nutrition were: length of small bowel, presence of ileocecal valve and intestinal anastomosis. Nutritional status at the end of HPN of most of the patients was satisfying.

Frontiers in psychology, 2016

Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituita... more Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation. CPP is associated with lower adult height and increased risk for development of psychological problems. Standard treatment of CPP is based on postponement of pubertal development by blockade of the HPG axis with gonadotropin releasing hormone analogs (GnRHa) leading to abolition of gonadal sex hormones synthesis. Whereas the hormonal and auxological effects of GnRHa are well-researched, there is a lack of knowledge whether GnRHa treatment influences psychological functioning of treated children, despite the fact that prevention of psychological problems is used as one of the main reasons for treatment initiation. In the present study we seek to address this issue by exploring differences in cognitive function, behavior, emotional reactivity, and psychosocial problems between GnRHa treated CPP girls and ...