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Papers by Isabel Goirigolzarri
The Open Autoimmunity Journal, 2009
Significant progresses on the anti-tissue transglutaminase antibodies (anti-tTG) ELISA tests have... more Significant progresses on the anti-tissue transglutaminase antibodies (anti-tTG) ELISA tests have been achieved since anti-tTG early development. Our goal was to study the optimization of the antigen immobilization and the antibody reaction conditions in an ELISA test for the detection of anti-tTG. Hence, three variants of an anti-tTG ELISA test were developed: tTG-Gliad-U, tTG-U and tTG-Gliad, according to the coating conditions (presence/absence of gli- adin) and the stringency in the sample buffer (presence/absence of urea). To assess IgA and IgG anti-tTG frequencies we used a group of 117 CD patients, 36 under a gluten-free diet and 14 with a selective IgA deficiency, and a control group of 165 non-celiac patients. Sensitivity of IgA anti-tTG in CD patients with villous atrophy was 95.5% (tTG-Gliad-U), 65.0% (tTG-U) and 92.5% (tTG-Gliad), respectively. Sensitivity of the IgG anti-tTG assay was 79.0%, 21.0% and 79.0%, re- spectively. Specificities ranged between 92.9% and 100%. S...
Http Www Libreriasaulamedica Com, 2009
Clinical Neurophysiology - CLIN NEUROPHYSIOL, 2010
Method: Focusing on corticospinal tract, the time course of FA in posterior limb of the internal ... more Method: Focusing on corticospinal tract, the time course of FA in posterior limb of the internal capsule (FA/PIC) was analyzed in group of normal control and of neurotrauma (A; shaken baby syndrome and infant acute subdural heamtoma, B; neonatal intracranial bleeding, C; congenital hydrocephalus, D; other). Using 1.5T MRI (GE Signa), DTI image was obtained with pulse sequence EPI, b value 1000, Matric 128×128, slice depth 4 mm, MPG 15 axis. On FA map, FA of PIC was mesured by manual ROI on both sides. Result: (1) FA/PIC was reliabe, independent of examiner. (2) In early infancy, FA/PIC showed steep increase in first 20 weeks and gradual afterward. (3) In Gp. A and D, the decrease of FA/PIC correlated with later motor development delay and spasticity. Conclusion: To evaluate the effect of neurotrauma on infant moter development, analysis FA/PIC was one handy method to detect and to prospect future developmental delay. DTI provide marked information of white matter damage which other modality could not, and futher case studies are required.
British Journal of Pharmacology, 2000
The Open Autoimmunity Journal, 2009
Significant progresses on the anti-tissue transglutaminase antibodies (anti-tTG) ELISA tests have... more Significant progresses on the anti-tissue transglutaminase antibodies (anti-tTG) ELISA tests have been achieved since anti-tTG early development. Our goal was to study the optimization of the antigen immobilization and the antibody reaction conditions in an ELISA test for the detection of anti-tTG. Hence, three variants of an anti-tTG ELISA test were developed: tTG-Gliad-U, tTG-U and tTG-Gliad, according to the coating conditions (presence/absence of gli- adin) and the stringency in the sample buffer (presence/absence of urea). To assess IgA and IgG anti-tTG frequencies we used a group of 117 CD patients, 36 under a gluten-free diet and 14 with a selective IgA deficiency, and a control group of 165 non-celiac patients. Sensitivity of IgA anti-tTG in CD patients with villous atrophy was 95.5% (tTG-Gliad-U), 65.0% (tTG-U) and 92.5% (tTG-Gliad), respectively. Sensitivity of the IgG anti-tTG assay was 79.0%, 21.0% and 79.0%, re- spectively. Specificities ranged between 92.9% and 100%. S...
Http Www Libreriasaulamedica Com, 2009
Clinical Neurophysiology - CLIN NEUROPHYSIOL, 2010
Method: Focusing on corticospinal tract, the time course of FA in posterior limb of the internal ... more Method: Focusing on corticospinal tract, the time course of FA in posterior limb of the internal capsule (FA/PIC) was analyzed in group of normal control and of neurotrauma (A; shaken baby syndrome and infant acute subdural heamtoma, B; neonatal intracranial bleeding, C; congenital hydrocephalus, D; other). Using 1.5T MRI (GE Signa), DTI image was obtained with pulse sequence EPI, b value 1000, Matric 128×128, slice depth 4 mm, MPG 15 axis. On FA map, FA of PIC was mesured by manual ROI on both sides. Result: (1) FA/PIC was reliabe, independent of examiner. (2) In early infancy, FA/PIC showed steep increase in first 20 weeks and gradual afterward. (3) In Gp. A and D, the decrease of FA/PIC correlated with later motor development delay and spasticity. Conclusion: To evaluate the effect of neurotrauma on infant moter development, analysis FA/PIC was one handy method to detect and to prospect future developmental delay. DTI provide marked information of white matter damage which other modality could not, and futher case studies are required.
British Journal of Pharmacology, 2000