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Papers by Isabella Durham
Since 2013, Mississippi State University has been offering research experiences for undergraduate... more Since 2013, Mississippi State University has been offering research experiences for undergraduates through formal programs which pair high-performing students in collaborative research with faculty mentors. The purpose of these programs is to provide students with the opportunity to enhance scholarly activity, participate in the discovery of new knowledge, and become a part of the scientific community. We tested the hypotheses that undergraduate research improves student participants’ educational experience (including personal and professional development), enhances retention of talented students in science careers, and leads to discovery of new information that contributes to the larger body of knowledge, while also looking at faculty motivations, benefits, and challenges they face in mentoring an undergraduate. Preliminary data from surveys of past program participants indicate improved discipline-specific knowledge, greater understanding of the scientific process, and enhanced in...
Frontiers in Molecular Neuroscience
Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their func... more Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their functionality they undergo extensive post-transcriptional modifications and, as such, are subject to regulation at multiple levels including transcription, transcript processing, localization and ribonucleoside base modification. Post-transcriptional enzyme-catalyzed modification of tRNA occurs at a number of base and sugar positions and influences specific anticodon-codon interactions and regulates translation, its efficiency and fidelity. This phenomenon of nucleoside modification is most remarkable and results in a rich structural diversity of tRNA of which over 100 modified nucleosides have been characterized. Most often these hypermodified nucleosides are found in the wobble position of tRNAs, where they play a direct role in codon recognition as well as in maintaining translational efficiency and fidelity, etc. Several recent studies have pointed to a link between defects in tRNA modifications and human diseases including neurological disorders. Therefore, defects in tRNA modifications in humans need intensive characterization at the enzymatic and mechanistic level in order to pave the way to understand how lack of such modifications are associated with neurological disorders with the ultimate goal of gaining insights into therapeutic interventions.
Since 2013, Mississippi State University has been offering research experiences for undergraduate... more Since 2013, Mississippi State University has been offering research experiences for undergraduates through formal programs which pair high-performing students in collaborative research with faculty mentors. The purpose of these programs is to provide students with the opportunity to enhance scholarly activity, participate in the discovery of new knowledge, and become a part of the scientific community. We tested the hypotheses that undergraduate research improves student participants’ educational experience (including personal and professional development), enhances retention of talented students in science careers, and leads to discovery of new information that contributes to the larger body of knowledge, while also looking at faculty motivations, benefits, and challenges they face in mentoring an undergraduate. Preliminary data from surveys of past program participants indicate improved discipline-specific knowledge, greater understanding of the scientific process, and enhanced in...
Frontiers in Molecular Neuroscience
Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their func... more Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their functionality they undergo extensive post-transcriptional modifications and, as such, are subject to regulation at multiple levels including transcription, transcript processing, localization and ribonucleoside base modification. Post-transcriptional enzyme-catalyzed modification of tRNA occurs at a number of base and sugar positions and influences specific anticodon-codon interactions and regulates translation, its efficiency and fidelity. This phenomenon of nucleoside modification is most remarkable and results in a rich structural diversity of tRNA of which over 100 modified nucleosides have been characterized. Most often these hypermodified nucleosides are found in the wobble position of tRNAs, where they play a direct role in codon recognition as well as in maintaining translational efficiency and fidelity, etc. Several recent studies have pointed to a link between defects in tRNA modifications and human diseases including neurological disorders. Therefore, defects in tRNA modifications in humans need intensive characterization at the enzymatic and mechanistic level in order to pave the way to understand how lack of such modifications are associated with neurological disorders with the ultimate goal of gaining insights into therapeutic interventions.