Sk Islam - Academia.edu (original) (raw)
Papers by Sk Islam
Transition Metal Chemistry
A polymer-anchored Pd(II) complex has been prepared and characterized using scanning electron mic... more A polymer-anchored Pd(II) complex has been prepared and characterized using scanning electron microscopy, elemental analysis, atomic absorption spectroscopy and FTIR. The catalyst shows excellent catalytic activity in the liquid-phase hydrogenation of substituted nitrobenzenes at normal pressure of hydrogen gas at 25 °C in DMF medium. We have also studied the liquid-phase hydrogenation of other organic substrates such as alkenes, alkynes, aromatic aldehydes, etc. The influences of various parameters such as amount of catalyst, concentration of substrate, temperature and solvent have been studied. The catalyst can be used five times without much loss in activity.
Journal of Organometallic Chemistry
A simple and industrially viable protocol for CeN and CeO coupling was reported here. The polymer... more A simple and industrially viable protocol for CeN and CeO coupling was reported here. The polymer supported heterogeneous copper catalyst was prepared from chloromethyl polystyrene using a simple procedure. O-Arylation of substituted phenols with various aryl halides was achieved using this copper catalyst in DMSO medium. This heterogeneous copper catalyst, also efficiently works for the N-arylation of NeH heterocycles with aryboronic acids in methanol. This catalyst was also effective in amination reaction of primary amines with aryl halides as well as arylboronic acids in DMSO medium. The effects of solvent, base and temperature for the O-Arylation and amination reactions were reported. Further, the catalyst can be easily recovered quantitatively by simple filtration and reused up to several times without sufficient loss of its catalytic activity.
European Journal of Clinical Nutrition, 2001
The study was carried out on the hypothesis that drug addicts would have reduced vitamin E, C and... more The study was carried out on the hypothesis that drug addicts would have reduced vitamin E, C and A status which could be influenced by drug habit, sexual practice and lifestyle factors. Method: Serum concentrations of Vitamin E, C and A of male drug addicts and cohort controls were analysed, and influence of drug habit, sexual practice and lifestyle factors of the addicts on the vitamin status was assessed. The study was conducted among 253 drug addicts who sought detoxification voluntarily during the period of June 1997 to July 1998 at the Central Drug Addiction Treatment Hospital, Dhaka, and 100 cohort control men. Research instruments were questionnaire and blood specimens. HPLC and spectrophotometric methods were used to determine the vitamin levels in sera of drug addicts. Results: a-Tocopherol (12.60AE 3.73 compared with 16.3 AE 3.37 mmol=l; t ¼ 8.6, P ¼ 0.05), ascorbic acid (21.59 AE 10.5 compared with 38.3 AE 13.62 mmol=l; t ¼ 10.93, P ¼ 0.003) and retinol (1.15 AE 0.39 compared with 1.33 AE 0.30 mmol=l; t ¼ 5.28, P ¼ 0.048) in the drug addicts were significantly low as compared to those in the cohort controls. Use of multiple illicit drugs for a longer period of time did result in reduced levels of these vitamins. A significant reduction in retinol concentration was noted among the multiple drug users (F(2,250) ¼ 3.23, P ¼ 0.041). Duration of addiction had a significant linear correlation with the level of reduction in retinol (F(2,250) ¼ 3.23, P ¼ 0.041) and a-tocopherol (F(2,250) ¼ 3.06, P ¼ 0.049). Apart from having a significant negative correlation between number of sexual partners and retinol level (F(3,247) ¼ 2.65, P ¼ 0.049), sexual practice did not have any influence on the vitamin status of the addicts. Occupation did have a significant effect on the ascorbic acid level (F(4,248) ¼ 2.46, P ¼ 0.046), but other socioeconomic factors like income, age etc did not influence the vitamin E, C and A levels. Body mass index had a positive linear correlation with the vitamins, but it was significant only with vitamin C (F(2,250) ¼ 7.06, P ¼ 0.001). Conclusions: These results could have important implications for providing an antioxidant therapy to drug addicts and thus rehabilitating them into normal life. Risk of HIV infection and transmission (if any) could be reduced or inhibited. Descriptors: drug addiction; antioxidant vitamins status; drug habit; sexual practice
Public Health, 2000
The sexual life style, drug habit and socio-demographic status of 253 male hospitalized drug addi... more The sexual life style, drug habit and socio-demographic status of 253 male hospitalized drug addicts were investigated. This study was conducted during the period June 1997 to July 1998, and each case was selected by the random sampling method. The research instrument was an interviewer-administered questionnaire, the sexual habits, number and quality of sex partners, use of condoms, sexually transmitted diseases, etc., were considered as indicators of the sexual life style of the drug addicts. Eighty-eight percent (n 233) of the addicts were heterosexual. Bisexuality was found only in 7% (n 18) of the addicts. Eighty-seven percent (n 240) of the addicts have multiple sex partners of either commercial or residential category. Most of the drug addicts (72%, n 181) did not use condoms. Fifty-seven percent (n 145) of the addicts were observed to have sexual diseases. As indicators of a drug habit, starting drug, choice of drug, period of addiction, sharing of needles, etc., were included. Cannabis was the starting substance for 59% (n 149) of the addicts. Heroin was the drug of choice for 60% (n 157) addicts. A single drug was taken only by 8% (n 20) of the addicts and the remaining 92% (n 233) took multiple drugs. The drug addicts (n 97) who used mostly injection (87%, n 84) shared needles. Education, occupation, income, age, marital status, in¯uencing factors for addiction were considered as socio-demographic characteristics. Young adults (79%, n 199), secondary educated (46%, n 116), low ± mid income (60%, n 150), businessmen (46%, n 150) and married (60%, n 151) people were found highly involved in addiction. Self-curiosity and a friend's incitement were revealed as the most important in¯uencing factors for taking drugs.
Bangladesh Medical Journal, 2009
Liver cirrhotic patients were investigated for their lifestyle, energy intake, BMI, biochemical a... more Liver cirrhotic patients were investigated for their lifestyle, energy intake, BMI, biochemical and serological indices and prevalent clinical signs. The study included 50 liver cirrhotic patients who were hospitalized in Bangabandhu Sheikh Mujib Medical University, Dhaka Medical College Hospital and BIRDEM Hospital during the period of 1999-2000. Of the fifty cirrhotic patients, hepatitis B virus infection was found responsible for
Substance Abuse Treatment Prevention and Policy, 2007
Background: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual pract... more Background: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual practice and socioeconomic factors influence the nutrient profile of drug dependent subjects. The literature on this issue is still insufficient. This study has tested the hypothesis that illicit drug use and lifestyle impair mineral status. To test this hypothesis, 253 men multiple drug users of age 18-45 years were recruited to investigate their serum copper, zinc and iron levels. Influence of illicit drugs and their lifestyle on the mineral levels was also examined. The study subjects were drug dependent who had shared needles and had sexual activity with multiple partners. Serum concentrations of the minerals were estimated by atomic absorption flame spectrometry.
Addiction Biology, 2004
The aim of this study was to investigate the serum immunoglobulins and white blood cells status o... more The aim of this study was to investigate the serum immunoglobulins and white blood cells status of drug addicts and to assess the extent of influence of drug habit and sexual practice on the immune components. The study was conducted among 253 male drug addicts and 100 non-addict controls of aged 18 - 45 years. An enzyme-linked immunosorbent assay (ELISA) was employed to analyse the serum immunoglobulin concentrations. White blood cells profile was estimated by counting 200 cells . Results showed a significant increase (p < 0.03) of serum IgG, IgA and IgM in the drug addicts (6.93 ? 1.53g/l, 2.90 ? 1.13g/l and 1.72 ? 0.73g/l, respectively) compared to those in the cohort controls (6.52 ? 1.05g/l, 2.61 ? 0.83g/l and 1.52 ? 0.59g/l, respectively). A significant (p = 0.00) decrease of peripheral lymphocytes (51.8 ? 15.2 vs. 71.9 ? 11.5) was noted in the drug addicts. Monocytes (8.3 ? 4.9), neutrophils (128.2 ? 18.9) and eosinophils (11.4 ? 5.8) were found to be increased in the drug addicts against those in the controls (5.2 ? 2.5, 113.2 ? 13.0 and 9.6 ? 5.8, respectively). Multiple drug abuse for longer period had resulted in a significant (p < 0.05) decrease of serum immunoglobulins and lymphocytes. The longer period of addiction had also made a significant (p < 0.05) decrease of eosinophils (p = 0.05) and an increase of monocytes and neutrophils. Sex with multiple sexual partners had shown a significant (p < 0.01) decrease of serum immunoglobulins and eosinophils.
Transition Metal Chemistry
A polymer-anchored Pd(II) complex has been prepared and characterized using scanning electron mic... more A polymer-anchored Pd(II) complex has been prepared and characterized using scanning electron microscopy, elemental analysis, atomic absorption spectroscopy and FTIR. The catalyst shows excellent catalytic activity in the liquid-phase hydrogenation of substituted nitrobenzenes at normal pressure of hydrogen gas at 25 °C in DMF medium. We have also studied the liquid-phase hydrogenation of other organic substrates such as alkenes, alkynes, aromatic aldehydes, etc. The influences of various parameters such as amount of catalyst, concentration of substrate, temperature and solvent have been studied. The catalyst can be used five times without much loss in activity.
Journal of Organometallic Chemistry
A simple and industrially viable protocol for CeN and CeO coupling was reported here. The polymer... more A simple and industrially viable protocol for CeN and CeO coupling was reported here. The polymer supported heterogeneous copper catalyst was prepared from chloromethyl polystyrene using a simple procedure. O-Arylation of substituted phenols with various aryl halides was achieved using this copper catalyst in DMSO medium. This heterogeneous copper catalyst, also efficiently works for the N-arylation of NeH heterocycles with aryboronic acids in methanol. This catalyst was also effective in amination reaction of primary amines with aryl halides as well as arylboronic acids in DMSO medium. The effects of solvent, base and temperature for the O-Arylation and amination reactions were reported. Further, the catalyst can be easily recovered quantitatively by simple filtration and reused up to several times without sufficient loss of its catalytic activity.
European Journal of Clinical Nutrition, 2001
The study was carried out on the hypothesis that drug addicts would have reduced vitamin E, C and... more The study was carried out on the hypothesis that drug addicts would have reduced vitamin E, C and A status which could be influenced by drug habit, sexual practice and lifestyle factors. Method: Serum concentrations of Vitamin E, C and A of male drug addicts and cohort controls were analysed, and influence of drug habit, sexual practice and lifestyle factors of the addicts on the vitamin status was assessed. The study was conducted among 253 drug addicts who sought detoxification voluntarily during the period of June 1997 to July 1998 at the Central Drug Addiction Treatment Hospital, Dhaka, and 100 cohort control men. Research instruments were questionnaire and blood specimens. HPLC and spectrophotometric methods were used to determine the vitamin levels in sera of drug addicts. Results: a-Tocopherol (12.60AE 3.73 compared with 16.3 AE 3.37 mmol=l; t ¼ 8.6, P ¼ 0.05), ascorbic acid (21.59 AE 10.5 compared with 38.3 AE 13.62 mmol=l; t ¼ 10.93, P ¼ 0.003) and retinol (1.15 AE 0.39 compared with 1.33 AE 0.30 mmol=l; t ¼ 5.28, P ¼ 0.048) in the drug addicts were significantly low as compared to those in the cohort controls. Use of multiple illicit drugs for a longer period of time did result in reduced levels of these vitamins. A significant reduction in retinol concentration was noted among the multiple drug users (F(2,250) ¼ 3.23, P ¼ 0.041). Duration of addiction had a significant linear correlation with the level of reduction in retinol (F(2,250) ¼ 3.23, P ¼ 0.041) and a-tocopherol (F(2,250) ¼ 3.06, P ¼ 0.049). Apart from having a significant negative correlation between number of sexual partners and retinol level (F(3,247) ¼ 2.65, P ¼ 0.049), sexual practice did not have any influence on the vitamin status of the addicts. Occupation did have a significant effect on the ascorbic acid level (F(4,248) ¼ 2.46, P ¼ 0.046), but other socioeconomic factors like income, age etc did not influence the vitamin E, C and A levels. Body mass index had a positive linear correlation with the vitamins, but it was significant only with vitamin C (F(2,250) ¼ 7.06, P ¼ 0.001). Conclusions: These results could have important implications for providing an antioxidant therapy to drug addicts and thus rehabilitating them into normal life. Risk of HIV infection and transmission (if any) could be reduced or inhibited. Descriptors: drug addiction; antioxidant vitamins status; drug habit; sexual practice
Public Health, 2000
The sexual life style, drug habit and socio-demographic status of 253 male hospitalized drug addi... more The sexual life style, drug habit and socio-demographic status of 253 male hospitalized drug addicts were investigated. This study was conducted during the period June 1997 to July 1998, and each case was selected by the random sampling method. The research instrument was an interviewer-administered questionnaire, the sexual habits, number and quality of sex partners, use of condoms, sexually transmitted diseases, etc., were considered as indicators of the sexual life style of the drug addicts. Eighty-eight percent (n 233) of the addicts were heterosexual. Bisexuality was found only in 7% (n 18) of the addicts. Eighty-seven percent (n 240) of the addicts have multiple sex partners of either commercial or residential category. Most of the drug addicts (72%, n 181) did not use condoms. Fifty-seven percent (n 145) of the addicts were observed to have sexual diseases. As indicators of a drug habit, starting drug, choice of drug, period of addiction, sharing of needles, etc., were included. Cannabis was the starting substance for 59% (n 149) of the addicts. Heroin was the drug of choice for 60% (n 157) addicts. A single drug was taken only by 8% (n 20) of the addicts and the remaining 92% (n 233) took multiple drugs. The drug addicts (n 97) who used mostly injection (87%, n 84) shared needles. Education, occupation, income, age, marital status, in¯uencing factors for addiction were considered as socio-demographic characteristics. Young adults (79%, n 199), secondary educated (46%, n 116), low ± mid income (60%, n 150), businessmen (46%, n 150) and married (60%, n 151) people were found highly involved in addiction. Self-curiosity and a friend's incitement were revealed as the most important in¯uencing factors for taking drugs.
Bangladesh Medical Journal, 2009
Liver cirrhotic patients were investigated for their lifestyle, energy intake, BMI, biochemical a... more Liver cirrhotic patients were investigated for their lifestyle, energy intake, BMI, biochemical and serological indices and prevalent clinical signs. The study included 50 liver cirrhotic patients who were hospitalized in Bangabandhu Sheikh Mujib Medical University, Dhaka Medical College Hospital and BIRDEM Hospital during the period of 1999-2000. Of the fifty cirrhotic patients, hepatitis B virus infection was found responsible for
Substance Abuse Treatment Prevention and Policy, 2007
Background: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual pract... more Background: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual practice and socioeconomic factors influence the nutrient profile of drug dependent subjects. The literature on this issue is still insufficient. This study has tested the hypothesis that illicit drug use and lifestyle impair mineral status. To test this hypothesis, 253 men multiple drug users of age 18-45 years were recruited to investigate their serum copper, zinc and iron levels. Influence of illicit drugs and their lifestyle on the mineral levels was also examined. The study subjects were drug dependent who had shared needles and had sexual activity with multiple partners. Serum concentrations of the minerals were estimated by atomic absorption flame spectrometry.
Addiction Biology, 2004
The aim of this study was to investigate the serum immunoglobulins and white blood cells status o... more The aim of this study was to investigate the serum immunoglobulins and white blood cells status of drug addicts and to assess the extent of influence of drug habit and sexual practice on the immune components. The study was conducted among 253 male drug addicts and 100 non-addict controls of aged 18 - 45 years. An enzyme-linked immunosorbent assay (ELISA) was employed to analyse the serum immunoglobulin concentrations. White blood cells profile was estimated by counting 200 cells . Results showed a significant increase (p < 0.03) of serum IgG, IgA and IgM in the drug addicts (6.93 ? 1.53g/l, 2.90 ? 1.13g/l and 1.72 ? 0.73g/l, respectively) compared to those in the cohort controls (6.52 ? 1.05g/l, 2.61 ? 0.83g/l and 1.52 ? 0.59g/l, respectively). A significant (p = 0.00) decrease of peripheral lymphocytes (51.8 ? 15.2 vs. 71.9 ? 11.5) was noted in the drug addicts. Monocytes (8.3 ? 4.9), neutrophils (128.2 ? 18.9) and eosinophils (11.4 ? 5.8) were found to be increased in the drug addicts against those in the controls (5.2 ? 2.5, 113.2 ? 13.0 and 9.6 ? 5.8, respectively). Multiple drug abuse for longer period had resulted in a significant (p < 0.05) decrease of serum immunoglobulins and lymphocytes. The longer period of addiction had also made a significant (p < 0.05) decrease of eosinophils (p = 0.05) and an increase of monocytes and neutrophils. Sex with multiple sexual partners had shown a significant (p < 0.01) decrease of serum immunoglobulins and eosinophils.