Issak Bhojani - Academia.edu (original) (raw)

Papers by Issak Bhojani

Research paper thumbnail of Diabetic Foot - GDG Membership List

Research paper thumbnail of The calcium paradox in mammalian heart muscle

Research paper thumbnail of Management of depression in the British South Asian and British White patients with long-term conditions in primary care: A cross sectional study

Journal of Psychosomatic Research, 2015

Depression and pain dimensions in the assessment of healthrelated quality of life in older adults... more Depression and pain dimensions in the assessment of healthrelated quality of life in older adults A.F. Allaz, C. Luthy, F. Herrmann, C. Ludwig, C. Cedraschi Division of General Medical Rehabilitation Beau-Sejour, SMIRG, University Hospital, Geneva, Switzerland, Division of Geriatric, University Hospitals Geneva, Switzerland, School of Health, University of Applied Sciences of Western Switzerland, Geneva, Switzerland

Research paper thumbnail of Vitamin D status and bone turnover in post-menopausal South Asian and Caucasian women living in Blackburn, UK

Proceedings of the Nutrition Society, 2008

Research paper thumbnail of Diet, lifestyle and osteoporotic fracture risk in post-menopausal South Asian women living in Blackburn, UK

Research paper thumbnail of The effects of bathing sodium ions upon the intracellular sodium activity in calcium-free media and the calcium paradox of isolated ferret ventricular muscle

Journal of Molecular and Cellular Cardiology, 1990

in Calcium-free Media and the Calcium Paradox of Isolated Ferret Ventricular Muscle. joumul of Mo... more in Calcium-free Media and the Calcium Paradox of Isolated Ferret Ventricular Muscle. joumul of Molmlur and Cellular Cardiologv (1990) 22, 507-522. Exposure of fine trabeculae isolated from the ferret right ventricle to media depleted of Ca'+, with a rapid perfusion system, causes a depolarization of the membrane and a rise in ah.. This rise in & is sigmoidally dependent upon the bathing free [Ca"], is antagonized by reduction of the [Na]e, raised [Mg]c and PN200-110 but augmented by removal of Mg2+ or inhibition of the Na-pump. On repletion of Ca 2c , t he strength of the resulting contracture depends upon the transmembrane Na-gradient at the moment of Ca-repletion. The effects of reduced [Na]c, during Ca-depletion, depend upon the cation used with replacement by Li % choline > tetramethylammonium.

Research paper thumbnail of Special considerations for vitamin D in the south Asian population in the UK

Therapeutic Advances in Musculoskeletal Disease

Research paper thumbnail of Diet, lifestyle and osteoporotic fracture risk in post-menopausal South Asian women living in Blackburn, UK

Research paper thumbnail of Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK

British Journal of Nutrition, 2010

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its ... more Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50-66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen beta C-telopeptide (betaCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10.5 v. C 47.1 nmol/l; P < 0.001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7.3 v. C 4.5 pmol/l; P < 0.01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23.0 v. C 20.0 U/l; P < 0.05). No significant differences were observed between the two groups for P1NP, betaCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

Research paper thumbnail of Vitamin D status and bone turnover in post-menopausal South Asian and Caucasian women living in Blackburn, UK

Proceedings of the Nutrition Society, 2008

Vitamin D deficiency impairs Ca and P absorption, resulting in poor mineralization of the skeleto... more Vitamin D deficiency impairs Ca and P absorption, resulting in poor mineralization of the skeleton . Evidence from recent studies indicates that a low serum level of 25-hydroxyvitamin D (cholecalciferol + ergocalciferol) is associated with low bone mineral density in older adults . Suboptimal vitamin D status has been reported in UK Asian populations (3) , which may lead to increased fracture risk post menopause. The purpose of the present study was to conduct a comparative investigation of vitamin D status, bone quality and bone turnover in post-menopausal South Asian (SA) and Caucasian (C) women living in Blackburn, Lancs., U.K.

Research paper thumbnail of Diabetic Foot - GDG Membership List

Research paper thumbnail of The calcium paradox in mammalian heart muscle

Research paper thumbnail of Management of depression in the British South Asian and British White patients with long-term conditions in primary care: A cross sectional study

Journal of Psychosomatic Research, 2015

Depression and pain dimensions in the assessment of healthrelated quality of life in older adults... more Depression and pain dimensions in the assessment of healthrelated quality of life in older adults A.F. Allaz, C. Luthy, F. Herrmann, C. Ludwig, C. Cedraschi Division of General Medical Rehabilitation Beau-Sejour, SMIRG, University Hospital, Geneva, Switzerland, Division of Geriatric, University Hospitals Geneva, Switzerland, School of Health, University of Applied Sciences of Western Switzerland, Geneva, Switzerland

Research paper thumbnail of Vitamin D status and bone turnover in post-menopausal South Asian and Caucasian women living in Blackburn, UK

Proceedings of the Nutrition Society, 2008

Research paper thumbnail of Diet, lifestyle and osteoporotic fracture risk in post-menopausal South Asian women living in Blackburn, UK

Research paper thumbnail of The effects of bathing sodium ions upon the intracellular sodium activity in calcium-free media and the calcium paradox of isolated ferret ventricular muscle

Journal of Molecular and Cellular Cardiology, 1990

in Calcium-free Media and the Calcium Paradox of Isolated Ferret Ventricular Muscle. joumul of Mo... more in Calcium-free Media and the Calcium Paradox of Isolated Ferret Ventricular Muscle. joumul of Molmlur and Cellular Cardiologv (1990) 22, 507-522. Exposure of fine trabeculae isolated from the ferret right ventricle to media depleted of Ca'+, with a rapid perfusion system, causes a depolarization of the membrane and a rise in ah.. This rise in & is sigmoidally dependent upon the bathing free [Ca"], is antagonized by reduction of the [Na]e, raised [Mg]c and PN200-110 but augmented by removal of Mg2+ or inhibition of the Na-pump. On repletion of Ca 2c , t he strength of the resulting contracture depends upon the transmembrane Na-gradient at the moment of Ca-repletion. The effects of reduced [Na]c, during Ca-depletion, depend upon the cation used with replacement by Li % choline > tetramethylammonium.

Research paper thumbnail of Special considerations for vitamin D in the south Asian population in the UK

Therapeutic Advances in Musculoskeletal Disease

Research paper thumbnail of Diet, lifestyle and osteoporotic fracture risk in post-menopausal South Asian women living in Blackburn, UK

Research paper thumbnail of Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK

British Journal of Nutrition, 2010

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its ... more Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50-66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen beta C-telopeptide (betaCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10.5 v. C 47.1 nmol/l; P < 0.001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7.3 v. C 4.5 pmol/l; P < 0.01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23.0 v. C 20.0 U/l; P < 0.05). No significant differences were observed between the two groups for P1NP, betaCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

Research paper thumbnail of Vitamin D status and bone turnover in post-menopausal South Asian and Caucasian women living in Blackburn, UK

Proceedings of the Nutrition Society, 2008

Vitamin D deficiency impairs Ca and P absorption, resulting in poor mineralization of the skeleto... more Vitamin D deficiency impairs Ca and P absorption, resulting in poor mineralization of the skeleton . Evidence from recent studies indicates that a low serum level of 25-hydroxyvitamin D (cholecalciferol + ergocalciferol) is associated with low bone mineral density in older adults . Suboptimal vitamin D status has been reported in UK Asian populations (3) , which may lead to increased fracture risk post menopause. The purpose of the present study was to conduct a comparative investigation of vitamin D status, bone quality and bone turnover in post-menopausal South Asian (SA) and Caucasian (C) women living in Blackburn, Lancs., U.K.