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Papers by Isuru Weerasinghe

Pediatric Neurology, 2021

BACKGROUND Prior work suggests that event-related potential (ERP) studies in infancy may help pre... more BACKGROUND Prior work suggests that event-related potential (ERP) studies in infancy may help predict developmental outcome. METHODS As part of a longitudinal study of early child development, we used the auditory oddball stimulus paradigm with a portable electroencephalography system to obtain ERP data from two-month-old infants (32 term, six preterm) in Sri Lanka. The mismatch negativity was calculated between 200 and 350 milliseconds after stimulus presentation. RESULTS We found a significant correlation between birth weight and mismatch negativity (P = 0.046), and our time-frequency analysis indicated power differences between standard and oddball tones at approximately 5 and 18 Hz. There was no significant difference between mismatch negativity in children undergoing ERP studies in a hospital setting (30) versus in the child's home (eight). CONCLUSIONS Although our modest sample size precludes drawing definitive conclusions, these preliminary results show that it is possible to acquire ERP datasets using currently available portable technology in a hospital or home setting, even in a developing nation such as Sri Lanka. Follow-up of this cohort will include developmental assessments, which will add to the growing literature relating early electrophysiology to developmental outcome.

Journal of the College of Community Physicians of Sri Lanka, 2021

Introduction: Clinical evidence suggests that hamstring tightness influences lumbar pelvic rhythm... more Introduction: Clinical evidence suggests that hamstring tightness influences lumbar pelvic rhythm and shortened hamstring increase the risk of injury to the spine. Objectives: To determine the association of hamstring tightness with pelvic tilt in standing position, trunk, and lumbar range of motion during forward bending among sewing machine operators Methods: A descriptive cross-sectional study was conducted among 169 sewing machine operators aged 18-55 years using passive knee extension test, tri-goniometric method, finger to floor test and modified Schober test to measure hamstring tightness, pelvic tilt, trunk flexion and lumbar flexion, respectively. Results: A weak negative correlation between hamstring tightness and lumbar range of motion during forward bending (r=-0.28; p=0.001). A significant association between trunk flexion and hamstring tightness (r=0.47; p=0.001). Conclusions & Recommendations: Hamstring tightness affects the lumbar and trunk range of motion during forward bending.

Ceylon Journal of Medical Science

Background: Hamstring is a key component of flexibility in the human body and it is more prone to... more Background: Hamstring is a key component of flexibility in the human body and it is more prone to get tightened. Inability to achieve greater than 160 degrees of knee extension when the hip is flexed to 90 degrees is considered as hamstring tightness. Objectives: This study aims to find the prevalence of hamstring tightness among sewing machine operators and to assess the association of hamstring tightness with prolonged sitting, body mass index, physical activity level and gender. Method: A descriptive cross sectional study was carried out among 169 sewing machine operators aged between 18-60 years of a selected garment factory. Passive knee extension (PKE) test was used to measure the hamstring tightness among sewing machine operators. A validated interviewer administered questionnaire was used to determine the physical activity level among the participants. Results: Prevalence of hamstring tightness among sewing machine operators is 83.4% (n=141) and it is higher in males (91.8%) than females (78.7%). There was a significant association between prolonged sitting and hamstring tightness in the dominant limb (p=0.02, chi square = 7.79). Significant associations were not found between hamstring tightness with the BMI level (p=0.46, r=-0.05) and physical activity (p=0.41, r=-0.06). Conclusion: Majority of the sewing machine operators have hamstring tightness. Prolonged sitting is a contributory factor in hamstring muscle tightness.

Ceylon Journal of Medical Science, Feb 10, 2020

Background: Hamstring is a key component of flexibility in the human body and it is more prone to... more Background: Hamstring is a key component of flexibility in the human body and it is more prone to get tightened. Inability to achieve greater than 160 degrees of knee extension when the hip is flexed to 90 degrees is considered as hamstring tightness. Objectives: This study aims to find the prevalence of hamstring tightness among sewing machine operators and to assess the association of hamstring tightness with prolonged sitting, body mass index, physical activity level and gender. Method: A descriptive cross sectional study was carried out among 169 sewing machine operators aged between 18-60 years of a selected garment factory. Passive knee extension (PKE) test was used to measure the hamstring tightness among sewing machine operators. A validated interviewer administered questionnaire was used to determine the physical activity level among the participants. Results: Prevalence of hamstring tightness among sewing machine operators is 83.4% (n=141) and it is higher in males (91.8%) than females (78.7%). There was a significant association between prolonged sitting and hamstring tightness in the dominant limb (p=0.02, chi square = 7.79). Significant associations were not found between hamstring tightness with the BMI level (p=0.46, r=-0.05) and physical activity (p=0.41, r=-0.06). Conclusion: Majority of the sewing machine operators have hamstring tightness. Prolonged sitting is a contributory factor in hamstring muscle tightness.

Pediatric Neurology, 2021

BACKGROUND Prior work suggests that event-related potential (ERP) studies in infancy may help pre... more BACKGROUND Prior work suggests that event-related potential (ERP) studies in infancy may help predict developmental outcome. METHODS As part of a longitudinal study of early child development, we used the auditory oddball stimulus paradigm with a portable electroencephalography system to obtain ERP data from two-month-old infants (32 term, six preterm) in Sri Lanka. The mismatch negativity was calculated between 200 and 350 milliseconds after stimulus presentation. RESULTS We found a significant correlation between birth weight and mismatch negativity (P = 0.046), and our time-frequency analysis indicated power differences between standard and oddball tones at approximately 5 and 18 Hz. There was no significant difference between mismatch negativity in children undergoing ERP studies in a hospital setting (30) versus in the child's home (eight). CONCLUSIONS Although our modest sample size precludes drawing definitive conclusions, these preliminary results show that it is possible to acquire ERP datasets using currently available portable technology in a hospital or home setting, even in a developing nation such as Sri Lanka. Follow-up of this cohort will include developmental assessments, which will add to the growing literature relating early electrophysiology to developmental outcome.

Journal of the College of Community Physicians of Sri Lanka, 2021

Introduction: Clinical evidence suggests that hamstring tightness influences lumbar pelvic rhythm... more Introduction: Clinical evidence suggests that hamstring tightness influences lumbar pelvic rhythm and shortened hamstring increase the risk of injury to the spine. Objectives: To determine the association of hamstring tightness with pelvic tilt in standing position, trunk, and lumbar range of motion during forward bending among sewing machine operators Methods: A descriptive cross-sectional study was conducted among 169 sewing machine operators aged 18-55 years using passive knee extension test, tri-goniometric method, finger to floor test and modified Schober test to measure hamstring tightness, pelvic tilt, trunk flexion and lumbar flexion, respectively. Results: A weak negative correlation between hamstring tightness and lumbar range of motion during forward bending (r=-0.28; p=0.001). A significant association between trunk flexion and hamstring tightness (r=0.47; p=0.001). Conclusions & Recommendations: Hamstring tightness affects the lumbar and trunk range of motion during forward bending.

Ceylon Journal of Medical Science

Background: Hamstring is a key component of flexibility in the human body and it is more prone to... more Background: Hamstring is a key component of flexibility in the human body and it is more prone to get tightened. Inability to achieve greater than 160 degrees of knee extension when the hip is flexed to 90 degrees is considered as hamstring tightness. Objectives: This study aims to find the prevalence of hamstring tightness among sewing machine operators and to assess the association of hamstring tightness with prolonged sitting, body mass index, physical activity level and gender. Method: A descriptive cross sectional study was carried out among 169 sewing machine operators aged between 18-60 years of a selected garment factory. Passive knee extension (PKE) test was used to measure the hamstring tightness among sewing machine operators. A validated interviewer administered questionnaire was used to determine the physical activity level among the participants. Results: Prevalence of hamstring tightness among sewing machine operators is 83.4% (n=141) and it is higher in males (91.8%) than females (78.7%). There was a significant association between prolonged sitting and hamstring tightness in the dominant limb (p=0.02, chi square = 7.79). Significant associations were not found between hamstring tightness with the BMI level (p=0.46, r=-0.05) and physical activity (p=0.41, r=-0.06). Conclusion: Majority of the sewing machine operators have hamstring tightness. Prolonged sitting is a contributory factor in hamstring muscle tightness.

Ceylon Journal of Medical Science, Feb 10, 2020

Background: Hamstring is a key component of flexibility in the human body and it is more prone to... more Background: Hamstring is a key component of flexibility in the human body and it is more prone to get tightened. Inability to achieve greater than 160 degrees of knee extension when the hip is flexed to 90 degrees is considered as hamstring tightness. Objectives: This study aims to find the prevalence of hamstring tightness among sewing machine operators and to assess the association of hamstring tightness with prolonged sitting, body mass index, physical activity level and gender. Method: A descriptive cross sectional study was carried out among 169 sewing machine operators aged between 18-60 years of a selected garment factory. Passive knee extension (PKE) test was used to measure the hamstring tightness among sewing machine operators. A validated interviewer administered questionnaire was used to determine the physical activity level among the participants. Results: Prevalence of hamstring tightness among sewing machine operators is 83.4% (n=141) and it is higher in males (91.8%) than females (78.7%). There was a significant association between prolonged sitting and hamstring tightness in the dominant limb (p=0.02, chi square = 7.79). Significant associations were not found between hamstring tightness with the BMI level (p=0.46, r=-0.05) and physical activity (p=0.41, r=-0.06). Conclusion: Majority of the sewing machine operators have hamstring tightness. Prolonged sitting is a contributory factor in hamstring muscle tightness.