Ibrahim I S Y A K U Muhammad (original) (raw)

Papers by Ibrahim I S Y A K U Muhammad

Open Science Publisher , 2024

The present study aimed to analyze the artemisinin content in various extracts of Artemisia annua... more The present study aimed to analyze the artemisinin content in various extracts of Artemisia annua L. using a validated HPTLC densitometry method and evaluate the inhibitory activity of artemisinin against serine hydroxyl methyltransferase (SHMT) of Plasmodium falciparum using in silico approach. High performance thin layer chromatography revealed that the petroleum ether extract of A. annua had the highest artemisinin content (0.71% ± 0.02 w/w), methanol extract (0.25% ± 0.02 w/w), chloroform extract (0.14% ± 0.01 w/w), and water extract (0.06% ± 0.01 w/w). Densitometry result indicated a well-defined and symmetrical peak in the petroleum ether extract, indicating excellent separation of high-purity artemisinin. In silico study of artemisinin with SHMT enzyme portrayed an excellent binding affinity (-9.1 kcal/mol) and convenient interactions compared with control. Moreover, both artemisinin and control compound showed good absorption, distribution, metabolism, excretion and toxicity properties. In conclusion, the study suggested that the petroleum ether extract of A. annua is the most suitable and efficient solvent for extracting highquantity artemisinin. The findings of the molecular docking analysis further supported the potential inhibitory activity of artemisinin against the SHTM of P. falciparum. This research contributes to the understanding of artemisinin's antimalarial properties and optimized method of its production efficiently.

Asian Journal of Empirical Research, 2020

This paper aims to establish the effect of capital structure on the firm value of fourteen (14) q... more This paper aims to establish the effect of capital structure on the firm value of fourteen (14) quoted industrial goods companies operating in Nigeria for ten years (2008 to 2017). Data were obtained from the annual reports and accounts of the sampled firms. The indicators for capital structure comprises of long term and short term debt, while proxies for firm value include return on equity and share price. Multiple regressions were used to analyze the data. Long-term debt appeared negative and significant, with a return on equity. Like previous studies, value seems to be enhanced when industrial goods companies employ more internal funding, short term debt than long term debt. Regarding the share price, short-term debt significantly increases share price. However, long-term debt does not impact the share price of listed industrial goods companies in Nigeria. This paper recommends that management and board of directors should ensure the optimum level of financing mix in their composition of capital that enhances their business worth, particularly by minimising long-term loans. Contribution/ Originality This study is an extension of previous research, where capital structure components are considered to examine their effect on return on equity and share price of listed industrial goods companies in Nigeria. A review of prior studies proves a dearth of literature in the Nigerian industrial goods industry despite their immense contribution to the economy. Therefore, this paper seeks to capture the value of industrial companies with regards to its capital composition due to its fundamental contribution to a large sector like manufacturing in Nigeria.

AkiNik, 2023

A field study was conducted at the Botanical Garden of the Biological Sciences Department, Federa... more A field study was conducted at the Botanical Garden of the Biological Sciences Department, Federal University Dutse, to assess the impact of varying concentrations of single super phosphate fertilizer on Groundnut (Arachis hypogea L.). The study included four treatment levels of single super phosphate: 0 g P/polythene bag (SSP1), 2.0 g P/polythene bag (SSP2), 4.0 g P/polythene bag (SSP3), and 6.0 g P/polythene bag (SSP4). The experiment followed a randomized complete design (RCD) with five replications. The results of the field study demonstrated that groundnut responded positively to all levels of single super phosphate fertilizer, and these responses were statistically significant (p<0.05) for all the recorded parameters. As the concentration of phosphate fertilizer increased, there was a corresponding increase in growth parameters, including fresh and dry weight, number of leaves, number of branches, number of flowers, and plant height. Notably, at 3, 4, and 5 weeks after planting (WAP), the values for plant height, number of leaves, branches, flowers, fresh and dry weight obtained in SSP2, SSP3 and SSP4 were significantly better than the control group (SSP1), which as depicted in table 3, 4, 5, 6, 7 and 8 respectively. However, SSP4 recorded the highest value for all the assessed parameters, which were significantly different from the control treatment. In conclusion, the study suggests that a single super phosphate fertilizer at a rate of 6.0 g/polythene bag is suitable for promoting the vegetative growth of Groundnut in the study area. This fertilizer concentration led to significant improvements in plant height, number of leaves, and number of branches, which are important indicators of plant health and productivity.

International Journal of Plant Pathology and Microbiology, 2023

Alstonia scholaris R. Br. is commonly known as saitan ka jhad in Hindi belongs to the family Apoc... more Alstonia scholaris R. Br. is commonly known as saitan ka jhad in Hindi belongs to the family Apocynaceae, is a classy and graceful evergreen tall tree grows up to 25m high which widely used as medicine and served as an important shade tree. Gall formation induced by psyllid herbivory Pauropsylla tuberculata, Crawf is of growing concern in A. Scholaris leaves infested with this insect developed an outgrowth called galls with change the leaf structure and alter physiological processes in the affected plant. A survey was conducted at Mewar University Rajasthan India Campus to access the incidence and severity from May to July 2020 and to study the total chlorophyll content and phenolic compound in the gall-infested leaves and uninfected viz (fresh leave, young gall, mature gall, and perforated gall) research survey depicted that incidence and severity of galls increase from May to July 2020 this is due to the onset of rainfall start in mid-June and gall require wet and warm temperature, activity of total chlorophyll were found to exhibit strong negative correlation with phenolic compound at different stages of gall development. The finding of this research can be enough to suggest that rainfall coupled with high-temperature increases galls incidence and severity and phenolic compound acts as a biochemical marker for foliar galls resistance in devil tree Alstonia scholaris.

International Journal of Botany studies, 2023

The roots and leaves of Annona senegalensis Pers were subjected to proximate and phytochemical an... more The roots and leaves of Annona senegalensis Pers were subjected to proximate and phytochemical analysis following the standard methods by Association of Official Analytical Chemists' (AOAC). The results of the proximate composition revealed that the root extracts contained 35.03% moisture, 5.77% ash, 23.13% lipids, 13.03% crude fiber, 7.67% crude protein, and 15.37% carbohydrate content. On the other hand, the leaf extracts contained 30.17% moisture, 6.73% ash, 7.67% lipids, 12.10% crude fiber, 21.87% crude protein, and 21.46% carbohydrate content. The phytochemicals detected in the root extracts were tannins, alkaloids, balsams, saponins, steroids, anthraquinones, carbohydrates, and terpenes, whereas flavonoids and cardiac glycosides were not detected. The leaf extracts contained tannins, alkaloids, saponins, steroids, carbohydrates, and terpenes. Cardiac glycoside was not detected in both the root and leaf extracts. Based on the results of this study, it is recommended that, GC-MS analysis should be carry out to determine and identify the total number of bioactive compounds in the root and leaf. The antimicrobial, antioxidant, and cytotoxicity study should be carry out to evaluate the antimicrobial efficacy as well as the toxicity of Annona senegalensis Pers.

International Journal of Botany studies , 2023

Zea mays, commonly known as maize or corn, are a widely consumed staple crop with significant nut... more Zea mays, commonly known as maize or corn, are a widely consumed staple crop with significant nutritional value. The proximate compositions of the seeds of the local maize variety (Hakorin Hajiya), the improved varieties of white maize (Sammaz14) and golden strawberry maize were analyzed in this study. The seed samples were dried on a clean tray and ground into powder for nutritional and mineral analysis using standard methods. The improved variety of white maize (Sammaz 14) was found to have higher percentage values of crude fat (0.22%), crude moisture (8%), crude protein (7.5%), sodium (42.5 mg/kg), potassium (140mg/kg), calcium (0.9 mg/kg), and magnesium (0.35 mg/kg). However, the local variety (Hakorin Hajiya) had higher crude ash (4%), fiber (0.07%). Golden strawberry maize had the highest carbohydrate (94.67%). This indicates that the seeds of the improved variety (Sammaz14) of white maize have higher nutritional value and can be used to supplement staple foods in both rural and urban areas. Additionally, individuals with hypoglycemia are advised to consume strawberry maize due to its high carbohydrate content. Overall, this study highlights the nutritional variations among different maize varieties and suggests the potential benefits of incorporating the improved variety of white maize (Sammaz 14) into diets to enhance nutritional intake.

International Journal of Botany Studies, 2021

Vitamin B6 act as a versatile cofactor for many enzymes catalyzing important biochemical reaction... more Vitamin B6 act as a versatile cofactor for many enzymes catalyzing important biochemical reactions, it has also been shown to function as a potent antioxidant molecule.B6 Vitamers is essential for plant development and their metabolism by modulating the endogenous phytohormone production, such as auxin (IAA). The recent explanation of the vitamin B6 biosynthesis pathways in plants provides opportunities for characterizing their importance during developmental processes and contact to stress. In plants, vitamin B6 are biosynthesized through salvage pathway is very similar to the bacterial variant. Pyridoxine, pyridoxal and pyridoxamine are inactive forms of vitamin B6 by the process of phosphorylation converted to active coenzymes forms pyridoxine 5' phosphate (PNP) Pyridoxal 5' phosphate (PLP) and pyridoxamine 5' phosphate (PMP) respectively. This research was performed on different varieties (Azam & Jalal) of Zea mays to check the natural variation response of various Zea mays varieties (Azam & Jalal) for efficacy of exogenously supplied pyridoxine-HCl to induce endogenous (IAA) production for growth promotion. Moreover, it is revealed that increased level of pyridoxine-HCl in Zea mays varieties (Azam & Jalal), differentially promoted the (IAA) level in plants in comparison to control. This research demonstrates an important link between vitamin B6 homeostasis and (IAA) biosynthesis in Zea mays.

The aim of this research study was to analyze qualitatively and quantitatively Proximate and Phyt... more The aim of this research study was to analyze qualitatively and quantitatively Proximate and Phytochemical composition of Aloe barbadensis. The Proximate composition involves the moisture content, crude protein, crude fibre, crude fat, ash content and carbohydrate.

AsianJournalofPharmaceuticalAnalysis and MedicinalChemistry, 2021

INTRODUCTION Coronaviruses are a type of RNA viruses that causes respiratory, intestinal and urog... more INTRODUCTION Coronaviruses are a type of RNA viruses that causes respiratory, intestinal and urogenital tract infection in birds and mammals. These SARS-CoV-2 contains positive-sense non segmented single-stranded RNA that are member of family Coronaviridae, subfamily ABSTRACT Coronaviruses are one of the transmissible viruses that are mostly reliable for respiratory, intestinal and urogenital tract infections. Various researchers demonstrated that the main protease (MPRO) protein might be an important drug target for SARS-CoV-2. The treatment of illnesses by the oral tradition have long been associated with Natural herbal remedies (NHRs). Modern medicine has potential effects, thanks to traditional medicine, the effectiveness of which derives from medicinal plants including with herbs and shrubs. Objective of this study is to confirm the ingredient of the natural origin compounds (NOCs) which have a potential of anti-viral effect (AVE) and can prevent the humans from SARS-CoV-2 infection. We are interested to figure out the interaction study between the molecules of natural origin compound and the protein of SARS-CoV-2 through molecular docking. The inhibition of Coronavirus (nCoV-2019) main protease enzyme is an important target of our study. All the compounds from Curcuma longa L. (Zingiberaceae family) had been screened for the inhibition of MPRO protein through in silico methods. From molecular docking report the results we obtained that is out of 235 molecules of natural origin the derivative of Curcumin are one of the best compounds determined through molecular docking and hydrogen bonding with interaction are proposed as the may be novel inhibitor for the SARS-CoV-2 main protease. We demonstrate using Swiss ADME online server tools that all sixteen molecules have better "drug-likeness" than control and does not violate any Ghose, Lipinski, Egan, Veber or Muegge rules. Importantly, all sixteen compounds may be more potent than chloroquine in treatment of COVID-19 according to Molecular docking, interactions and ADME Properties.

International journal of Botany studies, 2021

International Journal of Advanced Academic Research | Sciences, Technology and Engineering | ISSN: 2488-9849 Vol. 6, Issue 1 (January 2020), 2020

Books by Ibrahim I S Y A K U Muhammad

ONLINE EDUCATION DURING COVID-19 PERIODS, 2020

Online education is the use of information and communication technology (ICT) to enhance and/or ... more Online education is the use of information and communication technology (ICT) to
enhance and/or support learning. It is an approach to teaching and learning that
utilizes internet technologies to communicate and collaborate in an educational
context. This includes technology that supplements traditional classroom training
with web-based components and Learning environments where the educational
process is experienced online. The covid-19 pandemic has affected educational
systems worldwide, In an efforts to prevent the spread of covid-19 through nonpharmaceutical interventions and preventive measures such as social distancing
and self-isolation have prompted the widespread closure of primary, secondary and
tertiary schools all over the world leading to the near-total closures of schools,
universities and colleges worldwide. These nationwide closures are impacting over 72% of the world's student population. In response to school closures, UNESCO
recommended the use of distance learning programmes and open educational
applications and platforms that schools and teachers can use to reach learners
remotely and limit the disruption of education. Different countries worldwide have
introduced various solutions during the pandemic to continue the education
process. Online libraries, TV broadcasts, guidelines, resources, video lectures, online
channels were introduced. In response to the pandemic, many schools moved to
online distance learning via platforms like zoom. . However, several challenges were
reported during the application of online learning in the global wide according to
the literature. For example, Internet connection can be unreliable if there are
thousands of learners learning simultaneously, some instructors can find it difficult
to find online resources that are the most suitable in their teaching contexts, several
instructors and learners do not have the appropriate digital skills to teach and learn
online. This can make the online teaching/learning experience inconvenient for
them. Online learning is an excellent option in education, particularly when there
are hindrances to traditional learning. However some limitations are also noted that
should be considered in the future.