Itzhak Binderman - Academia.edu (original) (raw)
Papers by Itzhak Binderman
Bone and Mineral, Mar 1, 1989
we have demonstrated via marr"v atromat CEH Eld1"TC6 and the aaeoinductive rclpanm IO deminera. l... more we have demonstrated via marr"v atromat CEH Eld1"TC6 and the aaeoinductive rclpanm IO deminera. lized bone @tr (DSMj i.*, ,ilU cvr,icai bu.. &r&f in ,hc ovrrirtamized (CWX) ,a.t MueeLspostop) ispdmarilydue ,oimpaircdo~,eopraS~ni,orcellproliiera,ion. andthatdihydmtachy~tsrol (DHT) marmen, can be protective. In cultured marrow stromal cells from DVX rats. short-lem~ DHT-R, uaggera,ed the already subnormal pattern 01 ma,,ow stromal cell proliferation. However. in DBM grafts. DHT lrealmen, benefited the time-course of mcxnchymal cell DNAsyntheris asmsasurcd by triliated Ihymid,ne incorporation z!+ weagenic cell ma,u,a,irn as measured by alkaline phmphatase mncen,m,ian. and established a r"SSes,ive ,rcnd D ward normalizado" of bone forma,io~minera,iza,ion (24 h %a incorporation). The dam from this animal model infer that DHT could moderate the bone (OS normally ~fcn in ovarieclomized mavia an activation of the arfeapmgenitorcell population. Key wwdm Osreoinduaion; Bone morphogenetie protein; Deminerakzed bone; Dihydmrachywsrol; Alkaline phospharau; Ovaris,amy and cortical bone mass [I ,32.39].
Biochemical Journal, Apr 15, 1982
Several reports have appeared that suggest that 24,25-dihydroxycholecalciferol has a possible bio... more Several reports have appeared that suggest that 24,25-dihydroxycholecalciferol has a possible biological role in bone formation. We have utilized competition studies, saturation analysis, sucrose-density-gradient sedimentation and DEAE-cellulose chromatography to demonstrate that long bones of vitamin D-depleted newborn rats contain cytoplasmic and possibly nuclear receptors that bind 24,25-dihydroxycholecalciferol with specificity and high affinity (Kd = 1.79nM). Sucrose-densitygradient analysis of the cytoplasmic 24,25-dihydroxycholecalciferol-binding component showed a single binding macromolecule for 24,25-dihydroxycholecalciferol with a sedimentation coefficient of 3.1 S. DEAE-cellulose chromatography showed a [3H]24,25-dihydroxycholecalciferol-macromolecular complex that binds to DEAEcellulose and elutes between 0.15 and 0.21 M-KCI. The finding of 24,25-dihydroxycholecalciferol receptors in long bones of newborn rats suggests a possible involvement of 24,25-dihydroxycholecalciferol in the metabolism of developing skeletal tissues.
Calcified tissue research, Dec 1, 1976
The mode of transmission of mechanical stimuli into biochemical signals has intrigued research wo... more The mode of transmission of mechanical stimuli into biochemical signals has intrigued research workers for many years. Piatier-Piketty et al. [7], Rodan et al. [8], Davidowitch et al. [2] and Hong et al. [4] have described changes in cell membranes and in the amount of intracellular cyclic nucleotides [2, 7, 8] and of prostaglandins [4] produced by different forms of mechanical stress. The present paper reports evidence for the existence of a stimulus-receptor system in which a distortion of the cell membrane by mechanical perturbations initiates specific biochemical changes inside the cell. We have previously reported that cultured cells derived from the embryonal rat periosteum proliferate, differentiate, are metabolically active and retain their specific response to hormonal treatment. By using this system we were able to expose the cells to mechanical stress.
Brain & Development, 1985
Predictive estimates of future neurological maldevelopment as a result of vascular induced intrau... more Predictive estimates of future neurological maldevelopment as a result of vascular induced intrauterine injury are based on the assumption that the body is more affected than the brain resulting in asymmetrical intrauterine growth retarded (IUCR) newborns. The higher the brain:body ratio, the more severe the IUCR process and the greater the risk for the brain to be affected. This prompted us to study in human newborns, a cephalization index based on the ratio of head circumference to body weight to express the degree of brain maturity and possible vulnerability in relation to gestational age. The newborn cephalization index was correlated with neurodevelopment. A trend could be delineated; in the later gestational age, the higher the cephalization index reflecting a greater degree of brain vulnerability, the more severe the clinical pathology; especially the likelihood of cerebral palsy and severe psychomotor retardation. The cephalization index may serve as an additional screening device for high risk intrauterine growth retarded newborns.
Brain & Development, 1985
Vascular induced intrauterine growth retardation (IUGR) was achieved by total ligation of approxi... more Vascular induced intrauterine growth retardation (IUGR) was achieved by total ligation of approximately 30% of the placental vessels to half the fetuses in the last third of gestation in pregnant rabbits. A correlation between brain weight, body weight and head circumference was established in fetuses and rabbit pups in the perinatal period. The brain: body ratio in restricted IUGR animals was significantly higher than their homologous normal controls. A cephalization index based on the brain:body ratio is proposed to assess adverse effects on brain maturity in the presence of IUGR induced by placental insufficiency. Harel S, Yavin E, Tomer A, Barak Y, Binderman 1. Brain: body ratio and conceptional age in vascular-induced intrauterine growth retarded rabbits. Accumulation of clinical data in humans has strongly implicated an association between prolonged placental insufficiency from various causes and intrauterine growth retardation (IUGR) resulting in small-for-gestational age (SGA) newborns. Prenatal undernutrition has been extensively studied. Maternal dietary restriction has been shown to affect the brain growth of rats, guinea pigs and humans [I, 2]. Another approach to study this aspect of the problem in animals is to induce IUGR by uterine artery or placental vascular ligation and embolization. The classic work in this field was done by Wigglesworth [3] who experi-From the
Advances in Dental Research, Nov 1, 1995
Cambridge University Press eBooks, Apr 28, 1994
Journal of Dental Research, May 1, 1966
SYNOPSIS IN INTERLINGUA LE EFFECTO DE FLUORURO SUPER HYPERVITAMINOSIS D IN RATTOS.-Esseva usate r... more SYNOPSIS IN INTERLINGUA LE EFFECTO DE FLUORURO SUPER HYPERVITAMINOSIS D IN RATTOS.-Esseva usate rattos recipiente 0,2 mg de fluoruro per die (i.e., approximativemente le ingestion physiologic pro le ratto), rattos recipiente doses toxic de vitamina D, rattos recipiente vitamina D e fluoruro simultaneemente, e rattos de controlo. Esseva effectuate determinationes de calcium in le sero e le urina e del gravitate specific e del contento de cinere in le femure si ben como su contento de calcium. Le resultatos revelava que fluoruro age contra le syndrome de hypervitaminosis D per reducer usque ad valores quasi normal le concentrationes de calcium in le sero e le urina e etiam que illo preveni le resorption de osso. Es suggestionate que in hypervitaminosis D, le presentia de un augmentate concentration de iones de fluoruro in le liquidos del tissus induce un precipitation de fluoro-apatite.
Bone and Mineral, Apr 1, 1992
Journal of Dental Research, Sep 1, 1977
There have been numerous attempts to induce bone formation by dead bone, living bone or bone marr... more There have been numerous attempts to induce bone formation by dead bone, living bone or bone marrow tissue. Some of the positive results were interpreted as favoring the hypothesis that transformation of the surrounding connective tissue into bone is induced by osteogenic substances (AmITANI et al, GANN 66:327, 1975
Cardiovascular Revascularization Medicine, Apr 1, 2008
qualitative and quantitative techniques. Between January 1, 2003 and April 30, 2007, 175 patients... more qualitative and quantitative techniques. Between January 1, 2003 and April 30, 2007, 175 patients underwent PCI for STEMI with a high thrombus grade (TIMI grade ≥4). Fifty-three underwent RT followed by balloons or stents, and 122 underwent a nonthrombectomy approach (NRT). A comparative cohort of 223 patients with STEMI and a low thrombus grade (TIMI grade b4) underwent nonthrombectomy PCI. An angiographic adverse event was defined as the occurrence of no-reflow, slow flow, distal embolization, perforation, or abrupt closure. Results: Baseline clinical characteristics of the RTandNRT groups were similar. Table 1 shows the clinical and angiographic outcomes of the 3 study groups. Conclusion: (1) RT reduces the angiographic adverse event rates of highly thrombotic lesions in STEMI patients. (2) RT in such a high-risk group tended to be associated with a lower 30-day mortality. Further data analysis with additional patients is ongoing and will be announced at a later date.
Calcified tissue research, Dec 1, 1975
Conclusion Our data present evidence that in cultured bone cells 1) A rise of phosphate concent... more Conclusion Our data present evidence that in cultured bone cells 1) A rise of phosphate concentration in the medium and the subsequent rise of theintra cellular phosphate content stimulate calcium and phosphate uptake by bone cells and enhance the calcitonin effect, which seems to be dependent on the intracellular concentration of phosphate. 2) Calcitonin predominantly influences the intracellular shift of calcium.
Neonatology, 1988
Vascular placental insufficiency is considered a common pathogenic factor in human intrauterine g... more Vascular placental insufficiency is considered a common pathogenic factor in human intrauterine growth retardation. To mimic this condition, the rabbit, a ‘perinatal brain developer’ was utilized as an experimental model. Ischemic conditions were achieved by total ligation of approximately 30% of the uteroplacental vessels of half of the fetuses in each pregnant rabbit in the last third of gestation. The change in activity of the brain type isozyme of creatine kinase (CKBB), involved in energy regeneration and regulation, was assessed as a response marker to tissue ischemia in rabbit tissues: cerebellum, cerebrum, kidney, liver and placenta. A significant transient increase in CK-specific activity was found in the kidney and the cerebellum but not in the other organs tested, at 24 and 48 h after ligation. This increase was not seen with adenylate kinase, another enzyme involved in energy regeneration and regulation. It is proposed that an increase in CK-specific activity could serve as a metabolic marker of vascular insufficiency in rapidly developing tissues, representing part of a compensatory mechanism to overcome an energetic gap induced by ischemia.
The Journal of Clinical Endocrinology and Metabolism, Nov 1, 1986
We have used stimulation of the activity of the brain type creatine kinase (CK) isoenzyme as a re... more We have used stimulation of the activity of the brain type creatine kinase (CK) isoenzyme as a response marker to examine the effects of vitamin D metabolites, PTH, and calcitonin in cultured explants of placenta, decidua, and amnion from normal human deliveries. We found a biological response to PTH in placenta and amnion and to vitamin D metabolites in all three tissues. In the amnion, CK activity increased 2.3-fold after 24 h of incubation in 2.5 nM 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], 3.8-fold when incubated with 12.5 nM 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] and 2.7-fold when incubated with 10 U/ml bovine PTH. In the decidua, 24,25-(OH)2D3, but not 1,25-(OH)2D3 or bPTH caused a 1.7-fold increase in CK activity. In contrast, the placenta responded to 1,25-(OH)2D3 with a 1.6-fold increase in CK activity and to bPTH, with a 1.7-fold increase but did not respond to 24,25-(OH)2D3. Bovine calcitonin (100 ng/ml) had no effect on CK activity in any of the three tissues. Nearly all CK in both the unstimulated and stimulated explants was the brain type isoenzyme. CK activity increased significantly between 1 and 4 h after hormonal treatment in all experiments. The enzyme activity rose steeply with dose and reached a significant increase, and usually a plateau, at hormone concentrations considered to be physiological in vivo. [3H]Thymidine incorporation into DNA increased in parallel to stimulation of CK activity in all experiments, except that PTH did not increase DNA synthesis in the placenta. PTH did cause an increase in cAMP production in explants of amnion (1.5-fold) and placenta (2.6-fold).
PubMed, Apr 1, 1985
We evaluated the dental status of thirty children with chronic renal failure (CRF): 15 managed co... more We evaluated the dental status of thirty children with chronic renal failure (CRF): 15 managed conservatively, 9 on dialysis replacement therapy and 6 after kidney transplant. Dental age was delayed, but to a lesser extent than bone age; this delay was most marked where CRF occurred before 7 years of age. Eruption age was only minimally delayed. Eighteen patients (60%) showed enamel defects, mainly hypoplasia, the location of which was related to the age at which major metabolic changes of uremia appeared. In 9 children (30%) there was intrinsic discoloration of the teeth--this was also related to the severity and duration of CRF. Compared to normal Israeli children our patients showed poor oral hygiene and gingival condition, but a significantly lower prevalence of caries. Seven patients (23%) showed mild radiologic changes in the jawbones (mainly loss of lamina dura), the severity of which was related to the severity and duration of CRF. None of the above findings could be related to specific metabolic disturbances.
Journal of Clinical Periodontology
Bone and Mineral, Mar 1, 1989
we have demonstrated via marr"v atromat CEH Eld1"TC6 and the aaeoinductive rclpanm IO deminera. l... more we have demonstrated via marr"v atromat CEH Eld1"TC6 and the aaeoinductive rclpanm IO deminera. lized bone @tr (DSMj i.*, ,ilU cvr,icai bu.. &r&f in ,hc ovrrirtamized (CWX) ,a.t MueeLspostop) ispdmarilydue ,oimpaircdo~,eopraS~ni,orcellproliiera,ion. andthatdihydmtachy~tsrol (DHT) marmen, can be protective. In cultured marrow stromal cells from DVX rats. short-lem~ DHT-R, uaggera,ed the already subnormal pattern 01 ma,,ow stromal cell proliferation. However. in DBM grafts. DHT lrealmen, benefited the time-course of mcxnchymal cell DNAsyntheris asmsasurcd by triliated Ihymid,ne incorporation z!+ weagenic cell ma,u,a,irn as measured by alkaline phmphatase mncen,m,ian. and established a r"SSes,ive ,rcnd D ward normalizado" of bone forma,io~minera,iza,ion (24 h %a incorporation). The dam from this animal model infer that DHT could moderate the bone (OS normally ~fcn in ovarieclomized mavia an activation of the arfeapmgenitorcell population. Key wwdm Osreoinduaion; Bone morphogenetie protein; Deminerakzed bone; Dihydmrachywsrol; Alkaline phospharau; Ovaris,amy and cortical bone mass [I ,32.39].
Biochemical Journal, Apr 15, 1982
Several reports have appeared that suggest that 24,25-dihydroxycholecalciferol has a possible bio... more Several reports have appeared that suggest that 24,25-dihydroxycholecalciferol has a possible biological role in bone formation. We have utilized competition studies, saturation analysis, sucrose-density-gradient sedimentation and DEAE-cellulose chromatography to demonstrate that long bones of vitamin D-depleted newborn rats contain cytoplasmic and possibly nuclear receptors that bind 24,25-dihydroxycholecalciferol with specificity and high affinity (Kd = 1.79nM). Sucrose-densitygradient analysis of the cytoplasmic 24,25-dihydroxycholecalciferol-binding component showed a single binding macromolecule for 24,25-dihydroxycholecalciferol with a sedimentation coefficient of 3.1 S. DEAE-cellulose chromatography showed a [3H]24,25-dihydroxycholecalciferol-macromolecular complex that binds to DEAEcellulose and elutes between 0.15 and 0.21 M-KCI. The finding of 24,25-dihydroxycholecalciferol receptors in long bones of newborn rats suggests a possible involvement of 24,25-dihydroxycholecalciferol in the metabolism of developing skeletal tissues.
Calcified tissue research, Dec 1, 1976
The mode of transmission of mechanical stimuli into biochemical signals has intrigued research wo... more The mode of transmission of mechanical stimuli into biochemical signals has intrigued research workers for many years. Piatier-Piketty et al. [7], Rodan et al. [8], Davidowitch et al. [2] and Hong et al. [4] have described changes in cell membranes and in the amount of intracellular cyclic nucleotides [2, 7, 8] and of prostaglandins [4] produced by different forms of mechanical stress. The present paper reports evidence for the existence of a stimulus-receptor system in which a distortion of the cell membrane by mechanical perturbations initiates specific biochemical changes inside the cell. We have previously reported that cultured cells derived from the embryonal rat periosteum proliferate, differentiate, are metabolically active and retain their specific response to hormonal treatment. By using this system we were able to expose the cells to mechanical stress.
Brain & Development, 1985
Predictive estimates of future neurological maldevelopment as a result of vascular induced intrau... more Predictive estimates of future neurological maldevelopment as a result of vascular induced intrauterine injury are based on the assumption that the body is more affected than the brain resulting in asymmetrical intrauterine growth retarded (IUCR) newborns. The higher the brain:body ratio, the more severe the IUCR process and the greater the risk for the brain to be affected. This prompted us to study in human newborns, a cephalization index based on the ratio of head circumference to body weight to express the degree of brain maturity and possible vulnerability in relation to gestational age. The newborn cephalization index was correlated with neurodevelopment. A trend could be delineated; in the later gestational age, the higher the cephalization index reflecting a greater degree of brain vulnerability, the more severe the clinical pathology; especially the likelihood of cerebral palsy and severe psychomotor retardation. The cephalization index may serve as an additional screening device for high risk intrauterine growth retarded newborns.
Brain & Development, 1985
Vascular induced intrauterine growth retardation (IUGR) was achieved by total ligation of approxi... more Vascular induced intrauterine growth retardation (IUGR) was achieved by total ligation of approximately 30% of the placental vessels to half the fetuses in the last third of gestation in pregnant rabbits. A correlation between brain weight, body weight and head circumference was established in fetuses and rabbit pups in the perinatal period. The brain: body ratio in restricted IUGR animals was significantly higher than their homologous normal controls. A cephalization index based on the brain:body ratio is proposed to assess adverse effects on brain maturity in the presence of IUGR induced by placental insufficiency. Harel S, Yavin E, Tomer A, Barak Y, Binderman 1. Brain: body ratio and conceptional age in vascular-induced intrauterine growth retarded rabbits. Accumulation of clinical data in humans has strongly implicated an association between prolonged placental insufficiency from various causes and intrauterine growth retardation (IUGR) resulting in small-for-gestational age (SGA) newborns. Prenatal undernutrition has been extensively studied. Maternal dietary restriction has been shown to affect the brain growth of rats, guinea pigs and humans [I, 2]. Another approach to study this aspect of the problem in animals is to induce IUGR by uterine artery or placental vascular ligation and embolization. The classic work in this field was done by Wigglesworth [3] who experi-From the
Advances in Dental Research, Nov 1, 1995
Cambridge University Press eBooks, Apr 28, 1994
Journal of Dental Research, May 1, 1966
SYNOPSIS IN INTERLINGUA LE EFFECTO DE FLUORURO SUPER HYPERVITAMINOSIS D IN RATTOS.-Esseva usate r... more SYNOPSIS IN INTERLINGUA LE EFFECTO DE FLUORURO SUPER HYPERVITAMINOSIS D IN RATTOS.-Esseva usate rattos recipiente 0,2 mg de fluoruro per die (i.e., approximativemente le ingestion physiologic pro le ratto), rattos recipiente doses toxic de vitamina D, rattos recipiente vitamina D e fluoruro simultaneemente, e rattos de controlo. Esseva effectuate determinationes de calcium in le sero e le urina e del gravitate specific e del contento de cinere in le femure si ben como su contento de calcium. Le resultatos revelava que fluoruro age contra le syndrome de hypervitaminosis D per reducer usque ad valores quasi normal le concentrationes de calcium in le sero e le urina e etiam que illo preveni le resorption de osso. Es suggestionate que in hypervitaminosis D, le presentia de un augmentate concentration de iones de fluoruro in le liquidos del tissus induce un precipitation de fluoro-apatite.
Bone and Mineral, Apr 1, 1992
Journal of Dental Research, Sep 1, 1977
There have been numerous attempts to induce bone formation by dead bone, living bone or bone marr... more There have been numerous attempts to induce bone formation by dead bone, living bone or bone marrow tissue. Some of the positive results were interpreted as favoring the hypothesis that transformation of the surrounding connective tissue into bone is induced by osteogenic substances (AmITANI et al, GANN 66:327, 1975
Cardiovascular Revascularization Medicine, Apr 1, 2008
qualitative and quantitative techniques. Between January 1, 2003 and April 30, 2007, 175 patients... more qualitative and quantitative techniques. Between January 1, 2003 and April 30, 2007, 175 patients underwent PCI for STEMI with a high thrombus grade (TIMI grade ≥4). Fifty-three underwent RT followed by balloons or stents, and 122 underwent a nonthrombectomy approach (NRT). A comparative cohort of 223 patients with STEMI and a low thrombus grade (TIMI grade b4) underwent nonthrombectomy PCI. An angiographic adverse event was defined as the occurrence of no-reflow, slow flow, distal embolization, perforation, or abrupt closure. Results: Baseline clinical characteristics of the RTandNRT groups were similar. Table 1 shows the clinical and angiographic outcomes of the 3 study groups. Conclusion: (1) RT reduces the angiographic adverse event rates of highly thrombotic lesions in STEMI patients. (2) RT in such a high-risk group tended to be associated with a lower 30-day mortality. Further data analysis with additional patients is ongoing and will be announced at a later date.
Calcified tissue research, Dec 1, 1975
Conclusion Our data present evidence that in cultured bone cells 1) A rise of phosphate concent... more Conclusion Our data present evidence that in cultured bone cells 1) A rise of phosphate concentration in the medium and the subsequent rise of theintra cellular phosphate content stimulate calcium and phosphate uptake by bone cells and enhance the calcitonin effect, which seems to be dependent on the intracellular concentration of phosphate. 2) Calcitonin predominantly influences the intracellular shift of calcium.
Neonatology, 1988
Vascular placental insufficiency is considered a common pathogenic factor in human intrauterine g... more Vascular placental insufficiency is considered a common pathogenic factor in human intrauterine growth retardation. To mimic this condition, the rabbit, a ‘perinatal brain developer’ was utilized as an experimental model. Ischemic conditions were achieved by total ligation of approximately 30% of the uteroplacental vessels of half of the fetuses in each pregnant rabbit in the last third of gestation. The change in activity of the brain type isozyme of creatine kinase (CKBB), involved in energy regeneration and regulation, was assessed as a response marker to tissue ischemia in rabbit tissues: cerebellum, cerebrum, kidney, liver and placenta. A significant transient increase in CK-specific activity was found in the kidney and the cerebellum but not in the other organs tested, at 24 and 48 h after ligation. This increase was not seen with adenylate kinase, another enzyme involved in energy regeneration and regulation. It is proposed that an increase in CK-specific activity could serve as a metabolic marker of vascular insufficiency in rapidly developing tissues, representing part of a compensatory mechanism to overcome an energetic gap induced by ischemia.
The Journal of Clinical Endocrinology and Metabolism, Nov 1, 1986
We have used stimulation of the activity of the brain type creatine kinase (CK) isoenzyme as a re... more We have used stimulation of the activity of the brain type creatine kinase (CK) isoenzyme as a response marker to examine the effects of vitamin D metabolites, PTH, and calcitonin in cultured explants of placenta, decidua, and amnion from normal human deliveries. We found a biological response to PTH in placenta and amnion and to vitamin D metabolites in all three tissues. In the amnion, CK activity increased 2.3-fold after 24 h of incubation in 2.5 nM 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], 3.8-fold when incubated with 12.5 nM 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] and 2.7-fold when incubated with 10 U/ml bovine PTH. In the decidua, 24,25-(OH)2D3, but not 1,25-(OH)2D3 or bPTH caused a 1.7-fold increase in CK activity. In contrast, the placenta responded to 1,25-(OH)2D3 with a 1.6-fold increase in CK activity and to bPTH, with a 1.7-fold increase but did not respond to 24,25-(OH)2D3. Bovine calcitonin (100 ng/ml) had no effect on CK activity in any of the three tissues. Nearly all CK in both the unstimulated and stimulated explants was the brain type isoenzyme. CK activity increased significantly between 1 and 4 h after hormonal treatment in all experiments. The enzyme activity rose steeply with dose and reached a significant increase, and usually a plateau, at hormone concentrations considered to be physiological in vivo. [3H]Thymidine incorporation into DNA increased in parallel to stimulation of CK activity in all experiments, except that PTH did not increase DNA synthesis in the placenta. PTH did cause an increase in cAMP production in explants of amnion (1.5-fold) and placenta (2.6-fold).
PubMed, Apr 1, 1985
We evaluated the dental status of thirty children with chronic renal failure (CRF): 15 managed co... more We evaluated the dental status of thirty children with chronic renal failure (CRF): 15 managed conservatively, 9 on dialysis replacement therapy and 6 after kidney transplant. Dental age was delayed, but to a lesser extent than bone age; this delay was most marked where CRF occurred before 7 years of age. Eruption age was only minimally delayed. Eighteen patients (60%) showed enamel defects, mainly hypoplasia, the location of which was related to the age at which major metabolic changes of uremia appeared. In 9 children (30%) there was intrinsic discoloration of the teeth--this was also related to the severity and duration of CRF. Compared to normal Israeli children our patients showed poor oral hygiene and gingival condition, but a significantly lower prevalence of caries. Seven patients (23%) showed mild radiologic changes in the jawbones (mainly loss of lamina dura), the severity of which was related to the severity and duration of CRF. None of the above findings could be related to specific metabolic disturbances.
Journal of Clinical Periodontology