Iván Rodríguez - Academia.edu (original) (raw)
Papers by Iván Rodríguez
International Journal of Simulation and Process Modelling, 2011
Since the early 90s, when it was first released, Java has become one of the most widespread progr... more Since the early 90s, when it was first released, Java has become one of the most widespread programming languages. Discrete Event Simulation and also Parallel Discrete Event Simulation have attracted more and more projects which are Java-based. This paper presents a brief survey on the tools and facilities that make Java such an attractive option for parallel simulation developers. Nevertheless, several drawbacks and lacks of the language are also exposed.
Implementation Science, 2015
Background: Type 2 diabetes mellitus is a chronic disease whose health outcomes are related to pa... more Background: Type 2 diabetes mellitus is a chronic disease whose health outcomes are related to patients and healthcare professionals' decision-making. The Diabetes Intervention study in the Canary Islands (INDICA study) aims to evaluate the effectiveness and cost-effectiveness of educational interventions supported by new technology decision tools for type 2 diabetes patients and primary care professionals in the Canary Islands. Methods/design: The INDICA study is an open, community-based, multicenter, clinical controlled trial with random allocation by clusters to one of three interventions or to usual care. The setting is primary care where physicians and nurses are invited to participate. Patients with diabetes diagnosis, 18-65 years of age, and regular users of mobile phone were randomly selected. Patients with severe comorbidities were excluded. The clusters are primary healthcare practices with enough professionals and available places to provide the intervention. The calculated sample size was 2,300 patients. Patients in group 1 are receiving an educational group program of eight sessions every 3 months led by trained nurses and monitored by means of logs and a web-based platform and tailored semi-automated SMS for continuous support. Primary care professionals in group 2 are receiving a short educational program to update their diabetes knowledge, which includes a decision support tool embedded into the electronic clinical record and a monthly feedback report of patients' results. Group 3 is receiving a combination of the interventions for patients and professionals. The primary endpoint is the change in HbA1c in 2 years. Secondary endpoints are cardiovascular risk factors, macrovascular and microvascular diabetes complications, quality of life, psychological outcomes, diabetes knowledge, and healthcare utilization. Data is being collected from interviews, questionnaires, clinical examinations, and records. Generalized linear mixed models with repeated time measurements will be used to analyze changes in outcomes. The cost-effectiveness analysis, from the healthcare services perspective, involves direct medical costs per quality-adjusted life year gained and two periods, a 'within-trial' period and a lifetime Markov model. Deterministic and probabilistic sensitivity analyses are planned.
Journal of Alzheimer's disease : JAD, 2014
The use of cerebrospinal fluid (CSF) biomarkers could facilitate early detection of Alzheimer'... more The use of cerebrospinal fluid (CSF) biomarkers could facilitate early detection of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) and the differential diagnosis between AD and non-AD dementias. To determine the cost-effectiveness of the use of amyloid-β peptide (Aβ42), total tau and phosphorylated tau proteins in CSF to diagnose AD in MCI and dementia patients. An economic evaluation was performed by means of cost-effectiveness analysis comparing two AD diagnostic alternatives: the combined determination of Aβ42 proteins, total tau and phosphorylated tau in CSF as biomarkers of AD, and the standard clinical diagnosis based on the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINDS-ADRDA) criteria. A decision analytic model was developed to synthesize the identified evidence and to compare the costs and effectiveness associated with each diagnostic strategy. ...
Simulation-Based Case Studies in Logistics, 2009
Page 1. 65 Y. Merkuryev et al. (eds.), Simulation-Based Case Studies in Logistics © Springer 2009... more Page 1. 65 Y. Merkuryev et al. (eds.), Simulation-Based Case Studies in Logistics © Springer 2009 Abstract In this study, a discrete-event simulation conceptual model and a set of simulation models have been developed for ...
PEDIATRICS, 2015
BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase defi... more BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase deficiency (BD) ought to be incorporated into universal newborn screening (NBS) programs. The aim of this study was to evaluate the cost-effectiveness of adding BD to the panel of conditions currently screened under the national NBS program in Spain.
International Journal of Simulation and Process Modelling, 2011
Since the early 90s, when it was first released, Java has become one of the most widespread progr... more Since the early 90s, when it was first released, Java has become one of the most widespread programming languages. Discrete Event Simulation and also Parallel Discrete Event Simulation have attracted more and more projects which are Java-based. This paper presents a brief survey on the tools and facilities that make Java such an attractive option for parallel simulation developers. Nevertheless, several drawbacks and lacks of the language are also exposed.
Implementation Science, 2015
Background: Type 2 diabetes mellitus is a chronic disease whose health outcomes are related to pa... more Background: Type 2 diabetes mellitus is a chronic disease whose health outcomes are related to patients and healthcare professionals' decision-making. The Diabetes Intervention study in the Canary Islands (INDICA study) aims to evaluate the effectiveness and cost-effectiveness of educational interventions supported by new technology decision tools for type 2 diabetes patients and primary care professionals in the Canary Islands. Methods/design: The INDICA study is an open, community-based, multicenter, clinical controlled trial with random allocation by clusters to one of three interventions or to usual care. The setting is primary care where physicians and nurses are invited to participate. Patients with diabetes diagnosis, 18-65 years of age, and regular users of mobile phone were randomly selected. Patients with severe comorbidities were excluded. The clusters are primary healthcare practices with enough professionals and available places to provide the intervention. The calculated sample size was 2,300 patients. Patients in group 1 are receiving an educational group program of eight sessions every 3 months led by trained nurses and monitored by means of logs and a web-based platform and tailored semi-automated SMS for continuous support. Primary care professionals in group 2 are receiving a short educational program to update their diabetes knowledge, which includes a decision support tool embedded into the electronic clinical record and a monthly feedback report of patients' results. Group 3 is receiving a combination of the interventions for patients and professionals. The primary endpoint is the change in HbA1c in 2 years. Secondary endpoints are cardiovascular risk factors, macrovascular and microvascular diabetes complications, quality of life, psychological outcomes, diabetes knowledge, and healthcare utilization. Data is being collected from interviews, questionnaires, clinical examinations, and records. Generalized linear mixed models with repeated time measurements will be used to analyze changes in outcomes. The cost-effectiveness analysis, from the healthcare services perspective, involves direct medical costs per quality-adjusted life year gained and two periods, a 'within-trial' period and a lifetime Markov model. Deterministic and probabilistic sensitivity analyses are planned.
Journal of Alzheimer's disease : JAD, 2014
The use of cerebrospinal fluid (CSF) biomarkers could facilitate early detection of Alzheimer'... more The use of cerebrospinal fluid (CSF) biomarkers could facilitate early detection of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) and the differential diagnosis between AD and non-AD dementias. To determine the cost-effectiveness of the use of amyloid-β peptide (Aβ42), total tau and phosphorylated tau proteins in CSF to diagnose AD in MCI and dementia patients. An economic evaluation was performed by means of cost-effectiveness analysis comparing two AD diagnostic alternatives: the combined determination of Aβ42 proteins, total tau and phosphorylated tau in CSF as biomarkers of AD, and the standard clinical diagnosis based on the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINDS-ADRDA) criteria. A decision analytic model was developed to synthesize the identified evidence and to compare the costs and effectiveness associated with each diagnostic strategy. ...
Simulation-Based Case Studies in Logistics, 2009
Page 1. 65 Y. Merkuryev et al. (eds.), Simulation-Based Case Studies in Logistics © Springer 2009... more Page 1. 65 Y. Merkuryev et al. (eds.), Simulation-Based Case Studies in Logistics © Springer 2009 Abstract In this study, a discrete-event simulation conceptual model and a set of simulation models have been developed for ...
PEDIATRICS, 2015
BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase defi... more BACKGROUND AND OBJECTIVES: There are conflicting views as to whether testing for biotinidase deficiency (BD) ought to be incorporated into universal newborn screening (NBS) programs. The aim of this study was to evaluate the cost-effectiveness of adding BD to the panel of conditions currently screened under the national NBS program in Spain.