Ivana Tadic - Academia.edu (original) (raw)

Papers by Ivana Tadic

Value in Health, 2012

feasibility of combined neuroprotection in patients with AIS convincingly are substantiated by le... more feasibility of combined neuroprotection in patients with AIS convincingly are substantiated by leading Ukrainian neurologists. The aim is to evaluate the economic feasibility of combined regimens of neuroprotection compared with the traditional. METHODS: Analysis of the results of comparative clinical trial of three neuroprotective regimens therapy of patients with moderate and severe AIS: traditional ϩ citicoline (1 regimen); traditional ϩ citicoline ϩ actovegin (2 regimen); 3 regimen: traditional (pentoxifylline, heparin, acetylsalicylic acid, mannitol) (S. M. Vinychuk, O. A. Pustova, V.O. Mokchnach et al., 2008) was carried out. Cost-effectiveness analysis was used. Using a decision tree comparing the economic burden of the three regimens for one year was carried out. RESULTS: The number of patients who recovered completely after three months were used as efficacy. The efficacy for 1, 2 and 3 regimens were respectively 29.6%, 38.9% and 23.3%.

Intelligent Systems for Sustainable Person-Centered Healthcare, 2022

This chapter is divided into four sections. The first section introduces the concept of person-ce... more This chapter is divided into four sections. The first section introduces the concept of person-centred care within pharmaceutical care delivery and provides a historical context. The second section focuses on the professionals and explores the role of person-centred pharmaceutical care as part of multi-disciplinary health services delivery teams. The third section focuses on the patient and describes the role of health literacy in the implementation of person-centred pharmaceutical care. The last section examines E-pharmacy services and the implementation of telepharmacy with implications for person-centred care.

Frontiers in Public Health, 2021

Community pharmacists expanded their roles and engaged in vaccination services in many countries ... more Community pharmacists expanded their roles and engaged in vaccination services in many countries around the world, but not in Balkan countries. This research aimed to assess the perceptions of pharmacists on involvement in the coronavirus disease (COVID-19) vaccine administration in four Balkan countries (Albania, Bulgaria, Romania, and Serbia). A cross-sectional survey was conducted using an online questionnaire that was distributed to community pharmacists across these countries between February and March 2021. A total of 636 community pharmacists were included in the analysis of the survey. The willingness to administer vaccines for COVID-19 (or other vaccines well established in the practice, like a flu vaccine) in community pharmacies is significantly different among the countries: the pharmacists from Albania were more willing to administer vaccines. The factors associated with the eagerness to vaccinate are almost the same among the countries: the lack of training in the facu...

International Journal of Clinical Pharmacy, 2011

Serbian Journal of Experimental and Clinical Research, 2019

Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decre... more Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decrease antibiotics misuse within the process of self-medication. Current pilot study was undertaken with the aim to identify potential predictors of self-medication with antibiotics (SMA) and to describe SMA practice among nursing students in Serbia. Data have been collected during the period March-May, 2016 in Medical school of bachelor degree, in Belgrade. Self-reported questionnaire served as a data source. Descriptive statistic was used to analyse study sample characteristics. Chi-square test was used to test differences between groups. Study sample have included 138 participants. Almost half of them, 43.8%, practice SMA. Life style (smoking, alcohol consumption, sleeping habits and physical activity) and socio-demographic characteristics (excepted school grade) were not shown as SMA determinants. Time & money savings were stated as the most frequent reason for SMA, while common cold, s...

Serbian Journal of Experimental and Clinical Research, 2018

Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant f... more Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral anticoagulants, such as apixaban, dabigatran, and rivaroxaban, have recently demonstrated their safety and efficacy in patients undergoing major orthopaedic surgery. Selection of the appropriate drug should be adjusted according to patient needs. Major bleeding is rare with new oral anticoagulants and is comparable with the bleeding rate associated with low-molecular-weight heparins. Clinical data indicate that therapy with apixaban and rivaroxaban was more effective compared to enoxaparin, while dabigatran has a similar efficacy to enoxaparin. Cost-effectiveness studies of new oral anticoagulants showed that these medicines offer higher efficacy with acceptable costs for the healthcare system, even saving costs in certain cases. Clinical practice in Serbia reflects considerably more frequent use of traditional anticoagulant medicati...

Clinical rheumatology, 2018

The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse th... more The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52 years, mean disease duration < 2 years) with forced vital capacity (FVC) ≤ 80% and/or diffusing capacity of carbon monoxide (DLco) ≤ 70% were included. Monthly CYC pulses were given for 6 months (induction treatment), followed by 3-monthly maintenance pulses for the next 18 months, and during the next 5 years patients received other mild immunosupressive therapy brought by the competent rheumatologist. The efficacy was evaluated by comparing FVC% and DLco% after 6, 24, and 84 months from the baseline. All patients completed induction and maintenance treatment with CYC. Three patients were lost to follow-up. The rest of 27 patients, during the next 5 years, received other immunosupressive agents (14 azathioprine, 9 methot...

Vojnosanitetski pregled, 2017

Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim... more Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim of this study was to determine the level of knowledge about osteoporosis and osteoporosis related risk factors in postmenopausal women in Serbia. Methods. The study included postmenopausal women regardless if suffering from osteoporosis or not. Assessment of knowledge was carried out by using the Osteoporosis Knowledge Assessment Tool - Shorter Version (OKAT-S) questionnaire that was validated for Serbian population. Answers to the 9 questions were coded as 1 -true, or 0 - false or ?do not know?. Also, the following risk factors data for osteoporosis were collected: age, the onset and duration of menopause, body mass index (BMI), data on fractures, the incidence of falls, smoking, lifestyle (active, sedentary), regular sunbathing, calcium and vitamin D supplementation, intake of milk and dairy products. Results. A total of 132 postmenopausal women responded to the questionnaire with the...

Arhiv za farmaciju, 2015

Empirijska primena antimikotika u terapiji invazivnih gljivičnih infekcija (IGI) u febrilnoj neut... more Empirijska primena antimikotika u terapiji invazivnih gljivičnih infekcija (IGI) u febrilnoj neutropeniji predstavlja značajan trošak, ali je neophodna kod pacijenata sa leukemijom i nakon transplantacije matičnih ćelija hematopoeze. Brojne kliničke studije pokazale su male razlike u efikasnosti amfotericina B i kaspofungina u empirijskoj terapiji IGI, ali to ne oslikava u pravoj meri odnos trošak-efektivnost. Cilj rada je bio poređenje isplativosti kaspofungina i amfotericina B lipidni kompleks (ABLC) u empirijskoj antigljivičnoj terapiji kod pacijenata sa febrilnom neutropenijom kroz model-drvo odlučivanja, a iz perspektive Republičkog fonda za zdravstveno osiguranje (RFZO). Primenjena je analiza isplativosti, (cost-effectiveness analsys-CEA), za period od 14 dana terapije. U modelu su kombinovani podaci o efikasnosti iz randomizovanih kliničkih studija, dok su troškovi uzeti iz važećeg cenovnika zdravstvenih usluga i Liste lekova RFZO. Ukupan trošak po dodatno izlečenoj gljivičnoj infekciji za kaspofungin iznosi 639.750,06 RSD, dok je za ABLC 2.153.403,61 RSD. U analizi osetljivosti, primenom različite telesne težine pacijenata (50kg ili 70kg) i različite doze ABLC, kaspofungin je ponovo bio isplativija strategija empirijske antigljivične terapije. Kaspofungin, pored boljeg bezbednosnog profila je i troškovno isplativiji od ABLC. Ovu činjenicu bi trebalo imati u vidu prilikom odabira terapije za lečenje IGI kod pacijenata sa febrilnom neutropenijom.

Women and Birth, 2015

Background: The Edinburgh Postnatal Depression Scale (EPDS) is well accepted for detecting sympto... more Background: The Edinburgh Postnatal Depression Scale (EPDS) is well accepted for detecting symptoms of postnatal depression. The aim of this study was to examine psychometric properties and to evaluate structural models of the Serbian translation of EPDS in pregnant and postpartum women. Methods: The original English version of the EPDS was translated into Serbian, and checked by means of back-translation. Data were collected via an anonymous online questionnaire posted on a Serbian website devoted to pregnancy topics. The study sample included 201 women (76 pregnant, 125 postpartum). The internal consistency of the scale was measured by Cronbach's a coefficient. Principal component analysis was used to determine scale dimensions while confirmatory factor analysis was used to evaluate model fit. Findings: Cronbach a coefficient was 0.84 and 0.83 in pregnant and postpartum women, respectively, which indicated good internal consistency of the Serbian EPDS. Three dimensions of the scale were revealed in both groups of women. Goodness of fit indices described good and excellent model in pregnant and postpartum women, respectively. High level of depression symptoms (score !13) was recorded in 27.6% and 24.8% (p > 0.05) of pregnant and postpartum women, respectively. Moderate level of depression symptoms (score 10-12) was recorded in 21.1% and 16.8% (p > 0.05) of pregnant and postpartum women, respectively. Conclusion: The Serbian translation of the EPDS showed good consistency and good model characteristics in pregnant and postpartum women. However, cutoff values, sensitivity and specificity of the scale should be determined in the further studies with more representative samples of women.

Science and Engineering Ethics, 2015

Many problems that arise when providing pharmacy services may contain some ethical components and... more Many problems that arise when providing pharmacy services may contain some ethical components and the aims of this study were to develop and validate a scale that could assess difficulties of ethical issues, as well as the frequency of those occurrences in everyday practice of community pharmacists. Development and validation of the scale was conducted in three phases: (1) generating items for the initial survey instrument after qualitative analysis; (2) defining the design and format of the instrument; (3) validation of the instrument. The constructed Ethical Issue scale for community pharmacy setting has two parts containing the same 16 items for assessing the difficulty and frequency thereof. The results of the 171 completely filled out scales were analyzed (response rate 74.89 %). The Cronbach&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s α value of the part of the instrument that examines difficulties of the ethical situations was 0.83 and for the part of the instrument that examined frequency of the ethical situations was 0.84. Test-retest reliability for both parts of the instrument was satisfactory with all Interclass correlation coefficient (ICC) values above 0.6, (for the part that examines severity ICC = 0.809, for the part that examines frequency ICC = 0.929). The 16-item scale, as a self assessment tool, demonstrated a high degree of content, criterion, and construct validity and test-retest reliability. The results support its use as a research tool to asses difficulty and frequency of ethical issues in community pharmacy setting. The validated scale needs to be further employed on a larger sample of pharmacists.

Vojnosanitetski Pregled, 2010

Value in Health, 2011

positively correlated with one another (0.20ϽrϽ0.73), and significantly negatively correlated wit... more positively correlated with one another (0.20ϽrϽ0.73), and significantly negatively correlated with PDDS scores (-0.82ϽrϽ-0.07). The physical functioning domain correlated most strongly with PDDS scores (rϭ-0.82, pϽ0.001). Strong correlations were also noted among the role-physical (rϭ-0.58, pϽ0.001), social functioning (rϭ-0.37, pϽ0.001), and bodily pain (rϭ-0.28, pϽ0.001) domains. The domains correlating most weakly with PDDS scores were vitality (rϭ-0.23, pϽ0001) and mental health (rϭ-0.07, pϭ0.03). CONCLUSIONS: As expected, the patient-rated PDDS scores were more strongly associated with domains related to physical health status. To capture the broader psychosocial impact of MS on patient HRQL, additional patient-reported outcomes need to be utilized.

Value in Health, 2013

respectively. Ustekinumab 45mg&90mg-treated patients achieved greater improvements in patient ass... more respectively. Ustekinumab 45mg&90mg-treated patients achieved greater improvements in patient assessment of pain (25.9% &29.6% vs. 4.5%, P<0.001), patient assessment of disease activity (25.4% &27.6% vs. 7.6%, P<0.001)& greater reduction in impact of disease on work productivity (1.82& 2.64 vs. 0.78, P<0.001) versus PBO-treated patients, respectively. CONCLUSIONS: Ustekinumab improves general as well as arthritis &skin-related QoL, &reduces the impact of disease on work productivity in patients with active PsA.

Quality of Life Research, 2012

Health and Quality of Life Outcomes, 2012