Ives Hubloue - Academia.edu (original) (raw)
Papers by Ives Hubloue
International Journal of Stroke
Injury, 2015
Injury severity scores are important in the context of developing European and national goals on ... more Injury severity scores are important in the context of developing European and national goals on traffic safety, health-care benchmarking and improving patient communication. Various severity scores are available and are mostly based on Abbreviated Injury Scale (AIS) or International Classification of Diseases (ICD). The aim of this paper is to compare the predictive value for in-hospital mortality between the various severity scores if only International Classification of Diseases, 9th revision, Clinical Modification ICD-9-CM is reported. To estimate severity scores based on the AIS lexicon, ICD-9-CM codes were converted with ICD Programmes for Injury Categorization (ICDPIC) and four AIS-based severity scores were derived: Maximum AIS (MaxAIS), Injury Severity Score (ISS), New Injury Severity Score (NISS) and Exponential Injury Severity Score (EISS). Based on ICD-9-CM, six severity scores were calculated. Determined by the number of injuries taken into account and the means by which survival risk ratios (SRRs) were calculated, four different approaches were used to calculate the ICD-9-based Injury Severity Scores (ICISS). The Trauma Mortality Prediction Model (TMPM) was calculated with the ICD-9-CM-based model averaged regression coefficients (MARC) for both the single worst injury and multiple injuries. Severity scores were compared via model discrimination and calibration. Model comparisons were performed separately for the severity scores based on the single worst injury and multiple injuries. For ICD-9-based scales, estimation of area under the receiver operating characteristic curve (AUROC) ranges between 0.94 and 0.96, while AIS-based scales range between 0.72 and 0.76, respectively. The intercept in the calibration plots is not significantly different from 0 for MaxAIS, ICISS and TMPM. When only ICD-9-CM codes are reported, ICD-9-CM-based severity scores perform better than severity scores based on the conversion to AIS.
![Research paper thumbnail of [Psychiatric applications at the emergency department of the Brussels University Hospital between 2003 and 2012]](https://attachments.academia-assets.com/53166979/thumbnails/1.jpg)
](Tijdschrift voor psychiatrie
Although the emergency department in Belgian hospital is an important gateway to mental health ca... more Although the emergency department in Belgian hospital is an important gateway to mental health care, there is lack of information about the way in which this population has evolved. Various studies have reported on the increasing numbers of patients with psychiatric problems, particularly in the younger age group. To focus on the psychiatric applications at the emergency department of the Brussels University Hospital over a period of 10 years. All patients who arrived with a psychiatric problem were studied with regard to the following variables: age, gender, diagnosis, time of arrival, referral, destination and application for compulsory admission. The 10-year study involved a total of 6,519 patients. The largest group of patients were aged between 26 and 45. We noted that there were more depressive disorders in women than in men, but men had more psychotic and substance-related disorders. 60% of the applicants came on their own initiative. The number of patients who returned home ...
Clinical Intensive Care, 2000
Archives of Disease in Childhood, 2014
ABSTRACT
Acta clinica Belgica
In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory respo... more In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory response in the cerebrospinal fluid and subarachnoidal space, thereby improving neurological outcome. The clinical application of this concept was sustained by the European Dexamethasone Study which showed a beneficial effect of dexamethasone on neurological outcome and mortality in adult patients with bacterial -in particular S. pneumoniae -meningitis.
Prehospital and disaster medicine, 2014
On March 4, 2012, an arms dump exploded in a densely populated area in Brazzaville, Republic of t... more On March 4, 2012, an arms dump exploded in a densely populated area in Brazzaville, Republic of the Congo. At least 250 people were killed, 2,500 wounded, and 13,800 left homeless, of which 5,000 were relocated to a newly constructed internally displaced person (IDP) camp. Aim To describe the medical complaints of persons presenting to the IDP camp for medical evaluation. Patients and Methods All patients seen and treated by the Belgian First Aid and Support Team (B-FAST) in the IDP camp on March 10 and 11, 2012 were included. A unique number, age, gender, and inventory of complaints were registered on standard World Health Organization (WHO) forms. Out of 245 presenting patients, 242 files were processed. One in two patients were minors (<18 years-old), the male/female ratio was 50/50 in minors and 28/72 in adults; median (range) age in minors was three years (0-17) and for adults was 32.5 years (18-68). Twenty percent of the children were determined to be malnourished. Signs an...
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Jan 3, 2014
Belgian antibiotic (AB) policy guidelines discourage the use of ABs in sore throat in otherwise h... more Belgian antibiotic (AB) policy guidelines discourage the use of ABs in sore throat in otherwise healthy individuals; yet, 35% of all children with sore throat in our pediatric emergency department receive a prescription for ABs. To identify factors influencing our physician's prescription behavior. Using a retrospective study, we analyzed all medical records of children younger than 16 years of age diagnosed with sore throat (in 2009 and 2010). We included 1345 files. Children younger than 5 years of age received an AB prescription more easily (37.8 vs. 27.7%; P=0.0007). Children of White origin received less frequent ABs compared with non-Whites (31.6 vs. 37.8%; P=0.02). More ABs were prescribed during night shifts (38.7 vs. 31.8%; P=0.008). Physicians with a Belgian degree prescribed less frequently compared with those with a Dutch degree (23.4 vs. 46.4%; P<0.0001). We find several 'practical' factors to have an influence on the AB prescription rate.
BMJ open, 2013
Centor criteria (fever >38.5°C, swollen, tender anterior cervical lymph nodes, tonsillar exuda... more Centor criteria (fever >38.5°C, swollen, tender anterior cervical lymph nodes, tonsillar exudate and absence of cough) are an algorithm to assess the probability of group A β haemolytic Streptococcus (GABHS) as the origin of sore throat, developed for adults. We wanted to evaluate the correlation between Centor criteria and presence of GABHS in children with sore throat admitted to our paediatric emergency department (PED). Retrospective cohort study. The emergency department of a large tertiary university hospital in Brussels, with over 20 000 yearly visits for children below age 16. All medical records (from 2008 to 2010) of children between ages 2 and 16, who were diagnosed with pharyngitis, tonsillitis or sore throat and having a throat swab culture for GABHS. Children with underlying chronic respiratory, cardiac, haematological or immunological diseases and children who had already received antibiotics (AB) prior to the PED consult were excluded. Only records with a full dis...
Critical care (London, England), 2004
The role played by several vasoactive mediators that are synthesized and released by the pulmonar... more The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor blockade by candesartan would inhibit HPV. HPV was evaluated in anaesthetized dogs, with an intact pulmonary circulation, by examining the increase in the Ppa-Ppao gradient (mean pulmonary artery pressure minus occluded pulmonary artery pressure) that occurred in response to hypoxia (inspiratory oxygen fraction of 0.1) at constant pulmonary blood flow. Plasma renin activity and angiotensin II immunoreactivity were measured to determine whether activation or inhibition of the renin-angiotensin system was present. Administration of enalaprilat and candesartan did not affect the Ppa-Ppao gradient at baseline o...
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1994
Since the end of the nineteenth century adrenaline has been used for the treatment of cardiac arr... more Since the end of the nineteenth century adrenaline has been used for the treatment of cardiac arrest. Since the 1960s a standard 1 mg dose administered intravenously every 5 min is common practice in cardiopulmonary resuscitation. Because of growing interest in the pharmacological aspects of cardiopulmonary resuscitation, experimental studies in animals conducted in the 1980s suggested the use of higher doses of adrenaline. Several case reports of successfully resuscitated patients who had been given high dose adrenaline were published, but large, prospective, randomized, controlled clinical trials in humans found no statistically significant improvement in survival rates between high dose and standard dose resuscitated patients. It seems that 1 mg adrenaline given intravenously every 3-5 min during resuscitation for cardiac arrest remains the standard.
New Microbes and New Infections, 2014
In 2011, a large outbreak of infections caused by Shiga toxin-producing Escherichia coli (STEC) O... more In 2011, a large outbreak of infections caused by Shiga toxin-producing Escherichia coli (STEC) O104:H4 occurred in Germany. This exceptionally virulent strain combined virulence factors of enteroaggregative E. coli (EAggEC) and STEC. After the outbreak only a few sporadic cases of infection with this rare serotype were reported, most of which were related to travel to the Middle East or North Africa.
ed of these measures to improve stroke care, no major effects on prehospital delay or missed trea... more ed of these measures to improve stroke care, no major effects on prehospital delay or missed treatment opportunities have been demonstrated over the years. Most interventional studies showed little or no effect on the onset-to-door time, IV r-tPA utilization rates or outcome, except for prenotification of the receiving hospital by the EMS. No data are currently available on the cost-effectiveness of these commonly used measures. In the second part, we discuss new developments for the improvement of prehospital stroke diagnosis and treatment which could open new perspectives in the nearby future. These include the implementation of prehospital telestroke and the deployment of mobile stroke units. These approaches may improve patient care and could serve as a platform for prehospital clinical trials. Other opportunities include the implementation of noninvasive diagnostics (like transcranial ultrasound and blood-borne biomarkers) and the reevaluation of neuroprotective strategies in the prehospital phase. Key Messages: Timely initiation of treatment can effectively reduce the
European Journal of Emergency Medicine, 1996
As a result of the increasing accuracy in diagnosing acute pulmonary embolism by isotopic ventila... more As a result of the increasing accuracy in diagnosing acute pulmonary embolism by isotopic ventilation-perfusion scintigraphy and pulmonary arterial angiography, the electrocardiographic changes associated with acute cor pulmonale are being abandoned as a diagnostic tool for this life-threatening disease. Nevertheless, certain electrocardiographic findings can raise the suspicion of pulmonary embolism. In our view the electrocardiogram does have some merits in the emergency work-up of a patient with a high suspicion of pulmonary embolism. In this case report we emphasize the importance of the electrocardiographic findings which forwarded the diagnosis of pulmonary embolism. Hence the necessary invasive diagnostic and therapeutic measures, i.e. pulmonary arterial angiography and thrombolytic therapy, can be taken immediately after admission to the emergency department.
European Journal of Emergency Medicine, 1996
A case of medial inferior pontine syndrome or Foville's syndrome is described. The patien... more A case of medial inferior pontine syndrome or Foville's syndrome is described. The patient presented to the emergency department with an acute history of slurred speech, vertigo and diplopia as major complaints. He also mentioned the appearance of weakness and numbness in his left leg. The physical examination revealed a crossed neurological deficit (ipsilateral cranial nerve deficit with contralateral motor weakness) which is typical for posterior circulation stroke in the brainstem territory. In our patient the lesion was located in the right medial inferior pontine region. All the symptoms and signs disappeared within 24 hours confirming the importance of a detailed physical and neurological examination of each patient presenting at the emergency department with a neurological deficit.
European Journal of Emergency Medicine, 2010
We present the case report of a 57-year-old woman with severe monointoxication with dosulepine (P... more We present the case report of a 57-year-old woman with severe monointoxication with dosulepine (Prothiaden) who developed a Brugada-like electrocardiographic pattern. In tricyclic antidepressants (TCAs) poisoning the Brugada-like pattern on electrocardiogram is a characteristic albeit rare manifestation of the frequently occurring conduction abnormalities in the myocardium and its recognition is imperative as it is associated with a higher degree of morbidity and mortality. An overview of the literature is given and recommendations concerning treatment of TCA-induced arrhythmias are provided. After successful treatment, the electrocardiogram in the patient normalized. However, 4 days after intoxication, the ajmaline test was positive (pharmacological induction of a type I Brugada-like pattern), but a subsequent one, repeated after 11 days, was reportedly normal, probably because of the slow clearance of dosulepine. This raises questions about the specificity of ajmaline testing for Brugada syndrome in patients taking dosulepine and perhaps other TCAs and neuroleptic agents.
Critical Care Medicine, 2006
ABSTRACT To describe the erythropoietin pharmacokinetic profile after once-weekly epoetin alfa tr... more ABSTRACT To describe the erythropoietin pharmacokinetic profile after once-weekly epoetin alfa treatment in critically ill patients. Secondary objectives were to compare pharmacodynamic and safety profiles between active treatment and placebo in these patients. Randomized, double-blind, placebo-controlled study. Medical, surgical, or mixed medical/surgical intensive care units. A total of 73 anemic critically ill adults with an expected stay of >3 days and a hematocrit value of <38%. Patients were randomized 2:1 to epoetin alfa, 40,000 IU, administered subcutaneously once weekly (n=48) or matching placebo (n=25) for up to 4 wks. Serum erythropoietin concentration and hematologic variables (percentage reticulocytes [RETI], hemoglobin [Hb], and total red blood cell [RBC] counts) were measured, and area under the serum concentration-time curve from time 0 to the last blood sampling time at time t (t: 120, 144, or 168 hrs) postdose (AUC0-Tlast) for these three variables was determined. Mean serum erythropoietin concentrations in placebo patients were slightly higher than typical physiologic levels of erythropoietin in healthy subjects, although not appropriate for the degree of anemia in these patients. Overall, exposure of endogenous erythropoietin in the placebo group (in terms of AUC0-Tlast) was only about 20% of exposure to exogenous erythropoietin in the epoetin alfa group. Baseline hemoglobin levels were the same in both groups (9.9 g/dL). Mean change in hemoglobin level from baseline through day 29 was 1.9 g/dL and 1.6 g/dL in the epoetin alfa and placebo groups, respectively. Mean AUC(RETI)0-Tlast was higher with epoetin alfa than with placebo and was related to the AUC of erythropoietin. There were no apparent differences in AUC(Hb)0-Tlast and AUC(RBC)0-Tlast between epoetin alfa and placebo groups, which was most likely due to bleeding and transfusion events. Epoetin alfa was safe and well tolerated, with a rate of treatment-emergent complications similar to that seen with placebo. Epoetin alfa, once weekly, augmented the erythropoietic response in critically ill patients as indicated by the increased erythropoietin levels and larger AUC(RETI)0-Tlast in treated patients.
Critical Care, 2009
There is considerable uncertainty about the reproducibility of the various instruments used to me... more There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient's experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients. URGENT was a prospective multicenter trial designed to address these issues. Methods Patients were interviewed within 1 hour of first physician evaluation, in the emergency department or acute care setting, with dyspnea assessed by the patient using both a five-point Likert scale and a 10-point visual analog scale (VAS) in the sitting (60º) and then supine (20º) position if dyspnea had not been considered severe or very severe by the sitting versus decubitus dyspnea measurement. Results Very good agreements were found between the five-point Likert and VAS at baseline (0.891, P <0.0001) and between changes (from baseline to hour 6) in the five-point Likert and in VAS (0.800, P <0.0001) in acute heart failure (AHF) patients. Lower agreements were found when changes from baseline to H6 measured by Likert or VAS were compared with the seven-point comparative Likert (0.512 and 0.500 respectively) in AHF patients. The worse the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours; this relationship is stronger when dyspnea is measured with VAS (Spearman's rho coefficient = 0.672) than with the five-point Likert (0.272) (both P <0.0001) in AHF patients. By the five-point Likert, only nine patients (3% (1% to 5%)) reported an improvement in their dyspnea, 177 (51% (46% to 57%)) had no change, and 159 (46% (41% to 52%)) reported worse dyspnea supine compared with sitting up in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Conclusions Both clinical tools five-point Likert and VAS showed very good agreement at baseline and between changes from baseline to tests performed 6 hours later in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Dyspnea is improved within 6 hours in more than threequarters of the patients regardless of the tool used to measure the change in dyspnea. The greater the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours.
Cardiology, 1995
To assess possible age-related differences in the time of occurrence (hour of the day, day of the... more To assess possible age-related differences in the time of occurrence (hour of the day, day of the week, month of the year) of cardiopulmonary collapses of presumed cardiac etiology, 3,305 out-of-hospital patients registered by the Belgian Cardiopulmonary-Cerebral Resuscitation Study Group between 1983 and 1990 were studied. Occurrence of call-time was separately tabulated for patients less than versus above 60 years of age and tested for differences with the Kolmogorov-Smirnov two-sample test. Only the circadian patterns of all out-of-hospital cardiac arrests of presumed cardiac etiology showed a significant difference between the two age-groups; the prominent morning peak (6 a.m.-10 a.m.) in incidence was less pronounced in the younger age-group. The overall incidence is lower in the summer and during mid-week. These trends are similar for both age-groups.
Acta Clinica Belgica, 2011
In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory respo... more In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory response in the cerebrospinal fluid and subarachnoidal space, thereby improving neurological outcome. The clinical application of this concept was sustained by the European Dexamethasone Study which showed a beneficial effect of dexamethasone on neurological outcome and mortality in adult patients with bacterial -in particular S. pneumoniae -meningitis.
International Journal of Stroke
Injury, 2015
Injury severity scores are important in the context of developing European and national goals on ... more Injury severity scores are important in the context of developing European and national goals on traffic safety, health-care benchmarking and improving patient communication. Various severity scores are available and are mostly based on Abbreviated Injury Scale (AIS) or International Classification of Diseases (ICD). The aim of this paper is to compare the predictive value for in-hospital mortality between the various severity scores if only International Classification of Diseases, 9th revision, Clinical Modification ICD-9-CM is reported. To estimate severity scores based on the AIS lexicon, ICD-9-CM codes were converted with ICD Programmes for Injury Categorization (ICDPIC) and four AIS-based severity scores were derived: Maximum AIS (MaxAIS), Injury Severity Score (ISS), New Injury Severity Score (NISS) and Exponential Injury Severity Score (EISS). Based on ICD-9-CM, six severity scores were calculated. Determined by the number of injuries taken into account and the means by which survival risk ratios (SRRs) were calculated, four different approaches were used to calculate the ICD-9-based Injury Severity Scores (ICISS). The Trauma Mortality Prediction Model (TMPM) was calculated with the ICD-9-CM-based model averaged regression coefficients (MARC) for both the single worst injury and multiple injuries. Severity scores were compared via model discrimination and calibration. Model comparisons were performed separately for the severity scores based on the single worst injury and multiple injuries. For ICD-9-based scales, estimation of area under the receiver operating characteristic curve (AUROC) ranges between 0.94 and 0.96, while AIS-based scales range between 0.72 and 0.76, respectively. The intercept in the calibration plots is not significantly different from 0 for MaxAIS, ICISS and TMPM. When only ICD-9-CM codes are reported, ICD-9-CM-based severity scores perform better than severity scores based on the conversion to AIS.
Tijdschrift voor psychiatrie
Although the emergency department in Belgian hospital is an important gateway to mental health ca... more Although the emergency department in Belgian hospital is an important gateway to mental health care, there is lack of information about the way in which this population has evolved. Various studies have reported on the increasing numbers of patients with psychiatric problems, particularly in the younger age group. To focus on the psychiatric applications at the emergency department of the Brussels University Hospital over a period of 10 years. All patients who arrived with a psychiatric problem were studied with regard to the following variables: age, gender, diagnosis, time of arrival, referral, destination and application for compulsory admission. The 10-year study involved a total of 6,519 patients. The largest group of patients were aged between 26 and 45. We noted that there were more depressive disorders in women than in men, but men had more psychotic and substance-related disorders. 60% of the applicants came on their own initiative. The number of patients who returned home ...
Clinical Intensive Care, 2000
Archives of Disease in Childhood, 2014
ABSTRACT
Acta clinica Belgica
In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory respo... more In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory response in the cerebrospinal fluid and subarachnoidal space, thereby improving neurological outcome. The clinical application of this concept was sustained by the European Dexamethasone Study which showed a beneficial effect of dexamethasone on neurological outcome and mortality in adult patients with bacterial -in particular S. pneumoniae -meningitis.
Prehospital and disaster medicine, 2014
On March 4, 2012, an arms dump exploded in a densely populated area in Brazzaville, Republic of t... more On March 4, 2012, an arms dump exploded in a densely populated area in Brazzaville, Republic of the Congo. At least 250 people were killed, 2,500 wounded, and 13,800 left homeless, of which 5,000 were relocated to a newly constructed internally displaced person (IDP) camp. Aim To describe the medical complaints of persons presenting to the IDP camp for medical evaluation. Patients and Methods All patients seen and treated by the Belgian First Aid and Support Team (B-FAST) in the IDP camp on March 10 and 11, 2012 were included. A unique number, age, gender, and inventory of complaints were registered on standard World Health Organization (WHO) forms. Out of 245 presenting patients, 242 files were processed. One in two patients were minors (<18 years-old), the male/female ratio was 50/50 in minors and 28/72 in adults; median (range) age in minors was three years (0-17) and for adults was 32.5 years (18-68). Twenty percent of the children were determined to be malnourished. Signs an...
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Jan 3, 2014
Belgian antibiotic (AB) policy guidelines discourage the use of ABs in sore throat in otherwise h... more Belgian antibiotic (AB) policy guidelines discourage the use of ABs in sore throat in otherwise healthy individuals; yet, 35% of all children with sore throat in our pediatric emergency department receive a prescription for ABs. To identify factors influencing our physician's prescription behavior. Using a retrospective study, we analyzed all medical records of children younger than 16 years of age diagnosed with sore throat (in 2009 and 2010). We included 1345 files. Children younger than 5 years of age received an AB prescription more easily (37.8 vs. 27.7%; P=0.0007). Children of White origin received less frequent ABs compared with non-Whites (31.6 vs. 37.8%; P=0.02). More ABs were prescribed during night shifts (38.7 vs. 31.8%; P=0.008). Physicians with a Belgian degree prescribed less frequently compared with those with a Dutch degree (23.4 vs. 46.4%; P<0.0001). We find several 'practical' factors to have an influence on the AB prescription rate.
BMJ open, 2013
Centor criteria (fever >38.5°C, swollen, tender anterior cervical lymph nodes, tonsillar exuda... more Centor criteria (fever >38.5°C, swollen, tender anterior cervical lymph nodes, tonsillar exudate and absence of cough) are an algorithm to assess the probability of group A β haemolytic Streptococcus (GABHS) as the origin of sore throat, developed for adults. We wanted to evaluate the correlation between Centor criteria and presence of GABHS in children with sore throat admitted to our paediatric emergency department (PED). Retrospective cohort study. The emergency department of a large tertiary university hospital in Brussels, with over 20 000 yearly visits for children below age 16. All medical records (from 2008 to 2010) of children between ages 2 and 16, who were diagnosed with pharyngitis, tonsillitis or sore throat and having a throat swab culture for GABHS. Children with underlying chronic respiratory, cardiac, haematological or immunological diseases and children who had already received antibiotics (AB) prior to the PED consult were excluded. Only records with a full dis...
Critical care (London, England), 2004
The role played by several vasoactive mediators that are synthesized and released by the pulmonar... more The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor blockade by candesartan would inhibit HPV. HPV was evaluated in anaesthetized dogs, with an intact pulmonary circulation, by examining the increase in the Ppa-Ppao gradient (mean pulmonary artery pressure minus occluded pulmonary artery pressure) that occurred in response to hypoxia (inspiratory oxygen fraction of 0.1) at constant pulmonary blood flow. Plasma renin activity and angiotensin II immunoreactivity were measured to determine whether activation or inhibition of the renin-angiotensin system was present. Administration of enalaprilat and candesartan did not affect the Ppa-Ppao gradient at baseline o...
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1994
Since the end of the nineteenth century adrenaline has been used for the treatment of cardiac arr... more Since the end of the nineteenth century adrenaline has been used for the treatment of cardiac arrest. Since the 1960s a standard 1 mg dose administered intravenously every 5 min is common practice in cardiopulmonary resuscitation. Because of growing interest in the pharmacological aspects of cardiopulmonary resuscitation, experimental studies in animals conducted in the 1980s suggested the use of higher doses of adrenaline. Several case reports of successfully resuscitated patients who had been given high dose adrenaline were published, but large, prospective, randomized, controlled clinical trials in humans found no statistically significant improvement in survival rates between high dose and standard dose resuscitated patients. It seems that 1 mg adrenaline given intravenously every 3-5 min during resuscitation for cardiac arrest remains the standard.
New Microbes and New Infections, 2014
In 2011, a large outbreak of infections caused by Shiga toxin-producing Escherichia coli (STEC) O... more In 2011, a large outbreak of infections caused by Shiga toxin-producing Escherichia coli (STEC) O104:H4 occurred in Germany. This exceptionally virulent strain combined virulence factors of enteroaggregative E. coli (EAggEC) and STEC. After the outbreak only a few sporadic cases of infection with this rare serotype were reported, most of which were related to travel to the Middle East or North Africa.
ed of these measures to improve stroke care, no major effects on prehospital delay or missed trea... more ed of these measures to improve stroke care, no major effects on prehospital delay or missed treatment opportunities have been demonstrated over the years. Most interventional studies showed little or no effect on the onset-to-door time, IV r-tPA utilization rates or outcome, except for prenotification of the receiving hospital by the EMS. No data are currently available on the cost-effectiveness of these commonly used measures. In the second part, we discuss new developments for the improvement of prehospital stroke diagnosis and treatment which could open new perspectives in the nearby future. These include the implementation of prehospital telestroke and the deployment of mobile stroke units. These approaches may improve patient care and could serve as a platform for prehospital clinical trials. Other opportunities include the implementation of noninvasive diagnostics (like transcranial ultrasound and blood-borne biomarkers) and the reevaluation of neuroprotective strategies in the prehospital phase. Key Messages: Timely initiation of treatment can effectively reduce the
European Journal of Emergency Medicine, 1996
As a result of the increasing accuracy in diagnosing acute pulmonary embolism by isotopic ventila... more As a result of the increasing accuracy in diagnosing acute pulmonary embolism by isotopic ventilation-perfusion scintigraphy and pulmonary arterial angiography, the electrocardiographic changes associated with acute cor pulmonale are being abandoned as a diagnostic tool for this life-threatening disease. Nevertheless, certain electrocardiographic findings can raise the suspicion of pulmonary embolism. In our view the electrocardiogram does have some merits in the emergency work-up of a patient with a high suspicion of pulmonary embolism. In this case report we emphasize the importance of the electrocardiographic findings which forwarded the diagnosis of pulmonary embolism. Hence the necessary invasive diagnostic and therapeutic measures, i.e. pulmonary arterial angiography and thrombolytic therapy, can be taken immediately after admission to the emergency department.
European Journal of Emergency Medicine, 1996
A case of medial inferior pontine syndrome or Foville's syndrome is described. The patien... more A case of medial inferior pontine syndrome or Foville's syndrome is described. The patient presented to the emergency department with an acute history of slurred speech, vertigo and diplopia as major complaints. He also mentioned the appearance of weakness and numbness in his left leg. The physical examination revealed a crossed neurological deficit (ipsilateral cranial nerve deficit with contralateral motor weakness) which is typical for posterior circulation stroke in the brainstem territory. In our patient the lesion was located in the right medial inferior pontine region. All the symptoms and signs disappeared within 24 hours confirming the importance of a detailed physical and neurological examination of each patient presenting at the emergency department with a neurological deficit.
European Journal of Emergency Medicine, 2010
We present the case report of a 57-year-old woman with severe monointoxication with dosulepine (P... more We present the case report of a 57-year-old woman with severe monointoxication with dosulepine (Prothiaden) who developed a Brugada-like electrocardiographic pattern. In tricyclic antidepressants (TCAs) poisoning the Brugada-like pattern on electrocardiogram is a characteristic albeit rare manifestation of the frequently occurring conduction abnormalities in the myocardium and its recognition is imperative as it is associated with a higher degree of morbidity and mortality. An overview of the literature is given and recommendations concerning treatment of TCA-induced arrhythmias are provided. After successful treatment, the electrocardiogram in the patient normalized. However, 4 days after intoxication, the ajmaline test was positive (pharmacological induction of a type I Brugada-like pattern), but a subsequent one, repeated after 11 days, was reportedly normal, probably because of the slow clearance of dosulepine. This raises questions about the specificity of ajmaline testing for Brugada syndrome in patients taking dosulepine and perhaps other TCAs and neuroleptic agents.
Critical Care Medicine, 2006
ABSTRACT To describe the erythropoietin pharmacokinetic profile after once-weekly epoetin alfa tr... more ABSTRACT To describe the erythropoietin pharmacokinetic profile after once-weekly epoetin alfa treatment in critically ill patients. Secondary objectives were to compare pharmacodynamic and safety profiles between active treatment and placebo in these patients. Randomized, double-blind, placebo-controlled study. Medical, surgical, or mixed medical/surgical intensive care units. A total of 73 anemic critically ill adults with an expected stay of >3 days and a hematocrit value of <38%. Patients were randomized 2:1 to epoetin alfa, 40,000 IU, administered subcutaneously once weekly (n=48) or matching placebo (n=25) for up to 4 wks. Serum erythropoietin concentration and hematologic variables (percentage reticulocytes [RETI], hemoglobin [Hb], and total red blood cell [RBC] counts) were measured, and area under the serum concentration-time curve from time 0 to the last blood sampling time at time t (t: 120, 144, or 168 hrs) postdose (AUC0-Tlast) for these three variables was determined. Mean serum erythropoietin concentrations in placebo patients were slightly higher than typical physiologic levels of erythropoietin in healthy subjects, although not appropriate for the degree of anemia in these patients. Overall, exposure of endogenous erythropoietin in the placebo group (in terms of AUC0-Tlast) was only about 20% of exposure to exogenous erythropoietin in the epoetin alfa group. Baseline hemoglobin levels were the same in both groups (9.9 g/dL). Mean change in hemoglobin level from baseline through day 29 was 1.9 g/dL and 1.6 g/dL in the epoetin alfa and placebo groups, respectively. Mean AUC(RETI)0-Tlast was higher with epoetin alfa than with placebo and was related to the AUC of erythropoietin. There were no apparent differences in AUC(Hb)0-Tlast and AUC(RBC)0-Tlast between epoetin alfa and placebo groups, which was most likely due to bleeding and transfusion events. Epoetin alfa was safe and well tolerated, with a rate of treatment-emergent complications similar to that seen with placebo. Epoetin alfa, once weekly, augmented the erythropoietic response in critically ill patients as indicated by the increased erythropoietin levels and larger AUC(RETI)0-Tlast in treated patients.
Critical Care, 2009
There is considerable uncertainty about the reproducibility of the various instruments used to me... more There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient's experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients. URGENT was a prospective multicenter trial designed to address these issues. Methods Patients were interviewed within 1 hour of first physician evaluation, in the emergency department or acute care setting, with dyspnea assessed by the patient using both a five-point Likert scale and a 10-point visual analog scale (VAS) in the sitting (60º) and then supine (20º) position if dyspnea had not been considered severe or very severe by the sitting versus decubitus dyspnea measurement. Results Very good agreements were found between the five-point Likert and VAS at baseline (0.891, P <0.0001) and between changes (from baseline to hour 6) in the five-point Likert and in VAS (0.800, P <0.0001) in acute heart failure (AHF) patients. Lower agreements were found when changes from baseline to H6 measured by Likert or VAS were compared with the seven-point comparative Likert (0.512 and 0.500 respectively) in AHF patients. The worse the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours; this relationship is stronger when dyspnea is measured with VAS (Spearman's rho coefficient = 0.672) than with the five-point Likert (0.272) (both P <0.0001) in AHF patients. By the five-point Likert, only nine patients (3% (1% to 5%)) reported an improvement in their dyspnea, 177 (51% (46% to 57%)) had no change, and 159 (46% (41% to 52%)) reported worse dyspnea supine compared with sitting up in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Conclusions Both clinical tools five-point Likert and VAS showed very good agreement at baseline and between changes from baseline to tests performed 6 hours later in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Dyspnea is improved within 6 hours in more than threequarters of the patients regardless of the tool used to measure the change in dyspnea. The greater the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours.
Cardiology, 1995
To assess possible age-related differences in the time of occurrence (hour of the day, day of the... more To assess possible age-related differences in the time of occurrence (hour of the day, day of the week, month of the year) of cardiopulmonary collapses of presumed cardiac etiology, 3,305 out-of-hospital patients registered by the Belgian Cardiopulmonary-Cerebral Resuscitation Study Group between 1983 and 1990 were studied. Occurrence of call-time was separately tabulated for patients less than versus above 60 years of age and tested for differences with the Kolmogorov-Smirnov two-sample test. Only the circadian patterns of all out-of-hospital cardiac arrests of presumed cardiac etiology showed a significant difference between the two age-groups; the prominent morning peak (6 a.m.-10 a.m.) in incidence was less pronounced in the younger age-group. The overall incidence is lower in the summer and during mid-week. These trends are similar for both age-groups.
Acta Clinica Belgica, 2011
In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory respo... more In experimental bacterial meningitis, adjunctive steroid treatment reduces the inflammatory response in the cerebrospinal fluid and subarachnoidal space, thereby improving neurological outcome. The clinical application of this concept was sustained by the European Dexamethasone Study which showed a beneficial effect of dexamethasone on neurological outcome and mortality in adult patients with bacterial -in particular S. pneumoniae -meningitis.