JAGDISH KUMAR - Academia.edu (original) (raw)
Uploads
Papers by JAGDISH KUMAR
Letters in Drug Design & Discovery, 2018
Anti-inflammatory & anti-allergy agents in medicinal chemistry, Jan 16, 2017
Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propioni... more Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple metabolism, faster blood brain barrier crossing and high antinociceptive activity are the features responsible for its high use. But, free acidic moiety present in its structure is the major factor that declines its popularity by causing various gastric side effects .Many researchers have chemically modified this drug with the aim to discover an improved and safe NSAID candidate or a new drug with altered activity. We thoroughly searched the literature and found that during the period 2004-2016, more than fifty reportings are available on chemical modification of ketoprofen. Along with this, many patents involving chemical modification of ketoprofen have also been reported. However, it was very surprising to note that there are only few review articles available covering only its pharmacological and clinical properties. There...
Medicinal Chemistry Research, 2014
Letters in Drug Design & Discovery, 2018
Anti-inflammatory & anti-allergy agents in medicinal chemistry, Jan 16, 2017
Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propioni... more Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple metabolism, faster blood brain barrier crossing and high antinociceptive activity are the features responsible for its high use. But, free acidic moiety present in its structure is the major factor that declines its popularity by causing various gastric side effects .Many researchers have chemically modified this drug with the aim to discover an improved and safe NSAID candidate or a new drug with altered activity. We thoroughly searched the literature and found that during the period 2004-2016, more than fifty reportings are available on chemical modification of ketoprofen. Along with this, many patents involving chemical modification of ketoprofen have also been reported. However, it was very surprising to note that there are only few review articles available covering only its pharmacological and clinical properties. There...
Medicinal Chemistry Research, 2014