J. Boulenger - Academia.edu (original) (raw)

Papers by J. Boulenger

Research paper thumbnail of La conscience des troubles (insight) dans la schizophrénie : une revue critique

L'Encéphale, 2008

Research in neuropsychology and cognitive psychology has provided consistent results concerning t... more Research in neuropsychology and cognitive psychology has provided consistent results concerning the link between deficit in executive functions, frontal lobe dysfunction and poor insight. Recent studies on bias in cognitive information treatment and social cognition theories currently open new prospects.

Research paper thumbnail of Stress levels in nursing staff working in oncology

Care of cancer patients may be a source of considerable stress. As part of a large scale longitud... more Care of cancer patients may be a source of considerable stress. As part of a large scale longitudinal study of the interaction of biological, psychological and environmental factors in determining patient outcome, the mental and physical health status of 37 members of the nursing staff of a cancer hospital was examined. The study identifies risk factors for stress, professional 'burn-out' and psychiatric morbidity. An assessment questionnaire also examined work time, work organization, relationships with colleagues, identification of stressful situations, and treatment of pain. Each subject completed three scales designed to measure stress and psychiatric morbidity: the Nursing Stress Scale, the Maslasch Burnout Inventory and the General Health Questionnaire. Item analysis suggested that stress is primarily related to inadequate training, lack of time to deal with the psychological component of care giving especially terminal care, and relationship difficulties with other medical staff. Multiple analysis of correspondence indicated that in the face of stress, risk factors for professional burnout are high psychiatric symptomatology, lack of information at the time of diagnosis, poor perceived health, relationship difficulties with patients and their families, and work uncertainties.

Research paper thumbnail of Compared Efficacy of Prazepam and Clomipramine in Major Depression with Anxiety: a Multicenter Controlled Study

Pharmacopsychiatry, 1991

The efficacy of antidepressants is well established in major depressions, especially those with m... more The efficacy of antidepressants is well established in major depressions, especially those with melancholic features. However, some anxiolytics also appear to have antidepressant properties at least for outpatients. 118 outpatients (25 males, 93 females, age: 18-60) with major depression according to DSM-III criteria, neither melancholic nor suicidal, reaching at least 27 on Montgomery and Asberg depression rating scale (MADRS) and 19 on Hamilton anxiety rating scale (HARS) accepted to participate this double blind study carried out by 15 G.P.s coordinated by 3 psychiatrists. After a one week placebo wash-out-single-blind period, they were randomly, double blind, assigned to one of the two following groups: PR treated with prazepam (30-60 mg), a benzodiazepine anxiolytic or CL treated clomipramine, an imipramine antidepressant (75-150 mg). Patients were evaluated at days 0, 7, 14, and 28, using MADRS, HARS, Clinical Global Impression and Hopkins symptoms check list 58. In addition, G.P.s had to meet monthly for a case discussion group. groups were comparable at day 0. A highly significant improvement of MADRS and HARS scores (p less than 0.001) was observed in the total population. For the completer population evolution was also significantly positive in all the parameters studied but, considering MADRS and HSCL scores, a difference in favor of CL is observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Research paper thumbnail of The relationship of plasma-free MHPG to anxiety in psychophysical pain in normal volunteers

Pain, 1984

Combinations of orally ad~nistered tilidine (a narcotic) and naloxone were studied in a double-bl... more Combinations of orally ad~nistered tilidine (a narcotic) and naloxone were studied in a double-blind latin square design in 50 healthy human volunteers. Subjects experienced electrical skin stimulation with randomized intensities and somatosensory evoked potentials (SEPs) as well as pain ratings (PRs) served as dependent variables. A high correlation between SEP amplitudes and PRs was found for all treatments investigated. Tilidine (100 mg) decreased both SEP amplitude and PR by approximately 25% compared to a placebo. No significant differences were found between the analgesic effects of tilidine and a combination of tilidine 100 mg and naloxone 8 mg. The effects of both treatments were significantly different from those of the naloxone, placebo and the combination tilidine 100 mg and naloxone 32 mg. This indicated a marked naloxone-induced reversal of tilidine analgesia. EP amplitudes increased with 32 mg naloxone but no naloxone-induced hyperalgesia was seen in the pain ratings.

Research paper thumbnail of Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain

Neuroscience Letters, 1982

Research paper thumbnail of Chronic caffeine consumption increases the number of brain adenosine receptors

Research paper thumbnail of Lack of interaction between buspirone and triazolam

European Neuropsychopharmacology, 1993

Research paper thumbnail of Social priming enhances interpersonal synchronization and feeling of connectedness towards schizophrenia patients

Scientific Reports, 2015

What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remain... more What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remains obscure. Despite recent findings that human bonding is an interactive process influenced by coordination dynamics, the spatiotemporal organization of the bodily movements of schizophrenia patients when interacting with other people is poorly understood. Interpersonal motor coordination between dyads of patients (n 5 45) or healthy controls (n 5 45), and synchronization partners (n 5 90), was assessed with a hand-held pendulum task following implicit exposure to pro-social, non-social, or anti-social primes. We evaluated the socio-motor competence and the feeling of connectedness between participants and their synchronization partners with a measure of motor coordination stability. Immediately after the coordination task, all participants were also asked to rate the likeableness of their interacting partner. Our results showed greater stability during interpersonal synchrony in schizophrenia patients who received pro-social priming, inducing in their synchronization partner greater feelings of connectedness towards patients. This greater feeling of connectedness was positively correlated with stronger motor synchronization between participants suggesting that motor coordination partly underlies patients' social interactions and feelings of contact with others. Pro-social priming can have a pervasive effect on abnormal social interactions in schizophrenia patients.

Research paper thumbnail of La conscience des troubles (insight) dans la schizophrénie : une revue critique

L'Encéphale, 2008

Research in neuropsychology and cognitive psychology has provided consistent results concerning t... more Research in neuropsychology and cognitive psychology has provided consistent results concerning the link between deficit in executive functions, frontal lobe dysfunction and poor insight. Recent studies on bias in cognitive information treatment and social cognition theories currently open new prospects.

Research paper thumbnail of Stress levels in nursing staff working in oncology

Care of cancer patients may be a source of considerable stress. As part of a large scale longitud... more Care of cancer patients may be a source of considerable stress. As part of a large scale longitudinal study of the interaction of biological, psychological and environmental factors in determining patient outcome, the mental and physical health status of 37 members of the nursing staff of a cancer hospital was examined. The study identifies risk factors for stress, professional 'burn-out' and psychiatric morbidity. An assessment questionnaire also examined work time, work organization, relationships with colleagues, identification of stressful situations, and treatment of pain. Each subject completed three scales designed to measure stress and psychiatric morbidity: the Nursing Stress Scale, the Maslasch Burnout Inventory and the General Health Questionnaire. Item analysis suggested that stress is primarily related to inadequate training, lack of time to deal with the psychological component of care giving especially terminal care, and relationship difficulties with other medical staff. Multiple analysis of correspondence indicated that in the face of stress, risk factors for professional burnout are high psychiatric symptomatology, lack of information at the time of diagnosis, poor perceived health, relationship difficulties with patients and their families, and work uncertainties.

Research paper thumbnail of Compared Efficacy of Prazepam and Clomipramine in Major Depression with Anxiety: a Multicenter Controlled Study

Pharmacopsychiatry, 1991

The efficacy of antidepressants is well established in major depressions, especially those with m... more The efficacy of antidepressants is well established in major depressions, especially those with melancholic features. However, some anxiolytics also appear to have antidepressant properties at least for outpatients. 118 outpatients (25 males, 93 females, age: 18-60) with major depression according to DSM-III criteria, neither melancholic nor suicidal, reaching at least 27 on Montgomery and Asberg depression rating scale (MADRS) and 19 on Hamilton anxiety rating scale (HARS) accepted to participate this double blind study carried out by 15 G.P.s coordinated by 3 psychiatrists. After a one week placebo wash-out-single-blind period, they were randomly, double blind, assigned to one of the two following groups: PR treated with prazepam (30-60 mg), a benzodiazepine anxiolytic or CL treated clomipramine, an imipramine antidepressant (75-150 mg). Patients were evaluated at days 0, 7, 14, and 28, using MADRS, HARS, Clinical Global Impression and Hopkins symptoms check list 58. In addition, G.P.s had to meet monthly for a case discussion group. groups were comparable at day 0. A highly significant improvement of MADRS and HARS scores (p less than 0.001) was observed in the total population. For the completer population evolution was also significantly positive in all the parameters studied but, considering MADRS and HSCL scores, a difference in favor of CL is observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Research paper thumbnail of The relationship of plasma-free MHPG to anxiety in psychophysical pain in normal volunteers

Pain, 1984

Combinations of orally ad~nistered tilidine (a narcotic) and naloxone were studied in a double-bl... more Combinations of orally ad~nistered tilidine (a narcotic) and naloxone were studied in a double-blind latin square design in 50 healthy human volunteers. Subjects experienced electrical skin stimulation with randomized intensities and somatosensory evoked potentials (SEPs) as well as pain ratings (PRs) served as dependent variables. A high correlation between SEP amplitudes and PRs was found for all treatments investigated. Tilidine (100 mg) decreased both SEP amplitude and PR by approximately 25% compared to a placebo. No significant differences were found between the analgesic effects of tilidine and a combination of tilidine 100 mg and naloxone 8 mg. The effects of both treatments were significantly different from those of the naloxone, placebo and the combination tilidine 100 mg and naloxone 32 mg. This indicated a marked naloxone-induced reversal of tilidine analgesia. EP amplitudes increased with 32 mg naloxone but no naloxone-induced hyperalgesia was seen in the pain ratings.

Research paper thumbnail of Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain

Neuroscience Letters, 1982

Research paper thumbnail of Chronic caffeine consumption increases the number of brain adenosine receptors

Research paper thumbnail of Lack of interaction between buspirone and triazolam

European Neuropsychopharmacology, 1993

Research paper thumbnail of Social priming enhances interpersonal synchronization and feeling of connectedness towards schizophrenia patients

Scientific Reports, 2015

What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remain... more What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remains obscure. Despite recent findings that human bonding is an interactive process influenced by coordination dynamics, the spatiotemporal organization of the bodily movements of schizophrenia patients when interacting with other people is poorly understood. Interpersonal motor coordination between dyads of patients (n 5 45) or healthy controls (n 5 45), and synchronization partners (n 5 90), was assessed with a hand-held pendulum task following implicit exposure to pro-social, non-social, or anti-social primes. We evaluated the socio-motor competence and the feeling of connectedness between participants and their synchronization partners with a measure of motor coordination stability. Immediately after the coordination task, all participants were also asked to rate the likeableness of their interacting partner. Our results showed greater stability during interpersonal synchrony in schizophrenia patients who received pro-social priming, inducing in their synchronization partner greater feelings of connectedness towards patients. This greater feeling of connectedness was positively correlated with stronger motor synchronization between participants suggesting that motor coordination partly underlies patients' social interactions and feelings of contact with others. Pro-social priming can have a pervasive effect on abnormal social interactions in schizophrenia patients.