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Papers by JYOTHIS DEVASIA

The present study reports the synthesis and characterization of Aggregation-Induced Emission (AIE... more The present study reports the synthesis and characterization of Aggregation-Induced Emission (AIE)-Excited-state intramolecular proton transfer (ESIPT) active 2-(2-(4-(4-bromo phenyl) thiazol-2-yl)vinyl)phenol (BTVP). The AIE properties of BTVP in Acetone/Water solution are investigated, and fluorescent organic nanoparticles (FONs) (sizes ranging from 150-200 nm) are prepared in various water fractions (f H2O). The established visco-chromic property suggests that the restriction of intramolecular rotation is responsible for the AIE-ESIPT behavior of the molecule, providing a means to sense viscosity. The synthesized FONs act as fluorescence chemosensors to detect Al 3+ ions via a photoinduced electron transfer (PET) mechanism. Job's, Benesi-Hildebrand method, and 1 HNMR titration confirm the 1:1 binding of BTVP with the metal ion. Studies on the emission concerning pH reveal the high stability of FONs over a broad range of pH, and a gradual change in the emission wavelength for the BTVP-Al 3+ complex (BTVP-Al) is observed, providing a means to sense pH ranging from 2-8. The solid-state photoluminescence of BTVP is used for latent fingerprint detection, demonstrating its efficiency in detecting both primary and secondary information. Additionally, both BTVP FNOs and BTVP-Al are used in cell imaging, where specific nuclear staining with BTVP-Al and cytoplasm staining with BTVP are observed.

This work represents the facile and green synthesis of Molybdenum (Mo)-doped bismuth vanadate (Bi... more This work represents the facile and green synthesis of Molybdenum
(Mo)-doped bismuth vanadate (BiVO4). Green synthesis of Modoped
BiVO4 was done using combustion technique using
Mangifera indica (Mango) leaf extract as the fuel for combustion.
The material synthesised was pure and characterised using X-ray
diffraction, scanning electron microscopy, high resolution transmission
electron microscopy, ultraviolet–visible diffuse reflectance
spectroscopy, Fourier transform infrared spectroscopy and photoluminescence
(PL). It was found that Mo-doped BiVO4 had monoclinic
scheelite phase, with a bandgap of 3.71 eV. Various
application was possible from the synthesised material like photodegradation
of Malachite Green, a typical organic which showed
excellent degradation efficiency of 99% under 120 minutes. The
catalyst also gave up to 95% yields in the light-assisted oxidation of
aromatic alcohols to corresponding aldehydes. The material also
showed excellent antioxidant properties showing 6.7 μg of ascorbic
acid equivalence (AAE). It gave an excellent minimum lethal dosage
(MLD) of 500 μg against Penicillium and Trichoderma fungal strains
and showed maximum of 32 mm zone of inhibition. These applications
show the versatility of the material to be used in various
fields.

Nanomaterials (NMs) have piqued the attention of scientists and researchers across many biomedica... more Nanomaterials (NMs) have piqued the attention of scientists and researchers across many biomedical sciences due to their superior physical, chemical, and magnetic properties. The efficacy and efficiency of NMs depend on adapting to specific site conditions and soil composition. NMs have lately received much attention in the context of polycyclic aromatic hydrocarbons (PAHs) polluted soil remediation and water mitigation because of their unique properties resulting from their nanoscale sizes. The remediation of hazardous PAHs in water and soil is a hot research subject. Because the exposure of PAHs in water and soil results in pollution, which raises major human health concerns. The current review reports novel advancements in NMs that subsidize enhancement for degradation of PAHs. Challenges to the fabrication of high activity-based photocatalytic materials are also discussed. Furthermore, this review delivers exclusive and wide-ranging perspectives on the fabrication of nanomaterial-based photocatalytic systems. The knowledge of both soil remediation and water mitigation is also updated.

A new series of 3-aryl/heteroaryl-2-(1H-tetrazol-5-yl) acrylamides have been synthesized through ... more A new series of 3-aryl/heteroaryl-2-(1H-tetrazol-5-yl) acrylamides have been
synthesized through catalyst-free, one-pot cascade reactions, utilizing click
chemistry approach and evaluated for their anti-COVID activities against
two proteins in silico. The structural properties of the synthesized molecules
were evaluated based on DFT calculations. Total energy of the synthesized
tetrazole compounds were obtained through computational
analysis which indicate the high stability of the synthesized compounds.
The Frontier Molecular Orbitals (FMO) and associated energies and molecular
electrostatic potential (MEP) surfaces were generated for the compounds.
Spectral analysis by DFT gave additional evidence to the structural
properties of the synthesized molecules. All tetrazole analogues come
under good ADMET data as they followed the standard value for ADMET
parameters. Docking studies offered evidence of the molecules displaying
excellent biological properties as an anti-Covid drug. Compound 4 g exhibited
excellent anti-COVID-19 properties with four hydrogen binding interactions
with amino acids GLN 2.486 Å, GLN 2.436 Å, THR 2.186Å and HSD
2.468 Å with good full-fitness score (–1189.12) and DeltaG (–7.19). Similarly,
compound 4d shown potent activity against anti-COVID-19 mutant protein
(PDB: 3K7H) with three hydrogen binding interactions, i.e., SER 2.274 Å,
GLU 1.758 Å and GLU 1.853 Å with full-fitness score of –786.60) and DeltaG
(–6.85). The result of these studies revealed that the compounds have the
potential to become lead molecules in the drug discovery process

Magnetic iron oxide nanoparticles were immobilized on microporous molecular sieves (13X) via a pl... more Magnetic iron oxide nanoparticles were immobilized on microporous molecular sieves (13X) via a plant extract mediated green synthesis method. The prepared material was then characterized using XRD, FTIR, TGA, FESEM, and TEM techniques. The synthesized iron oxide nanoparticles-molecular sieves (Fe 2 O 3 /MS) composite showed excellent photodegradation of methylene blue (MB) at 99% efficiency. Enhanced photocatalytic properties were observed in comparison with the pure iron oxide (Fe 2 O 3) nanoparticles synthesized. Catalytic conversion of triglycerides to fatty-acid ethyl esters (FAEE) was carried out using sunflower oil, and the reaction showed very good catalytic activity in the transesterification of sunflower oil, converting 84% of the sunflower oil to FAEE. The catalyst was also used in the esterification reaction and found to have excellent applicability. The catalyst showed excellent reusability, and easy separation from the reaction mixture using an external magnet. This enables the synthesized material to act as a promising photocatalyst in degradation and organic synthesis. Very few reports are available on the synthesis of magnetic iron oxide coated on molecular sieves and used for photodegradation, transesterification, and esterification catalysis.

Polycyclic Aromatic Compounds, 2021

This article reviews current multistep synthesis strategies of azole-based antibacterial agents.... more This article reviews current multistep synthesis strategies of azole-based antibacterial
agents. In recent years, extensive use of chemical agents in treating
different diseases resulted in the development of drug resistance. The war
on multidrug resistance has resulted in the most significant loss to the
world’s economy. Thus, the expansion of development of novel and potential
candidates such as azoles and its derivatives is an escalating area in the
field of medicinal chemistry. Azole compounds are increasingly being considered
necessary in drug discovery paradigms as a number of them serve as
lead compounds for the discovery of potent therapeutic agents. They have
been used to treat bacterial, fungal, malarial, viral, and other general infections.
They have also been known for their anticancer and anti-inflammatory
activities. Their efficacy has been attributed to their electron-rich property,
resulting in the formation of non-covalent bonds to the receptor proteins.
Current research has given us a significant collection of synthetic strategies
in the progress of azole compounds. This review article describes the survey
of literature regarding multistep synthetic methods in the preparation of
azole-based compounds and their antibacterial properties in the last 5 years.

Polycyclic Aromatic Compounds, 2021