Joan Dalmau Carolà - Academia.edu (original) (raw)
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Papers by Joan Dalmau Carolà
Reports of coincident amyotrophic lateral sclerosis, rheumatoid arthritis, and anti- TNF treatmen... more Reports of coincident amyotrophic lateral sclerosis, rheumatoid arthritis, and anti- TNF treatment are scant. We report a new case of a patient with other comorbidities exposed to long-term adalimumab treatment in whom a potential neurotoxic side effect of the drug must be considered. We speculate whether continued exposure after the diagnosis of ALS could explain the severity of her outcome.
Medicine
To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effe... more To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ. A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted. Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ± 12.5 years, disease duration 8.7 ± 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was À11.2 ± 4.0 (P < .001). Mean Disease Activity Index score (DAS28) decreased from 5.5 ± 1.0 at baseline to 2.7 ± 1.3 (P < .001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was À5.4 ± 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively. Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients. Abbreviations: AEs = adverse events, BDI-II = Beck Depression Inventory, version II, CRP = C-reactive protein, DAS28 = Disease Activity Index score, DMARDs = disease-modifying antirheumatic drugs, ESR = erythrocyte sedimentation rate, EULAR = European League Against Rheumatism, FACIT-F = Functional Assessment Chronic Illness Therapy-Fatigue scale, HPA = hypothalamic-pituitary-adrenal, IL = interleukin, PROs = patient-reported outcomes, RA = rheumatoid arthritis, SJC = swollen joint count, TCZ = tocilizumab, TJC = tender joint count, SAEs = serious adverse events, TNF-alfa = tumor necrosis factor-alpha, VAS = visual analog scale.
Indian Journal of Rheumatology, 2016
Annals of the Rheumatic Diseases
Pain Practice, 2010
The quadratus femoris is an external rotator of the hip. Quadratus femoris injury can accompany d... more The quadratus femoris is an external rotator of the hip. Quadratus femoris injury can accompany damage to the surrounding muscles. Guided by the clinical symptoms, the injection technique described here can facilitate accurate diagnosis in selected cases.
Pain Practice, 2013
Iliopsoas impingement is an under recognized cause of failed total hip arthroplasty. We report 2 ... more Iliopsoas impingement is an under recognized cause of failed total hip arthroplasty. We report 2 cases of iliopsoas impingement resolution diagnosed with the aid of imaging techniques and fluoroscopically guided injection.
Revista Española de Enfermedades Metabólicas Óseas, 2006
International Journal of Rheumatic Diseases, 2013
ABSTRACT We present a case of erythema nodosum as a first complain secondary to probable tubercul... more ABSTRACT We present a case of erythema nodosum as a first complain secondary to probable tuberculous adenitis, a new complication that represents another “red flag” during anti-TNF therapy.
Accountability in Research, 2010
Pain Practice, 2005
The obturator internus muscle is an external rotator of the hip. Obturator internus injury may oc... more The obturator internus muscle is an external rotator of the hip. Obturator internus injury may occur and be hidden by the piriformis syndrome. Clinical symptoms may offer some clues to the clinician. The selective injection technique described here facilitates precise diagnosis.
Reports of coincident amyotrophic lateral sclerosis, rheumatoid arthritis, and anti- TNF treatmen... more Reports of coincident amyotrophic lateral sclerosis, rheumatoid arthritis, and anti- TNF treatment are scant. We report a new case of a patient with other comorbidities exposed to long-term adalimumab treatment in whom a potential neurotoxic side effect of the drug must be considered. We speculate whether continued exposure after the diagnosis of ALS could explain the severity of her outcome.
Medicine
To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effe... more To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ. A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted. Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ± 12.5 years, disease duration 8.7 ± 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was À11.2 ± 4.0 (P < .001). Mean Disease Activity Index score (DAS28) decreased from 5.5 ± 1.0 at baseline to 2.7 ± 1.3 (P < .001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was À5.4 ± 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively. Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients. Abbreviations: AEs = adverse events, BDI-II = Beck Depression Inventory, version II, CRP = C-reactive protein, DAS28 = Disease Activity Index score, DMARDs = disease-modifying antirheumatic drugs, ESR = erythrocyte sedimentation rate, EULAR = European League Against Rheumatism, FACIT-F = Functional Assessment Chronic Illness Therapy-Fatigue scale, HPA = hypothalamic-pituitary-adrenal, IL = interleukin, PROs = patient-reported outcomes, RA = rheumatoid arthritis, SJC = swollen joint count, TCZ = tocilizumab, TJC = tender joint count, SAEs = serious adverse events, TNF-alfa = tumor necrosis factor-alpha, VAS = visual analog scale.
Indian Journal of Rheumatology, 2016
Annals of the Rheumatic Diseases
Pain Practice, 2010
The quadratus femoris is an external rotator of the hip. Quadratus femoris injury can accompany d... more The quadratus femoris is an external rotator of the hip. Quadratus femoris injury can accompany damage to the surrounding muscles. Guided by the clinical symptoms, the injection technique described here can facilitate accurate diagnosis in selected cases.
Pain Practice, 2013
Iliopsoas impingement is an under recognized cause of failed total hip arthroplasty. We report 2 ... more Iliopsoas impingement is an under recognized cause of failed total hip arthroplasty. We report 2 cases of iliopsoas impingement resolution diagnosed with the aid of imaging techniques and fluoroscopically guided injection.
Revista Española de Enfermedades Metabólicas Óseas, 2006
International Journal of Rheumatic Diseases, 2013
ABSTRACT We present a case of erythema nodosum as a first complain secondary to probable tubercul... more ABSTRACT We present a case of erythema nodosum as a first complain secondary to probable tuberculous adenitis, a new complication that represents another “red flag” during anti-TNF therapy.
Accountability in Research, 2010
Pain Practice, 2005
The obturator internus muscle is an external rotator of the hip. Obturator internus injury may oc... more The obturator internus muscle is an external rotator of the hip. Obturator internus injury may occur and be hidden by the piriformis syndrome. Clinical symptoms may offer some clues to the clinician. The selective injection technique described here facilitates precise diagnosis.