Joy Gbadegoye - Academia.edu (original) (raw)

Papers by Joy Gbadegoye

Research paper thumbnail of Cardiac fibrogenesis: an immuno-metabolic perspective

Frontiers in physiology, Mar 21, 2024

Research paper thumbnail of Covid-19 and Cholera Co-Infection and Comorbidity in Africa and Asia: A Systematic Review and Meta Analysis

Research paper thumbnail of The re-emergence and transmission of Monkeypox virus in Nigeria: the role of one health

Frontiers in Public Health, Jan 4, 2024

Research paper thumbnail of In vitro antioxidant, anti‐inflammatory and antihypertensive activities of methanol leaf extract of <i>Peasea americana</i>

The FASEB Journal, May 1, 2022

Research paper thumbnail of The potential application of artificial intelligence in veterinary clinical practice and biomedical research

Frontiers in veterinary science, Jan 31, 2024

Artificial intelligence (AI) is a fast-paced technological advancement in terms of its applicatio... more Artificial intelligence (AI) is a fast-paced technological advancement in terms of its application to various fields of science and technology. In particular, AI has the potential to play various roles in veterinary clinical practice, enhancing the way veterinary care is delivered, improving outcomes for animals and ultimately humans. Also, in recent years, the emergence of AI has led to a new direction in biomedical research, especially in translational research with great potential, promising to revolutionize science. AI is applicable in antimicrobial resistance (AMR) research, cancer research, drug design and vaccine development, epidemiology, disease surveillance, and genomics. Here, we highlighted and discussed the potential impact of various aspects of AI in veterinary clinical practice and biomedical research, proposing this technology as a key tool for addressing pressing global health challenges across various domains.

Research paper thumbnail of Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Journal of Cardiovascular Development and Disease

Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen an... more Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review ai...

Research paper thumbnail of Amelioration of N?-nitro-L-arginine methyl ester (L-NAME) Induced Hypertension and Cardio-renal Oxidative Stress in Rat Model by Methanol Extract of Ficus exasperata Leaf

Physiology

Hypertension is a chronic cardiovascular disease and an important risk factor for many cardiovasc... more Hypertension is a chronic cardiovascular disease and an important risk factor for many cardiovascular complications which makes affordable, effective and efficient management protocols inevitable. Ficus exaspirata is a medicinal plant with antioxidant potentials that is being used in the management of diseases in Nigeria.We, therefore, investigated the ameliorative effects of Ficus exaspirata on L-NAME induced hypertension, oxidative stress and cardio-renal complicationsForty eight male rats (Wistar strain) were used in this study, and they were randomly divided into six experimental groups with eight rats in each group. Group A served as the controls and they received distilled water only for the period of 21 days. Group B was given L-NAME only at 40 mg/kg while groups C, D and E were given a daily dose of L-NAME at 40 mg/kg and methanol leaf extract at respective doses of 100 mg/kg, 200 mg/kg and 400 mg/kg for 21 days. Group F was given a daily dose of L-NAME (40 mg/kg) + Lisinopr...

Research paper thumbnail of Effect of Persea americana leave extract (PALE) on male reproduction

Physiology

Infertility affects about 30 million men globally and one of the leading causes of male infertili... more Infertility affects about 30 million men globally and one of the leading causes of male infertility is drug use or misuse. Various plant parts of Persea americana, commonly known as avocado, have been used as food and for managing pain, hyperglycemia, and high blood pressure among others. This research was conducted to determine the potential benefits and/or detriments of Persea americana leaves on the reproductive indices through the spermatogenic cycle of male Wistar rats. Male Wistar rats were orally given Persea americana leave extract (PALE) for 7 weeks at 100mg/kg and 200mg/kg. After each week of PALE administration, the sperm count, sperm motility, sperm morphology, sperm livability, testicular and epididymal histomorphology, and testosterone assay was conducted on rats from each group. Fertility test and conception rate as also determined by introducing rats from the individual group each week to female Wistar rats. Ultrasound was done on the female rats and litter size was ...

Research paper thumbnail of Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases

Frontiers in Immunology

There are overwhelming reports on the promotional effect of hypoxia on the malignant behavior of ... more There are overwhelming reports on the promotional effect of hypoxia on the malignant behavior of various forms of cancer cells. This has been proposed and tested exhaustively in the light of cancer immunotherapy. However, there could be more interesting functions of a hypoxic cellular micro-environment than malignancy. There is a highly intricate crosstalk between hypoxia inducible factor (HIF), a transcriptional factor produced during hypoxia, and nuclear factor kappa B (NF‐κB) which has been well characterized in various immune cell types. This important crosstalk shares common activating and inhibitory stimuli, regulators, and molecular targets. Impaired hydroxylase activity contributes to the activation of HIFs. Inflammatory ligands activate NF-κB activity, which leads to the expression of inflammatory and anti-apoptotic genes. The eventual sequelae of the interaction between these two molecular players in immune cells, either bolstering or abrogating functions, is largely cell-...

Research paper thumbnail of Cardiac fibrogenesis: an immuno-metabolic perspective

Frontiers in physiology, Mar 21, 2024

Research paper thumbnail of Covid-19 and Cholera Co-Infection and Comorbidity in Africa and Asia: A Systematic Review and Meta Analysis

Research paper thumbnail of The re-emergence and transmission of Monkeypox virus in Nigeria: the role of one health

Frontiers in Public Health, Jan 4, 2024

Research paper thumbnail of In vitro antioxidant, anti‐inflammatory and antihypertensive activities of methanol leaf extract of <i>Peasea americana</i>

The FASEB Journal, May 1, 2022

Research paper thumbnail of The potential application of artificial intelligence in veterinary clinical practice and biomedical research

Frontiers in veterinary science, Jan 31, 2024

Artificial intelligence (AI) is a fast-paced technological advancement in terms of its applicatio... more Artificial intelligence (AI) is a fast-paced technological advancement in terms of its application to various fields of science and technology. In particular, AI has the potential to play various roles in veterinary clinical practice, enhancing the way veterinary care is delivered, improving outcomes for animals and ultimately humans. Also, in recent years, the emergence of AI has led to a new direction in biomedical research, especially in translational research with great potential, promising to revolutionize science. AI is applicable in antimicrobial resistance (AMR) research, cancer research, drug design and vaccine development, epidemiology, disease surveillance, and genomics. Here, we highlighted and discussed the potential impact of various aspects of AI in veterinary clinical practice and biomedical research, proposing this technology as a key tool for addressing pressing global health challenges across various domains.

Research paper thumbnail of Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Journal of Cardiovascular Development and Disease

Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen an... more Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review ai...

Research paper thumbnail of Amelioration of N?-nitro-L-arginine methyl ester (L-NAME) Induced Hypertension and Cardio-renal Oxidative Stress in Rat Model by Methanol Extract of Ficus exasperata Leaf

Physiology

Hypertension is a chronic cardiovascular disease and an important risk factor for many cardiovasc... more Hypertension is a chronic cardiovascular disease and an important risk factor for many cardiovascular complications which makes affordable, effective and efficient management protocols inevitable. Ficus exaspirata is a medicinal plant with antioxidant potentials that is being used in the management of diseases in Nigeria.We, therefore, investigated the ameliorative effects of Ficus exaspirata on L-NAME induced hypertension, oxidative stress and cardio-renal complicationsForty eight male rats (Wistar strain) were used in this study, and they were randomly divided into six experimental groups with eight rats in each group. Group A served as the controls and they received distilled water only for the period of 21 days. Group B was given L-NAME only at 40 mg/kg while groups C, D and E were given a daily dose of L-NAME at 40 mg/kg and methanol leaf extract at respective doses of 100 mg/kg, 200 mg/kg and 400 mg/kg for 21 days. Group F was given a daily dose of L-NAME (40 mg/kg) + Lisinopr...

Research paper thumbnail of Effect of Persea americana leave extract (PALE) on male reproduction

Physiology

Infertility affects about 30 million men globally and one of the leading causes of male infertili... more Infertility affects about 30 million men globally and one of the leading causes of male infertility is drug use or misuse. Various plant parts of Persea americana, commonly known as avocado, have been used as food and for managing pain, hyperglycemia, and high blood pressure among others. This research was conducted to determine the potential benefits and/or detriments of Persea americana leaves on the reproductive indices through the spermatogenic cycle of male Wistar rats. Male Wistar rats were orally given Persea americana leave extract (PALE) for 7 weeks at 100mg/kg and 200mg/kg. After each week of PALE administration, the sperm count, sperm motility, sperm morphology, sperm livability, testicular and epididymal histomorphology, and testosterone assay was conducted on rats from each group. Fertility test and conception rate as also determined by introducing rats from the individual group each week to female Wistar rats. Ultrasound was done on the female rats and litter size was ...

Research paper thumbnail of Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases

Frontiers in Immunology

There are overwhelming reports on the promotional effect of hypoxia on the malignant behavior of ... more There are overwhelming reports on the promotional effect of hypoxia on the malignant behavior of various forms of cancer cells. This has been proposed and tested exhaustively in the light of cancer immunotherapy. However, there could be more interesting functions of a hypoxic cellular micro-environment than malignancy. There is a highly intricate crosstalk between hypoxia inducible factor (HIF), a transcriptional factor produced during hypoxia, and nuclear factor kappa B (NF‐κB) which has been well characterized in various immune cell types. This important crosstalk shares common activating and inhibitory stimuli, regulators, and molecular targets. Impaired hydroxylase activity contributes to the activation of HIFs. Inflammatory ligands activate NF-κB activity, which leads to the expression of inflammatory and anti-apoptotic genes. The eventual sequelae of the interaction between these two molecular players in immune cells, either bolstering or abrogating functions, is largely cell-...