J. Gudaityte - Academia.edu (original) (raw)

Papers by J. Gudaityte

Background and Goal of Study: The aim of this study was to compare analgesic ef fect of intraveno... more Background and Goal of Study: The aim of this study was to compare analgesic ef fect of intravenous acetaminophen with ketoprofen or the combination of these drugs in children undergoing adenotonsillectomy or tonsillectomy. Materials and methods: The prospective clinical study, approved by the Center for Bioethics included 147, 5-15 year old children, admit ted to the Hospital of Lithuanian University of Health Sciences for tonsillectomy or adenotonsillectomy. Children were randomly assigned to one of 3 groups, 49 children in each, using the envelope method. The children received i.v. ketoprofen 2 mg/kg (group K) or acetaminophen 15 mg/kg (group A) or the combination of these 2 drugs (group KA) af ter induction of anaesthesia. General anesthesia was induced with: sevoflurane via face mask or i/v propofol 3mg/kg, followed by atropine 0.02 mg/kg, mivacurium 0.2 mg/kg or atracurium 0.5 mg/kg, phentanyl 2-2.5 μg/kg and dexamethasone 0.15 mg/kg and maintained with sevoflurane. Pain was a...

Table 1. Median pain intensity in groups. (the range of median) The prospective clinical study, a... more Table 1. Median pain intensity in groups. (the range of median) The prospective clinical study, approved by the Centre for Bioethics included 5 -15 year old children, admitted to the Hospital of Lithuanian University of Health Sciences for tonsillectomy or adenotonsillectomy. Before surgery patients were blindly randomized to receive after induction of anaesthesia analgesics for postoperative pain relief: Flow chart 1.

Anesthesia & Analgesia, 2016

Materials & Methods: The retrospective study, approved by local Committee of Bioethics includ... more Materials & Methods: The retrospective study, approved by local Committee of Bioethics included adult colorectal surgery patients from January to November, 2013. Analysis was based on demographics, total blood count before and after surgery, perioperative management of anaemia, postoperative complications and outcomes. Anemia was diagnosed according to WHO: the level of hemoglobin (Hb) <120 g/l for females and <130 g/l for males. SPSSv17.0 software package, Student’s t, Mann-Whitney U, Pearson chi2 and Fisher’s tests were used for statistical analysis with p<0.05 regarded as statistically significant.

European Journal of Anaesthesiology, 2014

European Journal of Anaesthesiology, 2014

Background and Goal of Study: Patient position af fects cardiac function and hemodynamic paramete... more Background and Goal of Study: Patient position af fects cardiac function and hemodynamic parameters (1). The goal was to compare hemodynamic changes assessed by impedance cardiography during anorectal surgery under low-dose spinal anaesthesia in lithotomy and jack knife position. Materials and methods: Approved by local Ethics Commit tee, the randomized controlled study included 104, ASA I-II adult patients admit ted for elective anorectal surgery, randomly assigned to be performed in lithotomy (group L, n=51) or jack-knife position (group J, n=53) using the envelope method. Af ter arrival to OR and standard monitoring, impedance cardiography device niccomoTM was connected to the patient, and the following variables were recorded: cardiac output (CO), systemic vascular resistance (SVR), systolic index (SI), cardiac index (CI), acceleration index (ACI) measured at times of arrival to OR, placement for, start and end of surgery, placement to bed. Spinal block was made in the sit ting position with 4 mg of 0.5% hyperbaric bupivacaine+10 mkg of fentanyl injected over 2 min. Af ter sit ting for 10 min level of blockade was assessed, patient was placed to one of the two positions and surgery was started. Comparison was based on hemodynamic changes between and inside groups over time. Results and discussion: Data are presented as mean±SD, *p< 0.05 considered as statistically significant group J vs group L:

British journal of haematology, 2014

Previous studies have shown that total platelet count (TPC) inadequately predicts bleeding in thr... more Previous studies have shown that total platelet count (TPC) inadequately predicts bleeding in thrombocytopenic patients with haematological malignancies. This prospective cohort study evaluated whether rotational thromboelastometry (ROTEM), coagulation or other platelet parameters were more strongly associated with bleeding than TPC. Adults treated at two UK haematology centres for haematological malignancy were enrolled if they had thrombocytopenia (TPC ≤ 50 × 10(9) /l) at beginning of, or during treatment (International Standard Randomized Controlled Trial Number 81226121). TPC and bleeding symptoms were recorded daily for up to 30 d or until platelet count recovery, hospital discharge or death. Blood samples were tested thrice weekly using ROTEM, Platelet Function Analyser (PFA)-100(®) , coagulation and platelet cytometry assays. Bleeding symptoms and TPC from 49/50 enrolled participants who completed the study were recorded on 754/760 study days. Mean platelet volume and PFA-100...

Regional Anesthesia and Pain Medicine, 2008

Regional Anesthesia and Pain Medicine, 2008

Journal of Clinical Anesthesia, 2009

European Journal of Anaesthesiology, 2011

showed great improvement compared to control; propofol+RA showed great improvement compared to pr... more showed great improvement compared to control; propofol+RA showed great improvement compared to propofol. The mechanism of RA suggested one possibility to explain the RA ef fect on local anesthetic-induced cardiac toxicity might be that RA increases intracellular pH, which then causes a decrease in intracellular concentration of the active forms of the local anesthetics. The propofol+RA group even made a great improvement compared to the propofol group, which can also be considered an additional ef fect for propofol and RA in our study. Therefore, in RA, propofol, and propofol+RA treated cases, af ter the severe HR decrease, clinically there may be much more time available before stopping bupivacaine to avoid the myocardial depression. Conclusion: Both RA and propofol+RA at tenuated bupivacaine-induced cardiovascular toxicity. Propofol enhanced the threshold for bupivacaineinduced contractile depression.

Anesthesia & Analgesia, 2016

Regional Anesthesia and Pain Medicine, 2008

European Journal of Anaesthesiology, 2008

European Journal of Anaesthesiology, 2005

ABSTRACT

European Journal of Anaesthesiology, 2006

European Journal of Anaesthesiology, 2010

Colorectal Disease, 2010

Aim The aim of this systematic literature review and meta-analysis was to compare preoperative ra... more Aim The aim of this systematic literature review and meta-analysis was to compare preoperative radiotherapy (RT) with preoperative chemoradiotherapy (ChRT) in patients with stage II and III resectable rectal cancer.

European Journal of Anaesthesiology, 2011

Background and Goal of Study: The aim of this study was to compare analgesic ef fect of intraveno... more Background and Goal of Study: The aim of this study was to compare analgesic ef fect of intravenous acetaminophen with ketoprofen or the combination of these drugs in children undergoing adenotonsillectomy or tonsillectomy. Materials and methods: The prospective clinical study, approved by the Center for Bioethics included 147, 5-15 year old children, admit ted to the Hospital of Lithuanian University of Health Sciences for tonsillectomy or adenotonsillectomy. Children were randomly assigned to one of 3 groups, 49 children in each, using the envelope method. The children received i.v. ketoprofen 2 mg/kg (group K) or acetaminophen 15 mg/kg (group A) or the combination of these 2 drugs (group KA) af ter induction of anaesthesia. General anesthesia was induced with: sevoflurane via face mask or i/v propofol 3mg/kg, followed by atropine 0.02 mg/kg, mivacurium 0.2 mg/kg or atracurium 0.5 mg/kg, phentanyl 2-2.5 μg/kg and dexamethasone 0.15 mg/kg and maintained with sevoflurane. Pain was a...

Table 1. Median pain intensity in groups. (the range of median) The prospective clinical study, a... more Table 1. Median pain intensity in groups. (the range of median) The prospective clinical study, approved by the Centre for Bioethics included 5 -15 year old children, admitted to the Hospital of Lithuanian University of Health Sciences for tonsillectomy or adenotonsillectomy. Before surgery patients were blindly randomized to receive after induction of anaesthesia analgesics for postoperative pain relief: Flow chart 1.

Anesthesia & Analgesia, 2016

Materials & Methods: The retrospective study, approved by local Committee of Bioethics includ... more Materials & Methods: The retrospective study, approved by local Committee of Bioethics included adult colorectal surgery patients from January to November, 2013. Analysis was based on demographics, total blood count before and after surgery, perioperative management of anaemia, postoperative complications and outcomes. Anemia was diagnosed according to WHO: the level of hemoglobin (Hb) <120 g/l for females and <130 g/l for males. SPSSv17.0 software package, Student’s t, Mann-Whitney U, Pearson chi2 and Fisher’s tests were used for statistical analysis with p<0.05 regarded as statistically significant.

European Journal of Anaesthesiology, 2014

European Journal of Anaesthesiology, 2014

Background and Goal of Study: Patient position af fects cardiac function and hemodynamic paramete... more Background and Goal of Study: Patient position af fects cardiac function and hemodynamic parameters (1). The goal was to compare hemodynamic changes assessed by impedance cardiography during anorectal surgery under low-dose spinal anaesthesia in lithotomy and jack knife position. Materials and methods: Approved by local Ethics Commit tee, the randomized controlled study included 104, ASA I-II adult patients admit ted for elective anorectal surgery, randomly assigned to be performed in lithotomy (group L, n=51) or jack-knife position (group J, n=53) using the envelope method. Af ter arrival to OR and standard monitoring, impedance cardiography device niccomoTM was connected to the patient, and the following variables were recorded: cardiac output (CO), systemic vascular resistance (SVR), systolic index (SI), cardiac index (CI), acceleration index (ACI) measured at times of arrival to OR, placement for, start and end of surgery, placement to bed. Spinal block was made in the sit ting position with 4 mg of 0.5% hyperbaric bupivacaine+10 mkg of fentanyl injected over 2 min. Af ter sit ting for 10 min level of blockade was assessed, patient was placed to one of the two positions and surgery was started. Comparison was based on hemodynamic changes between and inside groups over time. Results and discussion: Data are presented as mean±SD, *p< 0.05 considered as statistically significant group J vs group L:

British journal of haematology, 2014

Previous studies have shown that total platelet count (TPC) inadequately predicts bleeding in thr... more Previous studies have shown that total platelet count (TPC) inadequately predicts bleeding in thrombocytopenic patients with haematological malignancies. This prospective cohort study evaluated whether rotational thromboelastometry (ROTEM), coagulation or other platelet parameters were more strongly associated with bleeding than TPC. Adults treated at two UK haematology centres for haematological malignancy were enrolled if they had thrombocytopenia (TPC ≤ 50 × 10(9) /l) at beginning of, or during treatment (International Standard Randomized Controlled Trial Number 81226121). TPC and bleeding symptoms were recorded daily for up to 30 d or until platelet count recovery, hospital discharge or death. Blood samples were tested thrice weekly using ROTEM, Platelet Function Analyser (PFA)-100(®) , coagulation and platelet cytometry assays. Bleeding symptoms and TPC from 49/50 enrolled participants who completed the study were recorded on 754/760 study days. Mean platelet volume and PFA-100...

Regional Anesthesia and Pain Medicine, 2008

Regional Anesthesia and Pain Medicine, 2008

Journal of Clinical Anesthesia, 2009

European Journal of Anaesthesiology, 2011

showed great improvement compared to control; propofol+RA showed great improvement compared to pr... more showed great improvement compared to control; propofol+RA showed great improvement compared to propofol. The mechanism of RA suggested one possibility to explain the RA ef fect on local anesthetic-induced cardiac toxicity might be that RA increases intracellular pH, which then causes a decrease in intracellular concentration of the active forms of the local anesthetics. The propofol+RA group even made a great improvement compared to the propofol group, which can also be considered an additional ef fect for propofol and RA in our study. Therefore, in RA, propofol, and propofol+RA treated cases, af ter the severe HR decrease, clinically there may be much more time available before stopping bupivacaine to avoid the myocardial depression. Conclusion: Both RA and propofol+RA at tenuated bupivacaine-induced cardiovascular toxicity. Propofol enhanced the threshold for bupivacaineinduced contractile depression.

Anesthesia & Analgesia, 2016

Regional Anesthesia and Pain Medicine, 2008

European Journal of Anaesthesiology, 2008

European Journal of Anaesthesiology, 2005

ABSTRACT

European Journal of Anaesthesiology, 2006

European Journal of Anaesthesiology, 2010

Colorectal Disease, 2010

Aim The aim of this systematic literature review and meta-analysis was to compare preoperative ra... more Aim The aim of this systematic literature review and meta-analysis was to compare preoperative radiotherapy (RT) with preoperative chemoradiotherapy (ChRT) in patients with stage II and III resectable rectal cancer.

European Journal of Anaesthesiology, 2011