JL Pauley - Academia.edu (original) (raw)
Papers by JL Pauley
Journal of the American Chemical Society, 1954
The applicability of the mixed-liquid method to the measurement of the dielectric constant of pow... more The applicability of the mixed-liquid method to the measurement of the dielectric constant of powdered solids was teste,! with several isotropic crystalline materials: potassium iodide, potassium chloride, sodium chloride and calcium fluoride By measurements on single crystals and powdered crystals it was found that, within the limits of error (about 2%), neithcr the amount of powder present nor the physical size of the particles affected the final results. Measurements on the systems nere made by a resonance method using substitution techniques to determine capacitance a t constant temperature and frequency. The dielectric constants of standard benzene-nitrobenzene solutions of different compositions first were determined in a conventional concentric-cylinder cell. The capacity of each of these solutions then was measured in a rigid parallel-plate cell, and finally redetermined after the addition of the solid material. The intersection of the curves formed on a capacity-dielectric conqtant plot by the series of solutions containing the given solid determined the dielectric con5tant of thih solid.
Journal of Colloid Science, 1964
Journal of the American Chemical Society, 1954
The Journal of Physical Chemistry, 1964
Journal of Inorganic and Nuclear Chemistry, 1971
Ion exchange of a series of quaternary ammonium salts against cesium on BioRad AG 50 W-XI was car... more Ion exchange of a series of quaternary ammonium salts against cesium on BioRad AG 50 W-XI was carried out in methanol-water and 2-propanol-water systems at 25°C. Alkali metal ion exchange against cesium in 2-propanol-water systems were carried out for comparison. For the quaternary ammonium ion exchanges a reversal of the usual order of selectivity based on ion size was noted at high water content which may be due to expulsion of the large ions by the solvent phase. At lower water contents the normal order of exchange was noted and the log of the selectivity coeffÉcients appeared to vary nearly linearly with the reciprocal of the dielectric constant of the solvent media. For the alkali metal exchanges, no similar inversion of normal order was noted but the logs of selectivity coefficients were not generally a linear function of I/D. Swelling data were obtained for all systems but no direct relationship between swelling and selectivity could be determined. Solvent distribution data indicated, generally, little selective solvation of the resin phase.
Transactions of the Kansas Academy of Science (1903-), 1957
converted largely into calcium stearate which gives a condensed solid film at moderate pressures.... more converted largely into calcium stearate which gives a condensed solid film at moderate pressures. The fresh distilled water may contain a minute concentration of metallic ions but not enough to give a condensed film immediately. In the case of the hydrochloric acid the film may be expected to be only stearic acid. Langmuir and Schaefer (5) have determined that the monolayer on a subphase of 10-4 molal calcium carbonate is the nearly neutral soap at pH 11, at pH 5.1 it is one half neutral soap, while at pH 3 it consists entirely of the free fatty acid. Adams"'3 and Lyons and Rideal(7 have observed that surface area pressure curves varied with pH of the substrate which was regulated by the use of buffer solutions. As the underlying solution was made more alkaline, the low pressure and large area form of the film gradually disappears with decreasing limiting area until, on relatively alkaline solutions, only a single straight line is obtained with the limiting area of 20.6 A(2). In most of the cases reported, no attempt was made to assure that only a single species of positive ion was present in the substrate. In most cases, pH was regulated by the use of buffer solutions which, of course, could serve as a source of foreign cations. To the authors' knowledge it has not been suggested, except for the formation of calcium soaps5"), that this change in surface area may be due to a simple exchange of the hydrogen ions of the surface film acid for cations of the substrate.
Journal of Chemical Education, 1986
Particularly with the advent of relatively inexpensive compdterri with graphics capabilities it i... more Particularly with the advent of relatively inexpensive compdterri with graphics capabilities it is useful and donvenient to compare some of the various proposed equations of state with experimental data. This can help to give the student a better understanding of the quality of results to be expected for predictions made using these equations of state and perhaps give an insight into the way models or theories develop. One difficulty has been the lack of readily accessible PVT data in a form that is convenient for this purpose.' 35,1357.
Annals of Pharmacotherapy, 2013
BACKGROUND Limited information exists regarding the use of posaconazole for treating systemic fun... more BACKGROUND Limited information exists regarding the use of posaconazole for treating systemic fungal infections in children, adolescents, and young adults with cancer. At St. Jude Children's Research Hospital, the recommended posaconazole dose in patients weighing less than 34 kg is 18–24 mg/kg daily, given in 4 divided doses. For patients aged 13 years or older or those weighing 34 kg or more, the recommended dose is 800 mg daily, given orally in 4 divided doses. OBJECTIVE To determine whether the current posaconazole dosing guidelines achieve target posaconazole plasma concentrations of 0.7 μg/mL or greater. METHODS This retrospective clinical study examined data from patients who received treatment-dose posaconazole and had at least 1 posaconazole plasma concentration measurement. RESULTS Data from 33 patients who received posaconazole for the treatment of fungal infections were analyzed. The median age of patients was 11.5 years (range 0.5–23.2). Twenty-one of 33 patients (6...
Analytical Chemistry, 1969
Alkali metal ion exchange on Bio-Rad AG 50W X-1 resin in 0, 5, 10, 25, 50, 75, and 90% methanol-w... more Alkali metal ion exchange on Bio-Rad AG 50W X-1 resin in 0, 5, 10, 25, 50, 75, and 90% methanol-water, ethanolwater, and dioxane-water and alkali metal barium ion exchange in acetic acid-water systems were investigated at 25 OC. In part, observed changes in selectivity coefficient with solvent changes can be explained on the basis of dielectric constant effects on coulombic interactions, but the observed maxima or minima and changes in order of selectivity as the water content of the solvent is decreased can be accounted for by the electrostatic model only if it is assumed that ion solvation also changes in an appropriate manner. Some correlation between selectivity data and swelling data was noted. Radiotracer techniques were used to determine alkali metal exchange coefficients and gravimetric techniques for exchanges involving barium. From the solvent distribution data, there appeared to be no selective solvation of the resin phase.
The Journal of Physical Chemistry, 1966
ION-EXCHANGE PROCESSES IN AQUEOUS DIMETHYLFORMAMIDE MIXTURES 52 1 heterogeneity in molecular weig... more ION-EXCHANGE PROCESSES IN AQUEOUS DIMETHYLFORMAMIDE MIXTURES 52 1 heterogeneity in molecular weight, but not for the strength of the hydrodynamic interaction h. temperature, the normal stress component ull-u33 was proportional to K~ and c/M over a wide range of variables, and the component u~~-u33 was negligible. The effect of solvent power on the normal stresses will be studied in the following paper. I n conclusion, in the present system near the 0 Acknowledgment. We are indebted to Professor Tadao Kotaka for his kind advice and stimulating discussions. Thanks are also tendered to the Ministry of Education of Japan for a grant-in-aid.
The Journal of Physical Chemistry, 1966
Journal of Colloid Science, 1964
Infrared techniques were used to determine the effect of pit on the composition of stearic acid f... more Infrared techniques were used to determine the effect of pit on the composition of stearic acid films on substrates containing dilute solutions of lead, copper, aluminum, calcium, barium, sodium, and quaternary ammonium salts. It was found that the pH region at which interaction of salts with the film occurs is characteristic for the particular salt and narrower than previously generally reported.
Journal of Polymer Science, 1956
The dielectric dispersion of solutions of cellulose nitrate has been reaffirmed; however, the dis... more The dielectric dispersion of solutions of cellulose nitrate has been reaffirmed; however, the dispersion has been attributed to the formation of a copper-cellulose nitrate complex. The phenomena can be explained in the light of present theories as a resonance phenomena and occurs in the unusual frequency region of 100 to 500 kc. The variation in the dispersion frequency can be explained in terms of a “lumped constant”, oscillating, polymer aggregate. The general properties of a stiffened random coil are experimentally confirmed.
Journal of the American Chemical Society, 1954
Journal of the American Chemical Society, 1954
The applicability of the mixed-liquid method to the measurement of the dielectric constant of pow... more The applicability of the mixed-liquid method to the measurement of the dielectric constant of powdered solids was teste,! with several isotropic crystalline materials: potassium iodide, potassium chloride, sodium chloride and calcium fluoride By measurements on single crystals and powdered crystals it was found that, within the limits of error (about 2%), neithcr the amount of powder present nor the physical size of the particles affected the final results. Measurements on the systems nere made by a resonance method using substitution techniques to determine capacitance a t constant temperature and frequency. The dielectric constants of standard benzene-nitrobenzene solutions of different compositions first were determined in a conventional concentric-cylinder cell. The capacity of each of these solutions then was measured in a rigid parallel-plate cell, and finally redetermined after the addition of the solid material. The intersection of the curves formed on a capacity-dielectric conqtant plot by the series of solutions containing the given solid determined the dielectric con5tant of thih solid.
Journal of Colloid Science, 1964
Journal of the American Chemical Society, 1954
The Journal of Physical Chemistry, 1964
Journal of Inorganic and Nuclear Chemistry, 1971
Ion exchange of a series of quaternary ammonium salts against cesium on BioRad AG 50 W-XI was car... more Ion exchange of a series of quaternary ammonium salts against cesium on BioRad AG 50 W-XI was carried out in methanol-water and 2-propanol-water systems at 25°C. Alkali metal ion exchange against cesium in 2-propanol-water systems were carried out for comparison. For the quaternary ammonium ion exchanges a reversal of the usual order of selectivity based on ion size was noted at high water content which may be due to expulsion of the large ions by the solvent phase. At lower water contents the normal order of exchange was noted and the log of the selectivity coeffÉcients appeared to vary nearly linearly with the reciprocal of the dielectric constant of the solvent media. For the alkali metal exchanges, no similar inversion of normal order was noted but the logs of selectivity coefficients were not generally a linear function of I/D. Swelling data were obtained for all systems but no direct relationship between swelling and selectivity could be determined. Solvent distribution data indicated, generally, little selective solvation of the resin phase.
Transactions of the Kansas Academy of Science (1903-), 1957
converted largely into calcium stearate which gives a condensed solid film at moderate pressures.... more converted largely into calcium stearate which gives a condensed solid film at moderate pressures. The fresh distilled water may contain a minute concentration of metallic ions but not enough to give a condensed film immediately. In the case of the hydrochloric acid the film may be expected to be only stearic acid. Langmuir and Schaefer (5) have determined that the monolayer on a subphase of 10-4 molal calcium carbonate is the nearly neutral soap at pH 11, at pH 5.1 it is one half neutral soap, while at pH 3 it consists entirely of the free fatty acid. Adams"'3 and Lyons and Rideal(7 have observed that surface area pressure curves varied with pH of the substrate which was regulated by the use of buffer solutions. As the underlying solution was made more alkaline, the low pressure and large area form of the film gradually disappears with decreasing limiting area until, on relatively alkaline solutions, only a single straight line is obtained with the limiting area of 20.6 A(2). In most of the cases reported, no attempt was made to assure that only a single species of positive ion was present in the substrate. In most cases, pH was regulated by the use of buffer solutions which, of course, could serve as a source of foreign cations. To the authors' knowledge it has not been suggested, except for the formation of calcium soaps5"), that this change in surface area may be due to a simple exchange of the hydrogen ions of the surface film acid for cations of the substrate.
Journal of Chemical Education, 1986
Particularly with the advent of relatively inexpensive compdterri with graphics capabilities it i... more Particularly with the advent of relatively inexpensive compdterri with graphics capabilities it is useful and donvenient to compare some of the various proposed equations of state with experimental data. This can help to give the student a better understanding of the quality of results to be expected for predictions made using these equations of state and perhaps give an insight into the way models or theories develop. One difficulty has been the lack of readily accessible PVT data in a form that is convenient for this purpose.' 35,1357.
Annals of Pharmacotherapy, 2013
BACKGROUND Limited information exists regarding the use of posaconazole for treating systemic fun... more BACKGROUND Limited information exists regarding the use of posaconazole for treating systemic fungal infections in children, adolescents, and young adults with cancer. At St. Jude Children's Research Hospital, the recommended posaconazole dose in patients weighing less than 34 kg is 18–24 mg/kg daily, given in 4 divided doses. For patients aged 13 years or older or those weighing 34 kg or more, the recommended dose is 800 mg daily, given orally in 4 divided doses. OBJECTIVE To determine whether the current posaconazole dosing guidelines achieve target posaconazole plasma concentrations of 0.7 μg/mL or greater. METHODS This retrospective clinical study examined data from patients who received treatment-dose posaconazole and had at least 1 posaconazole plasma concentration measurement. RESULTS Data from 33 patients who received posaconazole for the treatment of fungal infections were analyzed. The median age of patients was 11.5 years (range 0.5–23.2). Twenty-one of 33 patients (6...
Analytical Chemistry, 1969
Alkali metal ion exchange on Bio-Rad AG 50W X-1 resin in 0, 5, 10, 25, 50, 75, and 90% methanol-w... more Alkali metal ion exchange on Bio-Rad AG 50W X-1 resin in 0, 5, 10, 25, 50, 75, and 90% methanol-water, ethanolwater, and dioxane-water and alkali metal barium ion exchange in acetic acid-water systems were investigated at 25 OC. In part, observed changes in selectivity coefficient with solvent changes can be explained on the basis of dielectric constant effects on coulombic interactions, but the observed maxima or minima and changes in order of selectivity as the water content of the solvent is decreased can be accounted for by the electrostatic model only if it is assumed that ion solvation also changes in an appropriate manner. Some correlation between selectivity data and swelling data was noted. Radiotracer techniques were used to determine alkali metal exchange coefficients and gravimetric techniques for exchanges involving barium. From the solvent distribution data, there appeared to be no selective solvation of the resin phase.
The Journal of Physical Chemistry, 1966
ION-EXCHANGE PROCESSES IN AQUEOUS DIMETHYLFORMAMIDE MIXTURES 52 1 heterogeneity in molecular weig... more ION-EXCHANGE PROCESSES IN AQUEOUS DIMETHYLFORMAMIDE MIXTURES 52 1 heterogeneity in molecular weight, but not for the strength of the hydrodynamic interaction h. temperature, the normal stress component ull-u33 was proportional to K~ and c/M over a wide range of variables, and the component u~~-u33 was negligible. The effect of solvent power on the normal stresses will be studied in the following paper. I n conclusion, in the present system near the 0 Acknowledgment. We are indebted to Professor Tadao Kotaka for his kind advice and stimulating discussions. Thanks are also tendered to the Ministry of Education of Japan for a grant-in-aid.
The Journal of Physical Chemistry, 1966
Journal of Colloid Science, 1964
Infrared techniques were used to determine the effect of pit on the composition of stearic acid f... more Infrared techniques were used to determine the effect of pit on the composition of stearic acid films on substrates containing dilute solutions of lead, copper, aluminum, calcium, barium, sodium, and quaternary ammonium salts. It was found that the pH region at which interaction of salts with the film occurs is characteristic for the particular salt and narrower than previously generally reported.
Journal of Polymer Science, 1956
The dielectric dispersion of solutions of cellulose nitrate has been reaffirmed; however, the dis... more The dielectric dispersion of solutions of cellulose nitrate has been reaffirmed; however, the dispersion has been attributed to the formation of a copper-cellulose nitrate complex. The phenomena can be explained in the light of present theories as a resonance phenomena and occurs in the unusual frequency region of 100 to 500 kc. The variation in the dispersion frequency can be explained in terms of a “lumped constant”, oscillating, polymer aggregate. The general properties of a stiffened random coil are experimentally confirmed.
Journal of the American Chemical Society, 1954