JOHN KLEIDERSON CHAVARRIA FERNANDEZ - Academia.edu (original) (raw)
Papers by JOHN KLEIDERSON CHAVARRIA FERNANDEZ
Plastic and Reconstructive Surgery, 2008
Background: Although it is clear that radiation therapy can cause tissue injury, the degree of in... more Background: Although it is clear that radiation therapy can cause tissue injury, the degree of injury that is observed clinically can be highly variable. It is possible that variability in the methods by which ionizing radiation is delivered can contribute to some of the observed variability. Thus, the purpose of this study was to assess the effects of various fractionation schedules on the growth and differentiation potential of isolated mesenchymal stem cells in vitro. Methods: Isolated mesenchymal stem cells (triplicate studies) were exposed to a dose of 12 Gy of ionizing radiation as a single dose, in two doses of 6 Gy, or in six doses of 2 Gy. Cellular proliferation and the potential for differentiation along the bone and fat lineage were assessed. Potential mechanisms for injury and protection were evaluated by analyzing the expression of p21 and manganese superoxide dismutase. Results: Delivery of radiation in multiple doses confers significant radioprotection to mesenchymal stem cell proliferation and potential for differentiation. In contrast, delivery of 12 Gy of radiation as a single dose or as two equal doses of 6 Gy results in marked deficiencies in cellular proliferation and potential for multilineage cellular differentiation. Conclusions: The authors have demonstrated that even minor alterations in fractionation of radiation dose can result in significant effects on the potential of mesenchymal stem cells to differentiate. These findings imply that at least some of the variability in tissue damage after radiation therapy observed clinically may be attributable to differences in the delivery of ionizing radiation.
It has been generally recognised in India that artisanal fishermen are still the masters in tradi... more It has been generally recognised in India that artisanal fishermen are still the masters in traditional gear technology. Artisanal fishermen are continuously involved in innovating new fishing technologies and adapting them to their local marine environment. Technical capability of artisanal fishermen was kept in low profile and was confined and known mostly to regions of origin. The statements given in the note on the National Workshop on Technology for Small Scale Fishworker are highly relevant in respect of technology developments in artisanal sector.
Revista De La Universidad De Mexico, Dec 1, 1973
Plastic and Reconstructive Surgery, 2008
Background: Although it is clear that radiation therapy can cause tissue injury, the degree of in... more Background: Although it is clear that radiation therapy can cause tissue injury, the degree of injury that is observed clinically can be highly variable. It is possible that variability in the methods by which ionizing radiation is delivered can contribute to some of the observed variability. Thus, the purpose of this study was to assess the effects of various fractionation schedules on the growth and differentiation potential of isolated mesenchymal stem cells in vitro. Methods: Isolated mesenchymal stem cells (triplicate studies) were exposed to a dose of 12 Gy of ionizing radiation as a single dose, in two doses of 6 Gy, or in six doses of 2 Gy. Cellular proliferation and the potential for differentiation along the bone and fat lineage were assessed. Potential mechanisms for injury and protection were evaluated by analyzing the expression of p21 and manganese superoxide dismutase. Results: Delivery of radiation in multiple doses confers significant radioprotection to mesenchymal stem cell proliferation and potential for differentiation. In contrast, delivery of 12 Gy of radiation as a single dose or as two equal doses of 6 Gy results in marked deficiencies in cellular proliferation and potential for multilineage cellular differentiation. Conclusions: The authors have demonstrated that even minor alterations in fractionation of radiation dose can result in significant effects on the potential of mesenchymal stem cells to differentiate. These findings imply that at least some of the variability in tissue damage after radiation therapy observed clinically may be attributable to differences in the delivery of ionizing radiation.
Plastic and Reconstructive Surgery, 2008
Background: Although ionizing radiation is an important treatment modality for a number of malign... more Background: Although ionizing radiation is an important treatment modality for a number of malignancies, it can be associated with significant morbidity. The exact mechanisms by which ionizing radiation results in cellular injury remain unknown. Mesenchymal stem cells give rise to a number of tissues including bone, fat, and cartilage and provide an excellent cellular model with which to evaluate the effects of ionizing radiation on cellular survival and function. Methods: Rat mesenchymal stem cells were irradiated with 0, 7, and 12 Gy of ionizing radiation and assessed for changes in growth, apoptosis, cell-cycle profile, senescence, differentiation, and gene expression. Results: Ionizing radiation resulted in a significant decrease in cellular proliferation because of increased apoptosis, G 2 cell-cycle arrest, and premature senescence. In addition, ionizing radiation caused low-level spontaneous osteoblastic differentiation. Conversely, cellular differentiation in response to lineage-specific culture conditions for bone, fat, and cartilage was markedly decreased in irradiated cells, thereby demonstrating a deficit in the ability of irradiated mesenchymal stem cells to respond to environmental stimuli. Conclusions: Although the majority of mesenchymal stem cells survive injury from ionizing radiation, this injury results in a significant decrease in cellular proliferation. Furthermore, the differentiation potential of irradiated mesenchymal stem cells in response to environmental stimuli is markedly diminished. Thus, the negative effects of ionizing radiation may result from a decreased pool of progenitor cells with limited differentiation potential. Proposed radioprotection strategies aiming to reduce tissue injury should therefore evaluate not only cellular survival but also cellular function.
Proceedings of the 2011 IEEE International Symposium on Sustainable Systems and Technology, ISSST 2011, 2011
Page 1. Dynamic modeling of Singapore's urban resource flows: Historical trends and sustaina... more Page 1. Dynamic modeling of Singapore's urban resource flows: Historical trends and sustainable scenario development Tamas Abou-Abdo, Noel R. Davis, Jonathan S. Krones, Karen N. Welling, and John E. Fernández Abstract ...
OECD Regional Outlook 2011, 2011
This introduction to the OECD Regional Outlook Policy Forum presents a brief overview of the long... more This introduction to the OECD Regional Outlook Policy Forum presents a brief overview of the long-running debate over the "New Economic Geography" and its relevance for policy, before reflecting on the significance of this debate for the wider development agenda that is central to this Outlook. The introduction then examines some recent changes in US policy in the context of this discussion. This is followed by brief introductions of the contributions to the debate that follows.
Plastic and Reconstructive Surgery, 2008
Background: Although ionizing radiation is an important treatment modality for a number of malign... more Background: Although ionizing radiation is an important treatment modality for a number of malignancies, it can be associated with significant morbidity. The exact mechanisms by which ionizing radiation results in cellular injury remain unknown. Mesenchymal stem cells give rise to a number of tissues including bone, fat, and cartilage and provide an excellent cellular model with which to evaluate the effects of ionizing radiation on cellular survival and function. Methods: Rat mesenchymal stem cells were irradiated with 0, 7, and 12 Gy of ionizing radiation and assessed for changes in growth, apoptosis, cell-cycle profile, senescence, differentiation, and gene expression. Results: Ionizing radiation resulted in a significant decrease in cellular proliferation because of increased apoptosis, G 2 cell-cycle arrest, and premature senescence. In addition, ionizing radiation caused low-level spontaneous osteoblastic differentiation. Conversely, cellular differentiation in response to lineage-specific culture conditions for bone, fat, and cartilage was markedly decreased in irradiated cells, thereby demonstrating a deficit in the ability of irradiated mesenchymal stem cells to respond to environmental stimuli. Conclusions: Although the majority of mesenchymal stem cells survive injury from ionizing radiation, this injury results in a significant decrease in cellular proliferation. Furthermore, the differentiation potential of irradiated mesenchymal stem cells in response to environmental stimuli is markedly diminished. Thus, the negative effects of ionizing radiation may result from a decreased pool of progenitor cells with limited differentiation potential. Proposed radioprotection strategies aiming to reduce tissue injury should therefore evaluate not only cellular survival but also cellular function.
Plastic and Reconstructive Surgery, 2009
Energy Policy, 2011
... Daniel Wiesmann a , Corresponding Author Contact Information , E-mail The Corresponding Autho... more ... Daniel Wiesmann a , Corresponding Author Contact Information , E-mail The Corresponding Author , Inês Lima Azevedo b , Paulo Ferrão a and John E. Fernández c. a Instituto Superior Técnico, Technical University of Lisbon, Avenida Rovisco Pais 1, 1049-001 Lisbon, Portugal. ...
Australian & New Zealand Journal of Criminology, 2009
Previous research evaluating burglars' offending location choices has produced mixed findings... more Previous research evaluating burglars' offending location choices has produced mixed findings about the influence of physical barriers and connectors on offender movement patterns. Consequently, this article utilises the discrete spatial choice approach to formally evaluate the impact of barriers and connectors on residential burglars' macro-level offending location choices. Data from Perth, Western Australia, demonstrated that physical barriers and connectors exert significant influence on offender decision-making at this level, and that the influence of impermeable barriers increases with proximity of these obstacles to the offender's point of origin. These findings provide formalised evidence for the independent importance of physical barriers and connectors in offender movement and are discussed with respect to current environmental criminology theory.
Plastic and Reconstructive Surgery, 2009
Plastic and Reconstructive Surgery, 2009
Tissue engineering is often limited by the time required for culture expansion of cells necessary... more Tissue engineering is often limited by the time required for culture expansion of cells necessary for scaffold seeding. Cell cycle regulators control entry and exit into the cell cycle and as such regulate cellular proliferation rates. The authors hypothesized that transient alteration in cell cycle regulators can be utilized as a means to accelerate stem cell proliferation. Mesenchymal stem cells were harvested from wild-type mice and mice deficient in the cell cycle regulator p21. Wild-type cells were treated with small interfering RNA against p21 in two- or three-dimensional cultures in vitro. Cellular proliferation and the potential for cellular differentiation into the bone or fat lineage were assessed. Mesenchymal stem cells treated with small interfering RNA targeting p21 demonstrated a significant decrease in p21 protein and mRNA expression 96 hours after treatment. They also proliferated significantly faster than control cells (2.5 to three times) in both two- and three-dimensional culture. Similarly, cells harvested from p21-deficient mice demonstrated a significant acceleration in cellular proliferation. Inhibition of p21 expression was not associated with significant changes in spontaneous cellular differentiation. However, transient p21 inhibition promoted both osteoblastic and adipogenic differentiation when cells were exposed to differentiation medium. Transient inhibition of the cell cycle regulator p21 results in significant acceleration of mesenchymal stem cell proliferation without promoting spontaneous cellular differentiation. Exposure to differentiation medium results in increased cellular differentiation toward the osteoblast and fat lineage. Manipulation of cell cycle regulators may represent a novel means by which stem cell proliferation can be accelerated, thereby decreasing the time required for scaffold synthesis in tissue engineering.
Journal of the American College of Surgeons, 2010
Journal of the American College of Surgeons, Volume 211, Issue 3, Pages S84, September 2010, Auth... more Journal of the American College of Surgeons, Volume 211, Issue 3, Pages S84, September 2010, Authors:Tomer Avraham, MD; Marc Soares, MD; Jamie C. Zampell, MD; Alan Yan, MD; Sanjay V. Daluvoy, MD; Babak J. Mehrara, MD, FACS. ...
American Journal of Physiology-Heart and Circulatory Physiology, 2008
Although clinical studies have identified scarring/fibrosis as significant risk factors for lymph... more Although clinical studies have identified scarring/fibrosis as significant risk factors for lymphedema, the mechanisms by which lymphatic repair is impaired remain unknown. Transforming growth factor -β1(TGF-β1) is a critical regulator of tissue fibrosis/scarring and may therefore also play a role in the regulation of lymphatic regeneration. The purpose of this study was therefore to assess the role of TGF-β1on scarring/fibrosis and lymphatic regeneration in a mouse tail model. Acute lymphedema was induced in mouse tails by full-thickness skin excision and lymphatic ligation. TGF-β1expression and scarring were modulated by repairing the wounds with or without a topical collagen gel. Lymphatic function and histological analyses were performed at various time points. Finally, the effects of TGF-β1on lymphatic endothelial cells (LECs) in vitro were evaluated. As a result, the wound repair with collagen gel significantly reduced the expression of TGF-β1, decreased scarring/fibrosis, and...
Agronomia Colombiana, Jun 1, 2007
Evaluación de diferentes concentraciones de algunos reguladores de crecimiento en la multiplicaci... more Evaluación de diferentes concentraciones de algunos reguladores de crecimiento en la multiplicación y enraizamiento in vitro de Limonium var. Misty blue Evaluation of different concentrations of some plant growth regulators on in vitro multiplication and rooting of Limonium var. Misty blue
Agronomia Colombiana, Jan 30, 2013
Micropropagación eficiente de estragón francés (Artemisia dracunculus L.
Ensuring Minority Success in Corporate Management, 1988
The following comments drawn from the responses of 9,000 employees in 13 companies to surveys con... more The following comments drawn from the responses of 9,000 employees in 13 companies to surveys conducted in 1984 and 1985 stand in stark contrast to President Reagan’s avowal that America in the 1980’s, is color- and gender-blind.
Transplantation, 1990
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Tr... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Transplantation. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed ...
Kidney International, 1988
Outcome of patients with human immunodeficiency virus on maintenance hemodialysls. Fifty-one adul... more Outcome of patients with human immunodeficiency virus on maintenance hemodialysls. Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Regardless
Plastic and Reconstructive Surgery, 2008
Background: Although it is clear that radiation therapy can cause tissue injury, the degree of in... more Background: Although it is clear that radiation therapy can cause tissue injury, the degree of injury that is observed clinically can be highly variable. It is possible that variability in the methods by which ionizing radiation is delivered can contribute to some of the observed variability. Thus, the purpose of this study was to assess the effects of various fractionation schedules on the growth and differentiation potential of isolated mesenchymal stem cells in vitro. Methods: Isolated mesenchymal stem cells (triplicate studies) were exposed to a dose of 12 Gy of ionizing radiation as a single dose, in two doses of 6 Gy, or in six doses of 2 Gy. Cellular proliferation and the potential for differentiation along the bone and fat lineage were assessed. Potential mechanisms for injury and protection were evaluated by analyzing the expression of p21 and manganese superoxide dismutase. Results: Delivery of radiation in multiple doses confers significant radioprotection to mesenchymal stem cell proliferation and potential for differentiation. In contrast, delivery of 12 Gy of radiation as a single dose or as two equal doses of 6 Gy results in marked deficiencies in cellular proliferation and potential for multilineage cellular differentiation. Conclusions: The authors have demonstrated that even minor alterations in fractionation of radiation dose can result in significant effects on the potential of mesenchymal stem cells to differentiate. These findings imply that at least some of the variability in tissue damage after radiation therapy observed clinically may be attributable to differences in the delivery of ionizing radiation.
It has been generally recognised in India that artisanal fishermen are still the masters in tradi... more It has been generally recognised in India that artisanal fishermen are still the masters in traditional gear technology. Artisanal fishermen are continuously involved in innovating new fishing technologies and adapting them to their local marine environment. Technical capability of artisanal fishermen was kept in low profile and was confined and known mostly to regions of origin. The statements given in the note on the National Workshop on Technology for Small Scale Fishworker are highly relevant in respect of technology developments in artisanal sector.
Revista De La Universidad De Mexico, Dec 1, 1973
Plastic and Reconstructive Surgery, 2008
Background: Although it is clear that radiation therapy can cause tissue injury, the degree of in... more Background: Although it is clear that radiation therapy can cause tissue injury, the degree of injury that is observed clinically can be highly variable. It is possible that variability in the methods by which ionizing radiation is delivered can contribute to some of the observed variability. Thus, the purpose of this study was to assess the effects of various fractionation schedules on the growth and differentiation potential of isolated mesenchymal stem cells in vitro. Methods: Isolated mesenchymal stem cells (triplicate studies) were exposed to a dose of 12 Gy of ionizing radiation as a single dose, in two doses of 6 Gy, or in six doses of 2 Gy. Cellular proliferation and the potential for differentiation along the bone and fat lineage were assessed. Potential mechanisms for injury and protection were evaluated by analyzing the expression of p21 and manganese superoxide dismutase. Results: Delivery of radiation in multiple doses confers significant radioprotection to mesenchymal stem cell proliferation and potential for differentiation. In contrast, delivery of 12 Gy of radiation as a single dose or as two equal doses of 6 Gy results in marked deficiencies in cellular proliferation and potential for multilineage cellular differentiation. Conclusions: The authors have demonstrated that even minor alterations in fractionation of radiation dose can result in significant effects on the potential of mesenchymal stem cells to differentiate. These findings imply that at least some of the variability in tissue damage after radiation therapy observed clinically may be attributable to differences in the delivery of ionizing radiation.
Plastic and Reconstructive Surgery, 2008
Background: Although ionizing radiation is an important treatment modality for a number of malign... more Background: Although ionizing radiation is an important treatment modality for a number of malignancies, it can be associated with significant morbidity. The exact mechanisms by which ionizing radiation results in cellular injury remain unknown. Mesenchymal stem cells give rise to a number of tissues including bone, fat, and cartilage and provide an excellent cellular model with which to evaluate the effects of ionizing radiation on cellular survival and function. Methods: Rat mesenchymal stem cells were irradiated with 0, 7, and 12 Gy of ionizing radiation and assessed for changes in growth, apoptosis, cell-cycle profile, senescence, differentiation, and gene expression. Results: Ionizing radiation resulted in a significant decrease in cellular proliferation because of increased apoptosis, G 2 cell-cycle arrest, and premature senescence. In addition, ionizing radiation caused low-level spontaneous osteoblastic differentiation. Conversely, cellular differentiation in response to lineage-specific culture conditions for bone, fat, and cartilage was markedly decreased in irradiated cells, thereby demonstrating a deficit in the ability of irradiated mesenchymal stem cells to respond to environmental stimuli. Conclusions: Although the majority of mesenchymal stem cells survive injury from ionizing radiation, this injury results in a significant decrease in cellular proliferation. Furthermore, the differentiation potential of irradiated mesenchymal stem cells in response to environmental stimuli is markedly diminished. Thus, the negative effects of ionizing radiation may result from a decreased pool of progenitor cells with limited differentiation potential. Proposed radioprotection strategies aiming to reduce tissue injury should therefore evaluate not only cellular survival but also cellular function.
Proceedings of the 2011 IEEE International Symposium on Sustainable Systems and Technology, ISSST 2011, 2011
Page 1. Dynamic modeling of Singapore's urban resource flows: Historical trends and sustaina... more Page 1. Dynamic modeling of Singapore's urban resource flows: Historical trends and sustainable scenario development Tamas Abou-Abdo, Noel R. Davis, Jonathan S. Krones, Karen N. Welling, and John E. Fernández Abstract ...
OECD Regional Outlook 2011, 2011
This introduction to the OECD Regional Outlook Policy Forum presents a brief overview of the long... more This introduction to the OECD Regional Outlook Policy Forum presents a brief overview of the long-running debate over the "New Economic Geography" and its relevance for policy, before reflecting on the significance of this debate for the wider development agenda that is central to this Outlook. The introduction then examines some recent changes in US policy in the context of this discussion. This is followed by brief introductions of the contributions to the debate that follows.
Plastic and Reconstructive Surgery, 2008
Background: Although ionizing radiation is an important treatment modality for a number of malign... more Background: Although ionizing radiation is an important treatment modality for a number of malignancies, it can be associated with significant morbidity. The exact mechanisms by which ionizing radiation results in cellular injury remain unknown. Mesenchymal stem cells give rise to a number of tissues including bone, fat, and cartilage and provide an excellent cellular model with which to evaluate the effects of ionizing radiation on cellular survival and function. Methods: Rat mesenchymal stem cells were irradiated with 0, 7, and 12 Gy of ionizing radiation and assessed for changes in growth, apoptosis, cell-cycle profile, senescence, differentiation, and gene expression. Results: Ionizing radiation resulted in a significant decrease in cellular proliferation because of increased apoptosis, G 2 cell-cycle arrest, and premature senescence. In addition, ionizing radiation caused low-level spontaneous osteoblastic differentiation. Conversely, cellular differentiation in response to lineage-specific culture conditions for bone, fat, and cartilage was markedly decreased in irradiated cells, thereby demonstrating a deficit in the ability of irradiated mesenchymal stem cells to respond to environmental stimuli. Conclusions: Although the majority of mesenchymal stem cells survive injury from ionizing radiation, this injury results in a significant decrease in cellular proliferation. Furthermore, the differentiation potential of irradiated mesenchymal stem cells in response to environmental stimuli is markedly diminished. Thus, the negative effects of ionizing radiation may result from a decreased pool of progenitor cells with limited differentiation potential. Proposed radioprotection strategies aiming to reduce tissue injury should therefore evaluate not only cellular survival but also cellular function.
Plastic and Reconstructive Surgery, 2009
Energy Policy, 2011
... Daniel Wiesmann a , Corresponding Author Contact Information , E-mail The Corresponding Autho... more ... Daniel Wiesmann a , Corresponding Author Contact Information , E-mail The Corresponding Author , Inês Lima Azevedo b , Paulo Ferrão a and John E. Fernández c. a Instituto Superior Técnico, Technical University of Lisbon, Avenida Rovisco Pais 1, 1049-001 Lisbon, Portugal. ...
Australian & New Zealand Journal of Criminology, 2009
Previous research evaluating burglars' offending location choices has produced mixed findings... more Previous research evaluating burglars' offending location choices has produced mixed findings about the influence of physical barriers and connectors on offender movement patterns. Consequently, this article utilises the discrete spatial choice approach to formally evaluate the impact of barriers and connectors on residential burglars' macro-level offending location choices. Data from Perth, Western Australia, demonstrated that physical barriers and connectors exert significant influence on offender decision-making at this level, and that the influence of impermeable barriers increases with proximity of these obstacles to the offender's point of origin. These findings provide formalised evidence for the independent importance of physical barriers and connectors in offender movement and are discussed with respect to current environmental criminology theory.
Plastic and Reconstructive Surgery, 2009
Plastic and Reconstructive Surgery, 2009
Tissue engineering is often limited by the time required for culture expansion of cells necessary... more Tissue engineering is often limited by the time required for culture expansion of cells necessary for scaffold seeding. Cell cycle regulators control entry and exit into the cell cycle and as such regulate cellular proliferation rates. The authors hypothesized that transient alteration in cell cycle regulators can be utilized as a means to accelerate stem cell proliferation. Mesenchymal stem cells were harvested from wild-type mice and mice deficient in the cell cycle regulator p21. Wild-type cells were treated with small interfering RNA against p21 in two- or three-dimensional cultures in vitro. Cellular proliferation and the potential for cellular differentiation into the bone or fat lineage were assessed. Mesenchymal stem cells treated with small interfering RNA targeting p21 demonstrated a significant decrease in p21 protein and mRNA expression 96 hours after treatment. They also proliferated significantly faster than control cells (2.5 to three times) in both two- and three-dimensional culture. Similarly, cells harvested from p21-deficient mice demonstrated a significant acceleration in cellular proliferation. Inhibition of p21 expression was not associated with significant changes in spontaneous cellular differentiation. However, transient p21 inhibition promoted both osteoblastic and adipogenic differentiation when cells were exposed to differentiation medium. Transient inhibition of the cell cycle regulator p21 results in significant acceleration of mesenchymal stem cell proliferation without promoting spontaneous cellular differentiation. Exposure to differentiation medium results in increased cellular differentiation toward the osteoblast and fat lineage. Manipulation of cell cycle regulators may represent a novel means by which stem cell proliferation can be accelerated, thereby decreasing the time required for scaffold synthesis in tissue engineering.
Journal of the American College of Surgeons, 2010
Journal of the American College of Surgeons, Volume 211, Issue 3, Pages S84, September 2010, Auth... more Journal of the American College of Surgeons, Volume 211, Issue 3, Pages S84, September 2010, Authors:Tomer Avraham, MD; Marc Soares, MD; Jamie C. Zampell, MD; Alan Yan, MD; Sanjay V. Daluvoy, MD; Babak J. Mehrara, MD, FACS. ...
American Journal of Physiology-Heart and Circulatory Physiology, 2008
Although clinical studies have identified scarring/fibrosis as significant risk factors for lymph... more Although clinical studies have identified scarring/fibrosis as significant risk factors for lymphedema, the mechanisms by which lymphatic repair is impaired remain unknown. Transforming growth factor -β1(TGF-β1) is a critical regulator of tissue fibrosis/scarring and may therefore also play a role in the regulation of lymphatic regeneration. The purpose of this study was therefore to assess the role of TGF-β1on scarring/fibrosis and lymphatic regeneration in a mouse tail model. Acute lymphedema was induced in mouse tails by full-thickness skin excision and lymphatic ligation. TGF-β1expression and scarring were modulated by repairing the wounds with or without a topical collagen gel. Lymphatic function and histological analyses were performed at various time points. Finally, the effects of TGF-β1on lymphatic endothelial cells (LECs) in vitro were evaluated. As a result, the wound repair with collagen gel significantly reduced the expression of TGF-β1, decreased scarring/fibrosis, and...
Agronomia Colombiana, Jun 1, 2007
Evaluación de diferentes concentraciones de algunos reguladores de crecimiento en la multiplicaci... more Evaluación de diferentes concentraciones de algunos reguladores de crecimiento en la multiplicación y enraizamiento in vitro de Limonium var. Misty blue Evaluation of different concentrations of some plant growth regulators on in vitro multiplication and rooting of Limonium var. Misty blue
Agronomia Colombiana, Jan 30, 2013
Micropropagación eficiente de estragón francés (Artemisia dracunculus L.
Ensuring Minority Success in Corporate Management, 1988
The following comments drawn from the responses of 9,000 employees in 13 companies to surveys con... more The following comments drawn from the responses of 9,000 employees in 13 companies to surveys conducted in 1984 and 1985 stand in stark contrast to President Reagan’s avowal that America in the 1980’s, is color- and gender-blind.
Transplantation, 1990
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Tr... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Transplantation. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed ...
Kidney International, 1988
Outcome of patients with human immunodeficiency virus on maintenance hemodialysls. Fifty-one adul... more Outcome of patients with human immunodeficiency virus on maintenance hemodialysls. Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Regardless