JW Mak - Academia.edu (original) (raw)

Papers by JW Mak

Malaysian journal of science, 2008

Nasopharyngeal carcinoma (NPC) is a type of epithelial neoplasms arising from the nasopharynx. Th... more Nasopharyngeal carcinoma (NPC) is a type of epithelial neoplasms arising from the nasopharynx. The disease is frequently encountered in southern China, Taiwan and Hong Kong. Algae are known to be a potential source of bioactive compounds with antiproliferative activity on cancer cells. The objective of this study was to screen extracts of microalgae from the University of Malaya Algae Culture Collection (UMACC) for antiproliferative activity against NPC cell lines. Solvent and aqueous extracts of 19 microalgae from the UMACC were screened for antiproliferative activity on four NPC cell lines, namely CNE1, HONE1, TWO1 and TWO4. The methanol extracts from two microalgae, namely Ankistrodesmus convolutus UMACC 101 and Synechococcus elongatus UMACC 105 showed antiproliferative activity on the NPC cell lines, with IC50 values ranging from 95.7 to 98.0ptg/mL. The methanol extract from Synechococcus elongatus was subjected to fractionation by column and thin layer chromatography (TLC) usin...

Southeast Asian Journal of Tropical Medicine and Public Health, 1981

The American Journal of Tropical Medicine and Hygiene, 1993

A clinical trial on the efficacy of a single oral dose of ivermectin at 20, 50, 100, and 200 micr... more A clinical trial on the efficacy of a single oral dose of ivermectin at 20, 50, 100, and 200 micrograms/kg was carried out in 40 subjects with subperiodic Brugia malayi microfilaremia. There was no significant difference in the clearance of microfilaremia in the four treatment groups, and the lowest geometric mean microfilarial count (GMC) achieved in the 40 subjects was 8.8/ml or 8.3% of the initial count (106.1/ml), at two weeks post-treatment. The GMC started to increase at one month post-treatment and by six months was 22.2% of the initial GMC. Only 27.5%, 23.1%, 15.0%, and 18.9% of subjects were amicrofilaremic at two, four, 12, and 24 weeks post-treatment, respectively. Mild fever in 35% of the subjects was the primary side reaction and was more common in those with microfilarial counts > or = 500/ml (85.7%) than in those with counts < 500/ml (32%). The clearance of B. malayi microfilaremia by ivermectin was less rapid than that reported for Wuchereria bancrofti. The smaller number of side reactions encountered in the present study compared with those reported for bancroftian filariasis is probably related to the lower microfilarial density in the present subjects. Since ivermectin at a single oral dose of 20-200 micrograms/kg can reduce the GMC to less than 10% at two weeks and maintain it below 25% of the initial level even at six months post-treatment, it is recommended that the drug be seriously evaluated for use in the control of brugian filariasis.

The American Journal of Tropical Medicine and Hygiene, 1988

Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and i... more Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982-1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.

The Southeast Asian journal of tropical medicine and public health, 1996

The Aborigines or Orang Asli in Peninsular Malaysia who are still seminomadic are known to have a... more The Aborigines or Orang Asli in Peninsular Malaysia who are still seminomadic are known to have a close association with dogs. In this study, enzyme-linked immunosorbent assay (ELISA) was used to detect anti-Sarcoptes scabiei var canis antibodies in this community as a measure of exposure to the mite. Out of 312 Orang Asli tested, 24.7% were positive for polyvalent anti-Sarcoptes antibodies. No significant difference was found between the positive rates in males (26.1%) and females (23.6%). Only 1.9% were positive for IgA and none was positive for IgE anti-Sarcoptes antibodies. Since there were very few patients with clinical manifestation of scabies, there is a possibility that continuous exposure to the dogs mite confers cross-protective immunity in the community against human scabies.

The Southeast Asian journal of tropical medicine and public health, 1983

The Southeast Asian journal of tropical medicine and public health, 1984

A total of 37 species of mosquitoes from seven genera were collected in six villages in the Bengk... more A total of 37 species of mosquitoes from seven genera were collected in six villages in the Bengkoka Peninsula, Sabah State, during two visits in 1981 in connection with studies on malaria and filariasis. Fifty-five per cent of the total mosquitoes collected were Mansonia. An. collessi constituted a new record of the species from Sabah. An. balabacensis was found to be naturally infected with sporozoites. Ma. bonneae was found to be naturally infected with Brugia, probably B. malayi. Parous rates of An. balabacensis and Ma. bonneae were very high with consequent high probability of survival ideally suiting transmission of malaria and filariasis.

The Southeast Asian journal of tropical medicine and public health, 1981

The Medical journal of Malaysia, 1992

The Southeast Asian journal of tropical medicine and public health, 1992

In spite of more than 30 years of control activities, malaria continues to be the most important ... more In spite of more than 30 years of control activities, malaria continues to be the most important parasitic infection in Malaysia, accounting for 39,189 confirmed cases in 1991, giving an annual parasite incidence rate of 2.2 per 1,000 population. Some factors contributing to the continued transmission of malaria are the development of drug resistant Plasmodium falciparum, changes in vector behavior, and ecological changes due to socio-economic reasons. Malaria parasite rates are higher among the Aborigines, land scheme settlers and those in intimate contact with the jungle, like loggers. There has been no substantial change in the proportion of the three common malaria species responsible for infections, P. falciparum, P. vivax, P. malariae and mixed infections accounting for about 70%, 28%, 1% and 1%, respectively of all infections. Drug resistant P. falciparum is unevenly distributed in Malaysia, but based on clinical experience and in vitro drug sensitivity studies, chloroquine r...

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985

Seven villages in Banggi Island, Sabah, Malaysia, were surveyed four times to evaluate the roles ... more Seven villages in Banggi Island, Sabah, Malaysia, were surveyed four times to evaluate the roles of local mosquitoes as vectors of malaria and Bancroftian filariasis. 11 species of Atwpheles were found biting man. 53.9% of the anophelines caught were An. jlavirostris, 27.1% An. balabacensis, 6% An. donaldi and 4.2% An. subpictus. Infective malaria sporozoites, probably of human origin, were found in two of 336 An. flavirostris and 12 of 308 An. balabacensis. Sporozoites, probably of a nonrhuman Plasmodium, were found inAn. umbrosus. Nine of 1001 An. fivirostris and four of 365 An. balabacensis harboured L2 or L3 filarial larvae identified as those of Wuchereria bancrofti. This is the first record of An. flavirostris as a natural vector of malaria and W. bancrofti in Sabah.

The dynamics ofthe transmission of subperiodic Brugia malayi in a typical endemic area in Malaysi... more The dynamics ofthe transmission of subperiodic Brugia malayi in a typical endemic area in Malaysia was studied over a period of 4 years. Mass chemotherapeutic control with diethylcarbamazine citrate was found to be inefficient, new cases being detected even after the fifth treatment cycle of 6 mg/kg x 6 days per cycle. This is in marked contrast to the situation in periodic B. malayi areas where mass treatment efficiently controlled the infection. The disparity in results in these two areas is attributed to zoonotic transmission of subperiodic B. malayi from non-human primates where a mean infection rate of 76.39r was found.

Tropical biomedicine, 2017

Dengue fever (DF) is currently one of the most important mosquito-borne diseases that affects hum... more Dengue fever (DF) is currently one of the most important mosquito-borne diseases that affects humans. Dengue fever (DF) and dengue hemorrhagic fever (DHF) are caused by four serotypes of dengue viruses (DENV-1 to DENV-4). The main vector transmitting dengue is Aedes aegypti while Aedes albopictus acts as a secondary vector. As treatment is unavailable and the first dengue vaccine approved in Mexico, Dengvaxia® has yet to be accepted worldwide, prevention of the disease relies heavily on surveillance and control of mosquito vectors. A transgene driver, Wolbachia was found to limit the transmission of dengue virus in Aedes mosquitoes. Wolbachia alone was able to inhibit viral replication, dissemination and transmission in A. aeygpti mosquitoes in experimental studies. In A. albopictus, Wolbachia did not affect the replication of dengue virus but was able to reduce the viral infection of mosquito salivary glands and limit transmission. Studies on Wolbachia have all been carried out in ...

Tropical biomedicine, 2015

The global demand for edible bird nests (EBNs) is high, especially from Hong Kong and Peoples Rep... more The global demand for edible bird nests (EBNs) is high, especially from Hong Kong and Peoples Republic of China. Recently, this industry was greatly affected when China banned the import of all the EBNs from Malaysia (except for canned version) due to detection of high levels of nitrites. Several cases of anaphylaxis following ingestion of EBNs were reported. The source(s) of these allergens remain unknown. Mites have been reported to trigger allergic responses. Hence, this study was designed to quantify, isolate and identify the mites that are associated with EBNs. The raw EBNs were purchased from swiftlet farms in five locations in Peninsular Malaysia while the commercial nests were purchased from five different Chinese traditional medicinal shops. The average mite density of all the raw nests was 285 ± 603 mites per gram of EBN while the commercial nests had a much lower mean value of 21 ± 32 mites per gram of EBN (p = 0.082). Among the raw EBNs, the nests from Kajang had the hig...

Annals of Tropical Medicine & Parasitology, 1986

Field observations were made on Coquillettidia crassipes during a study of Mansonia in a swamp fo... more Field observations were made on Coquillettidia crassipes during a study of Mansonia in a swamp forest ecotype in Tanjong Karang. There was an increase in abundance in July consistent with the increase in abundance of Mansonia and an increase in rainfall. The biting cycle showed a dramatic early peak during the period 1900-2000 hours. The probability of daily survival through one day for the first three gonotrophic cycles was 0•770, 0•722 and 0•759. Two of the 54 Cq. crassipes dissected were infective, with two and 25 L3 larvae of Brugia. Both subperiodic B. malayi and B. pahangi developed into L3 larvae in laboratory bred Cq. crassipes. The index of experimental infection was higher for B. pahangi. Mansonia bonneae and Ma. uniformis showed higher indices of experimental infection than Cq. crassipes for subperiodic B. malayi. It is concluded that in an endemic area with a high density of Cq. crassipes it could act as a secondary vector ofBrugian filariasis.

The American Journal of Tropical Medicine and Hygiene, 1980

The indirect hemagglutination (IHA) test done with turkey red cells was applied to 173 serum samp... more The indirect hemagglutination (IHA) test done with turkey red cells was applied to 173 serum samples obtained from patients and persons exposed to Wuchereria bancrofti and Brugia malayi in endemic areas of Peninsular Malaysia. A crude extract of adult worms of the rat filaria, Breinlia booliati, was used as the antigen. When a titer of 1:16 was taken as negative, positive IHA test rates in sera from microfilaria-negative persons in endemic areas, microfilaremic cases, and patients with clinical filariasis were 13%, 75%, and 80%, respectively. Results of the IHA test correlated well with results obtained with the indirect fluorescent technique.

Annales de Parasitologie Humaine et Comparée, 1977

F ilariasis division, Jalan P ah an g, K uala L um pur, M alaisie. R ésum é. O nchocerca dew itte... more F ilariasis division, Jalan P ah an g, K uala L um pur, M alaisie. R ésum é. O nchocerca dew ittei n. sp. est récoltée chez le San glier au niveau d es m étatarses (tendons et conjonctif sous-cutané) ; elle est d istin cte p ar la cuticule de la ♀ , à côtes recti lignes se chevauchant dans les cham ps latéraux et la m icrofilaire relativem ent épaisse (228-247 µ de long et 6-7 µ de large). C ette O nchocerque de Suidé p résente certains caractères p rim itifs (côtes rectilign es, p ersistance de dix p aires de p apilles caudales chez le ♂), m ais est d an s l' ensem ble n ettem ent p lu s évoluée qu'O. raillieti B ain, M üller et coll., 1976, parasite d' E q u id és.

Annales de Parasitologie Humaine et Comparée, 1988

Comparaison de souches périodiques humaines de Brugia malayi, provenant d'Inde, Chine, Corée, Mal... more Comparaison de souches périodiques humaines de Brugia malayi, provenant d'Inde, Chine, Corée, Malaisie et Indonésie, par l'analyse morphologique des mâles. Les caractères clas siques (oesophage, papilles, spicules, etc.) sont semblables d'une région à l'autre. Par contre l'ornementation cuticulaire de la région postérieure du corps, formée par l'area rugosa et par un système de perles, réalise un appareil d'accouplement « antidérapant » qui montre des différences selon l'origine géographique. Une clé dichotomique basée sur ce caractère est proposée.

The Southeast Asian journal of tropical medicine and public health, 1978

Malaysian journal of science, 2008

Nasopharyngeal carcinoma (NPC) is a type of epithelial neoplasms arising from the nasopharynx. Th... more Nasopharyngeal carcinoma (NPC) is a type of epithelial neoplasms arising from the nasopharynx. The disease is frequently encountered in southern China, Taiwan and Hong Kong. Algae are known to be a potential source of bioactive compounds with antiproliferative activity on cancer cells. The objective of this study was to screen extracts of microalgae from the University of Malaya Algae Culture Collection (UMACC) for antiproliferative activity against NPC cell lines. Solvent and aqueous extracts of 19 microalgae from the UMACC were screened for antiproliferative activity on four NPC cell lines, namely CNE1, HONE1, TWO1 and TWO4. The methanol extracts from two microalgae, namely Ankistrodesmus convolutus UMACC 101 and Synechococcus elongatus UMACC 105 showed antiproliferative activity on the NPC cell lines, with IC50 values ranging from 95.7 to 98.0ptg/mL. The methanol extract from Synechococcus elongatus was subjected to fractionation by column and thin layer chromatography (TLC) usin...

Southeast Asian Journal of Tropical Medicine and Public Health, 1981

The American Journal of Tropical Medicine and Hygiene, 1993

A clinical trial on the efficacy of a single oral dose of ivermectin at 20, 50, 100, and 200 micr... more A clinical trial on the efficacy of a single oral dose of ivermectin at 20, 50, 100, and 200 micrograms/kg was carried out in 40 subjects with subperiodic Brugia malayi microfilaremia. There was no significant difference in the clearance of microfilaremia in the four treatment groups, and the lowest geometric mean microfilarial count (GMC) achieved in the 40 subjects was 8.8/ml or 8.3% of the initial count (106.1/ml), at two weeks post-treatment. The GMC started to increase at one month post-treatment and by six months was 22.2% of the initial GMC. Only 27.5%, 23.1%, 15.0%, and 18.9% of subjects were amicrofilaremic at two, four, 12, and 24 weeks post-treatment, respectively. Mild fever in 35% of the subjects was the primary side reaction and was more common in those with microfilarial counts > or = 500/ml (85.7%) than in those with counts < 500/ml (32%). The clearance of B. malayi microfilaremia by ivermectin was less rapid than that reported for Wuchereria bancrofti. The smaller number of side reactions encountered in the present study compared with those reported for bancroftian filariasis is probably related to the lower microfilarial density in the present subjects. Since ivermectin at a single oral dose of 20-200 micrograms/kg can reduce the GMC to less than 10% at two weeks and maintain it below 25% of the initial level even at six months post-treatment, it is recommended that the drug be seriously evaluated for use in the control of brugian filariasis.

The American Journal of Tropical Medicine and Hygiene, 1988

Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and i... more Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982-1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.

The Southeast Asian journal of tropical medicine and public health, 1996

The Aborigines or Orang Asli in Peninsular Malaysia who are still seminomadic are known to have a... more The Aborigines or Orang Asli in Peninsular Malaysia who are still seminomadic are known to have a close association with dogs. In this study, enzyme-linked immunosorbent assay (ELISA) was used to detect anti-Sarcoptes scabiei var canis antibodies in this community as a measure of exposure to the mite. Out of 312 Orang Asli tested, 24.7% were positive for polyvalent anti-Sarcoptes antibodies. No significant difference was found between the positive rates in males (26.1%) and females (23.6%). Only 1.9% were positive for IgA and none was positive for IgE anti-Sarcoptes antibodies. Since there were very few patients with clinical manifestation of scabies, there is a possibility that continuous exposure to the dogs mite confers cross-protective immunity in the community against human scabies.

The Southeast Asian journal of tropical medicine and public health, 1983

The Southeast Asian journal of tropical medicine and public health, 1984

A total of 37 species of mosquitoes from seven genera were collected in six villages in the Bengk... more A total of 37 species of mosquitoes from seven genera were collected in six villages in the Bengkoka Peninsula, Sabah State, during two visits in 1981 in connection with studies on malaria and filariasis. Fifty-five per cent of the total mosquitoes collected were Mansonia. An. collessi constituted a new record of the species from Sabah. An. balabacensis was found to be naturally infected with sporozoites. Ma. bonneae was found to be naturally infected with Brugia, probably B. malayi. Parous rates of An. balabacensis and Ma. bonneae were very high with consequent high probability of survival ideally suiting transmission of malaria and filariasis.

The Southeast Asian journal of tropical medicine and public health, 1981

The Medical journal of Malaysia, 1992

The Southeast Asian journal of tropical medicine and public health, 1992

In spite of more than 30 years of control activities, malaria continues to be the most important ... more In spite of more than 30 years of control activities, malaria continues to be the most important parasitic infection in Malaysia, accounting for 39,189 confirmed cases in 1991, giving an annual parasite incidence rate of 2.2 per 1,000 population. Some factors contributing to the continued transmission of malaria are the development of drug resistant Plasmodium falciparum, changes in vector behavior, and ecological changes due to socio-economic reasons. Malaria parasite rates are higher among the Aborigines, land scheme settlers and those in intimate contact with the jungle, like loggers. There has been no substantial change in the proportion of the three common malaria species responsible for infections, P. falciparum, P. vivax, P. malariae and mixed infections accounting for about 70%, 28%, 1% and 1%, respectively of all infections. Drug resistant P. falciparum is unevenly distributed in Malaysia, but based on clinical experience and in vitro drug sensitivity studies, chloroquine r...

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985

Seven villages in Banggi Island, Sabah, Malaysia, were surveyed four times to evaluate the roles ... more Seven villages in Banggi Island, Sabah, Malaysia, were surveyed four times to evaluate the roles of local mosquitoes as vectors of malaria and Bancroftian filariasis. 11 species of Atwpheles were found biting man. 53.9% of the anophelines caught were An. jlavirostris, 27.1% An. balabacensis, 6% An. donaldi and 4.2% An. subpictus. Infective malaria sporozoites, probably of human origin, were found in two of 336 An. flavirostris and 12 of 308 An. balabacensis. Sporozoites, probably of a nonrhuman Plasmodium, were found inAn. umbrosus. Nine of 1001 An. fivirostris and four of 365 An. balabacensis harboured L2 or L3 filarial larvae identified as those of Wuchereria bancrofti. This is the first record of An. flavirostris as a natural vector of malaria and W. bancrofti in Sabah.

The dynamics ofthe transmission of subperiodic Brugia malayi in a typical endemic area in Malaysi... more The dynamics ofthe transmission of subperiodic Brugia malayi in a typical endemic area in Malaysia was studied over a period of 4 years. Mass chemotherapeutic control with diethylcarbamazine citrate was found to be inefficient, new cases being detected even after the fifth treatment cycle of 6 mg/kg x 6 days per cycle. This is in marked contrast to the situation in periodic B. malayi areas where mass treatment efficiently controlled the infection. The disparity in results in these two areas is attributed to zoonotic transmission of subperiodic B. malayi from non-human primates where a mean infection rate of 76.39r was found.

Tropical biomedicine, 2017

Dengue fever (DF) is currently one of the most important mosquito-borne diseases that affects hum... more Dengue fever (DF) is currently one of the most important mosquito-borne diseases that affects humans. Dengue fever (DF) and dengue hemorrhagic fever (DHF) are caused by four serotypes of dengue viruses (DENV-1 to DENV-4). The main vector transmitting dengue is Aedes aegypti while Aedes albopictus acts as a secondary vector. As treatment is unavailable and the first dengue vaccine approved in Mexico, Dengvaxia® has yet to be accepted worldwide, prevention of the disease relies heavily on surveillance and control of mosquito vectors. A transgene driver, Wolbachia was found to limit the transmission of dengue virus in Aedes mosquitoes. Wolbachia alone was able to inhibit viral replication, dissemination and transmission in A. aeygpti mosquitoes in experimental studies. In A. albopictus, Wolbachia did not affect the replication of dengue virus but was able to reduce the viral infection of mosquito salivary glands and limit transmission. Studies on Wolbachia have all been carried out in ...

Tropical biomedicine, 2015

The global demand for edible bird nests (EBNs) is high, especially from Hong Kong and Peoples Rep... more The global demand for edible bird nests (EBNs) is high, especially from Hong Kong and Peoples Republic of China. Recently, this industry was greatly affected when China banned the import of all the EBNs from Malaysia (except for canned version) due to detection of high levels of nitrites. Several cases of anaphylaxis following ingestion of EBNs were reported. The source(s) of these allergens remain unknown. Mites have been reported to trigger allergic responses. Hence, this study was designed to quantify, isolate and identify the mites that are associated with EBNs. The raw EBNs were purchased from swiftlet farms in five locations in Peninsular Malaysia while the commercial nests were purchased from five different Chinese traditional medicinal shops. The average mite density of all the raw nests was 285 ± 603 mites per gram of EBN while the commercial nests had a much lower mean value of 21 ± 32 mites per gram of EBN (p = 0.082). Among the raw EBNs, the nests from Kajang had the hig...

Annals of Tropical Medicine & Parasitology, 1986

Field observations were made on Coquillettidia crassipes during a study of Mansonia in a swamp fo... more Field observations were made on Coquillettidia crassipes during a study of Mansonia in a swamp forest ecotype in Tanjong Karang. There was an increase in abundance in July consistent with the increase in abundance of Mansonia and an increase in rainfall. The biting cycle showed a dramatic early peak during the period 1900-2000 hours. The probability of daily survival through one day for the first three gonotrophic cycles was 0•770, 0•722 and 0•759. Two of the 54 Cq. crassipes dissected were infective, with two and 25 L3 larvae of Brugia. Both subperiodic B. malayi and B. pahangi developed into L3 larvae in laboratory bred Cq. crassipes. The index of experimental infection was higher for B. pahangi. Mansonia bonneae and Ma. uniformis showed higher indices of experimental infection than Cq. crassipes for subperiodic B. malayi. It is concluded that in an endemic area with a high density of Cq. crassipes it could act as a secondary vector ofBrugian filariasis.

The American Journal of Tropical Medicine and Hygiene, 1980

The indirect hemagglutination (IHA) test done with turkey red cells was applied to 173 serum samp... more The indirect hemagglutination (IHA) test done with turkey red cells was applied to 173 serum samples obtained from patients and persons exposed to Wuchereria bancrofti and Brugia malayi in endemic areas of Peninsular Malaysia. A crude extract of adult worms of the rat filaria, Breinlia booliati, was used as the antigen. When a titer of 1:16 was taken as negative, positive IHA test rates in sera from microfilaria-negative persons in endemic areas, microfilaremic cases, and patients with clinical filariasis were 13%, 75%, and 80%, respectively. Results of the IHA test correlated well with results obtained with the indirect fluorescent technique.

Annales de Parasitologie Humaine et Comparée, 1977

F ilariasis division, Jalan P ah an g, K uala L um pur, M alaisie. R ésum é. O nchocerca dew itte... more F ilariasis division, Jalan P ah an g, K uala L um pur, M alaisie. R ésum é. O nchocerca dew ittei n. sp. est récoltée chez le San glier au niveau d es m étatarses (tendons et conjonctif sous-cutané) ; elle est d istin cte p ar la cuticule de la ♀ , à côtes recti lignes se chevauchant dans les cham ps latéraux et la m icrofilaire relativem ent épaisse (228-247 µ de long et 6-7 µ de large). C ette O nchocerque de Suidé p résente certains caractères p rim itifs (côtes rectilign es, p ersistance de dix p aires de p apilles caudales chez le ♂), m ais est d an s l' ensem ble n ettem ent p lu s évoluée qu'O. raillieti B ain, M üller et coll., 1976, parasite d' E q u id és.

Annales de Parasitologie Humaine et Comparée, 1988

Comparaison de souches périodiques humaines de Brugia malayi, provenant d'Inde, Chine, Corée, Mal... more Comparaison de souches périodiques humaines de Brugia malayi, provenant d'Inde, Chine, Corée, Malaisie et Indonésie, par l'analyse morphologique des mâles. Les caractères clas siques (oesophage, papilles, spicules, etc.) sont semblables d'une région à l'autre. Par contre l'ornementation cuticulaire de la région postérieure du corps, formée par l'area rugosa et par un système de perles, réalise un appareil d'accouplement « antidérapant » qui montre des différences selon l'origine géographique. Une clé dichotomique basée sur ce caractère est proposée.

The Southeast Asian journal of tropical medicine and public health, 1978