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Papers by Jacob Turumin

Изучен уровень экспрессии циклооксигеназы2 (ЦОГ2) в зависимости от степени выраженностивоспалени... more Изучен уровень экспрессии циклооксигеназы2 (ЦОГ2) в зависимости от степени выраженностивоспаления в стенке желчных пузырей, полученных от больных хроническим калькулезным холециститом после холецистэктомии. Повышенная экспрессия ЦОГ2 была определена в 81 % в эпителиальных клетках, в 86 % – в гладкомышечных, в 57 % – в стромальных клетках, в 71 % – в стенкахсосудов, в 37 % – синусах РокитанскогоАшоффа. Выявлена положительная корреляция между выраженностью воспаления в стенке желчного пузыря и выраженностью экспрессии ЦОГ2 в гладкомышечных клетках и стенках сосудов.

Summary. He pathogenetically grounded treatment, carried out by the selective cyclooxygenase-2 in... more Summary. He pathogenetically grounded treatment, carried out by the selective cyclooxygenase-2 inhibitors (celecoxib) and Ursodeoxycholic acid in the patients with chronic acalculous cholecystitis with biliary sludge, promotes the restoration of absorption and elimination functions of hepatocytes, (disappearance of ’so\’ intrahepatic cholestasis and the decrease of lithogenicity of hepatic bile) and improvement of the accumulative-eliminative function of gallbladder (disappearance of chronic ’bland’ intragallbladder cholestasis and diminishing lithogenicity of gallbladder bile), disaggregation of biliary sludge, the increase of volumetric portal blood ™ow and the decrease of so\ serum total cholesterol. Key words: chronic acalculous cholecystitis, cyclooxygenase-2 inhibitors, Ursodeoxycholic acid, dynamic radionuclide scintigraphy, serum lipid.Ранее нами выявлена повышенная экспрессия ци-клооксигеназы 2-го типа (ЦОГ-2) в эпителиальных, гладкомышечных и стромальных клетках, способств...

The basic role of the gallbladder in a human is a protective. The gallbladder decreases the forma... more The basic role of the gallbladder in a human is a protective. The gallbladder decreases the formation of the secondary hydrophobic toxic bile acids (deoxycholic and lithocholic acids) by accumulating the primary bile acids (cholic and chenodeoxycholic acids) in the gallbladder, thus reducing their concentration in gallbladder-independent enterohepatic circulation and protecting the liver, the mucosa of the stomach, the gallbladder, and the colon from their effect. In mammals the presence or absence of the gallbladder is determined by the synthesis of hydrophobic or hydrophilic bile acids, respectively. Since the gallbladder is contracted in 5-20 minutes after food is available in a stomach, and “the gastric chyme” moves from the stomach into the duodenum only 1-3 hours later, the role of the gallbladder bile in digestion may be insignificant.

Summary. Th e studies of the system of glutathione and lipid level in blood in patients with chro... more Summary. Th e studies of the system of glutathione and lipid level in blood in patients with chronic cholecystitises (calculous and non-calculous) have been conducted depend ing on functional changes in liver and gallbladder which are based on results of dynamic radionuclide scintigraphy and ultrasonography. Increasing of concentration of total cholesterol, cholesterol of low density and decreasing of concentration of cholesterol of high density in the serum in patients with chronic cholecystitises are revealed. Increasing of concentration of total cholesterol, cholesterol of low density in the serum in pati ents with biliary diseases can be caused by presence of chronic «soft » intrahepatic cholestasis and decreasing of evacuative function of gallbladder. Increasing of activity of glutathione reductase and decreasing of glutathione transferase in erythrocytes, increasing of concentration of glutathione and activity of glutathione trasferase and γ-glutamyl transferase and activity o...

Cancers, 2020

Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant ... more Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant metastasis (sdMTS) growth in breast cancer (BC) (CoMPaS) was presented. The aim was to detect the diagnostic periods for visible sdMTS via CoMPaS in patients with different subtypes ER/PR/HER2/Ki-67 (Estrogen Receptor/Progesterone Receptor/Human Epidermal growth factor Receptor 2/Ki-67 marker) of breast cancer. CoMPaS is based on an exponential growth model and complementing formulas, and the model corresponds to the tumor-node-metastasis (TNM) staging system and BC subtypes (ER/PR/HER2/Ki-67). The CoMPaS model reflects (1) the subtypes of BC, such as ER/PR/HER2/Ki-67, and (2) the growth processes of the PT and sdMTSs in BC patients without or with lymph node metastases (MTSs) in accordance with the eighth edition American Joint Committee on Cancer prognostic staging system for breast cancer. CoMPaS correctly describes the growth of the PT in the ER/PR/HER2/Ki-67 subtypes of BC patients ...

Revista de gastroenterología de México

The basic function of the gallbladder in humans is one of protection. The accumulation of the pri... more The basic function of the gallbladder in humans is one of protection. The accumulation of the primary bile acids (cholic acid and chenodeoxycholic acid) in the gallbladder reduces the formation of the secondary bile acids (deoxycholic acid and lithocholic acid), thus diminishing their concentration in the so-called gallbladder-independent enterohepatic circulation and protecting the liver, the stomach mucosa, the gallbladder, and the colon from their toxic hydrophobic effects. The presence or absence of the gallbladder in mammals is a determining factor in the synthesis of hydrophobic or hydrophilic bile acids. Because the gallbladder contracts 5-20 min after food is in the stomach and the "gastric chyme" moves from the stomach to the duodenum 1-3 h later, the function of the gallbladder bile in digestion may be insignificant. The aim of this article was to provide a detailed review of the role of the gallbladder and the mechanisms related to bile formation in humans.

Applied Spectroscopy, 1990

The Raman scattering technique is used to obtain spectra from four kidney stones. An argon-ion la... more The Raman scattering technique is used to obtain spectra from four kidney stones. An argon-ion laser (514.5 nm) is focused directly on the surface of the stones. Three stones were known to be composed mainly of hydrates of calcium oxalate, CaC2O4·H2O, and CaC2O4·2H2O. The scattered Raman shift is examined and compared with that of the standard hydrates. Two stones have spectra almost identical to that of calcium oxalate monohydrate. The characteristic bands at 1465 and 1492 cm−1 are easily observed. The spectrum from the third stone shows a band at 1477 cm−1 characteristic of calcium oxalate dihydrate, but it also shows weaker bands at 1465 and 1492 cm−1, which are observed in spectra of calcium oxalate monohydrate. It is concluded that the first two stones are primarily composed of CaC2O4·H2O, while the third stone includes both hydrates in its structure. The fourth stone, from a Russian woman, shows bands at 627, 998, 1038, 1405, 1465, and 1492 cm−1. The first few bands are charac...

Applied Spectroscopy, 1993

Raman spectroscopic analysis of kidney stones of mixed composition and of unusual stones is prese... more Raman spectroscopic analysis of kidney stones of mixed composition and of unusual stones is presented. Raman spectroscopy was used to analyze the chemical composition of kidney stones without extraction. A kidney stone sample was irradiated by laser light of 514.5 nm, and the scattered light was analyzed by a Raman spectrometer. The first stone was determined to be a mixture of calcium oxalate dihydrate and hydroxyapatite and the second one to be a mixture of calcium oxalate monohydrate, uric acid, and hydroxyapatite. The third and fourth stones were not mixed-composition stones, but rather stones with unusual composition. One was concluded to be carboxyapatite, and the other was mucoprotein-type stone. The present investigation indicates that Raman spectroscopy is a useful tool for direct analysis of kidney stone without going through the usual procedure of crushing, extracting, and carrying out tedious wet chemical analysis.

Applied Spectroscopy, 1991

Phosphate-type kidney stones have been examined by the Raman spectroscopic technique by merely fo... more Phosphate-type kidney stones have been examined by the Raman spectroscopic technique by merely focusing laser light on the cut surface of the stones. Before examination of the kidney stones, Raman spectra of several standard phosphate compounds—such as calcium monobasic phosphate [Ca(H2PO4)2], calcium dibasic phosphate (CaHPO4), calcium tribasic phosphate [Ca10(PO4)6(OH)2], calcium orthophosphate [Ca3(PO4)2], brushite (CaHPO·2H2O), struvite (MgNH4PO4·6H2O), and hydroxyapatite [Ca10(PO4)6(OH)9]—were obtained. Hydroxyapatite has a distinctive line at 961 cm−1, and one kidney stone examined showed a comparable band. It was concluded that one stone is primarily hydroxyapatite and another one is brushite. The analysis of the kidney stones by Raman spectroscopy is direct, fast, and nondestructive, and does not require tedious sample preparation.

Applied Spectroscopy, 1990

Kidney stones of the uric acid type were examined by Raman spectroscopy. The fingerprint pattern ... more Kidney stones of the uric acid type were examined by Raman spectroscopy. The fingerprint pattern of the Raman spectra of these stones matched those of uric acid better than those of sodium urate. Although the Raman spectra of most stones were masked by the high fluorescence of the stones, with the use of a computer to correct the baseline, the Raman scattering bands became distinct. Uric acid has distinct Raman bands at 472, 562, 627, 784, 885, 999, 1039, 1122, 1234, 1288, 1046, 1499, 1595, and 1652 cm−1. The kidney stones examined also showed these bands, indicating that the stones were the uric acid type. Raman spectroscopy is a useful analytical tool for identifying the composition of kidney stones without much sample preparation.

Изучен уровень экспрессии циклооксигеназы2 (ЦОГ2) в зависимости от степени выраженностивоспалени... more Изучен уровень экспрессии циклооксигеназы2 (ЦОГ2) в зависимости от степени выраженностивоспаления в стенке желчных пузырей, полученных от больных хроническим калькулезным холециститом после холецистэктомии. Повышенная экспрессия ЦОГ2 была определена в 81 % в эпителиальных клетках, в 86 % – в гладкомышечных, в 57 % – в стромальных клетках, в 71 % – в стенкахсосудов, в 37 % – синусах РокитанскогоАшоффа. Выявлена положительная корреляция между выраженностью воспаления в стенке желчного пузыря и выраженностью экспрессии ЦОГ2 в гладкомышечных клетках и стенках сосудов.

Summary. He pathogenetically grounded treatment, carried out by the selective cyclooxygenase-2 in... more Summary. He pathogenetically grounded treatment, carried out by the selective cyclooxygenase-2 inhibitors (celecoxib) and Ursodeoxycholic acid in the patients with chronic acalculous cholecystitis with biliary sludge, promotes the restoration of absorption and elimination functions of hepatocytes, (disappearance of ’so\’ intrahepatic cholestasis and the decrease of lithogenicity of hepatic bile) and improvement of the accumulative-eliminative function of gallbladder (disappearance of chronic ’bland’ intragallbladder cholestasis and diminishing lithogenicity of gallbladder bile), disaggregation of biliary sludge, the increase of volumetric portal blood ™ow and the decrease of so\ serum total cholesterol. Key words: chronic acalculous cholecystitis, cyclooxygenase-2 inhibitors, Ursodeoxycholic acid, dynamic radionuclide scintigraphy, serum lipid.Ранее нами выявлена повышенная экспрессия ци-клооксигеназы 2-го типа (ЦОГ-2) в эпителиальных, гладкомышечных и стромальных клетках, способств...

The basic role of the gallbladder in a human is a protective. The gallbladder decreases the forma... more The basic role of the gallbladder in a human is a protective. The gallbladder decreases the formation of the secondary hydrophobic toxic bile acids (deoxycholic and lithocholic acids) by accumulating the primary bile acids (cholic and chenodeoxycholic acids) in the gallbladder, thus reducing their concentration in gallbladder-independent enterohepatic circulation and protecting the liver, the mucosa of the stomach, the gallbladder, and the colon from their effect. In mammals the presence or absence of the gallbladder is determined by the synthesis of hydrophobic or hydrophilic bile acids, respectively. Since the gallbladder is contracted in 5-20 minutes after food is available in a stomach, and “the gastric chyme” moves from the stomach into the duodenum only 1-3 hours later, the role of the gallbladder bile in digestion may be insignificant.

Summary. Th e studies of the system of glutathione and lipid level in blood in patients with chro... more Summary. Th e studies of the system of glutathione and lipid level in blood in patients with chronic cholecystitises (calculous and non-calculous) have been conducted depend ing on functional changes in liver and gallbladder which are based on results of dynamic radionuclide scintigraphy and ultrasonography. Increasing of concentration of total cholesterol, cholesterol of low density and decreasing of concentration of cholesterol of high density in the serum in patients with chronic cholecystitises are revealed. Increasing of concentration of total cholesterol, cholesterol of low density in the serum in pati ents with biliary diseases can be caused by presence of chronic «soft » intrahepatic cholestasis and decreasing of evacuative function of gallbladder. Increasing of activity of glutathione reductase and decreasing of glutathione transferase in erythrocytes, increasing of concentration of glutathione and activity of glutathione trasferase and γ-glutamyl transferase and activity o...

Cancers, 2020

Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant ... more Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant metastasis (sdMTS) growth in breast cancer (BC) (CoMPaS) was presented. The aim was to detect the diagnostic periods for visible sdMTS via CoMPaS in patients with different subtypes ER/PR/HER2/Ki-67 (Estrogen Receptor/Progesterone Receptor/Human Epidermal growth factor Receptor 2/Ki-67 marker) of breast cancer. CoMPaS is based on an exponential growth model and complementing formulas, and the model corresponds to the tumor-node-metastasis (TNM) staging system and BC subtypes (ER/PR/HER2/Ki-67). The CoMPaS model reflects (1) the subtypes of BC, such as ER/PR/HER2/Ki-67, and (2) the growth processes of the PT and sdMTSs in BC patients without or with lymph node metastases (MTSs) in accordance with the eighth edition American Joint Committee on Cancer prognostic staging system for breast cancer. CoMPaS correctly describes the growth of the PT in the ER/PR/HER2/Ki-67 subtypes of BC patients ...

Revista de gastroenterología de México

The basic function of the gallbladder in humans is one of protection. The accumulation of the pri... more The basic function of the gallbladder in humans is one of protection. The accumulation of the primary bile acids (cholic acid and chenodeoxycholic acid) in the gallbladder reduces the formation of the secondary bile acids (deoxycholic acid and lithocholic acid), thus diminishing their concentration in the so-called gallbladder-independent enterohepatic circulation and protecting the liver, the stomach mucosa, the gallbladder, and the colon from their toxic hydrophobic effects. The presence or absence of the gallbladder in mammals is a determining factor in the synthesis of hydrophobic or hydrophilic bile acids. Because the gallbladder contracts 5-20 min after food is in the stomach and the "gastric chyme" moves from the stomach to the duodenum 1-3 h later, the function of the gallbladder bile in digestion may be insignificant. The aim of this article was to provide a detailed review of the role of the gallbladder and the mechanisms related to bile formation in humans.

Applied Spectroscopy, 1990

The Raman scattering technique is used to obtain spectra from four kidney stones. An argon-ion la... more The Raman scattering technique is used to obtain spectra from four kidney stones. An argon-ion laser (514.5 nm) is focused directly on the surface of the stones. Three stones were known to be composed mainly of hydrates of calcium oxalate, CaC2O4·H2O, and CaC2O4·2H2O. The scattered Raman shift is examined and compared with that of the standard hydrates. Two stones have spectra almost identical to that of calcium oxalate monohydrate. The characteristic bands at 1465 and 1492 cm−1 are easily observed. The spectrum from the third stone shows a band at 1477 cm−1 characteristic of calcium oxalate dihydrate, but it also shows weaker bands at 1465 and 1492 cm−1, which are observed in spectra of calcium oxalate monohydrate. It is concluded that the first two stones are primarily composed of CaC2O4·H2O, while the third stone includes both hydrates in its structure. The fourth stone, from a Russian woman, shows bands at 627, 998, 1038, 1405, 1465, and 1492 cm−1. The first few bands are charac...

Applied Spectroscopy, 1993

Raman spectroscopic analysis of kidney stones of mixed composition and of unusual stones is prese... more Raman spectroscopic analysis of kidney stones of mixed composition and of unusual stones is presented. Raman spectroscopy was used to analyze the chemical composition of kidney stones without extraction. A kidney stone sample was irradiated by laser light of 514.5 nm, and the scattered light was analyzed by a Raman spectrometer. The first stone was determined to be a mixture of calcium oxalate dihydrate and hydroxyapatite and the second one to be a mixture of calcium oxalate monohydrate, uric acid, and hydroxyapatite. The third and fourth stones were not mixed-composition stones, but rather stones with unusual composition. One was concluded to be carboxyapatite, and the other was mucoprotein-type stone. The present investigation indicates that Raman spectroscopy is a useful tool for direct analysis of kidney stone without going through the usual procedure of crushing, extracting, and carrying out tedious wet chemical analysis.

Applied Spectroscopy, 1991

Phosphate-type kidney stones have been examined by the Raman spectroscopic technique by merely fo... more Phosphate-type kidney stones have been examined by the Raman spectroscopic technique by merely focusing laser light on the cut surface of the stones. Before examination of the kidney stones, Raman spectra of several standard phosphate compounds—such as calcium monobasic phosphate [Ca(H2PO4)2], calcium dibasic phosphate (CaHPO4), calcium tribasic phosphate [Ca10(PO4)6(OH)2], calcium orthophosphate [Ca3(PO4)2], brushite (CaHPO·2H2O), struvite (MgNH4PO4·6H2O), and hydroxyapatite [Ca10(PO4)6(OH)9]—were obtained. Hydroxyapatite has a distinctive line at 961 cm−1, and one kidney stone examined showed a comparable band. It was concluded that one stone is primarily hydroxyapatite and another one is brushite. The analysis of the kidney stones by Raman spectroscopy is direct, fast, and nondestructive, and does not require tedious sample preparation.

Applied Spectroscopy, 1990

Kidney stones of the uric acid type were examined by Raman spectroscopy. The fingerprint pattern ... more Kidney stones of the uric acid type were examined by Raman spectroscopy. The fingerprint pattern of the Raman spectra of these stones matched those of uric acid better than those of sodium urate. Although the Raman spectra of most stones were masked by the high fluorescence of the stones, with the use of a computer to correct the baseline, the Raman scattering bands became distinct. Uric acid has distinct Raman bands at 472, 562, 627, 784, 885, 999, 1039, 1122, 1234, 1288, 1046, 1499, 1595, and 1652 cm−1. The kidney stones examined also showed these bands, indicating that the stones were the uric acid type. Raman spectroscopy is a useful analytical tool for identifying the composition of kidney stones without much sample preparation.