Didier Jacqmin - Academia.edu (original) (raw)

Papers by Didier Jacqmin

European Urology Supplements, 2007

EAU Update Series, 2003

The adult renal tumors are represented for about 90% by renal cell carcinoma (RCC). These epithel... more The adult renal tumors are represented for about 90% by renal cell carcinoma (RCC). These epithelial malignant neoplasms are subclassified in five main types: conventional or common RCC, including clear and eosinophilic cell carcinoma, chromophobe RCC, ...

EAU Update Series, 2003

Laparoscopic surgery has been developed in recent years in urology. Is there a place for laparosc... more Laparoscopic surgery has been developed in recent years in urology. Is there a place for laparoscopic surgery in the treatment of kidney cancer?Radical nephrectomy done by laparoscopy seems to be efficient and mimics the open technique. The early results are satisfactory and at least as good as the gold standard. The only unknown issues are the oncological long-term results.Nephron-sparing laparoscopic surgery is feasible as it has been proven in several publications. Nevertheless, some problems have still to be overcome. A long haemostasis and the need for a vascular clamping have to be improve and long-term oncological results are still lacking.Conclusion: Laparoscopic radical nephrectomy will probably become soon a standard. More technical progress has to be made for laparoscopic nephron-sparing surgery which is a more demanding technique before it becomes a standard.

PURPOSE High Intensity focused Ultrasound (HIFU) is a non invasive thermal ablation proposed to c... more PURPOSE High Intensity focused Ultrasound (HIFU) is a non invasive thermal ablation proposed to cure localized prostate carcinoma. There is no consensus for a reliable way to assess local recurrency for deciding to retreat. The purpose of this prospective study was to compare the usefulness of TRUS with color Doppler (cdTRUS) and Endorectal MRI (erMR) in detecting patterns of recurrence following such therapy. METHOD AND MATERIALS From October 2003 to January 2005, 25 patients who had received HIFU treatment underwent erMR examination with an interval of 10 days before cdTRUS-guided biopsy. ErMR examinations were performed on a 1T MR unit using 3 planes T2w FSE (TR/TE : 3925/120ms, tf :14, 4 mm) and axial dynamic contrast SE T1w (TR/TE : 412/7, tf : 5, 4 mm, 18s, 8 repeated sequences). The interval between treatment and imaging ranged from 6 to 12 months. PSA levels ranged between 2 to 5 ng/mL. An area of low intensity and/or increased signal intensity on injected erMR (versus detec...

Cancer research, Jan 15, 2000

Alterations at microsatellite DNA markers in cells exfoliated in urine have been correlated to th... more Alterations at microsatellite DNA markers in cells exfoliated in urine have been correlated to the presence of bladder cancer. To check the feasibility of such noninvasive analysis to routinely diagnose bladder cancers, we have developed a highly sensitive method using fluorescent PCR to search for DNA microsatellite alterations in urine sediment compared with a blood paired sample. One hundred eighty-three patients were included in our study. This population comprised 103 bladder cancers (64 pTa stages), the complement representing controls and other benign or malignant diseases. Results of the analysis at 17 loci in a blinded study were compared with cystoscopy and/or pathology. The high reproducibility of this technique and the analysis of 26 control patients allowed us to determine for each microsatellite a cutoff characterizing a significant allelic imbalance. For bladder cancer detection, the overall sensitivity of the test was 84%. Using this procedure, we identified alterati...

There have been studies on the expression of growth factor receptors carried out this study to ex... more There have been studies on the expression of growth factor receptors carried out this study to examine the relationship between the expression of EGFR, c-erbB-2 and cancers in Koreans.

European Urology Supplements, 2008

Patard JJ, Bensalah KC, Pantuck AJ, Montorsi F., Karakiewicz PI, Mottet N., Zini L., Bertini R., ... more Patard JJ, Bensalah KC, Pantuck AJ, Montorsi F., Karakiewicz PI, Mottet N., Zini L., Bertini R., Salomon L., Abbou CC, Villers A., Soulie M., Bellec L., Rischmann P., De La Taille A., Avakian R., Crepel M., Verhoest G., Ferriere JM, Wallerand H., Bernhard JC, Dujardin T., ...

Urology, 2009

To assess cancer-specific survival of partial nephrectomy (PN) patients with Ն 7-cm lesions or un... more To assess cancer-specific survival of partial nephrectomy (PN) patients with Ն 7-cm lesions or unfavorable pathology (stage T3a or Fuhrman grades III-IV).

Progres en Urologie, 2007

La néphrolithotomie percutanée (NLPC) est l'une des interventions de référence dans la chirurgie ... more La néphrolithotomie percutanée (NLPC) est l'une des interventions de référence dans la chirurgie des calculs du rein en particulier après échec de LEC . La mise en place en fin d'intervention d'un drain de néphrostomie reste la règle. Les buts théoriques de cette néphrostomie sont de drainer les cavités rénales, d'améliorer l'hémostase et de maintenir un accès pour un deuxième temps de révision. Plusieurs modifications techniques ont été apportées afin de diminuer la morbidité [2] ainsi que la durée d'hospitalisation . Décrit par WICKHAM en 1984 [4] et révisé par BELLMAN en 1997 le concept de néphrolithotomie percutanée "tubeless" consistait à ne pas mettre de sonde de néphrostomie et à drainer les cavités rénales par une sonde double-J [5]. Les auteurs se proposent d'évaluer l'intérêt et la morbidité de la néphrolithotomie percutanée "tubeless", à propos de 37 cas.

Progres en Urologie, 2008

Reçu le 2 avril 2008 ; accepté le 7 mai 2008 Disponible sur Internet le 1 juillet 2008 MOTS CLÉS ... more Reçu le 2 avril 2008 ; accepté le 7 mai 2008 Disponible sur Internet le 1 juillet 2008 MOTS CLÉS Cystite interstitielle ; Syndrome de la vessie douloureuse ; Glomérulations Résumé Objectif. -Décrire les caractéristiques des patients diagnostiqués comme ayant une cystite interstitielle (CI), déterminer la proportion de ces patients répondant aux nouveaux critères de l'European Society for the Study of IC/PBS 2005 (ESSIC-cystite interstitielle/syndrome de la vessie douloureuse) et de préciser en quoi les patients qui répondaient à la nouvelle définition différaient de ceux qui n'y répondaient pas. Matériel et méthode. -Étude prospective de cohorte concernant 156 patients qui ont été suivis entre 1997 et 2007 pour une CI. Le diagnostic était suspecté à l'interrogatoire et confirmé par l'association d'un test d'hydrodistension vésicale, un bilan urodynamique, un catalogue mictionnel, un test au KCl et le questionnaire d'O'Leary-Sant. La démographie, les symptômes cliniques et les signes cliniques des patients ont été relevés. Nous avons ensuite déterminé la proportion de ces patients qui répondaient à la nouvelle définition de l'ESSIC 2005. Résultat. -La sex-ratio F/H était de 8/1. Le délai entre le début des symptômes et le diagnostic était de 7,3 ans. Il existait une envie mictionnelle douloureuse chez 100 % des patients, une pollakiurie diurne chez 82 %, une nycturie chez 62 % et une sensation de brûlure pelvienne chez 55 %. La douleur était périnéale chez 70 %, génitale chez 40 % et sus-pubienne chez 80 % des patients. Il existait à la cystoscopie après hydrodistension des pétéchies chez 88,4 % des patients. On retrouvait à la cystoscopie des lésions de Hünner chez 2 % des patients. Lorsque l'on appliquait les critères de l'ESSIC 2005 à ces 156 patients considérés comme ayant une CI, ଝ Niveau de preuve : 3.

Pelvi-perineologie, 2008

Reçu le 1 er octobre 2007 ; accepté le 25 février 2008 Disponible sur Internet le 23 avril 2008 M... more Reçu le 1 er octobre 2007 ; accepté le 25 février 2008 Disponible sur Internet le 23 avril 2008 MOTS CLÉS Bandelette sous-urétrale ; Incontinence urinaire ; Prostatectomie totale

Progres en Urologie, 2008

Pelvi-perineologie, 2009

77 patients (60%) had improved O'Leary-Sant scores, with 38 patients (30%) showing an improvement... more 77 patients (60%) had improved O'Leary-Sant scores, with 38 patients (30%) showing an improvement of over 50%. Conclusions: Patients suffering from IC experience symptoms for an average of 7.5 years before the condition is diagnosed. Symptoms vary, but all patients experience troublesome feelings of urgency, which is thus the main symptom to suggest a diagnosis of IVC, rather than pain above the pubic bone. Cimetidine is an effective treatment for some patients.

European Urology Supplements, 2007

Collecting duct renal cell carcinoma (CDRCC) is a rare, but reportedly aggressive histological su... more Collecting duct renal cell carcinoma (CDRCC) is a rare, but reportedly aggressive histological subtype. We assessed the stage and histological features of CDRCC patients. Moreover, we compared cancer-specific mortality in CDRCC and matched clear cell renal cell carcinoma (CRCC) patients. Material & Methods: Forty-one (0.6%) patients with CDRCC and 5246 CRCC patients were identified within a cohort of 6608 patients treated with either radical or partial nephrectomy for renal cancer. Within the 5246 CRCC cases, 105 were matched with CDRCC cases for grade, tumor size, as well as T, N and M stages. Kaplan-Meier and life table analyses addressed RCC-specific survival. Results: Of all CDRCC patients, 76% had pT3 disease at nephrectomy vs. 37% for CRCC. The predominant Fuhrman grades were 3 (56%) and 4 (22%) vs. II (42%) and III (28%) for CRCC. Moreover, 49% of CDRCC patients were pN1-2 vs. 8 % for CRCC. Of CDRCC patients 19% had distant metastases at nephrectomy vs. 14% for CRCC. Finally, 73% of CDRCC had either local or systemic symptoms vs. 56% for CRCC. After matching, the RCC-specific mortality of CDRCC patients was no different from CRCC patients (RR=1.1; p=0.8). One and 5 year CDRCC specific survival was 86 and 48%, respectively vs. 86 and 57% for matched CRCC controls. Conclusions: CDRCC patients present with more advanced stage and with more aggressive disease vs. CRCC. After nephrectomy, when CDRCC cases were matched with CRCC, the same causespecific survival was seen. The similarity in tumor biology may indicate that CDRCC patients could respond equally favourably to novel targeted therapies. Introduction & Objectives: Unclassified renal cell carcinoma (URCC) is a rare, but very aggressive histological subtype. We assessed the stage and histological features of URCC patients. Moreover, we compared cancer-specific mortality in URCC and matched clear cell renal cell carcinoma (CRCC) patients. Material & Methods: Eighty-five patients with URCC and 4322 CRCC patients were identified within a cohort of 6530 patients treated with either radical or partial nephrectomy at 15 institutions. Within the 4322 CRCC cases, 113 were matched with URCC cases for grade, tumor size, as well as T, N and M stages. Kaplan-Meier and life table analyses addressed RCC-specific survival. Results: Eighty percent of patients with URCC had Fuhrman grades 3 or 4 vs. 37.8% for CRCC. Moreover, 36.5% of URCC patients had pathologically proven nodal metastases vs. 8.6% for CRCC. Finally, 54.1% of URCC patients had metastases at the time of nephrectomy vs. 16.8% for CRCC. After matching, the RCC-specific mortality rate of URCC patients was 3.3fold higher vs. CRCC patients. One and 5 year RCC-SS of URCC patients was 48.7 and 32.6%, respectively vs. 85.5 and 67.1% for matched CRCC controls.

Magnetic Resonance Imaging, 1995

Purpose: to assess the value of the fast imaging sequence called RARE-MR-Urography (RMU) for the ... more Purpose: to assess the value of the fast imaging sequence called RARE-MR-Urography (RMU) for the diagnosis of pathologic ureterohydronephrosis during pregnancy. Materials and Methods: 15 pregnant women with an acute flank pain were examined with RMU. Results were compared with those of ultrasonography (US), X-rays, and the evolution of symptoms. Results: the accuracy of RMU in the detection of urinary tract dilatation and the localization of the level of obstruction was excellent (100%). The determination of the type of obstruction, intrinsic vs. extrinsic, was always exact. RMU alone cannot specify the exact nature of the intrinsic obstruction. Ultrasonography gave less sensitive information in terms of level (60%) and type of obstruction (53%). Conclusion: RMU is able to differentiate a physiological from a pathologic ureterohydronephrosis during pregnancy. It could be considered as a procedure of choice for special cases when US failed to establish this differential diagnosis. 15 pregnant women between 13 and 32 wk of gestation (age range: 22-36 yr) were explored by MRI. All patients presented RECEIVED 12/9/94; ACCEPTED 5/ 10/95.

The Journal of Urology, 1995

Embolization with platinum micro-coils delivered through the Tracker-18 micro-catheter was perfor... more Embolization with platinum micro-coils delivered through the Tracker-18 micro-catheter was performed in 6 patients when peripheral selective catheterization with standard angiographic catheters was not possible. The patients had a total of 7 peripheral renal vascular lesions (3 arteriovenous fistulas, 2 false aneurysms, 1 direct vascular trauma and 1 arteriovenous malformation). In all patients we initially used platinum micro-coils as the embolic agent. Two patients required repeat embolization with glue. Endo-vascular treatment was technically successful in all cases and no complications were encountered. There was no renal parenchyma infarction in 3 patients and small peripheral infarctions (10 to 15% of the renal parenchyma) occurred in 3. Super selective endo-vascular treatment with a variable stiffness catheter is safe and useful technique when classical methods of embolization are not possible.

Journal of the National Cancer Institute, 2000

Aberrations of the ratio between the copy numbers of two alleles of heterozygotes (microsatellite... more Aberrations of the ratio between the copy numbers of two alleles of heterozygotes (microsatellite analyses) or between the copy numbers of two different genes (quantitative polymerase chain reaction [QPCR]) (6-8) can be used to detect the abnormal genomes of cancer cells.

Journal of Endourology, 2008

To evaluate the feasibility and safety of replacing the Double-J stent with a ureteral catheter i... more To evaluate the feasibility and safety of replacing the Double-J stent with a ureteral catheter in tubeless percutaneous nephrolithotomy (PCNL). From August 1998 to February 2007, 33 patients underwent tubeless PCNL for renal calculi by the same surgeon. A retrograde 7F ureteral catheter was placed at the beginning of the surgery in all patients. A nephrostomy tube was not used in any patient. At the end of the procedure, the working tract was electrocauterized using a 26F resectoscope with a rollerball electrode; no hemostatic sealant was used. The ureteral catheter was the sole means of drainage left in place. The incidence and type of complications, the operative time, the length of hospitalization, the rate of transfusion, and the degree of pain were obtained by chart review. In this group of patients, the mean stone burden was 17.25 mm. The mean operative time was 71.5 min. The mean length of hospitalization was 1.9 day (range 1 to 7 days). The mean hemoglobin decrease was 0.8 g/dL. No blood transfusions were needed. The mean visual analog pain intensity scale was 1.87. Complications developed in five (15%) patients, of whom one needed a Double-J stent placement. The complications were pyelonephritis, urinary extravasation, sustained hematuria, and renal colic. The ureteral catheter was removed by postoperative day 1 in 91% of patients. Replacing the Double-J stent with a ureteral catheter in tubeless PCNL is an effective procedure and can be performed in patients with a moderate stone burden. The electrocauterization of the bleeding points at the end of percutaneous renal surgery with a rollerball resectoscope is safe.

Journal of Clinical Ultrasound, 2000

Purpose. Duplex Doppler sonography of the cavernosal arteries of the penis with intracavernous in... more Purpose. Duplex Doppler sonography of the cavernosal arteries of the penis with intracavernous injection (ICI) of vasoactive agents has been widely used to evaluate arterial insufficiency in impotence. Our goal was to assess the potential value of peak systolic velocity (PSV) measurements on the flaccid penis in the diagnosis of arteriogenic impotence.

European Urology Supplements, 2007

EAU Update Series, 2003

Cancer research, Jan 15, 2000

European Urology Supplements, 2008

Urology, 2009

Progres en Urologie, 2007

Progres en Urologie, 2008

Pelvi-perineologie, 2008

Progres en Urologie, 2008

Pelvi-perineologie, 2009

European Urology Supplements, 2007

Magnetic Resonance Imaging, 1995

The Journal of Urology, 1995

Journal of the National Cancer Institute, 2000

Journal of Endourology, 2008

Journal of Clinical Ultrasound, 2000