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Research paper thumbnail of Effect of Gd3+ substitution on proton relaxation and magnetic hyperthermia efficiency of cobalt ferrite nanoparticles

Materials Research Express, 2020

In this study, Gadolinium substituted Cobalt Ferrite nanoparticles (CoFe2-xGdxO4, 0 ≤ x ≤ 0.4) we... more In this study, Gadolinium substituted Cobalt Ferrite nanoparticles (CoFe2-xGdxO4, 0 ≤ x ≤ 0.4) were prepared via hydrothermal route using triethylamine as reducing agent at 180°C for 12 h. X-ray diffraction studies revealed the single phase cubic spinel structure for both Cobalt ferrite (CF) and Gadolinium substituted Cobalt Ferrite (CFG) nanoparticles (x ≤ 0.24). An increase in the Specific absorption rate (SAR) was observed with increase in Gd concentration. Further with increase in the molar concentration (x > 0.24), gadolinium hydroxide was observed as the secondary phase, which was also confirmed by the Gd–O stretching vibrations observed in Fourier transform Infrared spectroscopy. The evolution of Gadolinium hydroxide showed a strong influence in the relaxivity (r 1) and hyperthermia potential. Field emission scanning electron microscopy revealed that CF and CFG (x ≤ 0.24) nanoparticles were spherical in nature with particle size ranging from 10 to 25 nm, whereas the partic...

Research paper thumbnail of Effect of Ytterbium and Erbium co-doped NaYF4@NaSmF4 upconversion core-shell nanoparticles on their luminescence and morphological properties

Materials Research Express, 2019

In this study, novel upconversion (UC) core-shell NaYF4@NaSmF4 nanoparticles were synthesized via... more In this study, novel upconversion (UC) core-shell NaYF4@NaSmF4 nanoparticles were synthesized via hydrothermal route which is having a tendency to convert two or more lower energy near IR photons to single higher energy UV/Visible photon for biomedical imaging and therapeutic applications. The core (NaYF4) nanoparticles were synthesized by varying sodium fluoride concentration, and temperature of the reaction. The core-shell nanoparticles were prepared by growing the shell NaSmF4/NaSmF4:Yb, Er over the as-prepared core nanoparticles with optimized precursor-fluoride ratio, without any binding. The crystalline behaviour, morphology and particle size were investigated for core-shell nanoparticles using XRD, FESEM, EDS, DLS, and TEM. Photoluminescence spectra were recorded to find the emission wavelength and luminescence intensity. NaYF4@NaSmF4, the upconversion core-shell nanoparticles shown higher intensity luminescence spectra than core NaYF4. These core-shell nanoparticles have provided a platform for the spatially confining optical process, which possesses high luminescence efficiency.

Research paper thumbnail of Iron Oxide Nanoparticles and Nano-Composites: An Efficient Tool for Cancer Theranostics

Iron Oxide Nanoparticles [Working Title], 2022

In recent years, functional Iron oxides nanoparticles and nano-composites have gained a special t... more In recent years, functional Iron oxides nanoparticles and nano-composites have gained a special traction in the field of nano-biomedicine, owing to their multifunctional capabilities that includes the inherent magnetic resonance imaging, magnetic bioseparation, cargo delivery and magnetic hyperthermia behavior. Interestingly, there are various forms of iron oxides available, with each form having their own specific characteristics. The different polymorphic forms of iron oxides are obtained through various synthetic routes and are usually surface modified to prevent their oxidation. The chapter shall encompass the synthesis and surface modification of Iron oxides nanoparticles, physicochemical properties, and theranostic application of the magnetic iron oxide nanoparticles in cancer. Also, the future directions of Iron oxide nanoparticles and nano-composites towards the achievement of clinically realizable nanoformulation for cancer theranostic applications were highlighted.

Research paper thumbnail of Effect of Gd3+ substitution on proton relaxation and magnetic hyperthermia efficiency of cobalt ferrite nanoparticles

Materials Research Express, 2020

In this study, Gadolinium substituted Cobalt Ferrite nanoparticles (CoFe2-xGdxO4, 0 ≤ x ≤ 0.4) we... more In this study, Gadolinium substituted Cobalt Ferrite nanoparticles (CoFe2-xGdxO4, 0 ≤ x ≤ 0.4) were prepared via hydrothermal route using triethylamine as reducing agent at 180°C for 12 h. X-ray diffraction studies revealed the single phase cubic spinel structure for both Cobalt ferrite (CF) and Gadolinium substituted Cobalt Ferrite (CFG) nanoparticles (x ≤ 0.24). An increase in the Specific absorption rate (SAR) was observed with increase in Gd concentration. Further with increase in the molar concentration (x > 0.24), gadolinium hydroxide was observed as the secondary phase, which was also confirmed by the Gd–O stretching vibrations observed in Fourier transform Infrared spectroscopy. The evolution of Gadolinium hydroxide showed a strong influence in the relaxivity (r 1) and hyperthermia potential. Field emission scanning electron microscopy revealed that CF and CFG (x ≤ 0.24) nanoparticles were spherical in nature with particle size ranging from 10 to 25 nm, whereas the partic...

Research paper thumbnail of Effect of Ytterbium and Erbium co-doped NaYF4@NaSmF4 upconversion core-shell nanoparticles on their luminescence and morphological properties

Materials Research Express, 2019

In this study, novel upconversion (UC) core-shell NaYF4@NaSmF4 nanoparticles were synthesized via... more In this study, novel upconversion (UC) core-shell NaYF4@NaSmF4 nanoparticles were synthesized via hydrothermal route which is having a tendency to convert two or more lower energy near IR photons to single higher energy UV/Visible photon for biomedical imaging and therapeutic applications. The core (NaYF4) nanoparticles were synthesized by varying sodium fluoride concentration, and temperature of the reaction. The core-shell nanoparticles were prepared by growing the shell NaSmF4/NaSmF4:Yb, Er over the as-prepared core nanoparticles with optimized precursor-fluoride ratio, without any binding. The crystalline behaviour, morphology and particle size were investigated for core-shell nanoparticles using XRD, FESEM, EDS, DLS, and TEM. Photoluminescence spectra were recorded to find the emission wavelength and luminescence intensity. NaYF4@NaSmF4, the upconversion core-shell nanoparticles shown higher intensity luminescence spectra than core NaYF4. These core-shell nanoparticles have provided a platform for the spatially confining optical process, which possesses high luminescence efficiency.

Research paper thumbnail of Iron Oxide Nanoparticles and Nano-Composites: An Efficient Tool for Cancer Theranostics

Iron Oxide Nanoparticles [Working Title], 2022

In recent years, functional Iron oxides nanoparticles and nano-composites have gained a special t... more In recent years, functional Iron oxides nanoparticles and nano-composites have gained a special traction in the field of nano-biomedicine, owing to their multifunctional capabilities that includes the inherent magnetic resonance imaging, magnetic bioseparation, cargo delivery and magnetic hyperthermia behavior. Interestingly, there are various forms of iron oxides available, with each form having their own specific characteristics. The different polymorphic forms of iron oxides are obtained through various synthetic routes and are usually surface modified to prevent their oxidation. The chapter shall encompass the synthesis and surface modification of Iron oxides nanoparticles, physicochemical properties, and theranostic application of the magnetic iron oxide nanoparticles in cancer. Also, the future directions of Iron oxide nanoparticles and nano-composites towards the achievement of clinically realizable nanoformulation for cancer theranostic applications were highlighted.