Jameice DeCoster - Academia.edu (original) (raw)
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Papers by Jameice DeCoster
The purpose of this study was to gain insight and understanding on what constitutes a successful ... more The purpose of this study was to gain insight and understanding on what constitutes a successful outreach and educational program for African Americans that have Alzheimer’s Disease (AD) particularly in the Delaware Valley and to give recommendations to the Alzheimer’s Association of Delaware Valley. Key informants were identified for interview purposes after extensive research of their contributions to Alzheimer’s disease research and outreach. Key informants included a geriatric physician and neurologist, AD researchers and AD advocators. Interviews were audio recorded and transcribed. Analysis was used to identify themes. Over-arching important outreach and education themes were having race concordant people conducting outreach as well as having a consistent presence in the community. Another theme was having some collaboration with popular African American organizations like fraternities and sororities and churches. Although only seven key informants were able to participate in ...
Nature communications, 2013
Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K(+) channels that, in addi... more Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K(+) channels that, in addition to enhancing channel surface expression, potently accelerates their kinetics. The dipeptidyl-peptidase 6 gene has been associated with a number of human central nervous system disorders including autism spectrum disorders and schizophrenia. Here we employ knockdown and genetic deletion of dipeptidyl-peptidase 6 to reveal its importance for the formation and stability of dendritic filopodia during early neuronal development. We find that the hippocampal neurons lacking dipeptidyl-peptidase 6 show a sparser dendritic branching pattern along with fewer spines throughout development and into adulthood. In electrophysiological and imaging experiments, we show that these deficits lead to fewer functional synapses and occur independently of the potassium channel subunit Kv4.2. We report that dipeptidyl-peptidase 6 interacts with a filopodia-associated myosin as well as with fibronectin in ...
The purpose of this study was to gain insight and understanding on what constitutes a successful ... more The purpose of this study was to gain insight and understanding on what constitutes a successful outreach and educational program for African Americans that have Alzheimer’s Disease (AD) particularly in the Delaware Valley and to give recommendations to the Alzheimer’s Association of Delaware Valley. Key informants were identified for interview purposes after extensive research of their contributions to Alzheimer’s disease research and outreach. Key informants included a geriatric physician and neurologist, AD researchers and AD advocators. Interviews were audio recorded and transcribed. Analysis was used to identify themes. Over-arching important outreach and education themes were having race concordant people conducting outreach as well as having a consistent presence in the community. Another theme was having some collaboration with popular African American organizations like fraternities and sororities and churches. Although only seven key informants were able to participate in ...
Nature communications, 2013
Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K(+) channels that, in addi... more Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K(+) channels that, in addition to enhancing channel surface expression, potently accelerates their kinetics. The dipeptidyl-peptidase 6 gene has been associated with a number of human central nervous system disorders including autism spectrum disorders and schizophrenia. Here we employ knockdown and genetic deletion of dipeptidyl-peptidase 6 to reveal its importance for the formation and stability of dendritic filopodia during early neuronal development. We find that the hippocampal neurons lacking dipeptidyl-peptidase 6 show a sparser dendritic branching pattern along with fewer spines throughout development and into adulthood. In electrophysiological and imaging experiments, we show that these deficits lead to fewer functional synapses and occur independently of the potassium channel subunit Kv4.2. We report that dipeptidyl-peptidase 6 interacts with a filopodia-associated myosin as well as with fibronectin in ...