James Adams - Academia.edu (original) (raw)
Papers by James Adams
Clinical Chemistry, Sep 1, 1987
... Pyrimidine starvation induced by adenosine in fibroblastsand lymphoid cells: role of adenosin... more ... Pyrimidine starvation induced by adenosine in fibroblastsand lymphoid cells: role of adenosinedeaminase. ... Quantification of Glutathione and Glutathione Disuifide in Human Plasma, James D. Adams, Jan N. Johannessen,' and John P. Bacon' (College of Pharmacy, Washington ...
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021
Current Medicinal Chemistry, Mar 27, 2020
Molecular and Chemical Neuropathology, May 1, 1997
This in vivo study compared the pharmacokinetics of intracerebroventricularly administered tertia... more This in vivo study compared the pharmacokinetics of intracerebroventricularly administered tertiary butylhydroperoxide (tBuOOH) (109.7 mg/kg) among six different brain regions in two age groups of mice (2-and 8-mo-old mice). Brains were dissected at 11 time-points ranging from 0.5-60 min. Pharmacokhletics parameters did not differ between the two age groups. This demonstrates that previously reported age-related differences in tBuOOH toxicity may not be owing to pharmacokinetic differences between the two age groups. Differences were found when comparing the pharmacokinetics of tBuOOH among the various brain regions. Area under the curve (AUC) values were highest in the striatum and thalamus, and lowest in the cerebellum. The half-life of tBuOOH varied widely among the regions with the longest half-lives in the cortex and hippocampus, and the shortest in the striatum and cerebellum. The oxidation of glutathione and the induction of DNA damage are critical aspects of tBuOOH toxicity. These data show that region-dependent differences in toxicity reported previously may result from factors, such as tBuOOH-induced glutathione oxidation and DNA damage.
Bioorganic & Medicinal Chemistry Letters, Apr 1, 2018
Evidence-based Complementary and Alternative Medicine, 2005
Evidence-based Complementary and Alternative Medicine, 2006
Plants were, and still are, widely used for a number of conditions affecting women in California.... more Plants were, and still are, widely used for a number of conditions affecting women in California. This article discusses traditional remedies of the Chumash for dysmenorrhea, premenstrual syndrome, feminine hygiene, heavy menstruation, urinary tract infections, parturition, lactation, infant care, menopause, sexually transmitted diseases, fertility, contraception and abortions. Many plants are presented including Artemisia douglasiana, Paeonia californica, Trichostema lanatum, Salvia apiana, Ephedra viridis, Leymus condensatus, Vitis californica, Eschscholzia californica, Rosa californica, Scirpus acutus, Anemopsis californica and Phoradendron macrophyllum. By providing the specific uses of plants for specific diseases and discussing chemistry, efficacy and safety concerns for each plant, we hope that this article gives direction to women seeking to use plants in their health care.
Chronic pain & management, 2020
OBM integrative and complimentary medicine, Dec 17, 2018
Comparative biochemistry and physiology. B. Comparative biochemistry, 1976
PubMed, Dec 1, 1984
The plasma concentrations of glutathione and glutathione disulfide were measured in rats followin... more The plasma concentrations of glutathione and glutathione disulfide were measured in rats following the administration of diquat, metronidazole, nitrofurantoin, doxorubicin, dimethylnitrosamine or carbon tetrachloride. None of these agents significantly influenced the plasma concentrations of glutathione. Diquat, metronidazole and nitrofurantoin acutely increased plasma glutathione disulfide by 4 to 13 fold from 0.3 +/- 0.1 microM to 3.8 +/- 1.1 microM, 2.0 +/- 0.5 microM and 1.2 +/- 0.3 microM, respectively. Carbon tetrachloride, doxorubicin and dimethylnitrosamine did not affect plasma glutathione disulfide. The determination of plasma glutathione disulfide identifies compounds that generate potentially toxic amounts of reactive oxygen species during their metabolism and helps to distinguish these compounds from xenobiotics which generate organic free radicals and electrophilic metabolites under toxicologically relevant conditions.
Open journal of apoptosis, 2013
Letters in Drug Design & Discovery, Nov 1, 2005
Numerous studies have shown that nicotinamide can prevent cell death via both necrosis and apopto... more Numerous studies have shown that nicotinamide can prevent cell death via both necrosis and apoptosis. DNA fragmentation, NAD, poly(ADP-ribose) polymerase, apoptosis inducing factors, tumor necrosis factors, p53, caspases, inhibitor of apoptosis proteins and other factors are important in the action of nicotinamide. In this review, the regulatory effect of nicotinamide on individual pro-and anti-apoptotic proteins in neuronal cells have been delineated with a view to present a central molecular mechanism by which nicotinamide prevents apoptosis in the brain.
Biochimica Et Biophysica Acta - General Subjects, Feb 1, 2001
Pyridine nucleotides are critical during oxidative stress due to their roles in reductive reactio... more Pyridine nucleotides are critical during oxidative stress due to their roles in reductive reactions and energetics. The aim of the present study was to examine pyridine nucleotide changes in six brain regions of mice after an intracerebroventricular injection of the oxidative stress inducing agent, t-butyl hydroperoxide (t-BuOOH). A secondary aim was to investigate the correlation between NAD levels and DNA fragmentation. Here, we demonstrate that t-BuOOH induced a rapid oxidation of NADPH and a slow depletion of NAD in most brain regions. A slight increase in NADH also occurred in five brain regions. NAD depletion was associated with increased DNA fragmentation. This suggests the initiation of a death cascade involving poly(ADP-ribose) polymerase (PARP), NAD , ATP depletion and consequent cell death in brain tissue. PARP activity was accelerated in some brain regions after 20 min of oxidative stress. To counteract oxidative stress induced toxicity, NAD levels were increased in the brain using an intraperitoneal injection of nicotinamide. A surplus of brain NAD prevented DNA fragmentation in some brain regions. Nicotinamide administration also resulted in higher brain NADH, NADP and NADPH levels in some regions. Their synthesis was further upregulated during oxidative stress. Nicotinamide as a precursor for NAD may provide a useful therapeutic strategy in the treatment of neurodegeneration.
Molecular and Chemical Neuropathology, Jun 1, 1991
Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegen... more Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered association study testing 4692 single nucleotide polymorphism (SNPs). We identified a SNP within a putative transcription factor binding site in the NEDD9 gene (neural precursor cell expressed, developmentally down-regulated), that shows good evidence of association with disease risk in four out of five LOAD samples [N 5 3521, P 5 5.38310 26 , odds ratio (OR) 5 1.38 (1.20-1.59)] and in addition, we observed a similar pattern of association in two PD sample sets [N 5 1464, P 5 0.0145, OR 51.31 (1.05-1.62)]. In exploring a potential mechanism for the association, we observed that expression of NEDD9 and APOE show a strong inverse correlation in the hippocampus of Alzheimer's cases. These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD.
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021
Clinical Chemistry, Sep 1, 1987
... Pyrimidine starvation induced by adenosine in fibroblastsand lymphoid cells: role of adenosin... more ... Pyrimidine starvation induced by adenosine in fibroblastsand lymphoid cells: role of adenosinedeaminase. ... Quantification of Glutathione and Glutathione Disuifide in Human Plasma, James D. Adams, Jan N. Johannessen,&amp;#x27; and John P. Bacon&amp;#x27; (College of Pharmacy, Washington ...
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021
Current Medicinal Chemistry, Mar 27, 2020
Molecular and Chemical Neuropathology, May 1, 1997
This in vivo study compared the pharmacokinetics of intracerebroventricularly administered tertia... more This in vivo study compared the pharmacokinetics of intracerebroventricularly administered tertiary butylhydroperoxide (tBuOOH) (109.7 mg/kg) among six different brain regions in two age groups of mice (2-and 8-mo-old mice). Brains were dissected at 11 time-points ranging from 0.5-60 min. Pharmacokhletics parameters did not differ between the two age groups. This demonstrates that previously reported age-related differences in tBuOOH toxicity may not be owing to pharmacokinetic differences between the two age groups. Differences were found when comparing the pharmacokinetics of tBuOOH among the various brain regions. Area under the curve (AUC) values were highest in the striatum and thalamus, and lowest in the cerebellum. The half-life of tBuOOH varied widely among the regions with the longest half-lives in the cortex and hippocampus, and the shortest in the striatum and cerebellum. The oxidation of glutathione and the induction of DNA damage are critical aspects of tBuOOH toxicity. These data show that region-dependent differences in toxicity reported previously may result from factors, such as tBuOOH-induced glutathione oxidation and DNA damage.
Bioorganic & Medicinal Chemistry Letters, Apr 1, 2018
Evidence-based Complementary and Alternative Medicine, 2005
Evidence-based Complementary and Alternative Medicine, 2006
Plants were, and still are, widely used for a number of conditions affecting women in California.... more Plants were, and still are, widely used for a number of conditions affecting women in California. This article discusses traditional remedies of the Chumash for dysmenorrhea, premenstrual syndrome, feminine hygiene, heavy menstruation, urinary tract infections, parturition, lactation, infant care, menopause, sexually transmitted diseases, fertility, contraception and abortions. Many plants are presented including Artemisia douglasiana, Paeonia californica, Trichostema lanatum, Salvia apiana, Ephedra viridis, Leymus condensatus, Vitis californica, Eschscholzia californica, Rosa californica, Scirpus acutus, Anemopsis californica and Phoradendron macrophyllum. By providing the specific uses of plants for specific diseases and discussing chemistry, efficacy and safety concerns for each plant, we hope that this article gives direction to women seeking to use plants in their health care.
Chronic pain & management, 2020
OBM integrative and complimentary medicine, Dec 17, 2018
Comparative biochemistry and physiology. B. Comparative biochemistry, 1976
PubMed, Dec 1, 1984
The plasma concentrations of glutathione and glutathione disulfide were measured in rats followin... more The plasma concentrations of glutathione and glutathione disulfide were measured in rats following the administration of diquat, metronidazole, nitrofurantoin, doxorubicin, dimethylnitrosamine or carbon tetrachloride. None of these agents significantly influenced the plasma concentrations of glutathione. Diquat, metronidazole and nitrofurantoin acutely increased plasma glutathione disulfide by 4 to 13 fold from 0.3 +/- 0.1 microM to 3.8 +/- 1.1 microM, 2.0 +/- 0.5 microM and 1.2 +/- 0.3 microM, respectively. Carbon tetrachloride, doxorubicin and dimethylnitrosamine did not affect plasma glutathione disulfide. The determination of plasma glutathione disulfide identifies compounds that generate potentially toxic amounts of reactive oxygen species during their metabolism and helps to distinguish these compounds from xenobiotics which generate organic free radicals and electrophilic metabolites under toxicologically relevant conditions.
Open journal of apoptosis, 2013
Letters in Drug Design & Discovery, Nov 1, 2005
Numerous studies have shown that nicotinamide can prevent cell death via both necrosis and apopto... more Numerous studies have shown that nicotinamide can prevent cell death via both necrosis and apoptosis. DNA fragmentation, NAD, poly(ADP-ribose) polymerase, apoptosis inducing factors, tumor necrosis factors, p53, caspases, inhibitor of apoptosis proteins and other factors are important in the action of nicotinamide. In this review, the regulatory effect of nicotinamide on individual pro-and anti-apoptotic proteins in neuronal cells have been delineated with a view to present a central molecular mechanism by which nicotinamide prevents apoptosis in the brain.
Biochimica Et Biophysica Acta - General Subjects, Feb 1, 2001
Pyridine nucleotides are critical during oxidative stress due to their roles in reductive reactio... more Pyridine nucleotides are critical during oxidative stress due to their roles in reductive reactions and energetics. The aim of the present study was to examine pyridine nucleotide changes in six brain regions of mice after an intracerebroventricular injection of the oxidative stress inducing agent, t-butyl hydroperoxide (t-BuOOH). A secondary aim was to investigate the correlation between NAD levels and DNA fragmentation. Here, we demonstrate that t-BuOOH induced a rapid oxidation of NADPH and a slow depletion of NAD in most brain regions. A slight increase in NADH also occurred in five brain regions. NAD depletion was associated with increased DNA fragmentation. This suggests the initiation of a death cascade involving poly(ADP-ribose) polymerase (PARP), NAD , ATP depletion and consequent cell death in brain tissue. PARP activity was accelerated in some brain regions after 20 min of oxidative stress. To counteract oxidative stress induced toxicity, NAD levels were increased in the brain using an intraperitoneal injection of nicotinamide. A surplus of brain NAD prevented DNA fragmentation in some brain regions. Nicotinamide administration also resulted in higher brain NADH, NADP and NADPH levels in some regions. Their synthesis was further upregulated during oxidative stress. Nicotinamide as a precursor for NAD may provide a useful therapeutic strategy in the treatment of neurodegeneration.
Molecular and Chemical Neuropathology, Jun 1, 1991
Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegen... more Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered association study testing 4692 single nucleotide polymorphism (SNPs). We identified a SNP within a putative transcription factor binding site in the NEDD9 gene (neural precursor cell expressed, developmentally down-regulated), that shows good evidence of association with disease risk in four out of five LOAD samples [N 5 3521, P 5 5.38310 26 , odds ratio (OR) 5 1.38 (1.20-1.59)] and in addition, we observed a similar pattern of association in two PD sample sets [N 5 1464, P 5 0.0145, OR 51.31 (1.05-1.62)]. In exploring a potential mechanism for the association, we observed that expression of NEDD9 and APOE show a strong inverse correlation in the hippocampus of Alzheimer's cases. These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD.
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021
BENTHAM SCIENCE PUBLISHERS eBooks, Sep 13, 2021