James Chandler - Academia.edu (original) (raw)

Papers by James Chandler

Research paper thumbnail of CMET-11. Response to Stereotactic Radiosurgery for Multiple Brain Metastases Based on Histology-Specific Subtype Status

Neuro-Oncology, 2019

BACKGROUND This retrospective study evaluated the relationship between histologic subtype and tre... more BACKGROUND This retrospective study evaluated the relationship between histologic subtype and treatment outcomes following SRS for the treatment of multiple brain metastases (MBM). METHODS We analyzed patients with MBM, defined here as >= 3 lesions, treated with SRS at our institution. Primary histologies examined were NSCLC, breast, and melanoma. Patients were categorized according to histology-specific subtypes (NSCLC-EGFR, ALK, KRAS, PD-L1%; breast-HER2, ER, PR; melanoma-BRAF). The primary outcome was local control (defined by RANO-BM) and secondary outcomes included intracranial progression-free survival (iPFS) and overall survival (OS). RESULTS 141 patients met inclusion criteria (66 NSCLC, 61 breast, and 14 melanoma). HER2+ and BRAF V600E+ lesions had increased rates of local control following SRS (P=0.0048 and P=0.0256, respectively) compared to other breast/melanoma subtypes. EGFR mutation was not associated with increased local control with SRS (71 vs 74%), but increased...

Research paper thumbnail of Medical and Neuro-Oncology

Research paper thumbnail of Variability of interrill erosion at low slopes

Earth Surf Process Landf, 2010

Research paper thumbnail of Effect of Temperature and Propanil on Penoxsulam Efficacy, Absorption, and Translocation in Alligatorweed (Alternanthera philoxeroides)

Research paper thumbnail of Radiographic Detection of Strut Separations in Bj�rk�Shiley Convexo-Concave Mitral Valves

Research paper thumbnail of Determining exposure to auxin-like herbicides. II. Practical application to quantify volatility

Weed Technology, 2005

ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their deve... more ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their development. Research was conducted to describe a method of quantifying injury from auxin-like herbicides as a first step in determining crop damage. Reduced rates of 2,4-D, dicamba, and triclopyr were applied to cotton and soybean plants in the three-to-six-leaf stage in field and greenhouse studies. Injury to leaves and stems were evaluated separately, and the values were combined so that one injury estimate was obtained for each individual plant rated. Injury symptoms were typical for auxin-type herbicides and ranged from slight bending of stems or petioles and wrinkled leaves to necrosis. Specific descriptions of leaf and stem injury levels were used to describe plant injury consistently. These descriptions were very detailed for the lower injury levels, but the characterizations became more general as the injury increased because of the prominence of factors such as necrosis. The injury evaluation method provided repeatable results for each herbicide and herbicide rate used. This injury evaluation method has many possible uses in auxin-like herbicide research and lays the foundation for forecasting the impact of early-season injury to cotton and soybean yield.

Research paper thumbnail of Determining exposure to auxin-like herbicides. I. Quantifying injury to cotton and soybean

Weed Technology, 2005

ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their deve... more ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their development. Research was conducted to describe a method of quantifying injury from auxin-like herbicides as a first step in determining crop damage. Reduced rates of 2,4-D, dicamba, and triclopyr were applied to cotton and soybean plants in the three-to-six-leaf stage in field and greenhouse studies. Injury to leaves and stems were evaluated separately, and the values were combined so that one injury estimate was obtained for each individual plant rated. Injury symptoms were typical for auxin-type herbicides and ranged from slight bending of stems or petioles and wrinkled leaves to necrosis. Specific descriptions of leaf and stem injury levels were used to describe plant injury consistently. These descriptions were very detailed for the lower injury levels, but the characterizations became more general as the injury increased because of the prominence of factors such as necrosis. The injury evaluation method provided repeatable results for each herbicide and herbicide rate used. This injury evaluation method has many possible uses in auxin-like herbicide research and lays the foundation for forecasting the impact of early-season injury to cotton and soybean yield.

Research paper thumbnail of The Use of Stereotactic Radiosurgery in Recurrent Pituitary Tumors

Research paper thumbnail of Determining Resuscitability in Out-of-Hospital Cardiac Arrest

Research paper thumbnail of Is all red rice found in commercial rice really Oryza sativa?

Weed Sci, 2001

... Weed Sci 39:169–174. Kwon, SL, RJ Smith, and RE Talbert. 1992. Comparative growth and develop... more ... Weed Sci 39:169–174. Kwon, SL, RJ Smith, and RE Talbert. 1992. Comparative growth and development of red rice (Oryza sativa) and rice (O. sativa). ... Appl. Genet 100:697–712. CrossRef. Virk, PS, J. Zhu, HJ Newbury, GJ Bryan, MT Jackson, and BV Ford-Lloyd. 2000. ...

Research paper thumbnail of Controlled radio frequency vessel sealing system for surgical applications

Spie Proceedings Series, 1998

A radio frequency tissue welding system has been developed for occlusion of vessels during surger... more A radio frequency tissue welding system has been developed for occlusion of vessels during surgery. The system is designed to replace commonly used mechanical clip and suture ligation techniques. Other energy based ligation techniques are limited to use on small structures (<EQ 2 mm) due to slow heating, unreliable sealing, and charring/sticking to the forceps. The system consists of forceps and an RF electrosurgery generator, both of which are specifically designed for optimal tissue sealing. The method combines optimal pressure delivery to the tissue and energy delivery consisting of a high heat cycle, a low heat cycle and a cooling cycle. The generator output is also voltage limited and delivers high current in order to remodel the collagen in approximately 5 seconds with no sticking or charring. The vessel sealing system was compared to other energy based ligation techniques including ultrasonic sealing and other bipolar systems. The pressure required to burst the vessel was used for comparison. Average burst pressures on 3 - 7 mm arteries were 126 +/- 154 mmHg, 607 +/- 314 mmHg, and 913 +/- 304 mmHg for ultrasonic, standard bipolar, and vessel sealing, respectively. Histologic evaluation showed vessel wall fusion and minimal thermal damage to adjacent tissues for the vessel sealing system.

Research paper thumbnail of Determining Resuscitability in Out-of-Hospital Cardiac Arrest

Research paper thumbnail of In Response

Vascular and Endovascular Surgery, 2000

Research paper thumbnail of Seed longevity of red rice ecotypes buried in soil

Research paper thumbnail of Concordance of patient and caregiver reports in evaluating quality of life in patients with malignant gliomas and an assessment of caregiver burden

Neuro-oncology practice, 2014

Given the neurocognitive impairment experienced by many patients with malignant gliomas, caregive... more Given the neurocognitive impairment experienced by many patients with malignant gliomas, caregiver reports can be critical in assessing the quality of life (QOL) of these patients. In this study, we explored whether assessment of patient QOL by the primary caregiver shows concordance with the patient's self-reported QOL, and we quantified the burden faced by caregivers. QOL of 45 patients was evaluated by both the patient and primary caregiver on 3 or more separate occasions using the Functional Assessment of Cancer Therapy-Brain (FACT-Br) instrument, and concordance between the 2 reports was evaluated. Caregiver burden was measured using the Caregiver Quality of Life Index-Cancer (CQOL-C) instrument. Overall, good concordance was observed between the patient and caregiver FACT-Br reports (intraclass correlation coefficient = 0.74). Patient-reported FACT-Br scores were 4.75 (95% CI, 1.44-8.05) points higher than paired caregiver reports on the 200-point scale (P = .008); however...

Research paper thumbnail of Use of preoperative FLAIR MRI and ependymal proximity of tumor enhancement as surrogate markers of brain tumor origin

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Jan 5, 2015

Neural stem cells proliferate in the subventricular zone and give rise to progeny that differenti... more Neural stem cells proliferate in the subventricular zone and give rise to progeny that differentiate and migrate throughout the brain. We aimed to test the hypothesis that glioma behavior and grade may correlate with the identity of the tumor cell of origin. We evaluated three preoperative radiographic features (fluid attenuated inversion recovery [FLAIR] MRI characteristics, tumor proximity to ventricular ependyma, and subependymal representation) as surrogate markers of tumor origin using a retrospective cohort design. The medical records of 228 patients who underwent surgical resection of a glioma from January 2004 to August 2008 were reviewed. Average patient age was 54.5years (standard deviation [SD] 15.3) with a male predominance (62.9%). World Health Organization glioma grades amongst the cohort were Grade IV (71.6%), Grade III (21.3%) and Grade II (7.1%). Mean survival was 11.2months (SD 10.5) with a mean follow up of 12.8months (SD 11.3). Glioma tumor grade was significantl...

Research paper thumbnail of Synthesis of allenes via reduction of acetylenic tosylhydrazones

Journal of the Chemical Society, Chemical Communications, 1978

... By GEORGE W. KABALKA,* RAY J. NEWTON, Jr., and JAMES H. CHANDLER (Department of Chemistry, Un... more ... By GEORGE W. KABALKA,* RAY J. NEWTON, Jr., and JAMES H. CHANDLER (Department of Chemistry, University of Tennessee, Knoxville ... by catecholborane (CB) and other reagents2 provides a mild alternative to the Wolff-Kishner and Clemmensen reductions [equation ( 1) 1 ...

Research paper thumbnail of Treatment of Primary Venous Insufficiency by Endovenous Saphenous Vein Obliteration

Vascular and Endovascular Surgery, 2000

The objective of this paper is to evaluate treatment of primary venous insufficiency by endovenou... more The objective of this paper is to evaluate treatment of primary venous insufficiency by endovenous saphenous vein obliteration. Three hundred one limbs were treated in 206 women and 67 men with a mean CEAP Clinical Class of 2.4 ±0.9. Endovenous oblitera-tion was combined ...

Research paper thumbnail of Measurement of the de Sitter precession of the Moon: A relativistic three-body effect

Physical review letters, Jan 5, 1988

ABSTRACT

Research paper thumbnail of Paradoxical increase in rate of catabolism of low-density lipoproteins after hepatectomy

Science (New York, N.Y.), Jan 8, 1974

It has been suggested that the liver may be a major site for irreversible degradation of low-dens... more It has been suggested that the liver may be a major site for irreversible degradation of low-density lipoprotein (LDL). The disappearance of autologous (125)I-labeled LDL from plasma was compared in intact and in hepatectomized swine. Contrary to expectations, the rate of irreversible removal of LDL from plasma was increased rather then decreased by hepatectomy. These studies suggest that the liver is not a major site for LDL removal. We propose further that the liver (or some function requiring an intact liver) may affect the metabolism of LDL in a manner that prolongs its lifetime in the plasma compartment.

Research paper thumbnail of CMET-11. Response to Stereotactic Radiosurgery for Multiple Brain Metastases Based on Histology-Specific Subtype Status

Neuro-Oncology, 2019

BACKGROUND This retrospective study evaluated the relationship between histologic subtype and tre... more BACKGROUND This retrospective study evaluated the relationship between histologic subtype and treatment outcomes following SRS for the treatment of multiple brain metastases (MBM). METHODS We analyzed patients with MBM, defined here as >= 3 lesions, treated with SRS at our institution. Primary histologies examined were NSCLC, breast, and melanoma. Patients were categorized according to histology-specific subtypes (NSCLC-EGFR, ALK, KRAS, PD-L1%; breast-HER2, ER, PR; melanoma-BRAF). The primary outcome was local control (defined by RANO-BM) and secondary outcomes included intracranial progression-free survival (iPFS) and overall survival (OS). RESULTS 141 patients met inclusion criteria (66 NSCLC, 61 breast, and 14 melanoma). HER2+ and BRAF V600E+ lesions had increased rates of local control following SRS (P=0.0048 and P=0.0256, respectively) compared to other breast/melanoma subtypes. EGFR mutation was not associated with increased local control with SRS (71 vs 74%), but increased...

Research paper thumbnail of Medical and Neuro-Oncology

Research paper thumbnail of Variability of interrill erosion at low slopes

Earth Surf Process Landf, 2010

Research paper thumbnail of Effect of Temperature and Propanil on Penoxsulam Efficacy, Absorption, and Translocation in Alligatorweed (Alternanthera philoxeroides)

Research paper thumbnail of Radiographic Detection of Strut Separations in Bj�rk�Shiley Convexo-Concave Mitral Valves

Research paper thumbnail of Determining exposure to auxin-like herbicides. II. Practical application to quantify volatility

Weed Technology, 2005

ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their deve... more ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their development. Research was conducted to describe a method of quantifying injury from auxin-like herbicides as a first step in determining crop damage. Reduced rates of 2,4-D, dicamba, and triclopyr were applied to cotton and soybean plants in the three-to-six-leaf stage in field and greenhouse studies. Injury to leaves and stems were evaluated separately, and the values were combined so that one injury estimate was obtained for each individual plant rated. Injury symptoms were typical for auxin-type herbicides and ranged from slight bending of stems or petioles and wrinkled leaves to necrosis. Specific descriptions of leaf and stem injury levels were used to describe plant injury consistently. These descriptions were very detailed for the lower injury levels, but the characterizations became more general as the injury increased because of the prominence of factors such as necrosis. The injury evaluation method provided repeatable results for each herbicide and herbicide rate used. This injury evaluation method has many possible uses in auxin-like herbicide research and lays the foundation for forecasting the impact of early-season injury to cotton and soybean yield.

Research paper thumbnail of Determining exposure to auxin-like herbicides. I. Quantifying injury to cotton and soybean

Weed Technology, 2005

ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their deve... more ABSTRACT Crop injury caused by drift of auxin-like herbicides has been a concern since their development. Research was conducted to describe a method of quantifying injury from auxin-like herbicides as a first step in determining crop damage. Reduced rates of 2,4-D, dicamba, and triclopyr were applied to cotton and soybean plants in the three-to-six-leaf stage in field and greenhouse studies. Injury to leaves and stems were evaluated separately, and the values were combined so that one injury estimate was obtained for each individual plant rated. Injury symptoms were typical for auxin-type herbicides and ranged from slight bending of stems or petioles and wrinkled leaves to necrosis. Specific descriptions of leaf and stem injury levels were used to describe plant injury consistently. These descriptions were very detailed for the lower injury levels, but the characterizations became more general as the injury increased because of the prominence of factors such as necrosis. The injury evaluation method provided repeatable results for each herbicide and herbicide rate used. This injury evaluation method has many possible uses in auxin-like herbicide research and lays the foundation for forecasting the impact of early-season injury to cotton and soybean yield.

Research paper thumbnail of The Use of Stereotactic Radiosurgery in Recurrent Pituitary Tumors

Research paper thumbnail of Determining Resuscitability in Out-of-Hospital Cardiac Arrest

Research paper thumbnail of Is all red rice found in commercial rice really Oryza sativa?

Weed Sci, 2001

... Weed Sci 39:169–174. Kwon, SL, RJ Smith, and RE Talbert. 1992. Comparative growth and develop... more ... Weed Sci 39:169–174. Kwon, SL, RJ Smith, and RE Talbert. 1992. Comparative growth and development of red rice (Oryza sativa) and rice (O. sativa). ... Appl. Genet 100:697–712. CrossRef. Virk, PS, J. Zhu, HJ Newbury, GJ Bryan, MT Jackson, and BV Ford-Lloyd. 2000. ...

Research paper thumbnail of Controlled radio frequency vessel sealing system for surgical applications

Spie Proceedings Series, 1998

A radio frequency tissue welding system has been developed for occlusion of vessels during surger... more A radio frequency tissue welding system has been developed for occlusion of vessels during surgery. The system is designed to replace commonly used mechanical clip and suture ligation techniques. Other energy based ligation techniques are limited to use on small structures (<EQ 2 mm) due to slow heating, unreliable sealing, and charring/sticking to the forceps. The system consists of forceps and an RF electrosurgery generator, both of which are specifically designed for optimal tissue sealing. The method combines optimal pressure delivery to the tissue and energy delivery consisting of a high heat cycle, a low heat cycle and a cooling cycle. The generator output is also voltage limited and delivers high current in order to remodel the collagen in approximately 5 seconds with no sticking or charring. The vessel sealing system was compared to other energy based ligation techniques including ultrasonic sealing and other bipolar systems. The pressure required to burst the vessel was used for comparison. Average burst pressures on 3 - 7 mm arteries were 126 +/- 154 mmHg, 607 +/- 314 mmHg, and 913 +/- 304 mmHg for ultrasonic, standard bipolar, and vessel sealing, respectively. Histologic evaluation showed vessel wall fusion and minimal thermal damage to adjacent tissues for the vessel sealing system.

Research paper thumbnail of Determining Resuscitability in Out-of-Hospital Cardiac Arrest

Research paper thumbnail of In Response

Vascular and Endovascular Surgery, 2000

Research paper thumbnail of Seed longevity of red rice ecotypes buried in soil

Research paper thumbnail of Concordance of patient and caregiver reports in evaluating quality of life in patients with malignant gliomas and an assessment of caregiver burden

Neuro-oncology practice, 2014

Given the neurocognitive impairment experienced by many patients with malignant gliomas, caregive... more Given the neurocognitive impairment experienced by many patients with malignant gliomas, caregiver reports can be critical in assessing the quality of life (QOL) of these patients. In this study, we explored whether assessment of patient QOL by the primary caregiver shows concordance with the patient's self-reported QOL, and we quantified the burden faced by caregivers. QOL of 45 patients was evaluated by both the patient and primary caregiver on 3 or more separate occasions using the Functional Assessment of Cancer Therapy-Brain (FACT-Br) instrument, and concordance between the 2 reports was evaluated. Caregiver burden was measured using the Caregiver Quality of Life Index-Cancer (CQOL-C) instrument. Overall, good concordance was observed between the patient and caregiver FACT-Br reports (intraclass correlation coefficient = 0.74). Patient-reported FACT-Br scores were 4.75 (95% CI, 1.44-8.05) points higher than paired caregiver reports on the 200-point scale (P = .008); however...

Research paper thumbnail of Use of preoperative FLAIR MRI and ependymal proximity of tumor enhancement as surrogate markers of brain tumor origin

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Jan 5, 2015

Neural stem cells proliferate in the subventricular zone and give rise to progeny that differenti... more Neural stem cells proliferate in the subventricular zone and give rise to progeny that differentiate and migrate throughout the brain. We aimed to test the hypothesis that glioma behavior and grade may correlate with the identity of the tumor cell of origin. We evaluated three preoperative radiographic features (fluid attenuated inversion recovery [FLAIR] MRI characteristics, tumor proximity to ventricular ependyma, and subependymal representation) as surrogate markers of tumor origin using a retrospective cohort design. The medical records of 228 patients who underwent surgical resection of a glioma from January 2004 to August 2008 were reviewed. Average patient age was 54.5years (standard deviation [SD] 15.3) with a male predominance (62.9%). World Health Organization glioma grades amongst the cohort were Grade IV (71.6%), Grade III (21.3%) and Grade II (7.1%). Mean survival was 11.2months (SD 10.5) with a mean follow up of 12.8months (SD 11.3). Glioma tumor grade was significantl...

Research paper thumbnail of Synthesis of allenes via reduction of acetylenic tosylhydrazones

Journal of the Chemical Society, Chemical Communications, 1978

... By GEORGE W. KABALKA,* RAY J. NEWTON, Jr., and JAMES H. CHANDLER (Department of Chemistry, Un... more ... By GEORGE W. KABALKA,* RAY J. NEWTON, Jr., and JAMES H. CHANDLER (Department of Chemistry, University of Tennessee, Knoxville ... by catecholborane (CB) and other reagents2 provides a mild alternative to the Wolff-Kishner and Clemmensen reductions [equation ( 1) 1 ...

Research paper thumbnail of Treatment of Primary Venous Insufficiency by Endovenous Saphenous Vein Obliteration

Vascular and Endovascular Surgery, 2000

The objective of this paper is to evaluate treatment of primary venous insufficiency by endovenou... more The objective of this paper is to evaluate treatment of primary venous insufficiency by endovenous saphenous vein obliteration. Three hundred one limbs were treated in 206 women and 67 men with a mean CEAP Clinical Class of 2.4 ±0.9. Endovenous oblitera-tion was combined ...

Research paper thumbnail of Measurement of the de Sitter precession of the Moon: A relativistic three-body effect

Physical review letters, Jan 5, 1988

ABSTRACT

Research paper thumbnail of Paradoxical increase in rate of catabolism of low-density lipoproteins after hepatectomy

Science (New York, N.Y.), Jan 8, 1974

It has been suggested that the liver may be a major site for irreversible degradation of low-dens... more It has been suggested that the liver may be a major site for irreversible degradation of low-density lipoprotein (LDL). The disappearance of autologous (125)I-labeled LDL from plasma was compared in intact and in hepatectomized swine. Contrary to expectations, the rate of irreversible removal of LDL from plasma was increased rather then decreased by hepatectomy. These studies suggest that the liver is not a major site for LDL removal. We propose further that the liver (or some function requiring an intact liver) may affect the metabolism of LDL in a manner that prolongs its lifetime in the plasma compartment.