James Wimhurst - Academia.edu (original) (raw)

Papers by James Wimhurst

Introduction and Aims: This paper presents a treatment plan for femoral stem revision that has be... more Introduction and Aims: This paper presents a treatment plan for femoral stem revision that has been developed based on long-term studies of revision total hip replacement (THR) using cemented stems, cementless proximal fixation stems, cemented stems with impaction grafting and modular titanium long stems. Method: The clinical and radiographic results of femoral stem revision were compared using the following techniques: 1) a standard or long cemented collarless double taper Exeter or CPT stems (CCDT stems) [n=190]; 2) a proximally porous coated mid to long cementless stem [n=56]; 3) two series of CCDT stems with impaction grafting n=34]; and 4) a modular grit-blasted titanium taper stem [n=13] used for severe cortical damage. Treatment decisions were made based on the age of the patient, the appearance of the pre-operative radiograph and the extent of bone deficiency at surgery. Follow-up was from 17 to two years. Results: Only one hip was lost to follow-up. In the CCDT group, at a ...

Journal of Bone Joint Surgery British Volume, May 1, 2012

Background The process of osteolysis is well studied both in vivo and in vitro. Although multiple... more Background The process of osteolysis is well studied both in vivo and in vitro. Although multiple pathways have been implicated in osteolytic change and animal models have been developed there are few human tissue studies. There are no extensive human tissue studies comparing osteoarthritic hips to well fixed and loose prostheses. Methods We have investigated 96 genes previously implicated in the osteolytic pathway. Genes were included based on previous implication in osteolysis in basic science studies. Candidates included cytokines, growth factors, apoptotic factors, matrix proteinases, interleukins, apoptotic proteins and macrophage activators. Results One hundred patients were enrolled into the study and had intraoperative hip tissue removed after ethics approval. Patients were recruited from three cohorts, those undergoing primary hip replacement, revision of a well fixed prosthesis and revision for osteolytic change. A low density Taqman array method was used to determine gene expression for the 96 candidate genes. Expression of five housekeeping genes was measured and expression normalised between the samples. Statistical analysis was undertaken using significance testing and ROC analysis. There were seven candidate genes that were statistically significantly linked to aseptic loosening (p 0.77); these were BMP4, Frizzled related protein, fibroblast growth factor 18, IL8, IRAK 3, osteoprotegrin and PTGS2. There were a further nine genes which were highly predictive of osteolytic change (AUC >0.77), but did not reach significance (p>0.05): VEGFB, SFRP, TLR3, TLR5, TP53, IGF1, CTSK, CHIT 1 and CCL 18. Conclusion We have been able to distinguish for the first time between factors which are associated with osteolytic change, those associated with exposure to wear debris in a well fixed prosthesis and those associated with the process of osteoarthritis.

Introduction and Aims: To aid the comparison of results of different techniques of femoral revisi... more Introduction and Aims: To aid the comparison of results of different techniques of femoral revision at total hip replacement and in choosing types of revision, a number of radiographic classifications have been proposed. We aimed to determine the reliability of five popular radiographic classification systems for grading the extent of femoral bone deficiency. Method: Twenty pre-revision total hip replacement femoral radiographs were assessed by a senior consultant specialist in revision surgery, a junior consultant, a fellow and a trainee registrar. The femoral bone deficiency was classified using the systems of the American Academy of Orthopaedic Surgeons (AAOS) and EndoKlinik, and those described by Paprosky, Gross and Gustillo. Intra-observer agreement and inter-observer agreement between assessors were determined using the kappa coefficient. Radiographs were reassessed after a minimum of two weeks. Kappa coefficients of 0.6–0.8 (substantial) or >0.8 (almost perfect) were cons...

Introduction This study reviews the mid to long term results of revision THR with cemented, colla... more Introduction This study reviews the mid to long term results of revision THR with cemented, collarless double-tapered (CCDT) stems. Methods We prospectively studied 192 revisions, in 183 patients, of femoral stems using standard (42%) or long (58%) Exeter and CPT CCDT stems. Results were analysed according to the length of stem, extent of pre-operative deficiency (Paprosky I:II:IIIa:IIIb:IV = 4:20:44:20:12%) and intra-operative bone loss. Postoperative radiographs were independently analysed for loosening and stress shielding. Risk factors of poor outcome were examined by multivariate logistic regression. The median follow-up was six years (2 to 17 years) with 55 patients having died (28%) and no cases lost to follow-up. Results There were four stem re-revisions for sepsis (2%), three for aseptic loosening (1.5%) and three for component malpositioning (1.5%). The survivorship to femoral re-revision for aseptic loosening at eight years was 95% (95%CI=90–100%) for standard and 95% (90...

The Journal of Bone and Joint Surgery, 2002

P articulate prosthetic materials are often studied by adding them to monocytic cells in vitro an... more P articulate prosthetic materials are often studied by adding them to monocytic cells in vitro and measuring the release of cytokines as an indicator of their inflammatory potential. Endotoxin is known to be a contaminant of particle preparations and also stimulates the release of cytokines. It is usual to use a proprietary endotoxin test to avoid erroneous results.

The Journal of Bone and Joint Surgery, 2000

W e used a rat model in vivo to study the effects of the concentration of polyethylene particles ... more W e used a rat model in vivo to study the effects of the concentration of polyethylene particles on the bone-implant interface around stable implants in the proximal tibia. Intra-articular injections of 10 4 , 10 6 or 10 8 high-density polyethylene (HDPE) particles per joint were given 8, 10 and 12 weeks after surgery. The animals were killed after 14 and 26 weeks and the response at the interface determined. Fibrous tissue was seen at the bone-implant interface when the head of the implant was flush with the top of the tibia but not when it was sunk below the tibial plateau. In the latter case the implant was completely surrounded by a shell of bone. The area of fibrous tissue and that of the gap between the implant and bone was related to the concentration of particles in the 14-week group (p < 0.05).

The Journal of Bone and Joint Surgery, 2001

W e have investigated whether the particle-stimulated release of inflammatory cytokines from huma... more W e have investigated whether the particle-stimulated release of inflammatory cytokines from human primary macrophages in vitro was dependent upon the type of bone cement used. Particles of clinically relevant size were produced from Palacos R without radio-opacifier, Palacos R with BaSO 4 , Palacos R with ZrO 2 and from CMW3 which contains BaSO 4 . All four preparations produced significantly greater release of tumour necrosis factor alpha, interleukin-6 and interleukin-1 beta than a negative control but there were no significant differences between them. The differences in the ability to stimulate bone resorption and in clinical performance between proprietary bone cements previously recorded are not explained by the release of the cytokines most commonly implicated in osteolysis.

Journal of Bone and Joint Surgery - British Volume, 2006

In 20 patients undergoing hybrid total hip arthroplasty, the reproducibility and accuracy of temp... more In 20 patients undergoing hybrid total hip arthroplasty, the reproducibility and accuracy of templating using digital radiographs were assessed. Digital images were manipulated using either a ten-pence coin as a marker to scale for magnification, or two digital-line methods using computer software. On-screen images were templated with standard acetate templates and compared with templating performed on hard-copy digital prints.

The Journal of Bone and Joint Surgery (American), 2011

Conventional radiography is the primary imaging tool for routine follow-up of total hip replaceme... more Conventional radiography is the primary imaging tool for routine follow-up of total hip replacements, but the reliability of this method has been questioned. The aim of this study was to assess the reliability of commonly used measurements of the position of hip prostheses on postoperative radiographs with use of tools available on all standard picture archiving and communication system workstations. Fifty anteroposterior pelvic and lateral hip radiographs that were made after a unilateral total hip arthroplasty were included in this study. Acetabular inclination, lateral offset, lower-limb length, center of rotation, and femoral stem angle were independently assessed by two observers. Intraclass correlation coefficients were calculated for each measurement. The results demonstrated excellent reliability for acetabular angle (r = 0.95), lower-limb length (r = 0.91), and lateral offset (r = 0.95) measurements and good reliability for center of rotation (r = 0.73) and lateral femoral stem angle (r = 0.68) measurements. The position of total hip replacements can be reliably assessed with use of simple electronic tools and standard radiology workstations.

The Journal of Arthroplasty, 2009

We report on a case of metallosis initially presumed to be heterotopic ossification based on radi... more We report on a case of metallosis initially presumed to be heterotopic ossification based on radiologic findings. A 68-year-old man with a total hip arthroplasty experienced failure of the polyethylene liner, resulting in articulation of the ceramic head with the titanium acetabular shell. During revision surgery, extensive metallic debris was evident macroscopically throughout the periprosthetic tissue and was confirmed histologically to be metallosis.

The Journal of Arthroplasty, 2013

This study aims to assess the accuracy of metal ion analysis in the diagnosis of adverse reaction... more This study aims to assess the accuracy of metal ion analysis in the diagnosis of adverse reaction to metal debris (ARMD) in patients with metal-on-metal hip arthroplasties by comparing the cobalt and chromium levels in 57 patients (62 hips) to findings on metal artifact reduction magnetic resonance imaging (MRI). An ARMD was detected using MRI in 18 (29%) of the hips. Forty patients had cobalt levels less than 7 μg/L, and 33 had chromium levels less than 7 μg/L, but 8 of these had an ARMD on MRI and only minimal symptoms (Oxford Hip Score ≥ 44/48). The incidence of ARMD was significantly higher when chromium concentration was above 7 μg/L (P = .02), but normal metal ion levels can be misleading and metal artifact reduction MRI imaging is advised in all patients. Keywords: metal ion levels, MAR MRI, metal-on-metal, hip, arthroplasty.

The Journal of Arthroplasty, 2014

Accurate radiographic measurement of acetabular cup orientation is required in order to assess su... more Accurate radiographic measurement of acetabular cup orientation is required in order to assess susceptibility to impingement, dislocation, and edge loading wear. In this study, the accuracy and precision of a new radiographic cup orientation measurement system were assessed and compared to those of two commercially available systems. Two types of resurfacing hip prostheses and an uncemented prosthesis were assessed. Radiographic images of each prosthesis were created with the cup set at different, known angles of version and inclination in a measurement jig. The new system was the most accurate and precise and could repeatedly measure version and inclination to within a fraction of a degree. In addition it has a facility to distinguish cup retroversion from anteversion on anteroposterior radiographs.

International Journal of Gynecological Cancer, 2003

Ali ZA, Wimhurst JA, Ali AA, Tempest ME, Edwards DJ. Endometrial cancer metastasis presenting as ... more Ali ZA, Wimhurst JA, Ali AA, Tempest ME, Edwards DJ. Endometrial cancer metastasis presenting as a grossly swollen toe. Int J Gynecol Cancer 2003;13:909-911.

Injury, 2009

The purpose of this systematic review was to assess the literature evaluating the clinical and ra... more The purpose of this systematic review was to assess the literature evaluating the clinical and radiological outcomes following less invasive surgical stabilisation system (LISS) fixation of distal femoral fractures (AO 32/33). A review of EMBASE, Medline, CINAHL and AMED from their inception to November 2008, sources of grey literature and a pertinent hand search of specialist orthopaedic journals was undertaken. Twenty-one studies assessing 663 patients with 694 fractures were reviewed. The findings suggest that the LISS system may be an appropriate fixation method for the management of distal femoral fractures. However, there remains a high incidence of loss of reduction (n=134; 19%), delayed or non-union (n=40; 6%) and implant failure (n=38; 5%). On analysis, such complications were largely confined to articles published before 2005, therefore during the infancy of the widespread clinical application of this trauma system. On critical appraisal, the evidence-base remains limited by recruiting small, under-powered sample sizes and poorly accounting for confounding variables such as osteoporosis, diabetes, multi-trauma and fracture classification. Further study is required to assess the outcomes of LISS fixation in specific patient populations, and to compare the outcome of this fixation method to condylar plates and intrameduallary devices, to determine the optimal management strategy for this complex patient group.

Injury, 2005

The majority of midshaft clavicle fractures unite uneventfully. Although the indications for oper... more The majority of midshaft clavicle fractures unite uneventfully. Although the indications for operative intervention are limited and reported complication rates high, there are circumstances in which surgery is required. We describe a new, infraclavicular surgical approach to the clavicle used in a series of 89 patients over 9 years. Average time to union was 13.5 weeks. There was one case of deep infection and one of non-union, both of which resolved with further treatment. These results compare very favourably with previously published series and we submit that this operative approach allows safe management of an otherwise potentially hazardous procedure.

Injury, 2005

The effect of femoral neck-shaft angle and implant type on the accuracy of lag screw placement in... more The effect of femoral neck-shaft angle and implant type on the accuracy of lag screw placement in extra-capsular proximal femoral fracture fixation was investigated. Radiographs of all extra-capsular proximal femoral fractures seen in one unit over 18 months were reviewed. Of 399 cases, 307 (237 female, 70 male) were included in the study as they had no contra-lateral proximal femoral metal work. Femoral neck-shaft angle (NSA) of the uninjured hip and magnification adjusted tip-apex distance (TAD) of femoral head lag screw were measured. Type of fixation implant was 135 degrees classic hip screw (CHS) (n=144) or 130 degrees intra-medullary hip screw (IMHS) (n=163). Mean contra-lateral NSA was 130.2 degrees (112.9--148 degrees ) and 64 patients (58 female, 6 male) had a NSA &amp;amp;lt;125 degrees . Mean adjusted TAD was 18.7 mm (5.8--43.8mm) and 88.9% of cases had a TAD of less than 25 mm. TAD values were significantly greater using an IMHS if NSA was &amp;amp;lt;125 degrees than if NSA was &amp;amp;gt;125 degrees (p=0.028). This was not the case with the CHS. The use of the 130 degrees -IMHS in patients with a NSA &amp;amp;lt;125 degrees leads to poorer lag screw placement than if NSA &amp;amp;gt;125 degrees and caution is advocated when using this device in such cases.

Clinical Radiology, 2007

Plain films are the initial imaging method of choice for evaluation of hip arthroplasty. Recent a... more Plain films are the initial imaging method of choice for evaluation of hip arthroplasty. Recent advances in technology and imaging techniques have largely overcome the problems of beam hardening in computed tomography (CT) and magnetic susceptibility artefact in magnetic resonance imaging (MRI). CT and MRI have now become useful imaging techniques in the assessment of hip arthroplasty.

Introduction and Aims: This paper presents a treatment plan for femoral stem revision that has be... more Introduction and Aims: This paper presents a treatment plan for femoral stem revision that has been developed based on long-term studies of revision total hip replacement (THR) using cemented stems, cementless proximal fixation stems, cemented stems with impaction grafting and modular titanium long stems. Method: The clinical and radiographic results of femoral stem revision were compared using the following techniques: 1) a standard or long cemented collarless double taper Exeter or CPT stems (CCDT stems) [n=190]; 2) a proximally porous coated mid to long cementless stem [n=56]; 3) two series of CCDT stems with impaction grafting n=34]; and 4) a modular grit-blasted titanium taper stem [n=13] used for severe cortical damage. Treatment decisions were made based on the age of the patient, the appearance of the pre-operative radiograph and the extent of bone deficiency at surgery. Follow-up was from 17 to two years. Results: Only one hip was lost to follow-up. In the CCDT group, at a ...

Journal of Bone Joint Surgery British Volume, May 1, 2012

Background The process of osteolysis is well studied both in vivo and in vitro. Although multiple... more Background The process of osteolysis is well studied both in vivo and in vitro. Although multiple pathways have been implicated in osteolytic change and animal models have been developed there are few human tissue studies. There are no extensive human tissue studies comparing osteoarthritic hips to well fixed and loose prostheses. Methods We have investigated 96 genes previously implicated in the osteolytic pathway. Genes were included based on previous implication in osteolysis in basic science studies. Candidates included cytokines, growth factors, apoptotic factors, matrix proteinases, interleukins, apoptotic proteins and macrophage activators. Results One hundred patients were enrolled into the study and had intraoperative hip tissue removed after ethics approval. Patients were recruited from three cohorts, those undergoing primary hip replacement, revision of a well fixed prosthesis and revision for osteolytic change. A low density Taqman array method was used to determine gene expression for the 96 candidate genes. Expression of five housekeeping genes was measured and expression normalised between the samples. Statistical analysis was undertaken using significance testing and ROC analysis. There were seven candidate genes that were statistically significantly linked to aseptic loosening (p 0.77); these were BMP4, Frizzled related protein, fibroblast growth factor 18, IL8, IRAK 3, osteoprotegrin and PTGS2. There were a further nine genes which were highly predictive of osteolytic change (AUC >0.77), but did not reach significance (p>0.05): VEGFB, SFRP, TLR3, TLR5, TP53, IGF1, CTSK, CHIT 1 and CCL 18. Conclusion We have been able to distinguish for the first time between factors which are associated with osteolytic change, those associated with exposure to wear debris in a well fixed prosthesis and those associated with the process of osteoarthritis.

Introduction and Aims: To aid the comparison of results of different techniques of femoral revisi... more Introduction and Aims: To aid the comparison of results of different techniques of femoral revision at total hip replacement and in choosing types of revision, a number of radiographic classifications have been proposed. We aimed to determine the reliability of five popular radiographic classification systems for grading the extent of femoral bone deficiency. Method: Twenty pre-revision total hip replacement femoral radiographs were assessed by a senior consultant specialist in revision surgery, a junior consultant, a fellow and a trainee registrar. The femoral bone deficiency was classified using the systems of the American Academy of Orthopaedic Surgeons (AAOS) and EndoKlinik, and those described by Paprosky, Gross and Gustillo. Intra-observer agreement and inter-observer agreement between assessors were determined using the kappa coefficient. Radiographs were reassessed after a minimum of two weeks. Kappa coefficients of 0.6–0.8 (substantial) or >0.8 (almost perfect) were cons...

Introduction This study reviews the mid to long term results of revision THR with cemented, colla... more Introduction This study reviews the mid to long term results of revision THR with cemented, collarless double-tapered (CCDT) stems. Methods We prospectively studied 192 revisions, in 183 patients, of femoral stems using standard (42%) or long (58%) Exeter and CPT CCDT stems. Results were analysed according to the length of stem, extent of pre-operative deficiency (Paprosky I:II:IIIa:IIIb:IV = 4:20:44:20:12%) and intra-operative bone loss. Postoperative radiographs were independently analysed for loosening and stress shielding. Risk factors of poor outcome were examined by multivariate logistic regression. The median follow-up was six years (2 to 17 years) with 55 patients having died (28%) and no cases lost to follow-up. Results There were four stem re-revisions for sepsis (2%), three for aseptic loosening (1.5%) and three for component malpositioning (1.5%). The survivorship to femoral re-revision for aseptic loosening at eight years was 95% (95%CI=90–100%) for standard and 95% (90...

The Journal of Bone and Joint Surgery, 2002

P articulate prosthetic materials are often studied by adding them to monocytic cells in vitro an... more P articulate prosthetic materials are often studied by adding them to monocytic cells in vitro and measuring the release of cytokines as an indicator of their inflammatory potential. Endotoxin is known to be a contaminant of particle preparations and also stimulates the release of cytokines. It is usual to use a proprietary endotoxin test to avoid erroneous results.

The Journal of Bone and Joint Surgery, 2000

W e used a rat model in vivo to study the effects of the concentration of polyethylene particles ... more W e used a rat model in vivo to study the effects of the concentration of polyethylene particles on the bone-implant interface around stable implants in the proximal tibia. Intra-articular injections of 10 4 , 10 6 or 10 8 high-density polyethylene (HDPE) particles per joint were given 8, 10 and 12 weeks after surgery. The animals were killed after 14 and 26 weeks and the response at the interface determined. Fibrous tissue was seen at the bone-implant interface when the head of the implant was flush with the top of the tibia but not when it was sunk below the tibial plateau. In the latter case the implant was completely surrounded by a shell of bone. The area of fibrous tissue and that of the gap between the implant and bone was related to the concentration of particles in the 14-week group (p < 0.05).

The Journal of Bone and Joint Surgery, 2001

W e have investigated whether the particle-stimulated release of inflammatory cytokines from huma... more W e have investigated whether the particle-stimulated release of inflammatory cytokines from human primary macrophages in vitro was dependent upon the type of bone cement used. Particles of clinically relevant size were produced from Palacos R without radio-opacifier, Palacos R with BaSO 4 , Palacos R with ZrO 2 and from CMW3 which contains BaSO 4 . All four preparations produced significantly greater release of tumour necrosis factor alpha, interleukin-6 and interleukin-1 beta than a negative control but there were no significant differences between them. The differences in the ability to stimulate bone resorption and in clinical performance between proprietary bone cements previously recorded are not explained by the release of the cytokines most commonly implicated in osteolysis.

Journal of Bone and Joint Surgery - British Volume, 2006

In 20 patients undergoing hybrid total hip arthroplasty, the reproducibility and accuracy of temp... more In 20 patients undergoing hybrid total hip arthroplasty, the reproducibility and accuracy of templating using digital radiographs were assessed. Digital images were manipulated using either a ten-pence coin as a marker to scale for magnification, or two digital-line methods using computer software. On-screen images were templated with standard acetate templates and compared with templating performed on hard-copy digital prints.

The Journal of Bone and Joint Surgery (American), 2011

Conventional radiography is the primary imaging tool for routine follow-up of total hip replaceme... more Conventional radiography is the primary imaging tool for routine follow-up of total hip replacements, but the reliability of this method has been questioned. The aim of this study was to assess the reliability of commonly used measurements of the position of hip prostheses on postoperative radiographs with use of tools available on all standard picture archiving and communication system workstations. Fifty anteroposterior pelvic and lateral hip radiographs that were made after a unilateral total hip arthroplasty were included in this study. Acetabular inclination, lateral offset, lower-limb length, center of rotation, and femoral stem angle were independently assessed by two observers. Intraclass correlation coefficients were calculated for each measurement. The results demonstrated excellent reliability for acetabular angle (r = 0.95), lower-limb length (r = 0.91), and lateral offset (r = 0.95) measurements and good reliability for center of rotation (r = 0.73) and lateral femoral stem angle (r = 0.68) measurements. The position of total hip replacements can be reliably assessed with use of simple electronic tools and standard radiology workstations.

The Journal of Arthroplasty, 2009

We report on a case of metallosis initially presumed to be heterotopic ossification based on radi... more We report on a case of metallosis initially presumed to be heterotopic ossification based on radiologic findings. A 68-year-old man with a total hip arthroplasty experienced failure of the polyethylene liner, resulting in articulation of the ceramic head with the titanium acetabular shell. During revision surgery, extensive metallic debris was evident macroscopically throughout the periprosthetic tissue and was confirmed histologically to be metallosis.

The Journal of Arthroplasty, 2013

This study aims to assess the accuracy of metal ion analysis in the diagnosis of adverse reaction... more This study aims to assess the accuracy of metal ion analysis in the diagnosis of adverse reaction to metal debris (ARMD) in patients with metal-on-metal hip arthroplasties by comparing the cobalt and chromium levels in 57 patients (62 hips) to findings on metal artifact reduction magnetic resonance imaging (MRI). An ARMD was detected using MRI in 18 (29%) of the hips. Forty patients had cobalt levels less than 7 μg/L, and 33 had chromium levels less than 7 μg/L, but 8 of these had an ARMD on MRI and only minimal symptoms (Oxford Hip Score ≥ 44/48). The incidence of ARMD was significantly higher when chromium concentration was above 7 μg/L (P = .02), but normal metal ion levels can be misleading and metal artifact reduction MRI imaging is advised in all patients. Keywords: metal ion levels, MAR MRI, metal-on-metal, hip, arthroplasty.

The Journal of Arthroplasty, 2014

Accurate radiographic measurement of acetabular cup orientation is required in order to assess su... more Accurate radiographic measurement of acetabular cup orientation is required in order to assess susceptibility to impingement, dislocation, and edge loading wear. In this study, the accuracy and precision of a new radiographic cup orientation measurement system were assessed and compared to those of two commercially available systems. Two types of resurfacing hip prostheses and an uncemented prosthesis were assessed. Radiographic images of each prosthesis were created with the cup set at different, known angles of version and inclination in a measurement jig. The new system was the most accurate and precise and could repeatedly measure version and inclination to within a fraction of a degree. In addition it has a facility to distinguish cup retroversion from anteversion on anteroposterior radiographs.

International Journal of Gynecological Cancer, 2003

Ali ZA, Wimhurst JA, Ali AA, Tempest ME, Edwards DJ. Endometrial cancer metastasis presenting as ... more Ali ZA, Wimhurst JA, Ali AA, Tempest ME, Edwards DJ. Endometrial cancer metastasis presenting as a grossly swollen toe. Int J Gynecol Cancer 2003;13:909-911.

Injury, 2009

The purpose of this systematic review was to assess the literature evaluating the clinical and ra... more The purpose of this systematic review was to assess the literature evaluating the clinical and radiological outcomes following less invasive surgical stabilisation system (LISS) fixation of distal femoral fractures (AO 32/33). A review of EMBASE, Medline, CINAHL and AMED from their inception to November 2008, sources of grey literature and a pertinent hand search of specialist orthopaedic journals was undertaken. Twenty-one studies assessing 663 patients with 694 fractures were reviewed. The findings suggest that the LISS system may be an appropriate fixation method for the management of distal femoral fractures. However, there remains a high incidence of loss of reduction (n=134; 19%), delayed or non-union (n=40; 6%) and implant failure (n=38; 5%). On analysis, such complications were largely confined to articles published before 2005, therefore during the infancy of the widespread clinical application of this trauma system. On critical appraisal, the evidence-base remains limited by recruiting small, under-powered sample sizes and poorly accounting for confounding variables such as osteoporosis, diabetes, multi-trauma and fracture classification. Further study is required to assess the outcomes of LISS fixation in specific patient populations, and to compare the outcome of this fixation method to condylar plates and intrameduallary devices, to determine the optimal management strategy for this complex patient group.

Injury, 2005

The majority of midshaft clavicle fractures unite uneventfully. Although the indications for oper... more The majority of midshaft clavicle fractures unite uneventfully. Although the indications for operative intervention are limited and reported complication rates high, there are circumstances in which surgery is required. We describe a new, infraclavicular surgical approach to the clavicle used in a series of 89 patients over 9 years. Average time to union was 13.5 weeks. There was one case of deep infection and one of non-union, both of which resolved with further treatment. These results compare very favourably with previously published series and we submit that this operative approach allows safe management of an otherwise potentially hazardous procedure.

Injury, 2005

The effect of femoral neck-shaft angle and implant type on the accuracy of lag screw placement in... more The effect of femoral neck-shaft angle and implant type on the accuracy of lag screw placement in extra-capsular proximal femoral fracture fixation was investigated. Radiographs of all extra-capsular proximal femoral fractures seen in one unit over 18 months were reviewed. Of 399 cases, 307 (237 female, 70 male) were included in the study as they had no contra-lateral proximal femoral metal work. Femoral neck-shaft angle (NSA) of the uninjured hip and magnification adjusted tip-apex distance (TAD) of femoral head lag screw were measured. Type of fixation implant was 135 degrees classic hip screw (CHS) (n=144) or 130 degrees intra-medullary hip screw (IMHS) (n=163). Mean contra-lateral NSA was 130.2 degrees (112.9--148 degrees ) and 64 patients (58 female, 6 male) had a NSA &amp;amp;lt;125 degrees . Mean adjusted TAD was 18.7 mm (5.8--43.8mm) and 88.9% of cases had a TAD of less than 25 mm. TAD values were significantly greater using an IMHS if NSA was &amp;amp;lt;125 degrees than if NSA was &amp;amp;gt;125 degrees (p=0.028). This was not the case with the CHS. The use of the 130 degrees -IMHS in patients with a NSA &amp;amp;lt;125 degrees leads to poorer lag screw placement than if NSA &amp;amp;gt;125 degrees and caution is advocated when using this device in such cases.

Clinical Radiology, 2007

Plain films are the initial imaging method of choice for evaluation of hip arthroplasty. Recent a... more Plain films are the initial imaging method of choice for evaluation of hip arthroplasty. Recent advances in technology and imaging techniques have largely overcome the problems of beam hardening in computed tomography (CT) and magnetic susceptibility artefact in magnetic resonance imaging (MRI). CT and MRI have now become useful imaging techniques in the assessment of hip arthroplasty.