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Papers by Jamshid Jamshidi

Research paper thumbnail of Intracerebral Lipoma

Neurologia medico-chirurgica, 1986

Only four cases of intracranial lipoma confined to the sylvian fissure have so far been reported.... more Only four cases of intracranial lipoma confined to the sylvian fissure have so far been reported. In this paper we describe an intracerebral lipoma that apparently arose from the connective tissue of the syl vian fissure in a 31-year-old male. To our knowledge, no other case of this kind has been reported. We successfully excised the entire tumor, using microsurgical techniques. The patient developed a minor motor deficit postoperatively, but eventually fully recovered.

Research paper thumbnail of Central neurocytoma presenting with intratumoral hemorrhage

Neurosurgical Review, 2001

Research paper thumbnail of Does Craniopharyngioma Metastasize? Case Report and Review of the Literature

Neurosurgery, 2001

OBJECTIVE AND IMPORTANCE A rare case of recurrent craniopharyngioma at an ectopic location is des... more OBJECTIVE AND IMPORTANCE A rare case of recurrent craniopharyngioma at an ectopic location is described. This recurrence suggested cerebrospinal fluid seeding. CLINICAL PRESENTATION A 65-year-old man presented for follow-up of persisting visual field defect. He had undergone total resection of a suprasellar craniopharyngioma via a subfrontal approach 3 years before presentation. Recent magnetic resonance imaging scans revealed a contrast-enhancing tumor with cystic and solid components at the right temporal lobe. The primary tumor bed was intact. INTERVENTION A temporal craniotomy was performed for total resection of the tumor. Intraoperative findings revealed that the recurrent tumor was anatomically unrelated to the previous surgical track. Histological studies of the tumor specimen demonstrated a benign craniopharyngioma. Cerebrospinal fluid spreading was suspected to be the sole route for the recurrence. CONCLUSION The case presented here and a review of reports on remote recurr...

Research paper thumbnail of The quality of life and the care burden of family caregivers

Journal of Psychosomatic Research, 2003

Research paper thumbnail of Immunohistochemical study of metastatic brain tumors with astroprotein (GFAP), a glia-specific protein

Journal of Neurosurgery, 1985

✓ Tissues from 12 metastatic tumors of the brain were studied immunohistochemically with an antis... more ✓ Tissues from 12 metastatic tumors of the brain were studied immunohistochemically with an antiserum to a glia-specific protein, astroprotein (glial fibrillary acidic protein, GFAP). Emphasis was laid on demonstrating the tissue architecture of metastatic lesions incorporating brain-derived components (astrocytes and glial fibers). Of 12 samples, 11 manifested a number of irregular indentations at the tumor surface. These indentations, which contained astrocytic elements, extended into the tumor tissue in a tapering fashion. In seven cases, the deeper stromal portions of the tumor also contained astroprotein (GFAP)-positive elements. The presence of this glia-specific protein suggests that the stroma of the tumor tissue may in part be derived from preexisting brain tissue. This peculiar tissue architecture of the tumor supports the hypothesis that some of the blood vessels that are located in the stroma of the tumor tissue are also derived from the brain. These observations may be ...

Research paper thumbnail of Effects of glucocorticoid and chemotherapy on the peritumoral edema and astrocytic reaction in experimental brain tumor

Journal of Neuro-Oncology, 1992

To study the effects of glucocorticoids and chemotherapeutic agents on the pathophysiology of the... more To study the effects of glucocorticoids and chemotherapeutic agents on the pathophysiology of the tumorinduced brain edema, the site of Evans blue-albumin extravasation, the distribution of extravasated serum albumin, and the extent of local astrocytic reaction were examined in a rat model of implanted brain tumor. Experimental brain tumors were produced by implanting small pellets of Walker 256 carcinosarcoma into the cerebral cortex of Wistar rats. In the steroid group, rats were administered with intraperitoneal methylprednisolone succinate (15 mg/kg) daily on and after the 6th day postimplantation, and sacrificed on the 14th day. In the chemotherapy group, rats were given an intravenous injection of cyclophosphamide (30 mg/kg) on the 14th day, and sacrificed on the 21st day. Rats in the untreated group were sacrificed on the 14th day without any therapy. Each animal was sacrificed by the transcardiac perfusion with paraformaldehyde 30 rain after intravenous injection of Evans blue. Firstly, coronal blocks of the brain were examined for Evans blue staining macroscopically. Paraffin embedded sections were studied for the Evans blue fluorescence and for the immunohistochemical reaction to serum albumin and GFAP. The examination of Evans blue demonstrated that the origin of extravasation of serum albumin was the tumor and the adjacent brain with dense tumor cell infiltration in any group of rats. The extravasated serum albumin distributed widely and the astrocytic reaction was prominent in the brain of the untreated group. A positive correlation was observed between the intensity of albumin immunoreaction and the degree of astrocytic proliferation. Chemotherapy effectively decreased the size of tumor and reduced the extravasation of serum albumin. The astrocytic reaction was however, not reduced. In the steroid group, the size of tumor was not significantly affected but the albumin extravasation as well as astrocytic reaction was markedly reduced. It was concluded that glucocorticoid is an effective drug against tumor-induced brain edema, which not only reduces the extravasation of serum components but also prevents histologic alterations of the brain.

Research paper thumbnail of Pathology of brain parenchyna in meningeal carcinomatosis; Immunohistochemical study with astroprotein (GFAP) and tubulin

Journal of Neuro-Oncology, 1987

Effects of leptomeningeal tumor on the brain parenchyma was studied by the immunohistochemical me... more Effects of leptomeningeal tumor on the brain parenchyma was studied by the immunohistochemical method with astroprotein (GFAP) and tubulin in a rat model of meningeal carcinomatosis. Thickening of subpial glial lining (external glial layer) and hypertrophy of subpial astrocytes, detected by the antiserum to GFAP, was the early sign of parenchymal involvement. The glial lining was continuous as far as the tumor cells were confined to the subarachnoid space, however, penetration of tumor cells into subpial brain was associated with disruption of the glial lining. Speculative role of this lining in preventing the tumor cell to infiltrate into brain tissue was discussed. In contrast to the prominent immunohistochemical changes in astrocytes, neuronal tubulin immunoreactivity was not altered even in the late stage of the disease. The present study demonstrated that the leptomeningeal dissemination of tumor cells did cause pathologic change in brain parenchyma as was evidenced by the reactive change of astrocytes. However, the preserved immunoreaction for tubulin suggested that the nerve cell damage was not severe even at the advanced stage of the disease.

Research paper thumbnail of Intracerebral Lipoma

Neurologia medico-chirurgica, 1986

Only four cases of intracranial lipoma confined to the sylvian fissure have so far been reported.... more Only four cases of intracranial lipoma confined to the sylvian fissure have so far been reported. In this paper we describe an intracerebral lipoma that apparently arose from the connective tissue of the syl vian fissure in a 31-year-old male. To our knowledge, no other case of this kind has been reported. We successfully excised the entire tumor, using microsurgical techniques. The patient developed a minor motor deficit postoperatively, but eventually fully recovered.

Research paper thumbnail of Central neurocytoma presenting with intratumoral hemorrhage

Neurosurgical Review, 2001

Research paper thumbnail of Does Craniopharyngioma Metastasize? Case Report and Review of the Literature

Neurosurgery, 2001

OBJECTIVE AND IMPORTANCE A rare case of recurrent craniopharyngioma at an ectopic location is des... more OBJECTIVE AND IMPORTANCE A rare case of recurrent craniopharyngioma at an ectopic location is described. This recurrence suggested cerebrospinal fluid seeding. CLINICAL PRESENTATION A 65-year-old man presented for follow-up of persisting visual field defect. He had undergone total resection of a suprasellar craniopharyngioma via a subfrontal approach 3 years before presentation. Recent magnetic resonance imaging scans revealed a contrast-enhancing tumor with cystic and solid components at the right temporal lobe. The primary tumor bed was intact. INTERVENTION A temporal craniotomy was performed for total resection of the tumor. Intraoperative findings revealed that the recurrent tumor was anatomically unrelated to the previous surgical track. Histological studies of the tumor specimen demonstrated a benign craniopharyngioma. Cerebrospinal fluid spreading was suspected to be the sole route for the recurrence. CONCLUSION The case presented here and a review of reports on remote recurr...

Research paper thumbnail of The quality of life and the care burden of family caregivers

Journal of Psychosomatic Research, 2003

Research paper thumbnail of Immunohistochemical study of metastatic brain tumors with astroprotein (GFAP), a glia-specific protein

Journal of Neurosurgery, 1985

✓ Tissues from 12 metastatic tumors of the brain were studied immunohistochemically with an antis... more ✓ Tissues from 12 metastatic tumors of the brain were studied immunohistochemically with an antiserum to a glia-specific protein, astroprotein (glial fibrillary acidic protein, GFAP). Emphasis was laid on demonstrating the tissue architecture of metastatic lesions incorporating brain-derived components (astrocytes and glial fibers). Of 12 samples, 11 manifested a number of irregular indentations at the tumor surface. These indentations, which contained astrocytic elements, extended into the tumor tissue in a tapering fashion. In seven cases, the deeper stromal portions of the tumor also contained astroprotein (GFAP)-positive elements. The presence of this glia-specific protein suggests that the stroma of the tumor tissue may in part be derived from preexisting brain tissue. This peculiar tissue architecture of the tumor supports the hypothesis that some of the blood vessels that are located in the stroma of the tumor tissue are also derived from the brain. These observations may be ...

Research paper thumbnail of Effects of glucocorticoid and chemotherapy on the peritumoral edema and astrocytic reaction in experimental brain tumor

Journal of Neuro-Oncology, 1992

To study the effects of glucocorticoids and chemotherapeutic agents on the pathophysiology of the... more To study the effects of glucocorticoids and chemotherapeutic agents on the pathophysiology of the tumorinduced brain edema, the site of Evans blue-albumin extravasation, the distribution of extravasated serum albumin, and the extent of local astrocytic reaction were examined in a rat model of implanted brain tumor. Experimental brain tumors were produced by implanting small pellets of Walker 256 carcinosarcoma into the cerebral cortex of Wistar rats. In the steroid group, rats were administered with intraperitoneal methylprednisolone succinate (15 mg/kg) daily on and after the 6th day postimplantation, and sacrificed on the 14th day. In the chemotherapy group, rats were given an intravenous injection of cyclophosphamide (30 mg/kg) on the 14th day, and sacrificed on the 21st day. Rats in the untreated group were sacrificed on the 14th day without any therapy. Each animal was sacrificed by the transcardiac perfusion with paraformaldehyde 30 rain after intravenous injection of Evans blue. Firstly, coronal blocks of the brain were examined for Evans blue staining macroscopically. Paraffin embedded sections were studied for the Evans blue fluorescence and for the immunohistochemical reaction to serum albumin and GFAP. The examination of Evans blue demonstrated that the origin of extravasation of serum albumin was the tumor and the adjacent brain with dense tumor cell infiltration in any group of rats. The extravasated serum albumin distributed widely and the astrocytic reaction was prominent in the brain of the untreated group. A positive correlation was observed between the intensity of albumin immunoreaction and the degree of astrocytic proliferation. Chemotherapy effectively decreased the size of tumor and reduced the extravasation of serum albumin. The astrocytic reaction was however, not reduced. In the steroid group, the size of tumor was not significantly affected but the albumin extravasation as well as astrocytic reaction was markedly reduced. It was concluded that glucocorticoid is an effective drug against tumor-induced brain edema, which not only reduces the extravasation of serum components but also prevents histologic alterations of the brain.

Research paper thumbnail of Pathology of brain parenchyna in meningeal carcinomatosis; Immunohistochemical study with astroprotein (GFAP) and tubulin

Journal of Neuro-Oncology, 1987

Effects of leptomeningeal tumor on the brain parenchyma was studied by the immunohistochemical me... more Effects of leptomeningeal tumor on the brain parenchyma was studied by the immunohistochemical method with astroprotein (GFAP) and tubulin in a rat model of meningeal carcinomatosis. Thickening of subpial glial lining (external glial layer) and hypertrophy of subpial astrocytes, detected by the antiserum to GFAP, was the early sign of parenchymal involvement. The glial lining was continuous as far as the tumor cells were confined to the subarachnoid space, however, penetration of tumor cells into subpial brain was associated with disruption of the glial lining. Speculative role of this lining in preventing the tumor cell to infiltrate into brain tissue was discussed. In contrast to the prominent immunohistochemical changes in astrocytes, neuronal tubulin immunoreactivity was not altered even in the late stage of the disease. The present study demonstrated that the leptomeningeal dissemination of tumor cells did cause pathologic change in brain parenchyma as was evidenced by the reactive change of astrocytes. However, the preserved immunoreaction for tubulin suggested that the nerve cell damage was not severe even at the advanced stage of the disease.