Jan Mos - Academia.edu (original) (raw)
Papers by Jan Mos
Aggressive Behavior, 1989
Progress in clinical and biological research, 1984
European Neuropsychopharmacology, 1996
Dit rapport brengt verslag uit van vier jaar Strategisch Onderzoek RIVM (SOR), het eigen onderzoe... more Dit rapport brengt verslag uit van vier jaar Strategisch Onderzoek RIVM (SOR), het eigen onderzoeksbudget van het RIVM. Het SOR-budget is bedoeld voor onderzoek om het RIVM te voorzien van de benodigde expertise en kwaliteit, zodat het nu en in de toekomst taken voor opdrachtgevers adequaat kan uitvoeren. Het rapport geeft de inhoudelijke resultaten en toepassingsmogelijkheden weer van alle projecten over de periode 2007-2010. In totaal zijn in de onderzoeksperiode 86 projecten uitgevoerd, onderverdeeld in 6 strategische thema's. Ongeveer een derde deel van de projecten loopt nog door na 2011; de voorlopige resultaten van de lopende projecten zijn hier vermeld. De resultaten van dit SOR-programma bestaan uit een schat aan nieuw instrumentarium, nieuwe data en kennis, en verbetering van bestaand instrumentarium en bestaande kennis op het gebied van volksgezondheid en milieu. Deze resultaten dragen in belangrijke mate bij aan de uitvoering van de huidige kerntaken van het RIVM. Da...
Topics in the Neurosciences, 1987
Over the last fifteen years several hypotheses have emerged concerning the neurochemical control ... more Over the last fifteen years several hypotheses have emerged concerning the neurochemical control of aggressive behaviour. A variety of single neurotransmitters were suggested to control. aggression e.g. the “aggressive monoamines” (Eichelman and Thoa 973), acetylcholine (Smith et a1. 1970) and serotonin (Valzelli and Garattini 1968). Later, the theories of single neurotransmitter control were extended to multi-transmitter modulation of aggressive behaviour (Avis 1974; Daruna 1978; Pradhan 1915; Reis 1974).
Drug Development Research, 1992
ABSTRACT
Behavioural Pharmacology, 1992
Clinical Neuropharmacology, 1992
The Development of Sex Differences and Similarities in Behavior, 1993
The scope of this chapter is to compare the differences and similarities of the neuropharmacology... more The scope of this chapter is to compare the differences and similarities of the neuropharmacology of male and female aggression in rats. Unfortunately such a task is far from easy because aggression research in the realm of neuropharmacology has mainly focussed on males, notably in rodents. The reasons for this choice are obvious and valid. With some exceptions, under many circumstances males are more aggressive than females. However, the generality of our conclusions ana our knowledge on brain-behavior relationships is severily limited by this bias to study male aggression. In contrast to the more etho-ecologically oriented studies, in most psycho-pharmacological experiments there is no emphasis on the function of the observed behavior, which may profoundly differ in males and females. Indeed the adaptive or survival value of aggression in rodents housed under laboratory conditions can only be extrapolated from their feral counterparts. However, to study the neuropharmacological organization under more ecologically relevant conditions is not very practical, not to say impossible. We therefore have to rely on extrapolations from the laboratory situation to more naturalistic situations and vice versa. A comparison of the neuropharmacology of male and female aggression is interesting for different reasons. First, it is important to understand the regulation of aggression within different genders of the same species where internal and external factors evoking aggression may differ profoundly. Is the basic neuropharmacology similar despite the diversity in the other regulatory mechanisms? Second, it is of interest to know whether drugs that modulate aggression in males are equally effective and selective in both sexes. Our work was to a large extent governed by the latter interest. Since we have discovered and developed drugs that exert unique anti-aggressive actions in animals, we wanted to know whether these drugs could be equally useful for treating (pathological) aggression in males and females. 205
Serotonin (5-hydroxytryptamine; 5-HT) has for some time been implicated in the control of aggress... more Serotonin (5-hydroxytryptamine; 5-HT) has for some time been implicated in the control of aggression. Early work on 5-HT and aggression indicated that general 5-HT activation decreased aggression, whereas an overall inactivation of 5-HT by various means enhanced it (Valzelli, 1981).
The Biology of Aggression, 1981
ABSTRACT The aggressive responses during electrical stimulation in the hypothalamus may or may no... more ABSTRACT The aggressive responses during electrical stimulation in the hypothalamus may or may not derive from activation of a neural system especially subservient to aggression, for we do not know which neuronal elements mediate such effects. In order to identify these neurons one can try to define their location and to trace their anatomical connections. In addition it appears possible to estimate the physiological properties of the network involved, by threshold-intensity measurements at different preset parameters of the stimulating current. Such measurements may then provide a basis for comparison of the networks involved in stimulation-induced aggression and the networks involved in concomitant behavioral responses.
Animal models for psychiatric disorders should ideally fullfil the following criteria: the behavi... more Animal models for psychiatric disorders should ideally fullfil the following criteria: the behavioural abnormalities should be measurable in an appropriate context and the neurobiological causes for this deviant behaviour should be known. In case these criteria are met, these models might be called homologous, in a similar way as for instance used in functional morphology. It is clear that these conditions are not met by the current models for aggressive behaviour in animals.
Pharmacochemistry Library
Publisher Summary 5-HT 1A receptor agonists have been tested in a wide variety of animal models i... more Publisher Summary 5-HT 1A receptor agonists have been tested in a wide variety of animal models indicative of CNS functions. These range from models for motion sickness and emesis to models predictive for antipsychotic drugs. In most of these tests, 5-HT 1A receptor agonists appear to be active, although the degree of specificity varies. 5-HT 1A receptor agonists influence the total serotonin neurotransmission by acting on the somatodendritic autoreceptor as well as by acting on postsynaptic receptors. From many behavioral effects of 5-HT 1A receptor agonists, the precise molecular mechanism of action remains elusive and it is quite conceivable that similar behavioral effects can be induced by various manipulations of the serotonin neurotransmission.
Ethoexperimental Approaches to the Study of Behavior, 1989
Medical Science Symposia Series, 1993
Animal paradigms are important to detect anxiolytic properties of psychoactive compounds. Two ani... more Animal paradigms are important to detect anxiolytic properties of psychoactive compounds. Two animal anxiety paradigms are presented, ultrasonic distress vocalizations (USV) in rat pups and stress-induced hyperthermia (SIH) in mice, to describe the putative anxiolytic properties of serotonergic ligands. Both paradigms indicate that 5-HTAreceptor agonists are potent anxiolytics, whereas specific 5-HT reuptake blockers also exert some anxiolytic properties. 5-HT02antagonists may have some anxiogenic properties (in USV), whereas 5-HT, antagonists seem to be devoid of anxiolytic properties in the paradigms used.
Topics in the Neurosciences, 1987
The benzodiazepines (BDZ) are known for a wide variety of pharmacological effects, among which an... more The benzodiazepines (BDZ) are known for a wide variety of pharmacological effects, among which anxiolytic, hypnotic, sedatory, muscle relaxing and anticonvulsant actions are the most prominent. Much progress has been made in the elucidation of their mechanism of action by the discovery and characterization of high affinity binding sites for BDZ in the brain. However, not all complex behavioural actions are completely explained by the concepts derived from receptor binding. One such behavioural response is the intriguing question of the pro-aggressive action of low doses of benzodiazepines.
Aggressive Behavior, 1989
Progress in clinical and biological research, 1984
European Neuropsychopharmacology, 1996
Dit rapport brengt verslag uit van vier jaar Strategisch Onderzoek RIVM (SOR), het eigen onderzoe... more Dit rapport brengt verslag uit van vier jaar Strategisch Onderzoek RIVM (SOR), het eigen onderzoeksbudget van het RIVM. Het SOR-budget is bedoeld voor onderzoek om het RIVM te voorzien van de benodigde expertise en kwaliteit, zodat het nu en in de toekomst taken voor opdrachtgevers adequaat kan uitvoeren. Het rapport geeft de inhoudelijke resultaten en toepassingsmogelijkheden weer van alle projecten over de periode 2007-2010. In totaal zijn in de onderzoeksperiode 86 projecten uitgevoerd, onderverdeeld in 6 strategische thema's. Ongeveer een derde deel van de projecten loopt nog door na 2011; de voorlopige resultaten van de lopende projecten zijn hier vermeld. De resultaten van dit SOR-programma bestaan uit een schat aan nieuw instrumentarium, nieuwe data en kennis, en verbetering van bestaand instrumentarium en bestaande kennis op het gebied van volksgezondheid en milieu. Deze resultaten dragen in belangrijke mate bij aan de uitvoering van de huidige kerntaken van het RIVM. Da...
Topics in the Neurosciences, 1987
Over the last fifteen years several hypotheses have emerged concerning the neurochemical control ... more Over the last fifteen years several hypotheses have emerged concerning the neurochemical control of aggressive behaviour. A variety of single neurotransmitters were suggested to control. aggression e.g. the “aggressive monoamines” (Eichelman and Thoa 973), acetylcholine (Smith et a1. 1970) and serotonin (Valzelli and Garattini 1968). Later, the theories of single neurotransmitter control were extended to multi-transmitter modulation of aggressive behaviour (Avis 1974; Daruna 1978; Pradhan 1915; Reis 1974).
Drug Development Research, 1992
ABSTRACT
Behavioural Pharmacology, 1992
Clinical Neuropharmacology, 1992
The Development of Sex Differences and Similarities in Behavior, 1993
The scope of this chapter is to compare the differences and similarities of the neuropharmacology... more The scope of this chapter is to compare the differences and similarities of the neuropharmacology of male and female aggression in rats. Unfortunately such a task is far from easy because aggression research in the realm of neuropharmacology has mainly focussed on males, notably in rodents. The reasons for this choice are obvious and valid. With some exceptions, under many circumstances males are more aggressive than females. However, the generality of our conclusions ana our knowledge on brain-behavior relationships is severily limited by this bias to study male aggression. In contrast to the more etho-ecologically oriented studies, in most psycho-pharmacological experiments there is no emphasis on the function of the observed behavior, which may profoundly differ in males and females. Indeed the adaptive or survival value of aggression in rodents housed under laboratory conditions can only be extrapolated from their feral counterparts. However, to study the neuropharmacological organization under more ecologically relevant conditions is not very practical, not to say impossible. We therefore have to rely on extrapolations from the laboratory situation to more naturalistic situations and vice versa. A comparison of the neuropharmacology of male and female aggression is interesting for different reasons. First, it is important to understand the regulation of aggression within different genders of the same species where internal and external factors evoking aggression may differ profoundly. Is the basic neuropharmacology similar despite the diversity in the other regulatory mechanisms? Second, it is of interest to know whether drugs that modulate aggression in males are equally effective and selective in both sexes. Our work was to a large extent governed by the latter interest. Since we have discovered and developed drugs that exert unique anti-aggressive actions in animals, we wanted to know whether these drugs could be equally useful for treating (pathological) aggression in males and females. 205
Serotonin (5-hydroxytryptamine; 5-HT) has for some time been implicated in the control of aggress... more Serotonin (5-hydroxytryptamine; 5-HT) has for some time been implicated in the control of aggression. Early work on 5-HT and aggression indicated that general 5-HT activation decreased aggression, whereas an overall inactivation of 5-HT by various means enhanced it (Valzelli, 1981).
The Biology of Aggression, 1981
ABSTRACT The aggressive responses during electrical stimulation in the hypothalamus may or may no... more ABSTRACT The aggressive responses during electrical stimulation in the hypothalamus may or may not derive from activation of a neural system especially subservient to aggression, for we do not know which neuronal elements mediate such effects. In order to identify these neurons one can try to define their location and to trace their anatomical connections. In addition it appears possible to estimate the physiological properties of the network involved, by threshold-intensity measurements at different preset parameters of the stimulating current. Such measurements may then provide a basis for comparison of the networks involved in stimulation-induced aggression and the networks involved in concomitant behavioral responses.
Animal models for psychiatric disorders should ideally fullfil the following criteria: the behavi... more Animal models for psychiatric disorders should ideally fullfil the following criteria: the behavioural abnormalities should be measurable in an appropriate context and the neurobiological causes for this deviant behaviour should be known. In case these criteria are met, these models might be called homologous, in a similar way as for instance used in functional morphology. It is clear that these conditions are not met by the current models for aggressive behaviour in animals.
Pharmacochemistry Library
Publisher Summary 5-HT 1A receptor agonists have been tested in a wide variety of animal models i... more Publisher Summary 5-HT 1A receptor agonists have been tested in a wide variety of animal models indicative of CNS functions. These range from models for motion sickness and emesis to models predictive for antipsychotic drugs. In most of these tests, 5-HT 1A receptor agonists appear to be active, although the degree of specificity varies. 5-HT 1A receptor agonists influence the total serotonin neurotransmission by acting on the somatodendritic autoreceptor as well as by acting on postsynaptic receptors. From many behavioral effects of 5-HT 1A receptor agonists, the precise molecular mechanism of action remains elusive and it is quite conceivable that similar behavioral effects can be induced by various manipulations of the serotonin neurotransmission.
Ethoexperimental Approaches to the Study of Behavior, 1989
Medical Science Symposia Series, 1993
Animal paradigms are important to detect anxiolytic properties of psychoactive compounds. Two ani... more Animal paradigms are important to detect anxiolytic properties of psychoactive compounds. Two animal anxiety paradigms are presented, ultrasonic distress vocalizations (USV) in rat pups and stress-induced hyperthermia (SIH) in mice, to describe the putative anxiolytic properties of serotonergic ligands. Both paradigms indicate that 5-HTAreceptor agonists are potent anxiolytics, whereas specific 5-HT reuptake blockers also exert some anxiolytic properties. 5-HT02antagonists may have some anxiogenic properties (in USV), whereas 5-HT, antagonists seem to be devoid of anxiolytic properties in the paradigms used.
Topics in the Neurosciences, 1987
The benzodiazepines (BDZ) are known for a wide variety of pharmacological effects, among which an... more The benzodiazepines (BDZ) are known for a wide variety of pharmacological effects, among which anxiolytic, hypnotic, sedatory, muscle relaxing and anticonvulsant actions are the most prominent. Much progress has been made in the elucidation of their mechanism of action by the discovery and characterization of high affinity binding sites for BDZ in the brain. However, not all complex behavioural actions are completely explained by the concepts derived from receptor binding. One such behavioural response is the intriguing question of the pro-aggressive action of low doses of benzodiazepines.